Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q280_LEIMA

TriTrypDb:

LmjF.34.4610 , LMJLV39_340051100 , LMJSD75_340051600

Length:

555

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q280

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q280

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	30	34	PF00656	0.550
CLV_C14_Caspase3-7	522	526	PF00656	0.456
CLV_C14_Caspase3-7	79	83	PF00656	0.679
CLV_NRD_NRD_1	104	106	PF00675	0.571
CLV_NRD_NRD_1	256	258	PF00675	0.619
CLV_NRD_NRD_1	299	301	PF00675	0.681
CLV_NRD_NRD_1	347	349	PF00675	0.672
CLV_NRD_NRD_1	477	479	PF00675	0.684
CLV_NRD_NRD_1	505	507	PF00675	0.533
CLV_NRD_NRD_1	552	554	PF00675	0.689
CLV_PCSK_FUR_1	102	106	PF00082	0.626
CLV_PCSK_FUR_1	502	506	PF00082	0.564
CLV_PCSK_KEX2_1	104	106	PF00082	0.573
CLV_PCSK_KEX2_1	153	155	PF00082	0.647
CLV_PCSK_KEX2_1	256	258	PF00082	0.619
CLV_PCSK_KEX2_1	299	301	PF00082	0.681
CLV_PCSK_KEX2_1	347	349	PF00082	0.672
CLV_PCSK_KEX2_1	370	372	PF00082	0.717
CLV_PCSK_KEX2_1	479	481	PF00082	0.683
CLV_PCSK_KEX2_1	504	506	PF00082	0.553
CLV_PCSK_PC1ET2_1	153	155	PF00082	0.647
CLV_PCSK_PC1ET2_1	370	372	PF00082	0.624
CLV_PCSK_PC1ET2_1	479	481	PF00082	0.694
CLV_PCSK_PC1ET2_1	504	506	PF00082	0.527
CLV_PCSK_PC7_1	100	106	PF00082	0.628
CLV_PCSK_PC7_1	343	349	PF00082	0.648
CLV_PCSK_SKI1_1	104	108	PF00082	0.730
CLV_PCSK_SKI1_1	265	269	PF00082	0.526
CLV_PCSK_SKI1_1	505	509	PF00082	0.477
CLV_PCSK_SKI1_1	543	547	PF00082	0.546
CLV_PCSK_SKI1_1	65	69	PF00082	0.660
CLV_Separin_Metazoa	344	348	PF03568	0.685
DEG_APCC_DBOX_1	505	513	PF00400	0.479
DEG_Nend_Nbox_1	1	3	PF02207	0.683
DOC_CYCLIN_RxL_1	262	269	PF00134	0.525
DOC_CYCLIN_yCln2_LP_2	311	317	PF00134	0.643
DOC_MAPK_gen_1	502	511	PF00069	0.545
DOC_MAPK_MEF2A_6	444	453	PF00069	0.821
DOC_MAPK_RevD_3	285	300	PF00069	0.580
DOC_PP1_RVXF_1	152	159	PF00149	0.564
DOC_USP7_MATH_1	412	416	PF00917	0.629
DOC_USP7_MATH_1	418	422	PF00917	0.604
DOC_USP7_MATH_1	435	439	PF00917	0.664
DOC_USP7_MATH_1	463	467	PF00917	0.538
DOC_USP7_UBL2_3	450	454	PF12436	0.686
DOC_WW_Pin1_4	185	190	PF00397	0.580
DOC_WW_Pin1_4	276	281	PF00397	0.554
DOC_WW_Pin1_4	335	340	PF00397	0.709
DOC_WW_Pin1_4	34	39	PF00397	0.558
LIG_14-3-3_CanoR_1	170	175	PF00244	0.653
