Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q264_LEIMA

TriTrypDb:

LmjF.36.0140 , LMJLV39_360006500 , LMJSD75_360006500

Length:

650

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q264

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q264

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016310	phosphorylation	5	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	1
GO:0003824	catalytic activity	1	1
GO:0004672	protein kinase activity	3	1
GO:0005488	binding	1	1
GO:0005524	ATP binding	5	1
GO:0016301	kinase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	1
GO:0017076	purine nucleotide binding	4	1
GO:0030554	adenyl nucleotide binding	5	1
GO:0032553	ribonucleotide binding	3	1
GO:0032555	purine ribonucleotide binding	4	1
GO:0032559	adenyl ribonucleotide binding	5	1
GO:0035639	purine ribonucleoside triphosphate binding	4	1
GO:0036094	small molecule binding	2	1
GO:0043167	ion binding	2	1
GO:0043168	anion binding	3	1
GO:0097159	organic cyclic compound binding	2	1
GO:0097367	carbohydrate derivative binding	2	1
GO:0140096	catalytic activity, acting on a protein	2	1
GO:1901265	nucleoside phosphate binding	3	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	355	359	PF00656	0.491
CLV_MEL_PAP_1	109	115	PF00089	0.479
CLV_PCSK_KEX2_1	252	254	PF00082	0.494
CLV_PCSK_KEX2_1	414	416	PF00082	0.497
CLV_PCSK_KEX2_1	59	61	PF00082	0.507
CLV_PCSK_PC1ET2_1	252	254	PF00082	0.494
CLV_PCSK_PC1ET2_1	414	416	PF00082	0.481
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.507
CLV_PCSK_SKI1_1	221	225	PF00082	0.652
CLV_PCSK_SKI1_1	252	256	PF00082	0.497
CLV_PCSK_SKI1_1	3	7	PF00082	0.599
CLV_PCSK_SKI1_1	306	310	PF00082	0.473
CLV_PCSK_SKI1_1	324	328	PF00082	0.285
CLV_PCSK_SKI1_1	362	366	PF00082	0.382
CLV_PCSK_SKI1_1	447	451	PF00082	0.435
CLV_PCSK_SKI1_1	457	461	PF00082	0.495
CLV_PCSK_SKI1_1	498	502	PF00082	0.566
CLV_PCSK_SKI1_1	550	554	PF00082	0.508
CLV_PCSK_SKI1_1	59	63	PF00082	0.427
CLV_PCSK_SKI1_1	75	79	PF00082	0.361
DEG_APCC_DBOX_1	361	369	PF00400	0.381
DEG_Nend_Nbox_1	1	3	PF02207	0.562
DEG_ODPH_VHL_1	117	129	PF01847	0.468
DEG_SPOP_SBC_1	12	16	PF00917	0.402
DOC_CDC14_PxL_1	395	403	PF14671	0.484
DOC_CKS1_1	300	305	PF01111	0.533
DOC_CYCLIN_RxL_1	495	506	PF00134	0.569
DOC_CYCLIN_yCln2_LP_2	431	437	PF00134	0.434
DOC_CYCLIN_yCln2_LP_2	557	563	PF00134	0.493
DOC_MAPK_DCC_7	362	370	PF00069	0.434
DOC_MAPK_DCC_7	553	563	PF00069	0.567
DOC_MAPK_gen_1	382	391	PF00069	0.435
DOC_MAPK_gen_1	75	83	PF00069	0.504
DOC_MAPK_MEF2A_6	362	370	PF00069	0.348
DOC_MAPK_MEF2A_6	426	435	PF00069	0.405
