Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q261_LEIMA

TriTrypDb:

LmjF.36.0170 , LMJLV39_360006900 , LMJSD75_360006800

Length:

218

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q261

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q261

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	176	178	PF00675	0.607
CLV_NRD_NRD_1	214	216	PF00675	0.676
CLV_PCSK_KEX2_1	176	178	PF00082	0.645
CLV_PCSK_KEX2_1	214	216	PF00082	0.590
CLV_PCSK_SKI1_1	106	110	PF00082	0.530
CLV_PCSK_SKI1_1	44	48	PF00082	0.359
DEG_MDM2_SWIB_1	13	21	PF02201	0.405
DOC_MAPK_FxFP_2	50	53	PF00069	0.389
DOC_MAPK_MEF2A_6	36	43	PF00069	0.355
DOC_PP1_RVXF_1	8	14	PF00149	0.403
DOC_PP4_FxxP_1	20	23	PF00568	0.402
DOC_PP4_FxxP_1	50	53	PF00568	0.389
DOC_USP7_MATH_1	9	13	PF00917	0.403
DOC_WW_Pin1_4	2	7	PF00397	0.398
DOC_WW_Pin1_4	21	26	PF00397	0.370
DOC_WW_Pin1_4	73	78	PF00397	0.587
LIG_14-3-3_CanoR_1	10	14	PF00244	0.403
LIG_14-3-3_CanoR_1	44	53	PF00244	0.372
LIG_BIR_II_1	1	5	PF00653	0.407
LIG_deltaCOP1_diTrp_1	103	111	PF00928	0.465
LIG_eIF4E_1	118	124	PF01652	0.483
LIG_FHA_1	160	166	PF00498	0.657
LIG_FHA_2	107	113	PF00498	0.554
LIG_LIR_Apic_2	18	23	PF02991	0.399
LIG_LIR_Apic_2	48	53	PF02991	0.383
LIG_LIR_Gen_1	107	116	PF02991	0.473
LIG_LIR_Gen_1	138	148	PF02991	0.589
LIG_LIR_Gen_1	16	25	PF02991	0.398
LIG_LIR_Gen_1	67	77	PF02991	0.583
LIG_LIR_Nem_3	107	111	PF02991	0.501
LIG_LIR_Nem_3	115	121	PF02991	0.428
LIG_LIR_Nem_3	138	143	PF02991	0.512
LIG_LIR_Nem_3	16	20	PF02991	0.405
LIG_LIR_Nem_3	67	73	PF02991	0.595
LIG_PCNA_PIPBox_1	117	126	PF02747	0.552
LIG_PCNA_yPIPBox_3	117	129	PF02747	0.489
LIG_Pex14_1	104	108	PF04695	0.460
LIG_Pex14_2	13	17	PF04695	0.700
LIG_SH2_CRK	118	122	PF00017	0.481
LIG_SH2_CRK	140	144	PF00017	0.594
LIG_SH2_STAT5	151	154	PF00017	0.500
LIG_TYR_ITIM	116	121	PF00017	0.535
LIG_WRC_WIRS_1	105	110	PF05994	0.493
MOD_CK1_1	2	8	PF00069	0.398
MOD_CK1_1	68	74	PF00069	0.703
MOD_GlcNHglycan	156	159	PF01048	0.534
MOD_GlcNHglycan	47	50	PF01048	0.546
MOD_GSK3_1	106	113	PF00069	0.594
MOD_GSK3_1	64	71	PF00069	0.558
MOD_GSK3_1	9	16	PF00069	0.404
MOD_NEK2_1	1	6	PF00069	0.405
MOD_NEK2_1	13	18	PF00069	0.395
MOD_NEK2_1	159	164	PF00069	0.567
MOD_NEK2_1	64	69	PF00069	0.630
MOD_NEK2_2	15	20	PF00069	0.398
MOD_NEK2_2	9	14	PF00069	0.404
MOD_PKA_2	9	15	PF00069	0.404
MOD_Plk_4	9	15	PF00069	0.404
MOD_ProDKin_1	2	8	PF00069	0.398
MOD_ProDKin_1	21	27	PF00069	0.366
MOD_ProDKin_1	73	79	PF00069	0.584
MOD_SUMO_rev_2	196	204	PF00179	0.548
TRG_ENDOCYTIC_2	118	121	PF00928	0.475
TRG_ENDOCYTIC_2	140	143	PF00928	0.502
TRG_ENDOCYTIC_2	89	92	PF00928	0.656
TRG_ER_diArg_1	175	177	PF00400	0.645
TRG_ER_diArg_1	213	215	PF00400	0.585
TRG_Pf-PMV_PEXEL_1	176	180	PF00026	0.578
TRG_Pf-PMV_PEXEL_1	193	198	PF00026	0.458

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIV3	Leptomonas seymouri	84%	100%
A0A0S4JM35	Bodo saltans	59%	100%
A0A0S4JMY2	Bodo saltans	60%	100%
A0A1X0P999	Trypanosomatidae	66%	100%
A0A3S7XA69	Leishmania donovani	97%	100%
A4HNM4	Leishmania braziliensis	90%	100%
A4ICX0	Leishmania infantum	97%	100%
D0A2H9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	100%
E9ASD5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5DRU6	Trypanosoma cruzi	66%	100%