Cyclic nucleotide-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cyclic nucleotide-binding domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q279_LEIMA

TriTrypDb:

LmjF.34.4620 , LMJLV39_340051200 , LMJSD75_340051700

Length:

801

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q279

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q279

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009116	nucleoside metabolic process	4	2
GO:0009987	cellular process	1	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044281	small molecule metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0055086	nucleobase-containing small molecule metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:1901135	carbohydrate derivative metabolic process	3	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901657	glycosyl compound metabolic process	4	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	104	108	PF00656	0.258
CLV_C14_Caspase3-7	227	231	PF00656	0.724
CLV_C14_Caspase3-7	35	39	PF00656	0.711
CLV_NRD_NRD_1	143	145	PF00675	0.391
CLV_NRD_NRD_1	181	183	PF00675	0.459
CLV_NRD_NRD_1	234	236	PF00675	0.657
CLV_NRD_NRD_1	261	263	PF00675	0.625
CLV_NRD_NRD_1	275	277	PF00675	0.427
CLV_NRD_NRD_1	325	327	PF00675	0.435
CLV_NRD_NRD_1	746	748	PF00675	0.497
CLV_NRD_NRD_1	795	797	PF00675	0.451
CLV_PCSK_KEX2_1	137	139	PF00082	0.462
CLV_PCSK_KEX2_1	143	145	PF00082	0.391
CLV_PCSK_KEX2_1	234	236	PF00082	0.676
CLV_PCSK_KEX2_1	275	277	PF00082	0.363
CLV_PCSK_KEX2_1	323	325	PF00082	0.469
CLV_PCSK_KEX2_1	605	607	PF00082	0.572
CLV_PCSK_KEX2_1	746	748	PF00082	0.529
CLV_PCSK_KEX2_1	780	782	PF00082	0.546
CLV_PCSK_PC1ET2_1	137	139	PF00082	0.487
CLV_PCSK_PC1ET2_1	323	325	PF00082	0.548
CLV_PCSK_PC1ET2_1	605	607	PF00082	0.572
CLV_PCSK_PC1ET2_1	780	782	PF00082	0.546
CLV_PCSK_PC7_1	271	277	PF00082	0.466
CLV_PCSK_SKI1_1	134	138	PF00082	0.480
CLV_PCSK_SKI1_1	218	222	PF00082	0.432
CLV_PCSK_SKI1_1	382	386	PF00082	0.542
CLV_PCSK_SKI1_1	463	467	PF00082	0.522
CLV_PCSK_SKI1_1	491	495	PF00082	0.407
CLV_PCSK_SKI1_1	625	629	PF00082	0.529
CLV_PCSK_SKI1_1	659	663	PF00082	0.417
CLV_PCSK_SKI1_1	758	762	PF00082	0.442
CLV_PCSK_SKI1_1	792	796	PF00082	0.410
CLV_Separin_Metazoa	379	383	PF03568	0.578
DEG_APCC_DBOX_1	365	373	PF00400	0.450
DEG_APCC_DBOX_1	381	389	PF00400	0.502
DEG_APCC_DBOX_1	791	799	PF00400	0.424
DOC_CYCLIN_RxL_1	491	501	PF00134	0.367