LIG_14-3-3_CanoR_1	237	244	PF00244	0.505
LIG_14-3-3_CanoR_1	28	36	PF00244	0.649
LIG_14-3-3_CanoR_1	291	295	PF00244	0.444
LIG_14-3-3_CterR_2	553	555	PF00244	0.684
LIG_APCC_ABBA_1	388	393	PF00400	0.621
LIG_CSL_BTD_1	328	331	PF09270	0.504
LIG_DLG_GKlike_1	170	177	PF00625	0.648
LIG_EH1_1	46	54	PF00400	0.690
LIG_FHA_1	1	7	PF00498	0.744
LIG_FHA_1	105	111	PF00498	0.687
LIG_FHA_1	282	288	PF00498	0.463
LIG_FHA_1	291	297	PF00498	0.496
LIG_FHA_1	544	550	PF00498	0.562
LIG_FHA_1	64	70	PF00498	0.755
LIG_FHA_1	75	81	PF00498	0.566
LIG_FHA_2	138	144	PF00498	0.492
LIG_FHA_2	230	236	PF00498	0.669
LIG_FHA_2	246	252	PF00498	0.369
LIG_FHA_2	28	34	PF00498	0.647
LIG_FHA_2	440	446	PF00498	0.629
LIG_Integrin_RGD_1	70	72	PF01839	0.682
LIG_LIR_Gen_1	544	549	PF02991	0.559
LIG_LIR_Nem_3	178	184	PF02991	0.550
LIG_LIR_Nem_3	544	548	PF02991	0.601
LIG_MYND_1	314	318	PF01753	0.692
LIG_NRBOX	263	269	PF00104	0.565
LIG_PCNA_yPIPBox_3	144	154	PF02747	0.437
LIG_RPA_C_Fungi	252	264	PF08784	0.594
LIG_SH2_STAP1	2	6	PF00017	0.742
LIG_SH2_STAT3	141	144	PF00017	0.485
LIG_SH2_STAT3	531	534	PF00017	0.654
LIG_SH2_STAT5	2	5	PF00017	0.760
LIG_SH2_STAT5	315	318	PF00017	0.679
LIG_SH2_STAT5	531	534	PF00017	0.654
LIG_SH3_3	113	119	PF00018	0.525
LIG_SH3_3	325	331	PF00018	0.498
LIG_Sin3_3	285	292	PF02671	0.542
LIG_Sin3_3	353	360	PF02671	0.575
LIG_SUMO_SIM_par_1	21	26	PF11976	0.703
LIG_TRAF2_1	233	236	PF00917	0.654
LIG_TRAF2_1	248	251	PF00917	0.390
LIG_TRAF2_1	443	446	PF00917	0.598
LIG_UBA3_1	470	479	PF00899	0.681
LIG_WW_3	117	121	PF00397	0.516
LIG_WW_3	62	66	PF00397	0.724
MOD_CDK_SPK_2	185	190	PF00069	0.580
MOD_CDK_SPxxK_3	185	192	PF00069	0.573
MOD_CK1_1	11	17	PF00069	0.611
MOD_CK1_1	145	151	PF00069	0.577
MOD_CK1_1	222	228	PF00069	0.660
MOD_CK1_1	229	235	PF00069	0.512
MOD_CK1_1	290	296	PF00069	0.549
MOD_CK1_1	78	84	PF00069	0.756
MOD_CK2_1	185	191	PF00069	0.531
MOD_CK2_1	229	235	PF00069	0.576
MOD_CK2_1	245	251	PF00069	0.530
MOD_CK2_1	334	340	PF00069	0.623
MOD_CK2_1	439	445	PF00069	0.675
MOD_GlcNHglycan	10	13	PF01048	0.682
MOD_GlcNHglycan	160	163	PF01048	0.402
MOD_GlcNHglycan	221	224	PF01048	0.675
MOD_GlcNHglycan	238	241	PF01048	0.400
MOD_GlcNHglycan	24	28	PF01048	0.558
MOD_GlcNHglycan	382	385	PF01048	0.639
