Elongation factor 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Elongation factor 2

Gene product:

elongation factor 2

Species:

Leishmania major

UniProt:

Q4Q259_LEIMA

TriTrypDb:

LmjF.36.0180 , LMJLV39_360007100 , LMJSD75_360007000

Length:

845

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 2
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	yes	yes: 1
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 3

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0032991	protein-containing complex	1	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

Q4Q259

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q259

Function

Biological processes
Term	Name	Level	Count
GO:0006414	translational elongation	5	2
GO:0008152	metabolic process	1	2
GO:0009058	biosynthetic process	2	2
GO:0009059	macromolecule biosynthetic process	4	2
GO:0009987	cellular process	1	2
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:1901576	organic substance biosynthetic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	12
GO:0003746	translation elongation factor activity	4	12
GO:0003824	catalytic activity	1	12
GO:0003924	GTPase activity	7	12
GO:0005488	binding	1	12
GO:0005525	GTP binding	5	12
GO:0008135	translation factor activity, RNA binding	3	12
GO:0016462	pyrophosphatase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016817	hydrolase activity, acting on acid anhydrides	3	12
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	12
GO:0019001	guanyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032561	guanyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043021	ribonucleoprotein complex binding	3	2
GO:0043022	ribosome binding	4	2
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0044877	protein-containing complex binding	2	2
GO:0045182	translation regulator activity	1	12
GO:0090079	translation regulator activity, nucleic acid binding	2	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	260	264	PF00656	0.619
CLV_C14_Caspase3-7	34	38	PF00656	0.518
CLV_C14_Caspase3-7	661	665	PF00656	0.518
CLV_NRD_NRD_1	268	270	PF00675	0.318
CLV_NRD_NRD_1	633	635	PF00675	0.318
CLV_NRD_NRD_1	713	715	PF00675	0.318
CLV_NRD_NRD_1	753	755	PF00675	0.329
CLV_NRD_NRD_1	827	829	PF00675	0.501
CLV_PCSK_FUR_1	266	270	PF00082	0.318
CLV_PCSK_KEX2_1	268	270	PF00082	0.318
CLV_PCSK_KEX2_1	511	513	PF00082	0.327
CLV_PCSK_KEX2_1	54	56	PF00082	0.318
CLV_PCSK_KEX2_1	713	715	PF00082	0.318
CLV_PCSK_KEX2_1	752	754	PF00082	0.329
CLV_PCSK_KEX2_1	93	95	PF00082	0.329
CLV_PCSK_PC1ET2_1	511	513	PF00082	0.327
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.318