DOC_CYCLIN_RxL_1	622	633	PF00134	0.410
DOC_CYCLIN_RxL_1	752	765	PF00134	0.470
DOC_CYCLIN_yClb1_LxF_4	657	662	PF00134	0.440
DOC_CYCLIN_yCln2_LP_2	240	246	PF00134	0.437
DOC_MAPK_gen_1	182	188	PF00069	0.451
DOC_MAPK_gen_1	234	242	PF00069	0.499
DOC_MAPK_gen_1	275	283	PF00069	0.425
DOC_MAPK_gen_1	463	471	PF00069	0.481
DOC_MAPK_gen_1	602	612	PF00069	0.563
DOC_MAPK_MEF2A_6	235	244	PF00069	0.452
DOC_MAPK_MEF2A_6	275	283	PF00069	0.425
DOC_PP1_RVXF_1	520	527	PF00149	0.599
DOC_PP1_RVXF_1	657	663	PF00149	0.437
DOC_PP2B_LxvP_1	178	181	PF13499	0.417
DOC_PP2B_LxvP_1	240	243	PF13499	0.475
DOC_USP7_MATH_1	305	309	PF00917	0.460
DOC_USP7_MATH_1	550	554	PF00917	0.561
DOC_USP7_MATH_1	595	599	PF00917	0.619
DOC_USP7_MATH_1	71	75	PF00917	0.621
DOC_USP7_UBL2_3	133	137	PF12436	0.480
DOC_WW_Pin1_4	1	6	PF00397	0.674
DOC_WW_Pin1_4	189	194	PF00397	0.514
DOC_WW_Pin1_4	310	315	PF00397	0.598
DOC_WW_Pin1_4	371	376	PF00397	0.534
DOC_WW_Pin1_4	383	388	PF00397	0.505
DOC_WW_Pin1_4	485	490	PF00397	0.471
DOC_WW_Pin1_4	579	584	PF00397	0.546
DOC_WW_Pin1_4	67	72	PF00397	0.672
DOC_WW_Pin1_4	686	691	PF00397	0.518
LIG_14-3-3_CanoR_1	235	241	PF00244	0.546
LIG_14-3-3_CanoR_1	247	256	PF00244	0.532
LIG_14-3-3_CanoR_1	326	332	PF00244	0.470
LIG_14-3-3_CanoR_1	468	478	PF00244	0.560
LIG_14-3-3_CanoR_1	634	639	PF00244	0.469
LIG_Actin_WH2_2	123	139	PF00022	0.480
LIG_Actin_WH2_2	40	57	PF00022	0.664
LIG_Actin_WH2_2	780	798	PF00022	0.506
LIG_AP2alpha_1	185	189	PF02296	0.468
LIG_APCC_ABBA_1	210	215	PF00400	0.444
LIG_APCC_ABBA_1	430	435	PF00400	0.434
LIG_APCC_ABBA_1	688	693	PF00400	0.385
LIG_BIR_II_1	1	5	PF00653	0.682
LIG_BIR_III_4	230	234	PF00653	0.592
LIG_BRCT_BRCA1_1	191	195	PF00533	0.468
LIG_BRCT_BRCA1_1	297	301	PF00533	0.577
LIG_BRCT_BRCA1_1	403	407	PF00533	0.569
LIG_BRCT_BRCA1_1	445	449	PF00533	0.552
LIG_BRCT_BRCA1_1	556	560	PF00533	0.551
LIG_BRCT_BRCA1_1	679	683	PF00533	0.359
LIG_eIF4E_1	535	541	PF01652	0.477
LIG_FHA_1	124	130	PF00498	0.381
LIG_FHA_1	173	179	PF00498	0.392
LIG_FHA_1	27	33	PF00498	0.636
LIG_FHA_1	272	278	PF00498	0.462
LIG_FHA_1	282	288	PF00498	0.416
LIG_FHA_1	311	317	PF00498	0.632
LIG_FHA_1	335	341	PF00498	0.432
LIG_FHA_1	344	350	PF00498	0.387
LIG_FHA_1	39	45	PF00498	0.469
LIG_FHA_1	536	542	PF00498	0.479
LIG_FHA_1	670	676	PF00498	0.556
LIG_FHA_1	687	693	PF00498	0.363
LIG_FHA_1	85	91	PF00498	0.482
LIG_FHA_2	559	565	PF00498	0.454
LIG_FHA_2	664	670	PF00498	0.531
