Putative DNA damage repair protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA damage repair protein, putative

Species:

Leishmania major

UniProt:

Q4Q268_LEIMA

TriTrypDb:

LmjF.36.0100 , LMJLV39_360006100 , LMJSD75_360006100

Length:

619

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q268

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q268

Function

Biological processes
Term	Name	Level	Count
GO:0000731	DNA synthesis involved in DNA repair	6	2
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006281	DNA repair	5	12
GO:0006301	postreplication repair	6	2
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0006950	response to stress	2	12
GO:0006974	DNA damage response	4	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	2
GO:0009059	macromolecule biosynthetic process	4	2
GO:0009987	cellular process	1	12
GO:0018130	heterocycle biosynthetic process	4	2
GO:0019438	aromatic compound biosynthetic process	4	2
GO:0019985	translesion synthesis	7	2
GO:0033554	cellular response to stress	3	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034654	nucleobase-containing compound biosynthetic process	4	2
GO:0042276	error-prone translesion synthesis	8	2
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0044271	cellular nitrogen compound biosynthetic process	4	2
GO:0046483	heterocycle metabolic process	3	12
GO:0050896	response to stimulus	1	12
GO:0051716	cellular response to stimulus	2	12
GO:0070987	error-free translesion synthesis	8	2
GO:0071704	organic substance metabolic process	2	12
GO:0071897	DNA biosynthetic process	5	2
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901362	organic cyclic compound biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0003684	damaged DNA binding	5	12
GO:0003824	catalytic activity	1	3
GO:0003887	DNA-directed DNA polymerase activity	5	3
GO:0005488	binding	1	12
GO:0016740	transferase activity	2	3
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	3
GO:0016779	nucleotidyltransferase activity	4	3
GO:0017125	deoxycytidyl transferase activity	5	2
GO:0034061	DNA polymerase activity	4	3
GO:0097159	organic cyclic compound binding	2	12
GO:0140097	catalytic activity, acting on DNA	3	3
GO:0140640	catalytic activity, acting on a nucleic acid	2	3
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	263	267	PF00656	0.581
CLV_C14_Caspase3-7	535	539	PF00656	0.565
CLV_NRD_NRD_1	186	188	PF00675	0.303
CLV_NRD_NRD_1	359	361	PF00675	0.298
CLV_NRD_NRD_1	417	419	PF00675	0.290
CLV_PCSK_KEX2_1	186	188	PF00082	0.305
CLV_PCSK_KEX2_1	279	281	PF00082	0.457
CLV_PCSK_KEX2_1	289	291	PF00082	0.612
CLV_PCSK_KEX2_1	321	323	PF00082	0.524
CLV_PCSK_KEX2_1	359	361	PF00082	0.297
CLV_PCSK_KEX2_1	505	507	PF00082	0.607
CLV_PCSK_PC1ET2_1	279	281	PF00082	0.433
CLV_PCSK_PC1ET2_1	289	291	PF00082	0.614
CLV_PCSK_PC1ET2_1	321	323	PF00082	0.548
CLV_PCSK_PC1ET2_1	505	507	PF00082	0.595
CLV_PCSK_PC7_1	285	291	PF00082	0.458
CLV_PCSK_PC7_1	317	323	PF00082	0.653
CLV_PCSK_SKI1_1	137	141	PF00082	0.274
CLV_PCSK_SKI1_1	187	191	PF00082	0.339
CLV_PCSK_SKI1_1	209	213	PF00082	0.249
CLV_PCSK_SKI1_1	280	284	PF00082	0.428
