N-acetylglucosamine-6-phosphate deacetylase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

N-acetylglucosamine-6-phosphate deacetylase-like protein

Species:

Leishmania major

UniProt:

Q4Q275_LEIMA

TriTrypDb:

LmjF.36.0040 , LMJLV39_360005300 , LMJSD75_360005300

Length:

432

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q275

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q275

Function

Biological processes
Term	Name	Level	Count
GO:0006040	amino sugar metabolic process	4	2
GO:0006044	N-acetylglucosamine metabolic process	6	2
GO:0006046	N-acetylglucosamine catabolic process	7	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0046348	amino sugar catabolic process	5	2
GO:0071704	organic substance metabolic process	2	2
GO:1901071	glucosamine-containing compound metabolic process	5	2
GO:1901072	glucosamine-containing compound catabolic process	6	2
GO:1901135	carbohydrate derivative metabolic process	3	2
GO:1901136	carbohydrate derivative catabolic process	4	2
GO:1901575	organic substance catabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0008448	N-acetylglucosamine-6-phosphate deacetylase activity	4	3
GO:0016787	hydrolase activity	2	11
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	11
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	4	3
GO:0019213	deacetylase activity	3	3
GO:0047419	N-acetylgalactosamine-6-phosphate deacetylase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	121	125	PF00656	0.427
CLV_MEL_PAP_1	126	132	PF00089	0.225
CLV_NRD_NRD_1	40	42	PF00675	0.461
CLV_PCSK_KEX2_1	128	130	PF00082	0.243
CLV_PCSK_KEX2_1	169	171	PF00082	0.258
CLV_PCSK_KEX2_1	409	411	PF00082	0.310
CLV_PCSK_PC1ET2_1	128	130	PF00082	0.243
CLV_PCSK_PC1ET2_1	169	171	PF00082	0.258
CLV_PCSK_PC1ET2_1	409	411	PF00082	0.310
CLV_PCSK_SKI1_1	117	121	PF00082	0.235
CLV_PCSK_SKI1_1	179	183	PF00082	0.212
CLV_PCSK_SKI1_1	197	201	PF00082	0.212
CLV_PCSK_SKI1_1	205	209	PF00082	0.211
DEG_APCC_DBOX_1	40	48	PF00400	0.358
DOC_CYCLIN_RxL_1	194	201	PF00134	0.460
DOC_MAPK_DCC_7	267	276	PF00069	0.451
DOC_MAPK_gen_1	202	208	PF00069	0.479
DOC_MAPK_gen_1	267	276	PF00069	0.427
DOC_MAPK_gen_1	393	400	PF00069	0.414
DOC_MAPK_gen_1	41	47	PF00069	0.278
DOC_MAPK_MEF2A_6	267	276	PF00069	0.427
DOC_PP4_FxxP_1	64	67	PF00568	0.412
DOC_USP7_MATH_1	214	218	PF00917	0.458
DOC_USP7_MATH_1	293	297	PF00917	0.493
DOC_WW_Pin1_4	181	186	PF00397	0.412
LIG_14-3-3_CanoR_1	247	252	PF00244	0.460
LIG_14-3-3_CanoR_1	339	345	PF00244	0.425
LIG_APCC_ABBA_1	183	188	PF00400	0.425
LIG_BRCT_BRCA1_1	107	111	PF00533	0.414
LIG_Clathr_ClatBox_1	280	284	PF01394	0.468
LIG_Clathr_ClatBox_1	397	401	PF01394	0.458
LIG_Clathr_ClatBox_1	44	48	PF01394	0.278
LIG_FHA_1	118	124	PF00498	0.469
LIG_FHA_1	12	18	PF00498	0.486
LIG_FHA_1	271	277	PF00498	0.435
LIG_FHA_1	302	308	PF00498	0.425
LIG_FHA_1	346	352	PF00498	0.421
LIG_FHA_1	371	377	PF00498	0.476
LIG_FHA_2	130	136	PF00498	0.467
LIG_FHA_2	56	62	PF00498	0.486
LIG_Integrin_isoDGR_2	319	321	PF01839	0.212
LIG_LIR_Apic_2	61	67	PF02991	0.246
LIG_LIR_Gen_1	353	362	PF02991	0.413