LIG_FHA_2	727	733	PF00498	0.494
LIG_FHA_2	87	93	PF00498	0.464
LIG_HCF-1_HBM_1	117	120	PF13415	0.480
LIG_IBAR_NPY_1	452	454	PF08397	0.455
LIG_Integrin_RGD_1	651	653	PF01839	0.430
LIG_LIR_Gen_1	102	110	PF02991	0.386
LIG_LIR_Gen_1	209	216	PF02991	0.422
LIG_LIR_Gen_1	264	272	PF02991	0.503
LIG_LIR_Gen_1	282	293	PF02991	0.402
LIG_LIR_Gen_1	557	568	PF02991	0.455
LIG_LIR_Gen_1	77	86	PF02991	0.332
LIG_LIR_Nem_3	209	213	PF02991	0.405
LIG_LIR_Nem_3	264	270	PF02991	0.503
LIG_LIR_Nem_3	282	288	PF02991	0.391
LIG_LIR_Nem_3	531	537	PF02991	0.442
LIG_LIR_Nem_3	77	81	PF02991	0.345
LIG_NRBOX	536	542	PF00104	0.482
LIG_NRBOX	623	629	PF00104	0.418
LIG_Pex14_2	185	189	PF04695	0.368
LIG_Rb_LxCxE_1	353	374	PF01857	0.527
LIG_Rb_LxCxE_1	45	66	PF01857	0.521
LIG_SH2_CRK	722	726	PF00017	0.463
LIG_SH2_GRB2like	454	457	PF00017	0.486
LIG_SH2_PTP2	285	288	PF00017	0.519
LIG_SH2_SRC	115	118	PF00017	0.464
LIG_SH2_SRC	285	288	PF00017	0.519
LIG_SH2_STAP1	238	242	PF00017	0.355
LIG_SH2_STAP1	454	458	PF00017	0.468
LIG_SH2_STAT5	115	118	PF00017	0.440
LIG_SH2_STAT5	120	123	PF00017	0.455
LIG_SH2_STAT5	25	28	PF00017	0.571
LIG_SH2_STAT5	272	275	PF00017	0.451
LIG_SH2_STAT5	285	288	PF00017	0.398
LIG_SH2_STAT5	296	299	PF00017	0.542
LIG_SH2_STAT5	437	440	PF00017	0.448
LIG_SH2_STAT5	535	538	PF00017	0.447
LIG_SH2_STAT5	737	740	PF00017	0.420
LIG_SH2_STAT5	759	762	PF00017	0.435
LIG_SH3_1	65	71	PF00018	0.640
LIG_SH3_3	65	71	PF00018	0.699
LIG_SH3_3	651	657	PF00018	0.396
LIG_SH3_3	772	778	PF00018	0.730
LIG_SUMO_SIM_anti_2	126	132	PF11976	0.391
LIG_SUMO_SIM_anti_2	175	181	PF11976	0.394
LIG_SUMO_SIM_anti_2	284	290	PF11976	0.481
LIG_SUMO_SIM_anti_2	337	343	PF11976	0.494
LIG_SUMO_SIM_anti_2	94	100	PF11976	0.556
LIG_SUMO_SIM_par_1	284	290	PF11976	0.431
LIG_SUMO_SIM_par_1	571	577	PF11976	0.512
LIG_SUMO_SIM_par_1	86	92	PF11976	0.524
LIG_TRAF2_1	89	92	PF00917	0.567
LIG_TYR_ITIM	265	270	PF00017	0.410
LIG_TYR_ITIM	283	288	PF00017	0.332
LIG_UBA3_1	177	183	PF00899	0.374
LIG_UBA3_1	357	364	PF00899	0.500
LIG_UBA3_1	461	466	PF00899	0.393
LIG_UBA3_1	496	505	PF00899	0.521
LIG_WRC_WIRS_1	207	212	PF05994	0.469
LIG_WRC_WIRS_1	628	633	PF05994	0.464
LIG_WRC_WIRS_1	75	80	PF05994	0.495
MOD_CDC14_SPxK_1	488	491	PF00782	0.507
MOD_CDK_SPK_2	67	72	PF00069	0.703
MOD_CDK_SPxK_1	485	491	PF00069	0.494
MOD_CK1_1	172	178	PF00069	0.373
MOD_CK1_1	224	230	PF00069	0.630
MOD_CK1_1	236	242	PF00069	0.491
