LeishMANIAdb
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C2H2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
C2H2-type domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4Q282_LEIMA
TriTrypDb:
LmjF.34.4590 , LMJLV39_340050900 * , LMJSD75_340051400
Length:
358

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q282
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q282

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 115 117 PF00675 0.517
CLV_NRD_NRD_1 24 26 PF00675 0.630
CLV_NRD_NRD_1 50 52 PF00675 0.667
CLV_PCSK_KEX2_1 115 117 PF00082 0.490
CLV_PCSK_KEX2_1 24 26 PF00082 0.630
CLV_PCSK_KEX2_1 242 244 PF00082 0.649
CLV_PCSK_KEX2_1 52 54 PF00082 0.689
CLV_PCSK_PC1ET2_1 242 244 PF00082 0.649
CLV_PCSK_PC1ET2_1 52 54 PF00082 0.707
CLV_PCSK_SKI1_1 189 193 PF00082 0.569
CLV_PCSK_SKI1_1 24 28 PF00082 0.548
CLV_PCSK_SKI1_1 334 338 PF00082 0.514
CLV_PCSK_SKI1_1 40 44 PF00082 0.625
DEG_APCC_DBOX_1 167 175 PF00400 0.502
DEG_APCC_DBOX_1 39 47 PF00400 0.606
DOC_CKS1_1 46 51 PF01111 0.606
DOC_CYCLIN_RxL_1 21 30 PF00134 0.424
DOC_CYCLIN_RxL_1 331 339 PF00134 0.510
DOC_MAPK_DCC_7 232 241 PF00069 0.649
DOC_MAPK_DCC_7 242 250 PF00069 0.452
DOC_MAPK_gen_1 21 29 PF00069 0.617
DOC_MAPK_gen_1 242 250 PF00069 0.617
DOC_PP2B_LxvP_1 99 102 PF13499 0.440
DOC_USP7_UBL2_3 352 356 PF12436 0.582
DOC_WW_Pin1_4 120 125 PF00397 0.471
DOC_WW_Pin1_4 173 178 PF00397 0.576
DOC_WW_Pin1_4 209 214 PF00397 0.658
DOC_WW_Pin1_4 234 239 PF00397 0.621
DOC_WW_Pin1_4 45 50 PF00397 0.593
LIG_14-3-3_CanoR_1 196 206 PF00244 0.587
LIG_14-3-3_CanoR_1 227 236 PF00244 0.581
LIG_14-3-3_CanoR_1 53 59 PF00244 0.762
LIG_14-3-3_CanoR_1 77 86 PF00244 0.580
LIG_Actin_WH2_2 306 321 PF00022 0.623
LIG_BIR_II_1 1 5 PF00653 0.714
LIG_BRCT_BRCA1_1 137 141 PF00533 0.437
LIG_Clathr_ClatBox_1 26 30 PF01394 0.423
LIG_FHA_1 231 237 PF00498 0.663
LIG_FHA_1 3 9 PF00498 0.472
LIG_FHA_1 31 37 PF00498 0.630
LIG_FHA_1 55 61 PF00498 0.717
LIG_FHA_2 121 127 PF00498 0.527
LIG_LIR_Gen_1 105 114 PF02991 0.447
LIG_LIR_Gen_1 123 131 PF02991 0.513
LIG_LIR_Gen_1 215 225 PF02991 0.485
LIG_LIR_Nem_3 105 110 PF02991 0.473
LIG_LIR_Nem_3 121 125 PF02991 0.538
LIG_LIR_Nem_3 126 131 PF02991 0.500
LIG_LIR_Nem_3 159 163 PF02991 0.494
LIG_LIR_Nem_3 215 221 PF02991 0.492
LIG_NRBOX 201 207 PF00104 0.528
LIG_NRBOX 22 28 PF00104 0.591
LIG_NRBOX 263 269 PF00104 0.615