LIG_LIR_Nem_3	167	171	PF02991	0.414
LIG_LIR_Nem_3	353	358	PF02991	0.413
LIG_PDZ_Class_2	427	432	PF00595	0.330
LIG_PTB_Apo_2	86	93	PF02174	0.425
LIG_PTB_Phospho_1	86	92	PF10480	0.443
LIG_SH2_CRK	422	426	PF00017	0.332
LIG_SH2_NCK_1	60	64	PF00017	0.435
LIG_SH2_STAP1	60	64	PF00017	0.431
LIG_SH2_STAT5	133	136	PF00017	0.443
LIG_SH2_STAT5	198	201	PF00017	0.474
LIG_SH2_STAT5	332	335	PF00017	0.443
LIG_SH2_STAT5	43	46	PF00017	0.430
LIG_SH3_3	255	261	PF00018	0.458
LIG_Sin3_3	395	402	PF02671	0.427
LIG_SUMO_SIM_anti_2	273	279	PF11976	0.468
LIG_SUMO_SIM_anti_2	298	305	PF11976	0.426
LIG_SUMO_SIM_par_1	22	28	PF11976	0.387
LIG_SUMO_SIM_par_1	43	50	PF11976	0.511
LIG_TRAF2_1	227	230	PF00917	0.468
LIG_UBA3_1	219	224	PF00899	0.412
LIG_UBA3_1	357	364	PF00899	0.452
LIG_WRC_WIRS_1	241	246	PF05994	0.425
MOD_CK1_1	161	167	PF00069	0.515
MOD_CK1_1	174	180	PF00069	0.531
MOD_CK2_1	129	135	PF00069	0.490
MOD_CK2_1	212	218	PF00069	0.460
MOD_CK2_1	225	231	PF00069	0.420
MOD_CK2_1	55	61	PF00069	0.502
MOD_CK2_1	85	91	PF00069	0.425
MOD_Cter_Amidation	391	394	PF01082	0.200
MOD_GlcNHglycan	307	310	PF01048	0.285
MOD_GSK3_1	101	108	PF00069	0.419
MOD_GSK3_1	287	294	PF00069	0.495
MOD_GSK3_1	301	308	PF00069	0.387
MOD_LATS_1	115	121	PF00433	0.493
MOD_LATS_1	210	216	PF00433	0.412
MOD_N-GLC_1	2	7	PF02516	0.456
MOD_N-GLC_1	239	244	PF02516	0.296
MOD_N-GLC_1	35	40	PF02516	0.269
MOD_NEK2_1	111	116	PF00069	0.507
MOD_NEK2_1	171	176	PF00069	0.438
MOD_NEK2_1	233	238	PF00069	0.412
MOD_NEK2_1	29	34	PF00069	0.392
MOD_NEK2_1	333	338	PF00069	0.471
MOD_NEK2_1	47	52	PF00069	0.430
MOD_NEK2_2	90	95	PF00069	0.409
MOD_PKA_2	246	252	PF00069	0.495
MOD_PKA_2	320	326	PF00069	0.419
MOD_PKA_2	338	344	PF00069	0.412
MOD_Plk_1	161	167	PF00069	0.539
MOD_Plk_1	2	8	PF00069	0.426
MOD_Plk_1	239	245	PF00069	0.529
MOD_Plk_1	35	41	PF00069	0.273
MOD_Plk_1	90	96	PF00069	0.443
MOD_Plk_2-3	403	409	PF00069	0.609
MOD_Plk_4	105	111	PF00069	0.412
MOD_Plk_4	2	8	PF00069	0.387
MOD_Plk_4	247	253	PF00069	0.412
MOD_Plk_4	287	293	PF00069	0.468
MOD_Plk_4	320	326	PF00069	0.480
MOD_Plk_4	346	352	PF00069	0.466
MOD_Plk_4	425	431	PF00069	0.390
MOD_Plk_4	55	61	PF00069	0.450
MOD_ProDKin_1	181	187	PF00069	0.412
MOD_SUMO_rev_2	152	161	PF00179	0.485
MOD_SUMO_rev_2	162	171	PF00179	0.443
MOD_SUMO_rev_2	228	233	PF00179	0.536
MOD_SUMO_rev_2	385	395	PF00179	0.364
TRG_ENDOCYTIC_2	193	196	PF00928	0.412
TRG_ENDOCYTIC_2	422	425	PF00928	0.318
TRG_NES_CRM1_1	279	289	PF08389	0.507
TRG_Pf-PMV_PEXEL_1	197	201	PF00026	0.300
TRG_Pf-PMV_PEXEL_1	42	46	PF00026	0.371

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAM2	Leptomonas seymouri	78%	100%
A0A0S4JIK6	Bodo saltans	51%	98%
A0A1X0NNC6	Trypanosomatidae	59%	100%
A0A3R7KWA9	Trypanosoma rangeli	57%	100%
A0A3S7XA87	Leishmania donovani	95%	100%
A4HNK9	Leishmania braziliensis	87%	100%
A4ICY4	Leishmania infantum	95%	100%
E9ASC1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
O34450	Bacillus subtilis (strain 168)	25%	100%
Q84F86	Lysinibacillus sphaericus	24%	100%
Q8XAC3	Escherichia coli O157:H7	26%	100%
V5C012	Trypanosoma cruzi	56%	100%