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.343
CLV_PCSK_SKI1_1	142	146	PF00082	0.318
CLV_PCSK_SKI1_1	160	164	PF00082	0.318
CLV_PCSK_SKI1_1	254	258	PF00082	0.325
CLV_PCSK_SKI1_1	268	272	PF00082	0.299
CLV_PCSK_SKI1_1	296	300	PF00082	0.318
CLV_PCSK_SKI1_1	315	319	PF00082	0.318
CLV_PCSK_SKI1_1	434	438	PF00082	0.318
CLV_PCSK_SKI1_1	466	470	PF00082	0.318
CLV_PCSK_SKI1_1	481	485	PF00082	0.503
CLV_PCSK_SKI1_1	512	516	PF00082	0.336
CLV_PCSK_SKI1_1	66	70	PF00082	0.318
CLV_PCSK_SKI1_1	713	717	PF00082	0.329
CLV_PCSK_SKI1_1	829	833	PF00082	0.506
CLV_PCSK_SKI1_1	94	98	PF00082	0.318
DEG_APCC_DBOX_1	93	101	PF00400	0.518
DEG_SPOP_SBC_1	818	822	PF00917	0.578
DOC_CKS1_1	764	769	PF01111	0.529
DOC_CYCLIN_RxL_1	310	320	PF00134	0.518
DOC_CYCLIN_yCln2_LP_2	727	733	PF00134	0.619
DOC_MAPK_gen_1	148	155	PF00069	0.518
DOC_MAPK_gen_1	157	167	PF00069	0.518
DOC_MAPK_gen_1	293	303	PF00069	0.518
DOC_MAPK_gen_1	315	325	PF00069	0.518
DOC_MAPK_gen_1	404	413	PF00069	0.529
DOC_MAPK_gen_1	511	521	PF00069	0.518
DOC_MAPK_gen_1	752	758	PF00069	0.529
DOC_MAPK_gen_1	93	100	PF00069	0.529
DOC_MAPK_MEF2A_6	148	155	PF00069	0.518
DOC_MAPK_MEF2A_6	160	167	PF00069	0.518
DOC_MAPK_MEF2A_6	178	187	PF00069	0.518
DOC_MAPK_MEF2A_6	296	305	PF00069	0.528
DOC_MAPK_MEF2A_6	484	493	PF00069	0.506
DOC_MAPK_MEF2A_6	558	566	PF00069	0.468
DOC_MAPK_MEF2A_6	644	652	PF00069	0.518
DOC_MAPK_NFAT4_5	160	168	PF00069	0.518
DOC_PP1_RVXF_1	148	155	PF00149	0.518
DOC_USP7_MATH_1	208	212	PF00917	0.518
DOC_USP7_MATH_1	562	566	PF00917	0.454
DOC_USP7_UBL2_3	253	257	PF12436	0.529
DOC_USP7_UBL2_3	315	319	PF12436	0.518
DOC_USP7_UBL2_3	462	466	PF12436	0.518
DOC_USP7_UBL2_3	511	515	PF12436	0.524
DOC_USP7_UBL2_3	581	585	PF12436	0.452
DOC_WW_Pin1_4	100	105	PF00397	0.518
DOC_WW_Pin1_4	198	203	PF00397	0.585
DOC_WW_Pin1_4	339	344	PF00397	0.518
DOC_WW_Pin1_4	357	362	PF00397	0.461
DOC_WW_Pin1_4	473	478	PF00397	0.506
DOC_WW_Pin1_4	485	490	PF00397	0.497
DOC_WW_Pin1_4	721	726	PF00397	0.564
DOC_WW_Pin1_4	763	768	PF00397	0.529
LIG_14-3-3_CanoR_1	118	126	PF00244	0.518
LIG_14-3-3_CanoR_1	142	152	PF00244	0.518
LIG_14-3-3_CanoR_1	20	25	PF00244	0.518
LIG_14-3-3_CanoR_1	512	518	PF00244	0.518
LIG_Actin_WH2_2	126	144	PF00022	0.518
LIG_APCC_ABBA_1	694	699	PF00400	0.518
LIG_APCC_ABBAyCdc20_2	423	429	PF00400	0.518
LIG_BRCT_BRCA1_1	779	783	PF00533	0.529
LIG_Clathr_ClatBox_1	124	128	PF01394	0.518
LIG_Clathr_ClatBox_1	457	461	PF01394	0.518
LIG_deltaCOP1_diTrp_1	240	248	PF00928	0.518
LIG_FAT_LD_1	294	302	PF03623	0.518
LIG_FHA_1	112	118	PF00498	0.518
LIG_FHA_1	135	141	PF00498	0.518
LIG_FHA_1	144	150	PF00498	0.518
LIG_FHA_1	204	210	PF00498	0.518