CLV_PCSK_SKI1_1	305	309	PF00082	0.418
CLV_PCSK_SKI1_1	348	352	PF00082	0.265
CLV_PCSK_SKI1_1	468	472	PF00082	0.290
CLV_PCSK_SKI1_1	582	586	PF00082	0.423
DEG_APCC_DBOX_1	279	287	PF00400	0.438
DEG_APCC_DBOX_1	347	355	PF00400	0.462
DEG_APCC_DBOX_1	581	589	PF00400	0.494
DOC_CYCLIN_RxL_1	184	193	PF00134	0.504
DOC_CYCLIN_RxL_1	345	353	PF00134	0.459
DOC_CYCLIN_yCln2_LP_2	612	618	PF00134	0.398
DOC_MAPK_DCC_7	418	426	PF00069	0.504
DOC_MAPK_gen_1	119	128	PF00069	0.539
DOC_MAPK_gen_1	137	147	PF00069	0.542
DOC_MAPK_gen_1	214	222	PF00069	0.489
DOC_MAPK_gen_1	389	397	PF00069	0.533
DOC_MAPK_gen_1	418	426	PF00069	0.589
DOC_MAPK_gen_1	505	515	PF00069	0.689
DOC_MAPK_MEF2A_6	389	397	PF00069	0.532
DOC_MAPK_MEF2A_6	57	64	PF00069	0.400
DOC_PP1_RVXF_1	21	27	PF00149	0.349
DOC_PP2B_LxvP_1	612	615	PF13499	0.419
DOC_USP7_MATH_1	243	247	PF00917	0.490
DOC_USP7_MATH_1	455	459	PF00917	0.453
DOC_USP7_MATH_1	532	536	PF00917	0.580
DOC_USP7_UBL2_3	381	385	PF12436	0.437
DOC_WW_Pin1_4	440	445	PF00397	0.379
DOC_WW_Pin1_4	516	521	PF00397	0.679
LIG_14-3-3_CanoR_1	137	143	PF00244	0.539
LIG_14-3-3_CanoR_1	209	217	PF00244	0.472
LIG_14-3-3_CanoR_1	369	373	PF00244	0.495
LIG_14-3-3_CanoR_1	468	473	PF00244	0.526
LIG_14-3-3_CanoR_1	506	515	PF00244	0.652
LIG_Actin_WH2_2	225	240	PF00022	0.499
LIG_Actin_WH2_2	343	361	PF00022	0.527
LIG_Actin_WH2_2	444	462	PF00022	0.512
LIG_APCC_ABBA_1	178	183	PF00400	0.388
LIG_APCC_ABBAyCdc20_2	57	63	PF00400	0.448
LIG_BIR_III_4	266	270	PF00653	0.436
LIG_CaM_IQ_9	15	31	PF13499	0.353
LIG_CaM_IQ_9	272	287	PF13499	0.364
LIG_deltaCOP1_diTrp_1	40	48	PF00928	0.445
LIG_FHA_1	359	365	PF00498	0.457
LIG_FHA_1	451	457	PF00498	0.450
LIG_FHA_1	507	513	PF00498	0.533
LIG_FHA_1	539	545	PF00498	0.567
LIG_FHA_1	81	87	PF00498	0.491
LIG_FHA_2	30	36	PF00498	0.492
LIG_FHA_2	369	375	PF00498	0.458
LIG_FHA_2	512	518	PF00498	0.777
LIG_GBD_Chelix_1	364	372	PF00786	0.339
LIG_LIR_Apic_2	589	594	PF02991	0.456
LIG_LIR_Gen_1	141	151	PF02991	0.457
LIG_LIR_Gen_1	172	181	PF02991	0.488
LIG_LIR_Gen_1	293	303	PF02991	0.429
LIG_LIR_Gen_1	58	67	PF02991	0.311
LIG_LIR_Gen_1	600	608	PF02991	0.506
LIG_LIR_Gen_1	77	86	PF02991	0.362
LIG_LIR_Nem_3	141	146	PF02991	0.504
LIG_LIR_Nem_3	172	178	PF02991	0.504
LIG_LIR_Nem_3	293	299	PF02991	0.363
LIG_LIR_Nem_3	341	347	PF02991	0.478
LIG_LIR_Nem_3	541	546	PF02991	0.515
LIG_LIR_Nem_3	573	577	PF02991	0.453
LIG_LIR_Nem_3	58	62	PF02991	0.335
LIG_LIR_Nem_3	600	604	PF02991	0.411
LIG_LIR_Nem_3	65	71	PF02991	0.414
LIG_LIR_Nem_3	77	81	PF02991	0.362
LIG_LYPXL_yS_3	574	577	PF13949	0.484
LIG_MAD2	305	313	PF02301	0.532
LIG_PDZ_Class_3	614	619	PF00595	0.522
LIG_Pex14_2	26	30	PF04695	0.350
LIG_Pex14_2	38	42	PF04695	0.376
LIG_REV1ctd_RIR_1	499	506	PF16727	0.689
LIG_SH2_CRK	143	147	PF00017	0.437
LIG_SH2_CRK	175	179	PF00017	0.539
LIG_SH2_CRK	296	300	PF00017	0.424
LIG_SH2_GRB2like	114	117	PF00017	0.448
LIG_SH2_SRC	114	117	PF00017	0.448
LIG_SH2_SRC	143	146	PF00017	0.457
LIG_SH2_SRC	239	242	PF00017	0.465
LIG_SH2_STAP1	130	134	PF00017	0.527
LIG_SH2_STAT5	102	105	PF00017	0.437
LIG_SH2_STAT5	114	117	PF00017	0.437
LIG_SH2_STAT5	239	242	PF00017	0.454