DOC_MAPK_RevD_3	90	104	PF00069	0.412
DOC_PP1_RVXF_1	102	109	PF00149	0.414
DOC_PP1_RVXF_1	496	503	PF00149	0.482
DOC_PP2B_LxvP_1	182	185	PF13499	0.554
DOC_PP2B_LxvP_1	284	287	PF13499	0.501
DOC_PP2B_LxvP_1	431	434	PF13499	0.435
DOC_PP2B_LxvP_1	468	471	PF13499	0.504
DOC_PP4_FxxP_1	175	178	PF00568	0.449
DOC_PP4_FxxP_1	300	303	PF00568	0.548
DOC_PP4_FxxP_1	363	366	PF00568	0.417
DOC_USP7_MATH_1	12	16	PF00917	0.583
DOC_USP7_MATH_1	156	160	PF00917	0.421
DOC_USP7_MATH_1	191	195	PF00917	0.487
DOC_USP7_MATH_1	520	524	PF00917	0.519
DOC_USP7_MATH_1	551	555	PF00917	0.493
DOC_USP7_MATH_1	573	577	PF00917	0.509
DOC_USP7_MATH_1	611	615	PF00917	0.743
DOC_USP7_MATH_1	620	624	PF00917	0.789
DOC_USP7_MATH_1	638	642	PF00917	0.646
DOC_WW_Pin1_4	13	18	PF00397	0.442
DOC_WW_Pin1_4	183	188	PF00397	0.516
DOC_WW_Pin1_4	299	304	PF00397	0.543
DOC_WW_Pin1_4	460	465	PF00397	0.497
DOC_WW_Pin1_4	543	548	PF00397	0.531
DOC_WW_Pin1_4	605	610	PF00397	0.567
DOC_WW_Pin1_4	631	636	PF00397	0.612
LIG_14-3-3_CanoR_1	112	116	PF00244	0.423
LIG_14-3-3_CanoR_1	179	185	PF00244	0.520
LIG_14-3-3_CanoR_1	266	275	PF00244	0.487
LIG_14-3-3_CanoR_1	288	296	PF00244	0.490
LIG_14-3-3_CanoR_1	639	645	PF00244	0.472
LIG_14-3-3_CanoR_1	64	74	PF00244	0.448
LIG_BRCT_BRCA1_1	275	279	PF00533	0.476
LIG_BRCT_BRCA1_1	33	37	PF00533	0.471
LIG_BRCT_BRCA1_1	522	526	PF00533	0.504
LIG_BRCT_BRCA1_2	33	39	PF00533	0.462
LIG_deltaCOP1_diTrp_1	164	175	PF00928	0.456
LIG_deltaCOP1_diTrp_1	621	630	PF00928	0.555
LIG_EH1_1	571	579	PF00400	0.488
LIG_EVH1_1	286	290	PF00568	0.495
LIG_EVH1_2	188	192	PF00568	0.556
LIG_FAT_LD_1	531	539	PF03623	0.463
LIG_FHA_1	203	209	PF00498	0.452
LIG_FHA_1	243	249	PF00498	0.403
LIG_FHA_1	291	297	PF00498	0.514
LIG_FHA_1	391	397	PF00498	0.447
LIG_FHA_1	426	432	PF00498	0.379
LIG_FHA_1	461	467	PF00498	0.523
LIG_FHA_1	514	520	PF00498	0.570
LIG_FHA_1	53	59	PF00498	0.401
LIG_FHA_2	332	338	PF00498	0.537
LIG_FHA_2	505	511	PF00498	0.553
LIG_FHA_2	64	70	PF00498	0.409
LIG_LIR_Apic_2	172	178	PF02991	0.459
LIG_LIR_Apic_2	297	303	PF02991	0.559
LIG_LIR_Apic_2	621	627	PF02991	0.657
LIG_LIR_Gen_1	205	215	PF02991	0.489
LIG_LIR_Gen_1	238	249	PF02991	0.378
LIG_LIR_Gen_1	386	396	PF02991	0.389
LIG_LIR_Gen_1	523	534	PF02991	0.540
LIG_LIR_Gen_1	642	650	PF02991	0.585
LIG_LIR_Nem_3	205	210	PF02991	0.451
LIG_LIR_Nem_3	236	242	PF02991	0.343
LIG_LIR_Nem_3	320	326	PF02991	0.407
LIG_LIR_Nem_3	386	391	PF02991	0.392
LIG_LIR_Nem_3	454	459	PF02991	0.453
LIG_LIR_Nem_3	487	491	PF02991	0.441
LIG_LIR_Nem_3	523	529	PF02991	0.563
