Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q267_LEIMA

TriTrypDb:

LmjF.36.0110 , LMJLV39_360006200 , LMJSD75_360006200

Length:

938

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q267

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q267

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	275	279	PF00656	0.573
CLV_C14_Caspase3-7	748	752	PF00656	0.747
CLV_NRD_NRD_1	133	135	PF00675	0.574
CLV_NRD_NRD_1	195	197	PF00675	0.682
CLV_NRD_NRD_1	223	225	PF00675	0.590
CLV_NRD_NRD_1	271	273	PF00675	0.598
CLV_NRD_NRD_1	288	290	PF00675	0.463
CLV_NRD_NRD_1	379	381	PF00675	0.525
CLV_NRD_NRD_1	429	431	PF00675	0.609
CLV_NRD_NRD_1	436	438	PF00675	0.633
CLV_NRD_NRD_1	461	463	PF00675	0.598
CLV_NRD_NRD_1	680	682	PF00675	0.640
CLV_NRD_NRD_1	694	696	PF00675	0.467
CLV_NRD_NRD_1	705	707	PF00675	0.576
CLV_PCSK_FUR_1	131	135	PF00082	0.599
CLV_PCSK_KEX2_1	133	135	PF00082	0.581
CLV_PCSK_KEX2_1	195	197	PF00082	0.608
CLV_PCSK_KEX2_1	223	225	PF00082	0.552
CLV_PCSK_KEX2_1	271	273	PF00082	0.594
CLV_PCSK_KEX2_1	288	290	PF00082	0.461
CLV_PCSK_KEX2_1	345	347	PF00082	0.612
CLV_PCSK_KEX2_1	379	381	PF00082	0.598
CLV_PCSK_KEX2_1	429	431	PF00082	0.573
CLV_PCSK_KEX2_1	436	438	PF00082	0.571
CLV_PCSK_KEX2_1	455	457	PF00082	0.392
CLV_PCSK_KEX2_1	461	463	PF00082	0.577
CLV_PCSK_KEX2_1	679	681	PF00082	0.662
CLV_PCSK_KEX2_1	694	696	PF00082	0.441
CLV_PCSK_KEX2_1	705	707	PF00082	0.537
CLV_PCSK_PC1ET2_1	345	347	PF00082	0.612
CLV_PCSK_PC1ET2_1	455	457	PF00082	0.617
CLV_PCSK_PC1ET2_1	705	707	PF00082	0.474
CLV_PCSK_SKI1_1	104	108	PF00082	0.719
CLV_PCSK_SKI1_1	196	200	PF00082	0.709
CLV_PCSK_SKI1_1	394	398	PF00082	0.580
CLV_PCSK_SKI1_1	4	8	PF00082	0.459
CLV_PCSK_SKI1_1	409	413	PF00082	0.462
CLV_PCSK_SKI1_1	452	456	PF00082	0.630
CLV_PCSK_SKI1_1	461	465	PF00082	0.520
CLV_PCSK_SKI1_1	602	606	PF00082	0.669
CLV_PCSK_SKI1_1	62	66	PF00082	0.483
CLV_PCSK_SKI1_1	665	669	PF00082	0.634
CLV_PCSK_SKI1_1	695	699	PF00082	0.634
CLV_PCSK_SKI1_1	839	843	PF00082	0.507
DEG_APCC_DBOX_1	103	111	PF00400	0.720
DEG_APCC_DBOX_1	253	261	PF00400	0.707
DEG_APCC_DBOX_1	317	325	PF00400	0.452
DEG_APCC_DBOX_1	436	444	PF00400	0.598
DEG_APCC_DBOX_1	61	69	PF00400	0.487
DEG_APCC_DBOX_1	651	659	PF00400	0.666
DEG_APCC_DBOX_1	798	806	PF00400	0.639
DEG_MDM2_SWIB_1	400	407	PF02201	0.665
DEG_SPOP_SBC_1	110	114	PF00917	0.660
DOC_CDC14_PxL_1	6	14	PF14671	0.448
DOC_CDC14_PxL_1	726	734	PF14671	0.533
DOC_CYCLIN_RxL_1	231	242	PF00134	0.668
DOC_CYCLIN_RxL_1	376	387	PF00134	0.458
DOC_MAPK_DCC_7	4	14	PF00069	0.452
