PUB domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PUB domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q265_LEIMA

TriTrypDb:

LmjF.36.0130 , LMJLV39_360006400 , LMJSD75_360006400

Length:

367

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4Q265

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q265

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	234	238	PF00656	0.532
CLV_C14_Caspase3-7	31	35	PF00656	0.711
CLV_NRD_NRD_1	120	122	PF00675	0.608
CLV_NRD_NRD_1	131	133	PF00675	0.414
CLV_NRD_NRD_1	141	143	PF00675	0.450
CLV_NRD_NRD_1	155	157	PF00675	0.467
CLV_NRD_NRD_1	164	166	PF00675	0.430
CLV_NRD_NRD_1	175	177	PF00675	0.434
CLV_NRD_NRD_1	188	190	PF00675	0.475
CLV_NRD_NRD_1	355	357	PF00675	0.500
CLV_PCSK_FUR_1	118	122	PF00082	0.494
CLV_PCSK_KEX2_1	100	102	PF00082	0.528
CLV_PCSK_KEX2_1	120	122	PF00082	0.376
CLV_PCSK_KEX2_1	155	157	PF00082	0.450
CLV_PCSK_KEX2_1	164	166	PF00082	0.467
CLV_PCSK_KEX2_1	174	176	PF00082	0.375
CLV_PCSK_KEX2_1	188	190	PF00082	0.482
CLV_PCSK_KEX2_1	276	278	PF00082	0.528
CLV_PCSK_KEX2_1	306	308	PF00082	0.274
CLV_PCSK_KEX2_1	355	357	PF00082	0.430
CLV_PCSK_PC1ET2_1	100	102	PF00082	0.528
CLV_PCSK_PC1ET2_1	276	278	PF00082	0.528
CLV_PCSK_PC1ET2_1	306	308	PF00082	0.274
CLV_PCSK_SKI1_1	100	104	PF00082	0.484
CLV_PCSK_SKI1_1	108	112	PF00082	0.436
CLV_PCSK_SKI1_1	142	146	PF00082	0.507
CLV_PCSK_SKI1_1	175	179	PF00082	0.444
CLV_PCSK_SKI1_1	291	295	PF00082	0.300
DEG_APCC_DBOX_1	290	298	PF00400	0.368
DEG_SPOP_SBC_1	232	236	PF00917	0.505
DOC_MAPK_gen_1	120	130	PF00069	0.565
DOC_MAPK_gen_1	132	140	PF00069	0.414
DOC_MAPK_gen_1	174	181	PF00069	0.399
DOC_MAPK_gen_1	305	311	PF00069	0.417
DOC_MAPK_gen_1	314	323	PF00069	0.417
DOC_MAPK_gen_1	355	363	PF00069	0.494
DOC_MAPK_MEF2A_6	174	181	PF00069	0.397
DOC_PP1_RVXF_1	326	333	PF00149	0.352
DOC_USP7_MATH_1	232	236	PF00917	0.621
DOC_USP7_MATH_2	23	29	PF00917	0.576
DOC_USP7_UBL2_3	123	127	PF12436	0.454
LIG_14-3-3_CanoR_1	146	154	PF00244	0.612
LIG_14-3-3_CanoR_1	310	316	PF00244	0.300
LIG_14-3-3_CanoR_1	51	58	PF00244	0.598
LIG_AP2alpha_2	300	302	PF02296	0.417
LIG_BIR_II_1	1	5	PF00653	0.635
LIG_BRCT_BRCA1_1	298	302	PF00533	0.460
LIG_EH1_1	357	365	PF00400	0.277
LIG_FHA_1	287	293	PF00498	0.417
LIG_FHA_1	306	312	PF00498	0.185
LIG_FHA_1	344	350	PF00498	0.322
LIG_FHA_1	35	41	PF00498	0.508
LIG_FHA_1	71	77	PF00498	0.406
LIG_FHA_2	102	108	PF00498	0.458
LIG_FHA_2	190	196	PF00498	0.527
LIG_FHA_2	31	37	PF00498	0.623
LIG_FHA_2	85	91	PF00498	0.503
LIG_GBD_Chelix_1	353	361	PF00786	0.376
LIG_LIR_Gen_1	73	83	PF02991	0.467
LIG_PCNA_PIPBox_1	252	261	PF02747	0.492
LIG_RPA_C_Fungi	207	219	PF08784	0.489
LIG_SH2_NCK_1	204	208	PF00017	0.568