LIG_FHA_1	595	601	PF00498	0.445
LIG_FHA_1	651	657	PF00498	0.518
LIG_FHA_1	782	788	PF00498	0.529
LIG_FHA_1	818	824	PF00498	0.467
LIG_FHA_2	187	193	PF00498	0.518
LIG_FHA_2	258	264	PF00498	0.619
LIG_FHA_2	304	310	PF00498	0.518
LIG_FHA_2	32	38	PF00498	0.518
LIG_FHA_2	467	473	PF00498	0.518
LIG_FHA_2	567	573	PF00498	0.454
LIG_FHA_2	57	63	PF00498	0.518
LIG_IRF3_LxIS_1	377	383	PF10401	0.405
LIG_LIR_Apic_2	189	193	PF02991	0.519
LIG_LIR_Apic_2	76	82	PF02991	0.529
LIG_LIR_Gen_1	221	231	PF02991	0.529
LIG_LIR_Gen_1	277	287	PF02991	0.523
LIG_LIR_LC3C_4	121	126	PF02991	0.518
LIG_LIR_LC3C_4	516	521	PF02991	0.518
LIG_LIR_Nem_3	170	176	PF02991	0.518
LIG_LIR_Nem_3	277	283	PF02991	0.518
LIG_LIR_Nem_3	363	369	PF02991	0.417
LIG_LIR_Nem_3	802	807	PF02991	0.529
LIG_PCNA_APIM_2	460	466	PF02747	0.518
LIG_PDZ_Class_3	840	845	PF00595	0.487
LIG_Pex14_1	243	247	PF04695	0.518
LIG_Pex14_2	397	401	PF04695	0.518
LIG_Pex14_2	666	670	PF04695	0.518
LIG_REV1ctd_RIR_1	245	255	PF16727	0.518
LIG_SH2_CRK	747	751	PF00017	0.529
LIG_SH2_CRK	79	83	PF00017	0.529
LIG_SH2_NCK_1	190	194	PF00017	0.585
LIG_SH2_SRC	418	421	PF00017	0.543
LIG_SH2_SRC	442	445	PF00017	0.518
LIG_SH2_SRC	774	777	PF00017	0.543
LIG_SH2_STAP1	227	231	PF00017	0.518
LIG_SH2_STAP1	626	630	PF00017	0.619
LIG_SH2_STAP1	717	721	PF00017	0.518
LIG_SH2_STAT3	15	18	PF00017	0.467
LIG_SH2_STAT5	365	368	PF00017	0.440
LIG_SH2_STAT5	381	384	PF00017	0.369
LIG_SH2_STAT5	418	421	PF00017	0.520
LIG_SH2_STAT5	463	466	PF00017	0.518
LIG_SH2_STAT5	774	777	PF00017	0.543
LIG_SH3_3	371	377	PF00018	0.451
LIG_SH3_3	761	767	PF00018	0.529
LIG_SH3_3	805	811	PF00018	0.529
LIG_SH3_3	830	836	PF00018	0.489
LIG_SUMO_SIM_par_1	123	128	PF11976	0.518
LIG_SUMO_SIM_par_1	205	211	PF11976	0.518
LIG_SUMO_SIM_par_1	516	523	PF11976	0.518
LIG_SUMO_SIM_par_1	648	653	PF11976	0.518
LIG_SUMO_SIM_par_1	732	738	PF11976	0.619
LIG_TRAF2_1	306	309	PF00917	0.543
LIG_TRAF2_1	523	526	PF00917	0.518
LIG_TRAF2_1	603	606	PF00917	0.629
LIG_TRFH_1	274	278	PF08558	0.356
LIG_UBA3_1	378	384	PF00899	0.390
LIG_UBA3_1	85	93	PF00899	0.391
LIG_Vh1_VBS_1	126	144	PF01044	0.356
LIG_WRC_WIRS_1	563	568	PF05994	0.441
MOD_CDC14_SPxK_1	201	204	PF00782	0.450
MOD_CDC14_SPxK_1	342	345	PF00782	0.421
MOD_CDK_SPK_2	339	344	PF00069	0.356
MOD_CDK_SPK_2	721	726	PF00069	0.391
MOD_CDK_SPxK_1	198	204	PF00069	0.450
MOD_CDK_SPxK_1	339	345	PF00069	0.356
MOD_CDK_SPxxK_3	357	364	PF00069	0.539
MOD_CDK_SPxxK_3	485	492	PF00069	0.474
MOD_CK1_1	111	117	PF00069	0.356
MOD_CK1_1	33	39	PF00069	0.356
MOD_CK2_1	303	309	PF00069	0.356
MOD_CK2_1	520	526	PF00069	0.361
MOD_CK2_1	562	568	PF00069	0.446