DOC_MAPK_DCC_7	62	70	PF00069	0.453
DOC_MAPK_gen_1	269	276	PF00069	0.595
DOC_MAPK_gen_1	345	351	PF00069	0.619
DOC_MAPK_gen_1	379	385	PF00069	0.461
DOC_MAPK_gen_1	560	568	PF00069	0.547
DOC_MAPK_gen_1	580	588	PF00069	0.401
DOC_MAPK_MEF2A_6	22	30	PF00069	0.455
DOC_MAPK_MEF2A_6	323	331	PF00069	0.575
DOC_MAPK_MEF2A_6	560	568	PF00069	0.663
DOC_MAPK_MEF2A_6	580	588	PF00069	0.362
DOC_MAPK_MEF2A_6	62	70	PF00069	0.488
DOC_MAPK_MEF2A_6	919	928	PF00069	0.653
DOC_PP1_RVXF_1	124	131	PF00149	0.755
DOC_PP1_RVXF_1	307	313	PF00149	0.726
DOC_PP1_RVXF_1	335	341	PF00149	0.528
DOC_PP1_RVXF_1	868	875	PF00149	0.780
DOC_PP2B_LxvP_1	5	8	PF13499	0.455
DOC_PP2B_LxvP_1	924	927	PF13499	0.612
DOC_PP4_FxxP_1	874	877	PF00568	0.674
DOC_USP7_MATH_1	147	151	PF00917	0.532
DOC_USP7_MATH_1	241	245	PF00917	0.644
DOC_USP7_MATH_1	669	673	PF00917	0.674
DOC_USP7_MATH_1	728	732	PF00917	0.692
DOC_USP7_MATH_1	79	83	PF00917	0.539
DOC_USP7_MATH_1	8	12	PF00917	0.445
DOC_USP7_MATH_1	815	819	PF00917	0.702
DOC_USP7_MATH_1	918	922	PF00917	0.648
DOC_USP7_MATH_1	927	931	PF00917	0.551
DOC_USP7_UBL2_3	707	711	PF12436	0.634
DOC_WW_Pin1_4	111	116	PF00397	0.496
DOC_WW_Pin1_4	47	52	PF00397	0.507
LIG_14-3-3_CanoR_1	223	227	PF00244	0.627
LIG_14-3-3_CanoR_1	254	258	PF00244	0.504
LIG_14-3-3_CanoR_1	318	322	PF00244	0.680
LIG_14-3-3_CanoR_1	323	328	PF00244	0.600
LIG_14-3-3_CanoR_1	356	364	PF00244	0.677
LIG_14-3-3_CanoR_1	380	386	PF00244	0.632
LIG_14-3-3_CanoR_1	436	444	PF00244	0.442
LIG_14-3-3_CanoR_1	502	506	PF00244	0.717
LIG_14-3-3_CanoR_1	602	610	PF00244	0.578
LIG_14-3-3_CanoR_1	625	631	PF00244	0.663
LIG_14-3-3_CanoR_1	665	674	PF00244	0.611
LIG_14-3-3_CanoR_1	680	690	PF00244	0.487
LIG_14-3-3_CanoR_1	734	742	PF00244	0.735
LIG_14-3-3_CanoR_1	870	875	PF00244	0.782
LIG_Actin_WH2_2	368	384	PF00022	0.613
LIG_BRCT_BRCA1_1	72	76	PF00533	0.691
LIG_CaM_IQ_9	444	460	PF13499	0.452
LIG_CaM_IQ_9	566	582	PF13499	0.511
LIG_Clathr_ClatBox_1	585	589	PF01394	0.621
LIG_Clathr_ClatBox_1	655	659	PF01394	0.665
LIG_CtBP_PxDLS_1	768	772	PF00389	0.518
LIG_deltaCOP1_diTrp_1	699	703	PF00928	0.579
LIG_deltaCOP1_diTrp_1	740	749	PF00928	0.646
LIG_eIF4E_1	787	793	PF01652	0.626
LIG_FHA_1	166	172	PF00498	0.568
LIG_FHA_1	357	363	PF00498	0.596
LIG_FHA_1	449	455	PF00498	0.615
LIG_FHA_1	48	54	PF00498	0.565
LIG_FHA_1	604	610	PF00498	0.602
LIG_FHA_1	666	672	PF00498	0.572
LIG_FHA_1	67	73	PF00498	0.462
LIG_FHA_1	721	727	PF00498	0.593
LIG_FHA_1	880	886	PF00498	0.790
LIG_FHA_1	909	915	PF00498	0.688
LIG_FHA_2	382	388	PF00498	0.649