MOD_CK1_1	443	449	PF00069	0.585
MOD_CK1_1	512	518	PF00069	0.586
MOD_CK1_1	579	585	PF00069	0.521
MOD_CK1_1	598	604	PF00069	0.516
MOD_CK1_1	663	669	PF00069	0.457
MOD_CK1_1	74	80	PF00069	0.520
MOD_CK2_1	373	379	PF00069	0.544
MOD_CK2_1	383	389	PF00069	0.505
MOD_CK2_1	405	411	PF00069	0.449
MOD_CK2_1	469	475	PF00069	0.583
MOD_CK2_1	558	564	PF00069	0.492
MOD_CK2_1	579	585	PF00069	0.564
MOD_CK2_1	663	669	PF00069	0.473
MOD_CK2_1	86	92	PF00069	0.473
MOD_Cter_Amidation	232	235	PF01082	0.667
MOD_Cter_Amidation	321	324	PF01082	0.562
MOD_Cter_Amidation	603	606	PF01082	0.590
MOD_GlcNHglycan	123	126	PF01048	0.391
MOD_GlcNHglycan	226	229	PF01048	0.678
MOD_GlcNHglycan	235	238	PF01048	0.542
MOD_GlcNHglycan	251	254	PF01048	0.403
MOD_GlcNHglycan	375	378	PF01048	0.561
MOD_GlcNHglycan	392	395	PF01048	0.632
MOD_GlcNHglycan	500	503	PF01048	0.463
MOD_GlcNHglycan	513	517	PF01048	0.571
MOD_GlcNHglycan	568	571	PF01048	0.445
MOD_GlcNHglycan	696	699	PF01048	0.532
MOD_GSK3_1	165	172	PF00069	0.375
MOD_GSK3_1	222	229	PF00069	0.606
MOD_GSK3_1	401	408	PF00069	0.530
MOD_GSK3_1	443	450	PF00069	0.577
MOD_GSK3_1	485	492	PF00069	0.408
MOD_GSK3_1	550	557	PF00069	0.539
MOD_GSK3_1	579	586	PF00069	0.531
MOD_GSK3_1	623	630	PF00069	0.406
MOD_GSK3_1	63	70	PF00069	0.697
MOD_GSK3_1	634	641	PF00069	0.406
MOD_GSK3_1	677	684	PF00069	0.451
MOD_GSK3_1	783	790	PF00069	0.437
MOD_LATS_1	142	148	PF00433	0.391
MOD_N-GLC_1	173	178	PF02516	0.475
MOD_N-GLC_1	197	202	PF02516	0.530
MOD_N-GLC_1	279	284	PF02516	0.414
MOD_N-GLC_1	36	41	PF02516	0.708
MOD_N-GLC_1	390	395	PF02516	0.655
MOD_N-GLC_1	489	494	PF02516	0.432
MOD_N-GLC_1	509	514	PF02516	0.339
MOD_N-GLC_1	579	584	PF02516	0.490
MOD_N-GLC_1	638	643	PF02516	0.430
MOD_N-GLC_1	771	776	PF02516	0.665
MOD_N-GLC_2	354	356	PF02516	0.411
MOD_NEK2_1	221	226	PF00069	0.577
MOD_NEK2_1	248	253	PF00069	0.494
MOD_NEK2_1	627	632	PF00069	0.443
MOD_NEK2_1	660	665	PF00069	0.432
MOD_NEK2_1	677	682	PF00069	0.465
MOD_NEK2_1	692	697	PF00069	0.564
MOD_NEK2_1	712	717	PF00069	0.438
MOD_NEK2_1	721	726	PF00069	0.432
MOD_NEK2_1	733	738	PF00069	0.365
MOD_NEK2_1	751	756	PF00069	0.452
MOD_NEK2_2	208	213	PF00069	0.527
MOD_NEK2_2	489	494	PF00069	0.520
MOD_PIKK_1	198	204	PF00454	0.545
MOD_PIKK_1	287	293	PF00454	0.498
MOD_PIKK_1	305	311	PF00454	0.392
MOD_PIKK_1	712	718	PF00454	0.509
MOD_PK_1	634	640	PF00069	0.466
MOD_PKA_2	233	239	PF00069	0.581