LIG_SH2_STAT5	25	28	PF00017	0.538
LIG_SH2_STAT5	543	546	PF00017	0.409
LIG_SH2_STAT5	580	583	PF00017	0.394
LIG_SH3_3	374	380	PF00018	0.437
LIG_SH3_3	392	398	PF00018	0.437
LIG_SH3_3	40	46	PF00018	0.316
LIG_SH3_3	512	518	PF00018	0.618
LIG_SH3_3	525	531	PF00018	0.643
LIG_SUMO_SIM_anti_2	511	517	PF11976	0.669
LIG_SUMO_SIM_par_1	422	428	PF11976	0.526
LIG_SUMO_SIM_par_1	452	458	PF11976	0.435
LIG_SUMO_SIM_par_1	511	517	PF11976	0.700
LIG_TRFH_1	147	151	PF08558	0.445
LIG_TYR_ITIM	572	577	PF00017	0.439
LIG_TYR_ITSM	139	146	PF00017	0.539
LIG_TYR_ITSM	292	299	PF00017	0.420
LIG_WRC_WIRS_1	604	609	PF05994	0.451
MOD_CK1_1	95	101	PF00069	0.437
MOD_CK2_1	114	120	PF00069	0.526
MOD_CK2_1	159	165	PF00069	0.448
MOD_CK2_1	243	249	PF00069	0.567
MOD_CK2_1	29	35	PF00069	0.491
MOD_CK2_1	368	374	PF00069	0.445
MOD_CK2_1	429	435	PF00069	0.472
MOD_CK2_1	440	446	PF00069	0.492
MOD_CK2_1	511	517	PF00069	0.722
MOD_Cter_Amidation	287	290	PF01082	0.443
MOD_Cter_Amidation	319	322	PF01082	0.535
MOD_GlcNHglycan	116	119	PF01048	0.291
MOD_GlcNHglycan	190	193	PF01048	0.300
MOD_GlcNHglycan	490	493	PF01048	0.705
MOD_GlcNHglycan	566	569	PF01048	0.514
MOD_GSK3_1	425	432	PF00069	0.515
MOD_GSK3_1	468	475	PF00069	0.482
MOD_GSK3_1	603	610	PF00069	0.405
MOD_GSK3_1	92	99	PF00069	0.457
MOD_NEK2_1	181	186	PF00069	0.470
MOD_NEK2_1	190	195	PF00069	0.430
MOD_NEK2_1	368	373	PF00069	0.447
MOD_NEK2_1	4	9	PF00069	0.604
MOD_NEK2_1	425	430	PF00069	0.500
MOD_NEK2_1	607	612	PF00069	0.484
MOD_NEK2_1	67	72	PF00069	0.448
MOD_NEK2_2	455	460	PF00069	0.488
MOD_NEK2_2	524	529	PF00069	0.598
MOD_PIKK_1	380	386	PF00454	0.462
MOD_PIKK_1	506	512	PF00454	0.570
MOD_PKA_2	358	364	PF00069	0.472
MOD_PKA_2	368	374	PF00069	0.411
MOD_PKA_2	488	494	PF00069	0.646
MOD_Plk_2-3	159	165	PF00069	0.450
MOD_Plk_2-3	511	517	PF00069	0.669
MOD_Plk_4	138	144	PF00069	0.504
MOD_Plk_4	291	297	PF00069	0.515
MOD_Plk_4	368	374	PF00069	0.432
MOD_Plk_4	511	517	PF00069	0.712
MOD_Plk_4	538	544	PF00069	0.454
MOD_ProDKin_1	440	446	PF00069	0.379
MOD_ProDKin_1	516	522	PF00069	0.680
MOD_SUMO_for_1	278	281	PF00179	0.490
MOD_SUMO_for_1	74	77	PF00179	0.462
TRG_DiLeu_BaLyEn_6	420	425	PF01217	0.504
TRG_ENDOCYTIC_2	143	146	PF00928	0.437
TRG_ENDOCYTIC_2	175	178	PF00928	0.504
TRG_ENDOCYTIC_2	296	299	PF00928	0.421
TRG_ENDOCYTIC_2	574	577	PF00928	0.409
TRG_ENDOCYTIC_2	78	81	PF00928	0.591
TRG_ER_diArg_1	185	187	PF00400	0.488
TRG_ER_diArg_1	358	360	PF00400	0.520
TRG_ER_diArg_1	487	490	PF00400	0.738
TRG_NES_CRM1_1	63	77	PF08389	0.437
TRG_NLS_MonoCore_2	504	509	PF00514	0.655
TRG_Pf-PMV_PEXEL_1	253	257	PF00026	0.536
TRG_Pf-PMV_PEXEL_1	348	352	PF00026	0.268
TRG_Pf-PMV_PEXEL_1	429	433	PF00026	0.278

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA19	Leptomonas seymouri	70%	100%
A0A0S4JRX6	Bodo saltans	42%	87%
A0A1X0P8Q5	Trypanosomatidae	50%	98%
A0A3S7XA64	Leishmania donovani	95%	100%
A0A422NAZ8	Trypanosoma rangeli	49%	100%
A4HNL7	Leishmania braziliensis	82%	99%
A4ICX7	Leishmania infantum	94%	100%
D0A2H2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9ASC8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5BV86	Trypanosoma cruzi	49%	100%