LIG_FHA_2	627	633	PF00498	0.565
LIG_LIR_Apic_2	871	877	PF02991	0.675
LIG_LIR_Gen_1	200	210	PF02991	0.582
LIG_LIR_Gen_1	52	63	PF02991	0.524
LIG_LIR_Gen_1	561	569	PF02991	0.663
LIG_LIR_Gen_1	772	782	PF02991	0.657
LIG_LIR_Gen_1	800	805	PF02991	0.756
LIG_LIR_Nem_3	199	205	PF02991	0.634
LIG_LIR_Nem_3	232	237	PF02991	0.668
LIG_LIR_Nem_3	418	424	PF02991	0.601
LIG_LIR_Nem_3	52	58	PF02991	0.534
LIG_LIR_Nem_3	561	566	PF02991	0.578
LIG_LIR_Nem_3	611	617	PF02991	0.569
LIG_LIR_Nem_3	739	745	PF02991	0.742
LIG_LIR_Nem_3	772	777	PF02991	0.661
LIG_LIR_Nem_3	800	804	PF02991	0.654
LIG_LIR_Nem_3	821	827	PF02991	0.522
LIG_MLH1_MIPbox_1	72	76	PF16413	0.451
LIG_MYND_1	117	121	PF01753	0.679
LIG_NRBOX	328	334	PF00104	0.602
LIG_NRBOX	439	445	PF00104	0.598
LIG_OCRL_FandH_1	209	221	PF00620	0.582
LIG_PCNA_PIPBox_1	287	296	PF02747	0.605
LIG_Pex14_1	404	408	PF04695	0.560
LIG_Pex14_2	400	404	PF04695	0.665
LIG_Pex14_2	842	846	PF04695	0.677
LIG_Pex14_2	852	856	PF04695	0.672
LIG_PTB_Apo_2	169	176	PF02174	0.688
LIG_PTB_Phospho_1	169	175	PF10480	0.685
LIG_Rb_LxCxE_1	137	154	PF01857	0.570
LIG_Rb_LxCxE_1	222	242	PF01857	0.702
LIG_Rb_LxCxE_1	368	389	PF01857	0.586
LIG_Rb_LxCxE_1	535	553	PF01857	0.605
LIG_RPA_C_Fungi	425	437	PF08784	0.667
LIG_SH2_CRK	408	412	PF00017	0.578
LIG_SH2_CRK	55	59	PF00017	0.478
LIG_SH2_CRK	614	618	PF00017	0.437
LIG_SH2_CRK	774	778	PF00017	0.664
LIG_SH2_PTP2	563	566	PF00017	0.655
LIG_SH2_SRC	468	471	PF00017	0.579
LIG_SH2_SRC	563	566	PF00017	0.531
LIG_SH2_STAP1	20	24	PF00017	0.450
LIG_SH2_STAP1	325	329	PF00017	0.595
LIG_SH2_STAP1	55	59	PF00017	0.478
LIG_SH2_STAT5	468	471	PF00017	0.696
LIG_SH2_STAT5	532	535	PF00017	0.677
LIG_SH2_STAT5	55	58	PF00017	0.482
LIG_SH2_STAT5	563	566	PF00017	0.553
LIG_SH2_STAT5	787	790	PF00017	0.631
LIG_SH3_2	121	126	PF14604	0.658
LIG_SH3_3	117	123	PF00018	0.682
LIG_SH3_3	203	209	PF00018	0.703
LIG_SH3_3	60	66	PF00018	0.455
LIG_SH3_3	7	13	PF00018	0.444
LIG_SH3_3	724	730	PF00018	0.686
LIG_SH3_3	851	857	PF00018	0.764
LIG_SH3_3	92	98	PF00018	0.579
LIG_SUMO_SIM_anti_2	347	353	PF11976	0.563
LIG_SUMO_SIM_par_1	272	278	PF11976	0.657
LIG_SUMO_SIM_par_1	329	335	PF11976	0.576
LIG_SUMO_SIM_par_1	347	353	PF11976	0.370
LIG_SUMO_SIM_par_1	504	510	PF11976	0.635
LIG_SUMO_SIM_par_1	584	591	PF11976	0.622
LIG_SUMO_SIM_par_1	66	71	PF11976	0.460
LIG_TRAF2_1	259	262	PF00917	0.604
LIG_TRAF2_1	264	267	PF00917	0.592
LIG_TRAF2_1	384	387	PF00917	0.626
LIG_TRAF2_1	476	479	PF00917	0.703
LIG_TRAF2_1	507	510	PF00917	0.713
LIG_TRAF2_1	549	552	PF00917	0.683