MOD_PKA_2	249	255	PF00069	0.462
MOD_PKA_2	595	601	PF00069	0.496
MOD_PKA_2	751	757	PF00069	0.549
MOD_PKB_1	552	560	PF00069	0.540
MOD_Plk_1	165	171	PF00069	0.367
MOD_Plk_1	173	179	PF00069	0.346
MOD_Plk_1	279	285	PF00069	0.493
MOD_Plk_1	420	426	PF00069	0.521
MOD_Plk_1	489	495	PF00069	0.465
MOD_Plk_1	612	618	PF00069	0.428
MOD_Plk_1	91	97	PF00069	0.527
MOD_Plk_2-3	295	301	PF00069	0.606
MOD_Plk_2-3	509	515	PF00069	0.642
MOD_Plk_2-3	669	675	PF00069	0.501
MOD_Plk_2-3	92	98	PF00069	0.546
MOD_Plk_4	144	150	PF00069	0.455
MOD_Plk_4	173	179	PF00069	0.375
MOD_Plk_4	281	287	PF00069	0.384
MOD_Plk_4	334	340	PF00069	0.480
MOD_Plk_4	414	420	PF00069	0.505
MOD_Plk_4	457	463	PF00069	0.485
MOD_Plk_4	733	739	PF00069	0.466
MOD_Plk_4	74	80	PF00069	0.569
MOD_Plk_4	771	777	PF00069	0.638
MOD_Plk_4	783	789	PF00069	0.517
MOD_ProDKin_1	1	7	PF00069	0.676
MOD_ProDKin_1	189	195	PF00069	0.505
MOD_ProDKin_1	310	316	PF00069	0.585
MOD_ProDKin_1	371	377	PF00069	0.524
MOD_ProDKin_1	383	389	PF00069	0.518
MOD_ProDKin_1	485	491	PF00069	0.477
MOD_ProDKin_1	579	585	PF00069	0.548
MOD_ProDKin_1	67	73	PF00069	0.658
MOD_ProDKin_1	686	692	PF00069	0.516
TRG_DiLeu_BaEn_1	56	61	PF01217	0.734
TRG_DiLeu_BaEn_4	111	117	PF01217	0.443
TRG_DiLeu_BaEn_4	91	97	PF01217	0.557
TRG_ENDOCYTIC_2	103	106	PF00928	0.370
TRG_ENDOCYTIC_2	267	270	PF00928	0.552
TRG_ENDOCYTIC_2	285	288	PF00928	0.470
TRG_ENDOCYTIC_2	428	431	PF00928	0.410
TRG_ENDOCYTIC_2	533	536	PF00928	0.499
TRG_ENDOCYTIC_2	722	725	PF00928	0.426
TRG_ER_diArg_1	143	145	PF00400	0.391
TRG_ER_diArg_1	275	277	PF00400	0.513
TRG_ER_diArg_1	324	326	PF00400	0.433
TRG_ER_diArg_1	365	368	PF00400	0.407
TRG_ER_diArg_1	551	554	PF00400	0.543
TRG_NES_CRM1_1	347	361	PF08389	0.379
TRG_NES_CRM1_1	80	92	PF08389	0.531
TRG_NLS_MonoCore_2	322	327	PF00514	0.557
TRG_Pf-PMV_PEXEL_1	740	744	PF00026	0.438
TRG_Pf-PMV_PEXEL_1	796	800	PF00026	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ14	Leptomonas seymouri	76%	100%
A0A0S4JKK7	Bodo saltans	34%	100%
A0A1X0NTY5	Trypanosomatidae	30%	82%
A0A1X0PB50	Trypanosomatidae	47%	100%
A0A3Q8IHX4	Leishmania donovani	92%	100%
A0A3R7L5E3	Trypanosoma rangeli	31%	82%
A0A3R7MMZ6	Trypanosoma rangeli	46%	100%
A4H882	Leishmania braziliensis	29%	76%
A4HBG8	Leishmania braziliensis	81%	100%
A4IAJ9	Leishmania infantum	93%	100%
E9B5N9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BRC6	Trypanosoma cruzi	47%	100%