LIG_RPA_C_Fungi 191 203 PF08784 0.569
LIG_SH2_SRC 347 350 PF00017 0.601
LIG_SH2_STAT5 152 155 PF00017 0.615
LIG_SH2_STAT5 240 243 PF00017 0.489
LIG_SH2_STAT5 7 10 PF00017 0.534
LIG_SH3_3 171 177 PF00018 0.536
LIG_SH3_3 207 213 PF00018 0.584
LIG_SUMO_SIM_par_1 25 30 PF11976 0.660
LIG_UBA3_1 345 352 PF00899 0.529
MOD_CDK_SPxK_1 45 51 PF00069 0.600
MOD_CDK_SPxxK_3 209 216 PF00069 0.656
MOD_CDK_SPxxK_3 45 52 PF00069 0.606
MOD_CK1_1 2 8 PF00069 0.566
MOD_CK1_1 230 236 PF00069 0.590
MOD_CK2_1 120 126 PF00069 0.532
MOD_GlcNHglycan 8 11 PF01048 0.545
MOD_GSK3_1 197 204 PF00069 0.635
MOD_GSK3_1 2 9 PF00069 0.558
MOD_GSK3_1 226 233 PF00069 0.659
MOD_N-GLC_1 269 274 PF02516 0.698
MOD_N-GLC_1 30 35 PF02516 0.419
MOD_N-GLC_2 15 17 PF02516 0.508
MOD_NEK2_1 197 202 PF00069 0.505
MOD_NEK2_1 271 276 PF00069 0.690
MOD_NEK2_1 298 303 PF00069 0.624
MOD_NEK2_1 318 323 PF00069 0.335
MOD_NEK2_1 336 341 PF00069 0.507
MOD_PIKK_1 197 203 PF00454 0.531
MOD_PKA_1 54 60 PF00069 0.776
MOD_PKA_2 195 201 PF00069 0.593
MOD_PKA_2 226 232 PF00069 0.622
MOD_PKA_2 318 324 PF00069 0.660
MOD_PKA_2 54 60 PF00069 0.730
MOD_PKA_2 76 82 PF00069 0.612
MOD_PKB_1 75 83 PF00069 0.616
MOD_Plk_1 269 275 PF00069 0.689
MOD_Plk_4 201 207 PF00069 0.630
MOD_Plk_4 32 38 PF00069 0.660
MOD_ProDKin_1 120 126 PF00069 0.473
MOD_ProDKin_1 173 179 PF00069 0.578
MOD_ProDKin_1 209 215 PF00069 0.664
MOD_ProDKin_1 234 240 PF00069 0.613
MOD_ProDKin_1 45 51 PF00069 0.600
MOD_SUMO_for_1 241 244 PF00179 0.633
TRG_DiLeu_BaEn_1 32 37 PF01217 0.657
TRG_DiLeu_BaLyEn_6 22 27 PF01217 0.425
TRG_ENDOCYTIC_2 125 128 PF00928 0.498
TRG_ENDOCYTIC_2 131 134 PF00928 0.478
TRG_ENDOCYTIC_2 261 264 PF00928 0.523
TRG_ER_diArg_1 114 116 PF00400 0.494
TRG_ER_diArg_1 167 170 PF00400 0.490
TRG_ER_diArg_1 184 187 PF00400 0.565
TRG_ER_diArg_1 23 25 PF00400 0.620
TRG_ER_diArg_1 75 78 PF00400 0.645
TRG_NLS_MonoCore_2 50 55 PF00514 0.767
TRG_NLS_MonoExtC_3 50 55 PF00514 0.704
TRG_NLS_MonoExtN_4 49 56 PF00514 0.802
TRG_Pf-PMV_PEXEL_1 25 30 PF00026 0.638
TRG_Pf-PMV_PEXEL_1 293 297 PF00026 0.503
TRG_Pf-PMV_PEXEL_1 300 305 PF00026 0.525

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HRX1 Leptomonas seymouri 45% 100%
A0A3Q8ILM5 Leishmania donovani 90% 100%
A4HBG5 Leishmania braziliensis 75% 100%
A4IAL1 Leishmania infantum 90% 100%
E9B5N6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS