Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q262_LEIMA

TriTrypDb:

LmjF.36.0160 , LMJLV39_360006700 , LMJSD75_360006700

Length:

285

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 6, no: 1
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q262

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q262

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	137	139	PF00675	0.694
CLV_NRD_NRD_1	234	236	PF00675	0.481
CLV_PCSK_KEX2_1	137	139	PF00082	0.685
CLV_PCSK_KEX2_1	281	283	PF00082	0.476
CLV_PCSK_PC1ET2_1	281	283	PF00082	0.497
CLV_PCSK_SKI1_1	230	234	PF00082	0.463
DEG_Nend_UBRbox_3	1	3	PF02207	0.641
DOC_CKS1_1	154	159	PF01111	0.447
DOC_CYCLIN_yCln2_LP_2	154	160	PF00134	0.480
DOC_MAPK_MEF2A_6	94	103	PF00069	0.448
DOC_MAPK_RevD_3	220	236	PF00069	0.603
DOC_USP7_MATH_1	200	204	PF00917	0.573
DOC_USP7_MATH_1	273	277	PF00917	0.638
DOC_USP7_UBL2_3	56	60	PF12436	0.402
DOC_WW_Pin1_4	119	124	PF00397	0.420
DOC_WW_Pin1_4	153	158	PF00397	0.431
DOC_WW_Pin1_4	250	255	PF00397	0.748
LIG_14-3-3_CanoR_1	247	253	PF00244	0.601
LIG_Actin_WH2_2	88	104	PF00022	0.531
LIG_BRCT_BRCA1_1	210	214	PF00533	0.212
LIG_EH1_1	213	221	PF00400	0.268
LIG_FHA_1	174	180	PF00498	0.459
LIG_FHA_1	253	259	PF00498	0.650
LIG_FHA_1	29	35	PF00498	0.480
LIG_FHA_1	62	68	PF00498	0.520
LIG_FHA_2	56	62	PF00498	0.538
LIG_LIR_Apic_2	118	123	PF02991	0.433
LIG_LIR_Nem_3	195	201	PF02991	0.376
LIG_MYND_2	96	100	PF01753	0.371
LIG_NRBOX	11	17	PF00104	0.529
LIG_PDZ_Class_1	280	285	PF00595	0.772
LIG_Rb_pABgroove_1	65	73	PF01858	0.472
LIG_SH2_CRK	198	202	PF00017	0.522
LIG_SH2_CRK	82	86	PF00017	0.481
LIG_SH2_STAP1	48	52	PF00017	0.503
LIG_SH2_STAT5	164	167	PF00017	0.406
LIG_SH2_STAT5	231	234	PF00017	0.593
LIG_SH3_1	138	144	PF00018	0.489
LIG_SH3_3	138	144	PF00018	0.447
LIG_SUMO_SIM_anti_2	170	176	PF11976	0.346
LIG_SUMO_SIM_par_1	170	176	PF11976	0.387
LIG_TYR_ITIM	196	201	PF00017	0.465
LIG_TYR_ITIM	80	85	PF00017	0.613
LIG_WRC_WIRS_1	126	131	PF05994	0.618
LIG_WW_1	45	48	PF00397	0.652
MOD_CDK_SPxK_1	153	159	PF00069	0.616
MOD_CDK_SPxxK_3	250	257	PF00069	0.694
MOD_CK1_1	147	153	PF00069	0.475
MOD_CK1_1	207	213	PF00069	0.628
MOD_CK2_1	200	206	PF00069	0.605
MOD_CK2_1	55	61	PF00069	0.700
MOD_GlcNHglycan	146	149	PF01048	0.625
MOD_GlcNHglycan	183	186	PF01048	0.509
MOD_GlcNHglycan	202	205	PF01048	0.709
MOD_GlcNHglycan	23	26	PF01048	0.654
MOD_GlcNHglycan	274	278	PF01048	0.574
MOD_GlcNHglycan	6	9	PF01048	0.624
MOD_GSK3_1	115	122	PF00069	0.623
MOD_GSK3_1	16	23	PF00069	0.553
MOD_GSK3_1	200	207	PF00069	0.599
MOD_GSK3_1	208	215	PF00069	0.326
MOD_GSK3_1	248	255	PF00069	0.584
MOD_GSK3_1	28	35	PF00069	0.489
MOD_NEK2_1	16	21	PF00069	0.494
MOD_NEK2_1	173	178	PF00069	0.459
MOD_NEK2_1	239	244	PF00069	0.625
MOD_NEK2_1	4	9	PF00069	0.630
MOD_NEK2_2	17	22	PF00069	0.638
MOD_NEK2_2	55	60	PF00069	0.667
MOD_PIKK_1	183	189	PF00454	0.678
MOD_PIKK_1	252	258	PF00454	0.613
MOD_PKA_2	21	27	PF00069	0.669
MOD_PKA_2	61	67	PF00069	0.521
MOD_PKB_1	245	253	PF00069	0.503
MOD_Plk_1	239	245	PF00069	0.602
MOD_Plk_1	32	38	PF00069	0.496
MOD_Plk_1	48	54	PF00069	0.602
MOD_Plk_4	115	121	PF00069	0.622
MOD_Plk_4	209	215	PF00069	0.436
MOD_Plk_4	33	39	PF00069	0.576
MOD_Plk_4	95	101	PF00069	0.672
MOD_ProDKin_1	119	125	PF00069	0.517
MOD_ProDKin_1	153	159	PF00069	0.535
MOD_ProDKin_1	250	256	PF00069	0.695
MOD_SUMO_for_1	271	274	PF00179	0.516
TRG_DiLeu_BaEn_1	130	135	PF01217	0.582
TRG_DiLeu_BaLyEn_6	223	228	PF01217	0.501
TRG_ENDOCYTIC_2	198	201	PF00928	0.530
TRG_ENDOCYTIC_2	82	85	PF00928	0.605
TRG_ER_diArg_1	137	139	PF00400	0.605
TRG_ER_diArg_1	158	161	PF00400	0.504
TRG_ER_diArg_1	244	247	PF00400	0.560

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3B3	Leptomonas seymouri	43%	99%
A0A1X0P8Q0	Trypanosomatidae	23%	100%
A0A3Q8IN72	Leishmania donovani	90%	100%
A4HNM3	Leishmania braziliensis	76%	100%
A4ICX1	Leishmania infantum	91%	100%
E9ASD4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%