WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q283_LEIMA

TriTrypDb:

LmjF.34.4580 , LMJLV39_340050700 , LMJSD75_340051200

Length:

325

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q283

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q283

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	303	307	PF00656	0.357
CLV_NRD_NRD_1	101	103	PF00675	0.433
CLV_PCSK_KEX2_1	101	103	PF00082	0.547
CLV_PCSK_SKI1_1	123	127	PF00082	0.402
CLV_PCSK_SKI1_1	169	173	PF00082	0.470
CLV_PCSK_SKI1_1	292	296	PF00082	0.405
CLV_PCSK_SKI1_1	56	60	PF00082	0.566
DEG_SPOP_SBC_1	212	216	PF00917	0.301
DOC_MAPK_gen_1	194	202	PF00069	0.411
DOC_MAPK_HePTP_8	311	323	PF00069	0.458
DOC_MAPK_MEF2A_6	314	323	PF00069	0.463
DOC_PP2B_LxvP_1	59	62	PF13499	0.398
DOC_USP7_MATH_1	175	179	PF00917	0.444
DOC_USP7_MATH_1	192	196	PF00917	0.287
DOC_USP7_MATH_1	211	215	PF00917	0.509
DOC_WW_Pin1_4	116	121	PF00397	0.395
DOC_WW_Pin1_4	139	144	PF00397	0.522
DOC_WW_Pin1_4	180	185	PF00397	0.427
DOC_WW_Pin1_4	20	25	PF00397	0.329
DOC_WW_Pin1_4	219	224	PF00397	0.496
DOC_WW_Pin1_4	272	277	PF00397	0.445
DOC_WW_Pin1_4	295	300	PF00397	0.476
LIG_14-3-3_CanoR_1	164	169	PF00244	0.337
LIG_BIR_II_1	1	5	PF00653	0.471
LIG_BRCT_BRCA1_1	166	170	PF00533	0.329
LIG_CtBP_PxDLS_1	299	303	PF00389	0.469
LIG_DLG_GKlike_1	164	171	PF00625	0.313
LIG_FHA_1	146	152	PF00498	0.461
LIG_FHA_1	160	166	PF00498	0.311
LIG_FHA_1	213	219	PF00498	0.391
LIG_FHA_1	224	230	PF00498	0.317
LIG_FHA_1	234	240	PF00498	0.487
LIG_FHA_1	24	30	PF00498	0.419
LIG_FHA_1	5	11	PF00498	0.493
LIG_FHA_2	301	307	PF00498	0.346
LIG_LIR_Apic_2	178	184	PF02991	0.409
LIG_LIR_Gen_1	45	54	PF02991	0.382
LIG_LIR_Gen_1	57	66	PF02991	0.407
LIG_LIR_Gen_1	7	13	PF02991	0.555
LIG_LIR_Nem_3	45	49	PF02991	0.354
LIG_LIR_Nem_3	57	61	PF02991	0.387
LIG_LIR_Nem_3	7	11	PF02991	0.434
LIG_Pex14_2	166	170	PF04695	0.322
LIG_Rb_pABgroove_1	131	139	PF01858	0.479
LIG_SH2_STAP1	137	141	PF00017	0.484
LIG_SH3_3	217	223	PF00018	0.492
LIG_SH3_3	271	277	PF00018	0.350
LIG_SUMO_SIM_anti_2	112	117	PF11976	0.354
LIG_SUMO_SIM_anti_2	214	222	PF11976	0.528
LIG_SUMO_SIM_anti_2	278	283	PF11976	0.428
LIG_SUMO_SIM_par_1	114	119	PF11976	0.397
LIG_SUMO_SIM_par_1	214	222	PF11976	0.507
LIG_TRAF2_2	184	189	PF00917	0.330
MOD_CDK_SPK_2	219	224	PF00069	0.486
MOD_CDK_SPxxK_3	116	123	PF00069	0.455
MOD_CDK_SPxxK_3	20	27	PF00069	0.349
MOD_CK1_1	139	145	PF00069	0.484
MOD_CK1_1	222	228	PF00069	0.472
MOD_CK1_1	23	29	PF00069	0.449
MOD_CK1_1	275	281	PF00069	0.477
MOD_GlcNHglycan	120	123	PF01048	0.493
MOD_GlcNHglycan	177	180	PF01048	0.302
MOD_GlcNHglycan	285	288	PF01048	0.406
MOD_GSK3_1	219	226	PF00069	0.411
MOD_N-GLC_1	300	305	PF02516	0.428
MOD_NEK2_1	319	324	PF00069	0.386
MOD_NEK2_1	79	84	PF00069	0.344
MOD_PIKK_1	18	24	PF00454	0.499
MOD_PIKK_1	246	252	PF00454	0.513
MOD_PK_1	305	311	PF00069	0.349
MOD_Plk_1	300	306	PF00069	0.423
MOD_Plk_1	96	102	PF00069	0.501
MOD_Plk_4	213	219	PF00069	0.383
MOD_Plk_4	275	281	PF00069	0.448
MOD_Plk_4	305	311	PF00069	0.472
MOD_ProDKin_1	116	122	PF00069	0.392
MOD_ProDKin_1	139	145	PF00069	0.520
MOD_ProDKin_1	180	186	PF00069	0.422
MOD_ProDKin_1	20	26	PF00069	0.334
MOD_ProDKin_1	219	225	PF00069	0.504
MOD_ProDKin_1	272	278	PF00069	0.440
MOD_ProDKin_1	295	301	PF00069	0.469
MOD_SUMO_rev_2	21	29	PF00179	0.377
TRG_ENDOCYTIC_2	8	11	PF00928	0.354
TRG_ER_diArg_1	100	102	PF00400	0.524
TRG_Pf-PMV_PEXEL_1	169	173	PF00026	0.477
TRG_Pf-PMV_PEXEL_1	238	242	PF00026	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGS3	Leptomonas seymouri	56%	100%
A0A0S4IPM9	Bodo saltans	36%	96%
A0A0S4IXK3	Bodo saltans	28%	87%
A0A0S4JA66	Bodo saltans	24%	99%
A0A1X0PB94	Trypanosomatidae	39%	96%
A0A3R7RJK1	Trypanosoma rangeli	37%	97%
A0A3S7X8N9	Leishmania donovani	95%	100%
A4HBG4	Leishmania braziliensis	74%	100%
A4IAL0	Leishmania infantum	94%	100%
C9ZLN0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	98%
E9B5N5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
V5BRD1	Trypanosoma cruzi	37%	97%