SAP domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SAP domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q272_LEIMA

TriTrypDb:

LmjF.36.0065 , LMJLV39_360005600 , LMJSD75_360005600

Length:

322

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q272

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q272

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	233	235	PF00675	0.647
CLV_NRD_NRD_1	264	266	PF00675	0.745
CLV_NRD_NRD_1	318	320	PF00675	0.652
CLV_NRD_NRD_1	6	8	PF00675	0.588
CLV_PCSK_KEX2_1	208	210	PF00082	0.430
CLV_PCSK_KEX2_1	233	235	PF00082	0.647
CLV_PCSK_KEX2_1	264	266	PF00082	0.597
CLV_PCSK_KEX2_1	317	319	PF00082	0.675
CLV_PCSK_KEX2_1	5	7	PF00082	0.593
CLV_PCSK_PC1ET2_1	208	210	PF00082	0.501
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.593
CLV_PCSK_PC7_1	260	266	PF00082	0.593
CLV_PCSK_SKI1_1	105	109	PF00082	0.656
CLV_PCSK_SKI1_1	112	116	PF00082	0.570
CLV_PCSK_SKI1_1	163	167	PF00082	0.709
CLV_PCSK_SKI1_1	189	193	PF00082	0.366
CLV_PCSK_SKI1_1	233	237	PF00082	0.691
CLV_PCSK_SKI1_1	74	78	PF00082	0.634
CLV_Separin_Metazoa	190	194	PF03568	0.410
DEG_Nend_UBRbox_2	1	3	PF02207	0.655
DEG_SPOP_SBC_1	136	140	PF00917	0.712
DEG_SPOP_SBC_1	42	46	PF00917	0.715
DOC_CKS1_1	92	97	PF01111	0.637
DOC_CYCLIN_yCln2_LP_2	36	42	PF00134	0.723
DOC_MAPK_gen_1	29	38	PF00069	0.664
DOC_MAPK_gen_1	5	11	PF00069	0.582
DOC_MAPK_MEF2A_6	32	40	PF00069	0.673
DOC_PP2B_LxvP_1	36	39	PF13499	0.676
DOC_PP2B_LxvP_1	40	43	PF13499	0.663
DOC_PP4_FxxP_1	92	95	PF00568	0.644
DOC_USP7_MATH_1	136	140	PF00917	0.677
DOC_USP7_MATH_1	168	172	PF00917	0.691
DOC_USP7_MATH_1	215	219	PF00917	0.707
DOC_USP7_MATH_1	259	263	PF00917	0.765
DOC_USP7_MATH_1	295	299	PF00917	0.615
DOC_USP7_MATH_1	43	47	PF00917	0.713
DOC_USP7_UBL2_3	208	212	PF12436	0.501
DOC_WW_Pin1_4	154	159	PF00397	0.801
DOC_WW_Pin1_4	176	181	PF00397	0.605
DOC_WW_Pin1_4	22	27	PF00397	0.639
DOC_WW_Pin1_4	251	256	PF00397	0.731
DOC_WW_Pin1_4	263	268	PF00397	0.722
DOC_WW_Pin1_4	38	43	PF00397	0.665
DOC_WW_Pin1_4	46	51	PF00397	0.658
DOC_WW_Pin1_4	91	96	PF00397	0.653
LIG_14-3-3_CanoR_1	172	180	PF00244	0.675
LIG_14-3-3_CanoR_1	220	228	PF00244	0.717
LIG_14-3-3_CanoR_1	296	300	PF00244	0.650
LIG_14-3-3_CanoR_1	91	95	PF00244	0.671
LIG_14-3-3_CterR_2	317	322	PF00244	0.641
LIG_BRCT_BRCA1_1	287	291	PF00533	0.560
LIG_BRCT_BRCA1_1	297	301	PF00533	0.645
LIG_BRCT_BRCA1_1	88	92	PF00533	0.645
LIG_FHA_1	222	228	PF00498	0.773
LIG_FHA_1	32	38	PF00498	0.797
LIG_FHA_2	138	144	PF00498	0.690
LIG_FHA_2	150	156	PF00498	0.731
LIG_FHA_2	269	275	PF00498	0.688
LIG_FHA_2	92	98	PF00498	0.645
LIG_LIR_Apic_2	89	95	PF02991	0.632
LIG_LIR_Nem_3	278	283	PF02991	0.575
LIG_LIR_Nem_3	79	83	PF02991	0.634
LIG_MYND_1	255	259	PF01753	0.719
LIG_NRBOX	187	193	PF00104	0.410
LIG_PDZ_Class_2	317	322	PF00595	0.712
LIG_Pex14_2	114	118	PF04695	0.644
LIG_SH2_STAT5	10	13	PF00017	0.567
LIG_SH3_3	118	124	PF00018	0.467