MOD_GlcNHglycan	399	402	PF01048	0.702
MOD_GlcNHglycan	414	417	PF01048	0.627
MOD_GlcNHglycan	49	52	PF01048	0.671
MOD_GSK3_1	104	111	PF00069	0.627
MOD_GSK3_1	142	149	PF00069	0.660
MOD_GSK3_1	222	229	PF00069	0.537
MOD_GSK3_1	23	30	PF00069	0.661
MOD_GSK3_1	276	283	PF00069	0.519
MOD_GSK3_1	331	338	PF00069	0.672
MOD_GSK3_1	4	11	PF00069	0.683
MOD_GSK3_1	435	442	PF00069	0.623
MOD_GSK3_1	543	550	PF00069	0.515
MOD_GSK3_1	74	81	PF00069	0.682
MOD_N-GLC_1	170	175	PF02516	0.551
MOD_NEK2_1	110	115	PF00069	0.660
MOD_NEK2_1	219	224	PF00069	0.600
MOD_NEK2_1	226	231	PF00069	0.592
MOD_NEK2_1	287	292	PF00069	0.463
MOD_NEK2_1	548	553	PF00069	0.666
MOD_NEK2_1	76	81	PF00069	0.607
MOD_NEK2_1	98	103	PF00069	0.598
MOD_PKA_1	104	110	PF00069	0.731
MOD_PKA_2	104	110	PF00069	0.731
MOD_PKA_2	236	242	PF00069	0.619
MOD_PKA_2	27	33	PF00069	0.645
MOD_PKA_2	290	296	PF00069	0.521
MOD_PKA_2	391	397	PF00069	0.753
MOD_PKA_2	8	14	PF00069	0.752
MOD_PKB_1	102	110	PF00069	0.730
MOD_Plk_1	124	130	PF00069	0.593
MOD_Plk_1	142	148	PF00069	0.489
MOD_Plk_1	170	176	PF00069	0.518
MOD_Plk_1	543	549	PF00069	0.563
MOD_Plk_1	81	87	PF00069	0.713
MOD_Plk_4	142	148	PF00069	0.664
MOD_Plk_4	204	210	PF00069	0.563
MOD_Plk_4	226	232	PF00069	0.646
MOD_Plk_4	391	397	PF00069	0.761
MOD_Plk_4	544	550	PF00069	0.447
MOD_ProDKin_1	185	191	PF00069	0.577
MOD_ProDKin_1	276	282	PF00069	0.547
MOD_ProDKin_1	335	341	PF00069	0.704
MOD_ProDKin_1	34	40	PF00069	0.558
MOD_SUMO_rev_2	432	438	PF00179	0.702
MOD_SUMO_rev_2	445	451	PF00179	0.676
MOD_SUMO_rev_2	50	59	PF00179	0.685
MOD_SUMO_rev_2	522	528	PF00179	0.546
TRG_DiLeu_BaEn_1	191	196	PF01217	0.528
TRG_DiLeu_BaLyEn_6	164	169	PF01217	0.561
TRG_DiLeu_BaLyEn_6	419	424	PF01217	0.611
TRG_ER_diArg_1	102	105	PF00400	0.577
TRG_ER_diArg_1	346	348	PF00400	0.690
TRG_ER_diArg_1	420	423	PF00400	0.619
TRG_NLS_MonoExtC_3	477	482	PF00514	0.695
TRG_NLS_MonoExtN_4	476	483	PF00514	0.704
TRG_NLS_MonoExtN_4	502	508	PF00514	0.483
TRG_Pf-PMV_PEXEL_1	265	269	PF00026	0.489

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2P1	Leptomonas seymouri	42%	99%
A0A3S7X8N2	Leishmania donovani	87%	100%
A4HBG7	Leishmania braziliensis	73%	100%
A4IAL3	Leishmania infantum	86%	100%
E9B5N8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%