LIG_TRAF2_1	629	632	PF00917	0.603
LIG_TYR_ITIM	53	58	PF00017	0.485
LIG_UBA3_1	329	337	PF00899	0.530
LIG_WRC_WIRS_1	148	153	PF05994	0.506
MOD_CK1_1	352	358	PF00069	0.666
MOD_CK1_1	415	421	PF00069	0.587
MOD_CK1_1	43	49	PF00069	0.507
MOD_CK1_1	438	444	PF00069	0.465
MOD_CK1_1	608	614	PF00069	0.645
MOD_CK1_1	733	739	PF00069	0.642
MOD_CK1_1	814	820	PF00069	0.633
MOD_CK1_1	848	854	PF00069	0.768
MOD_CK2_1	146	152	PF00069	0.523
MOD_CK2_1	261	267	PF00069	0.610
MOD_CK2_1	32	38	PF00069	0.476
MOD_CK2_1	381	387	PF00069	0.645
MOD_CK2_1	473	479	PF00069	0.706
MOD_CK2_1	615	621	PF00069	0.624
MOD_CK2_1	626	632	PF00069	0.517
MOD_CK2_1	669	675	PF00069	0.670
MOD_CK2_1	681	687	PF00069	0.609
MOD_CK2_1	810	816	PF00069	0.738
MOD_GlcNHglycan	241	244	PF01048	0.595
MOD_GlcNHglycan	34	37	PF01048	0.510
MOD_GlcNHglycan	42	45	PF01048	0.521
MOD_GlcNHglycan	475	478	PF01048	0.470
MOD_GlcNHglycan	589	593	PF01048	0.694
MOD_GlcNHglycan	617	620	PF01048	0.456
MOD_GlcNHglycan	671	674	PF01048	0.662
MOD_GlcNHglycan	684	687	PF01048	0.456
MOD_GlcNHglycan	759	762	PF01048	0.535
MOD_GlcNHglycan	77	80	PF01048	0.622
MOD_GlcNHglycan	813	816	PF01048	0.692
MOD_GlcNHglycan	817	820	PF01048	0.654
MOD_GlcNHglycan	90	93	PF01048	0.597
MOD_GlcNHglycan	920	923	PF01048	0.677
MOD_GSK3_1	111	118	PF00069	0.663
MOD_GSK3_1	352	359	PF00069	0.598
MOD_GSK3_1	390	397	PF00069	0.441
MOD_GSK3_1	412	419	PF00069	0.602
MOD_GSK3_1	43	50	PF00069	0.527
MOD_GSK3_1	435	442	PF00069	0.471
MOD_GSK3_1	626	633	PF00069	0.449
MOD_GSK3_1	66	73	PF00069	0.454
MOD_GSK3_1	665	672	PF00069	0.681
MOD_GSK3_1	716	723	PF00069	0.690
MOD_GSK3_1	75	82	PF00069	0.516
MOD_GSK3_1	751	758	PF00069	0.744
MOD_GSK3_1	769	776	PF00069	0.446
MOD_GSK3_1	806	813	PF00069	0.698
MOD_GSK3_1	848	855	PF00069	0.685
MOD_N-GLC_1	811	816	PF02516	0.578
MOD_N-GLC_1	848	853	PF02516	0.688
MOD_NEK2_1	14	19	PF00069	0.476
MOD_NEK2_1	239	244	PF00069	0.612
MOD_NEK2_1	53	58	PF00069	0.507
MOD_NEK2_1	605	610	PF00069	0.651
MOD_NEK2_1	68	73	PF00069	0.739
MOD_NEK2_1	720	725	PF00069	0.711
MOD_NEK2_1	75	80	PF00069	0.610
MOD_NEK2_1	852	857	PF00069	0.716
MOD_NEK2_2	769	774	PF00069	0.733
MOD_NEK2_2	79	84	PF00069	0.501
MOD_PIKK_1	356	362	PF00454	0.672
MOD_PIKK_1	394	400	PF00454	0.687
MOD_PIKK_1	856	862	PF00454	0.663
MOD_PK_1	705	711	PF00069	0.593
MOD_PKA_1	705	711	PF00069	0.593
MOD_PKA_2	222	228	PF00069	0.561
MOD_PKA_2	239	245	PF00069	0.517
MOD_PKA_2	253	259	PF00069	0.439
MOD_PKA_2	317	323	PF00069	0.661
MOD_PKA_2	355	361	PF00069	0.675
MOD_PKA_2	381	387	PF00069	0.621