LIG_LIR_Nem_3	642	648	PF02991	0.587
LIG_MLH1_MIPbox_1	275	279	PF16413	0.548
LIG_MYND_1	399	403	PF01753	0.498
LIG_MYND_1	556	560	PF01753	0.496
LIG_MYND_1	627	631	PF01753	0.676
LIG_PCNA_PIPBox_1	305	314	PF02747	0.446
LIG_Pex14_2	489	493	PF04695	0.453
LIG_Pex14_2	645	649	PF04695	0.556
LIG_PROFILIN_1	594	600	PF00235	0.530
LIG_Rb_pABgroove_1	324	332	PF01858	0.458
LIG_SH2_CRK	239	243	PF00017	0.424
LIG_SH2_CRK	330	334	PF00017	0.400
LIG_SH2_CRK	580	584	PF00017	0.486
LIG_SH2_STAP1	407	411	PF00017	0.452
LIG_SH2_STAP1	580	584	PF00017	0.602
LIG_SH2_STAT3	407	410	PF00017	0.457
LIG_SH2_STAT5	161	164	PF00017	0.411
LIG_SH2_STAT5	202	205	PF00017	0.365
LIG_SH2_STAT5	207	210	PF00017	0.403
LIG_SH2_STAT5	278	281	PF00017	0.500
LIG_SH2_STAT5	387	390	PF00017	0.385
LIG_SH3_3	113	119	PF00018	0.523
LIG_SH3_3	182	188	PF00018	0.551
LIG_SH3_3	192	198	PF00018	0.447
LIG_SH3_3	284	290	PF00018	0.491
LIG_SH3_3	590	596	PF00018	0.640
LIG_SH3_3	614	620	PF00018	0.701
LIG_SH3_5	198	202	PF00018	0.389
LIG_SUMO_SIM_anti_2	245	250	PF11976	0.409
LIG_SUMO_SIM_anti_2	68	75	PF11976	0.511
LIG_SUMO_SIM_anti_2	79	85	PF11976	0.387
LIG_SUMO_SIM_par_1	242	247	PF11976	0.421
LIG_SUMO_SIM_par_1	292	297	PF11976	0.516
LIG_SUMO_SIM_par_1	348	355	PF11976	0.434
LIG_SUMO_SIM_par_1	91	96	PF11976	0.460
LIG_TYR_ITIM	578	583	PF00017	0.474
LIG_UBA3_1	1	6	PF00899	0.607
LIG_UBA3_1	431	438	PF00899	0.428
LIG_UBA3_1	53	59	PF00899	0.446
LIG_UBA3_1	537	544	PF00899	0.563
LIG_WRC_WIRS_1	499	504	PF05994	0.483
MOD_CDK_SPxxK_3	299	306	PF00069	0.539
MOD_CDK_SPxxK_3	460	467	PF00069	0.494
MOD_CDK_SPxxK_3	543	550	PF00069	0.519
MOD_CK1_1	11	17	PF00069	0.531
MOD_CK1_1	183	189	PF00069	0.461
MOD_CK1_1	26	32	PF00069	0.397
MOD_CK1_1	376	382	PF00069	0.527
MOD_CK1_1	390	396	PF00069	0.379
MOD_CK1_1	52	58	PF00069	0.355
MOD_CK1_1	525	531	PF00069	0.484
MOD_CK1_1	603	609	PF00069	0.692
MOD_CK2_1	266	272	PF00069	0.511
MOD_CK2_1	500	506	PF00069	0.567
MOD_CK2_1	63	69	PF00069	0.432
MOD_Cter_Amidation	250	253	PF01082	0.470
MOD_Cter_Amidation	47	50	PF01082	0.489
MOD_GlcNHglycan	10	13	PF01048	0.600
MOD_GlcNHglycan	182	185	PF01048	0.457
MOD_GlcNHglycan	24	28	PF01048	0.472
MOD_GlcNHglycan	268	271	PF01048	0.459
MOD_GlcNHglycan	375	378	PF01048	0.423
MOD_GlcNHglycan	502	505	PF01048	0.409
MOD_GlcNHglycan	587	590	PF01048	0.720
MOD_GlcNHglycan	602	605	PF01048	0.783
MOD_GlcNHglycan	609	612	PF01048	0.703
MOD_GlcNHglycan	613	616	PF01048	0.679
MOD_GlcNHglycan	631	634	PF01048	0.687
MOD_GSK3_1	156	163	PF00069	0.402
MOD_GSK3_1	22	29	PF00069	0.408
MOD_GSK3_1	290	297	PF00069	0.481