LIG_SH3_3	249	255	PF00018	0.741
LIG_SH3_3	36	42	PF00018	0.723
LIG_SH3_3	50	56	PF00018	0.734
LIG_SH3_CIN85_PxpxPR_1	158	163	PF14604	0.688
LIG_WW_3	55	59	PF00397	0.708
MOD_CDK_SPK_2	255	260	PF00069	0.610
MOD_CDK_SPK_2	91	96	PF00069	0.724
MOD_CDK_SPxxK_3	154	161	PF00069	0.802
MOD_CDK_SPxxK_3	22	29	PF00069	0.639
MOD_CDK_SPxxK_3	51	58	PF00069	0.730
MOD_CK1_1	128	134	PF00069	0.662
MOD_CK1_1	137	143	PF00069	0.635
MOD_CK1_1	154	160	PF00069	0.682
MOD_CK1_1	181	187	PF00069	0.350
MOD_CK1_1	20	26	PF00069	0.651
MOD_CK1_1	248	254	PF00069	0.713
MOD_CK1_1	31	37	PF00069	0.647
MOD_CK1_1	41	47	PF00069	0.669
MOD_CK2_1	137	143	PF00069	0.676
MOD_CK2_1	144	150	PF00069	0.655
MOD_GlcNHglycan	127	130	PF01048	0.697
MOD_GlcNHglycan	133	136	PF01048	0.745
MOD_GlcNHglycan	21	25	PF01048	0.693
MOD_GlcNHglycan	247	250	PF01048	0.727
MOD_GlcNHglycan	87	91	PF01048	0.553
MOD_GSK3_1	130	137	PF00069	0.717
MOD_GSK3_1	150	157	PF00069	0.660
MOD_GSK3_1	168	175	PF00069	0.665
MOD_GSK3_1	215	222	PF00069	0.674
MOD_GSK3_1	241	248	PF00069	0.747
MOD_GSK3_1	251	258	PF00069	0.551
MOD_GSK3_1	259	266	PF00069	0.538
MOD_GSK3_1	38	45	PF00069	0.717
MOD_GSK3_1	86	93	PF00069	0.653
MOD_N-GLC_1	275	280	PF02516	0.641
MOD_NEK2_1	149	154	PF00069	0.783
MOD_NEK2_1	183	188	PF00069	0.303
MOD_NEK2_1	229	234	PF00069	0.743
MOD_NEK2_1	236	241	PF00069	0.722
MOD_NEK2_2	107	112	PF00069	0.552
MOD_PIKK_1	178	184	PF00454	0.385
MOD_PIKK_1	259	265	PF00454	0.745
MOD_PIKK_1	43	49	PF00454	0.714
MOD_PK_1	195	201	PF00069	0.424
MOD_PK_1	275	281	PF00069	0.642
MOD_PKA_2	168	174	PF00069	0.684
MOD_PKA_2	219	225	PF00069	0.720
MOD_PKA_2	259	265	PF00069	0.770
MOD_PKA_2	28	34	PF00069	0.658
MOD_PKA_2	295	301	PF00069	0.651
MOD_PKA_2	90	96	PF00069	0.724
MOD_PKB_1	193	201	PF00069	0.424
MOD_Plk_1	275	281	PF00069	0.608
MOD_Plk_2-3	144	150	PF00069	0.752
MOD_Plk_2-3	151	157	PF00069	0.698
MOD_Plk_4	137	143	PF00069	0.711
MOD_Plk_4	275	281	PF00069	0.697
MOD_ProDKin_1	154	160	PF00069	0.802
MOD_ProDKin_1	176	182	PF00069	0.602
MOD_ProDKin_1	22	28	PF00069	0.638
MOD_ProDKin_1	251	257	PF00069	0.736
MOD_ProDKin_1	263	269	PF00069	0.722
MOD_ProDKin_1	38	44	PF00069	0.667
MOD_ProDKin_1	46	52	PF00069	0.661
MOD_ProDKin_1	91	97	PF00069	0.645
MOD_SUMO_rev_2	239	246	PF00179	0.682
TRG_DiLeu_BaEn_1	14	19	PF01217	0.590
TRG_DiLeu_BaEn_4	144	150	PF01217	0.798
TRG_DiLeu_BaLyEn_6	32	37	PF01217	0.682
TRG_ENDOCYTIC_2	80	83	PF00928	0.687
TRG_ER_diArg_1	160	163	PF00400	0.632
TRG_ER_diArg_1	192	195	PF00400	0.485
TRG_ER_diArg_1	317	319	PF00400	0.678
TRG_ER_diArg_1	6	8	PF00400	0.588
TRG_NLS_MonoExtN_4	3	9	PF00514	0.637

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II75	Leptomonas seymouri	55%	100%
A0A1X0P8R1	Trypanosomatidae	29%	100%
A0A3S7XA97	Leishmania donovani	89%	100%
A4HNL1	Leishmania braziliensis	67%	99%
A4ICY1	Leishmania infantum	90%	100%
E9ASC4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%