MOD_PKA_2	435	441	PF00069	0.438
MOD_PKA_2	501	507	PF00069	0.715
MOD_PKA_2	626	632	PF00069	0.681
MOD_PKA_2	705	711	PF00069	0.632
MOD_PKA_2	716	722	PF00069	0.533
MOD_PKA_2	733	739	PF00069	0.553
MOD_PKA_2	887	893	PF00069	0.744
MOD_PKA_2	96	102	PF00069	0.726
MOD_PKB_1	679	687	PF00069	0.527
MOD_Plk_1	229	235	PF00069	0.636
MOD_Plk_1	415	421	PF00069	0.673
MOD_Plk_1	438	444	PF00069	0.539
MOD_Plk_1	815	821	PF00069	0.766
MOD_Plk_1	848	854	PF00069	0.683
MOD_Plk_1	868	874	PF00069	0.448
MOD_Plk_4	115	121	PF00069	0.698
MOD_Plk_4	15	21	PF00069	0.467
MOD_Plk_4	416	422	PF00069	0.657
MOD_Plk_4	439	445	PF00069	0.595
MOD_Plk_4	501	507	PF00069	0.715
MOD_Plk_4	594	600	PF00069	0.617
MOD_Plk_4	605	611	PF00069	0.599
MOD_Plk_4	70	76	PF00069	0.450
MOD_Plk_4	820	826	PF00069	0.492
MOD_Plk_4	902	908	PF00069	0.616
MOD_ProDKin_1	111	117	PF00069	0.500
MOD_ProDKin_1	47	53	PF00069	0.507
MOD_SUMO_rev_2	137	142	PF00179	0.654
TRG_DiLeu_BaEn_1	154	159	PF01217	0.640
TRG_DiLeu_BaEn_1	183	188	PF01217	0.631
TRG_DiLeu_BaEn_1	439	444	PF01217	0.677
TRG_DiLeu_BaEn_1	635	640	PF01217	0.597
TRG_DiLeu_BaEn_1	687	692	PF01217	0.601
TRG_DiLeu_BaEn_4	137	143	PF01217	0.660
TRG_DiLeu_BaEn_4	551	557	PF01217	0.672
TRG_DiLeu_BaLyEn_6	269	274	PF01217	0.702
TRG_DiLeu_BaLyEn_6	63	68	PF01217	0.452
TRG_ENDOCYTIC_2	408	411	PF00928	0.577
TRG_ENDOCYTIC_2	55	58	PF00928	0.482
TRG_ENDOCYTIC_2	563	566	PF00928	0.655
TRG_ENDOCYTIC_2	614	617	PF00928	0.539
TRG_ENDOCYTIC_2	774	777	PF00928	0.662
TRG_ENDOCYTIC_2	824	827	PF00928	0.485
TRG_ER_diArg_1	130	133	PF00400	0.616
TRG_ER_diArg_1	164	167	PF00400	0.512
TRG_ER_diArg_1	271	273	PF00400	0.606
TRG_ER_diArg_1	28	31	PF00400	0.477
TRG_ER_diArg_1	288	290	PF00400	0.618
TRG_ER_diArg_1	307	310	PF00400	0.746
TRG_ER_diArg_1	379	382	PF00400	0.682
TRG_ER_diArg_1	428	430	PF00400	0.572
TRG_ER_diArg_1	545	548	PF00400	0.664
TRG_ER_diArg_1	624	627	PF00400	0.701
TRG_ER_diArg_1	679	681	PF00400	0.700
TRG_ER_diArg_1	693	695	PF00400	0.466
TRG_NES_CRM1_1	322	335	PF08389	0.579
TRG_Pf-PMV_PEXEL_1	133	137	PF00026	0.676
TRG_Pf-PMV_PEXEL_1	224	229	PF00026	0.637
TRG_Pf-PMV_PEXEL_1	271	275	PF00026	0.704
TRG_Pf-PMV_PEXEL_1	430	434	PF00026	0.560
TRG_Pf-PMV_PEXEL_1	462	466	PF00026	0.593
TRG_Pf-PMV_PEXEL_1	583	587	PF00026	0.639

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVC9	Leptomonas seymouri	43%	100%
A0A3S7XA57	Leishmania donovani	90%	100%
A4HNL8	Leishmania braziliensis	71%	100%
A4ICX6	Leishmania infantum	89%	100%
E9ASC9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%