MOD_GSK3_1	421	428	PF00069	0.376
MOD_GSK3_1	458	465	PF00069	0.464
MOD_GSK3_1	498	505	PF00069	0.420
MOD_GSK3_1	520	527	PF00069	0.544
MOD_GSK3_1	585	592	PF00069	0.672
MOD_GSK3_1	599	606	PF00069	0.606
MOD_GSK3_1	607	614	PF00069	0.650
MOD_GSK3_1	8	15	PF00069	0.578
MOD_N-GLC_1	513	518	PF02516	0.527
MOD_N-GLC_1	520	525	PF02516	0.526
MOD_N-GLC_1	565	570	PF02516	0.429
MOD_NEK2_1	155	160	PF00069	0.376
MOD_NEK2_1	23	28	PF00069	0.499
MOD_NEK2_1	5	10	PF00069	0.599
MOD_NEK2_1	500	505	PF00069	0.556
MOD_NEK2_1	583	588	PF00069	0.675
MOD_NEK2_2	156	161	PF00069	0.421
MOD_NEK2_2	565	570	PF00069	0.459
MOD_PIKK_1	458	464	PF00454	0.484
MOD_PIKK_1	622	628	PF00454	0.773
MOD_PK_1	49	55	PF00069	0.362
MOD_PKA_1	49	55	PF00069	0.439
MOD_PKA_2	111	117	PF00069	0.395
MOD_PKA_2	63	69	PF00069	0.532
MOD_PKA_2	638	644	PF00069	0.524
MOD_Plk_1	520	526	PF00069	0.486
MOD_Plk_4	111	117	PF00069	0.364
MOD_Plk_4	156	162	PF00069	0.421
MOD_Plk_4	290	296	PF00069	0.442
MOD_Plk_4	387	393	PF00069	0.390
MOD_Plk_4	427	433	PF00069	0.395
MOD_Plk_4	49	55	PF00069	0.385
MOD_Plk_4	5	11	PF00069	0.522
MOD_Plk_4	573	579	PF00069	0.448
MOD_Plk_4	644	650	PF00069	0.572
MOD_ProDKin_1	13	19	PF00069	0.438
MOD_ProDKin_1	183	189	PF00069	0.518
MOD_ProDKin_1	299	305	PF00069	0.536
MOD_ProDKin_1	460	466	PF00069	0.508
MOD_ProDKin_1	543	549	PF00069	0.524
MOD_ProDKin_1	605	611	PF00069	0.563
MOD_ProDKin_1	631	637	PF00069	0.612
MOD_SUMO_rev_2	96	106	PF00179	0.566
TRG_DiLeu_BaEn_1	146	151	PF01217	0.462
TRG_DiLeu_BaEn_1	69	74	PF01217	0.446
TRG_DiLeu_BaEn_1	79	84	PF01217	0.323
TRG_DiLeu_BaEn_2	138	144	PF01217	0.506
TRG_DiLeu_BaLyEn_6	195	200	PF01217	0.449
TRG_DiLeu_BaLyEn_6	321	326	PF01217	0.460
TRG_DiLeu_BaLyEn_6	431	436	PF01217	0.438
TRG_DiLeu_BaLyEn_6	444	449	PF01217	0.501
TRG_DiLeu_BaLyEn_6	474	479	PF01217	0.461
TRG_DiLeu_BaLyEn_6	553	558	PF01217	0.437
TRG_ENDOCYTIC_2	207	210	PF00928	0.472
TRG_ENDOCYTIC_2	239	242	PF00928	0.424
TRG_ENDOCYTIC_2	330	333	PF00928	0.433
TRG_ENDOCYTIC_2	580	583	PF00928	0.523
TRG_Pf-PMV_PEXEL_1	142	146	PF00026	0.452
TRG_Pf-PMV_PEXEL_1	3	7	PF00026	0.593
TRG_Pf-PMV_PEXEL_1	382	386	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	539	543	PF00026	0.488

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P470	Leptomonas seymouri	71%	100%
A0A1X0P8C9	Trypanosomatidae	33%	100%
A0A3Q8IIL7	Leishmania donovani	92%	100%
A4HNM1	Leishmania braziliensis	76%	100%
A4ICX3	Leishmania infantum	92%	100%
E9ASD2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
F4I313	Arabidopsis thaliana	22%	71%
Q9C9H8	Arabidopsis thaliana	21%	72%