LIG_SH2_SRC	204	207	PF00017	0.431
LIG_SH2_STAP1	204	208	PF00017	0.437
LIG_SH2_STAT5	38	41	PF00017	0.480
LIG_SH3_3	17	23	PF00018	0.766
LIG_SH3_3	295	301	PF00018	0.388
LIG_SUMO_SIM_anti_2	90	97	PF11976	0.454
LIG_UBA3_1	144	148	PF00899	0.550
MOD_CK1_1	24	30	PF00069	0.637
MOD_CK1_1	243	249	PF00069	0.581
MOD_CK1_1	250	256	PF00069	0.502
MOD_CK2_1	101	107	PF00069	0.397
MOD_CK2_1	146	152	PF00069	0.441
MOD_CK2_1	189	195	PF00069	0.472
MOD_CK2_1	25	31	PF00069	0.637
MOD_CK2_1	84	90	PF00069	0.526
MOD_Cter_Amidation	140	143	PF01082	0.474
MOD_GlcNHglycan	15	19	PF01048	0.640
MOD_GlcNHglycan	242	245	PF01048	0.605
MOD_GlcNHglycan	249	252	PF01048	0.605
MOD_GSK3_1	21	28	PF00069	0.688
MOD_GSK3_1	218	225	PF00069	0.504
MOD_GSK3_1	228	235	PF00069	0.641
MOD_GSK3_1	243	250	PF00069	0.614
MOD_GSK3_1	30	37	PF00069	0.595
MOD_GSK3_1	301	308	PF00069	0.338
MOD_GSK3_1	343	350	PF00069	0.271
MOD_N-GLC_1	240	245	PF02516	0.679
MOD_N-GLC_1	25	30	PF02516	0.733
MOD_N-GLC_1	343	348	PF02516	0.313
MOD_NEK2_1	222	227	PF00069	0.582
MOD_NEK2_1	309	314	PF00069	0.302
MOD_NEK2_1	316	321	PF00069	0.301
MOD_NEK2_1	347	352	PF00069	0.364
MOD_NEK2_1	44	49	PF00069	0.316
MOD_NEK2_2	286	291	PF00069	0.368
MOD_OFUCOSY	66	72	PF10250	0.400
MOD_PIKK_1	222	228	PF00454	0.604
MOD_PIKK_1	38	44	PF00454	0.411
MOD_PIKK_1	70	76	PF00454	0.415
MOD_PKA_1	305	311	PF00069	0.334
MOD_PKA_2	309	315	PF00069	0.417
MOD_PKA_2	316	322	PF00069	0.417
MOD_Plk_1	240	246	PF00069	0.621
MOD_Plk_1	343	349	PF00069	0.343
MOD_Plk_4	251	257	PF00069	0.562
MOD_Plk_4	316	322	PF00069	0.394
MOD_Plk_4	348	354	PF00069	0.285
MOD_Plk_4	58	64	PF00069	0.378
MOD_SUMO_for_1	147	150	PF00179	0.504
MOD_SUMO_for_1	217	220	PF00179	0.454
MOD_SUMO_rev_2	105	112	PF00179	0.446
MOD_SUMO_rev_2	124	128	PF00179	0.525
MOD_SUMO_rev_2	2	8	PF00179	0.628
TRG_DiLeu_BaEn_1	325	330	PF01217	0.350
TRG_DiLeu_BaEn_4	125	131	PF01217	0.494
TRG_DiLeu_BaLyEn_6	288	293	PF01217	0.476
TRG_DiLeu_LyEn_5	325	330	PF01217	0.302
TRG_ER_diArg_1	118	121	PF00400	0.495
TRG_ER_diArg_1	154	156	PF00400	0.449
TRG_ER_diArg_1	174	176	PF00400	0.416
TRG_ER_diArg_1	354	356	PF00400	0.449
TRG_Pf-PMV_PEXEL_1	101	105	PF00026	0.496
TRG_Pf-PMV_PEXEL_1	113	117	PF00026	0.449
TRG_Pf-PMV_PEXEL_1	355	359	PF00026	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I208	Leptomonas seymouri	62%	99%
A0A0S4JLL2	Bodo saltans	42%	94%
A0A1X0P8K7	Trypanosomatidae	50%	100%
A0A3S5IQV7	Trypanosoma rangeli	46%	100%
A0A3S7XA96	Leishmania donovani	91%	100%
A4HNM0	Leishmania braziliensis	78%	100%
A4ICX4	Leishmania infantum	90%	100%
D0A2H5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	89%
E9ASD1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5BQK6	Trypanosoma cruzi	43%	100%