MOD_Cter_Amidation	420	423	PF01082	0.356
MOD_DYRK1A_RPxSP_1	763	767	PF00069	0.371
MOD_GlcNHglycan	210	213	PF01048	0.356
MOD_GlcNHglycan	355	358	PF01048	0.443
MOD_GlcNHglycan	401	404	PF01048	0.376
MOD_GlcNHglycan	406	409	PF01048	0.336
MOD_GlcNHglycan	466	469	PF01048	0.356
MOD_GlcNHglycan	525	529	PF01048	0.356
MOD_GlcNHglycan	581	584	PF01048	0.443
MOD_GSK3_1	107	114	PF00069	0.356
MOD_GSK3_1	297	304	PF00069	0.450
MOD_GSK3_1	31	38	PF00069	0.356
MOD_GSK3_1	353	360	PF00069	0.531
MOD_GSK3_1	464	471	PF00069	0.356
MOD_GSK3_1	520	527	PF00069	0.377
MOD_GSK3_1	562	569	PF00069	0.443
MOD_GSK3_1	66	73	PF00069	0.356
MOD_GSK3_1	777	784	PF00069	0.371
MOD_GSK3_1	813	820	PF00069	0.480
MOD_N-GLC_1	2	7	PF02516	0.490
MOD_N-GLC_1	20	25	PF02516	0.356
MOD_N-GLC_1	818	823	PF02516	0.543
MOD_NEK2_1	176	181	PF00069	0.356
MOD_NEK2_1	218	223	PF00069	0.371
MOD_NEK2_1	297	302	PF00069	0.359
MOD_NEK2_1	317	322	PF00069	0.222
MOD_NEK2_1	35	40	PF00069	0.356
MOD_NEK2_1	380	385	PF00069	0.409
MOD_NEK2_1	483	488	PF00069	0.504
MOD_NEK2_1	566	571	PF00069	0.425
MOD_NEK2_1	579	584	PF00069	0.432
MOD_NEK2_1	662	667	PF00069	0.356
MOD_NEK2_1	817	822	PF00069	0.506
MOD_NEK2_2	562	567	PF00069	0.452
MOD_PIKK_1	572	578	PF00454	0.560
MOD_PK_1	20	26	PF00069	0.356
MOD_PKA_2	117	123	PF00069	0.356
MOD_PKA_2	566	572	PF00069	0.431
MOD_Plk_1	2	8	PF00069	0.489
MOD_Plk_1	20	26	PF00069	0.356
MOD_Plk_1	692	698	PF00069	0.360
MOD_Plk_1	818	824	PF00069	0.549
MOD_Plk_2-3	735	741	PF00069	0.356
MOD_Plk_4	136	142	PF00069	0.356
MOD_Plk_4	20	26	PF00069	0.356
MOD_Plk_4	317	323	PF00069	0.356
MOD_Plk_4	328	334	PF00069	0.356
MOD_Plk_4	35	41	PF00069	0.356
MOD_Plk_4	662	668	PF00069	0.356
MOD_ProDKin_1	100	106	PF00069	0.356
MOD_ProDKin_1	198	204	PF00069	0.450
MOD_ProDKin_1	339	345	PF00069	0.356
MOD_ProDKin_1	357	363	PF00069	0.457
MOD_ProDKin_1	473	479	PF00069	0.499
MOD_ProDKin_1	485	491	PF00069	0.488
MOD_ProDKin_1	721	727	PF00069	0.420
MOD_ProDKin_1	763	769	PF00069	0.371
MOD_SUMO_for_1	256	259	PF00179	0.391
MOD_SUMO_for_1	46	49	PF00179	0.356
MOD_SUMO_rev_2	234	238	PF00179	0.360
MOD_SUMO_rev_2	356	366	PF00179	0.541
MOD_SUMO_rev_2	425	432	PF00179	0.356
MOD_SUMO_rev_2	476	486	PF00179	0.543
MOD_SUMO_rev_2	612	617	PF00179	0.385
MOD_SUMO_rev_2	810	817	PF00179	0.493
TRG_DiLeu_BaEn_2	361	367	PF01217	0.527
TRG_ENDOCYTIC_2	173	176	PF00928	0.356
TRG_ENDOCYTIC_2	280	283	PF00928	0.371
TRG_ENDOCYTIC_2	747	750	PF00928	0.371
TRG_ENDOCYTIC_2	774	777	PF00928	0.391
TRG_ER_diArg_1	148	151	PF00400	0.356
TRG_ER_diArg_1	266	269	PF00400	0.356
TRG_ER_diArg_1	391	394	PF00400	0.493
TRG_ER_diArg_1	617	620	PF00400	0.358
TRG_ER_diArg_1	713	715	PF00400	0.356
TRG_ER_diArg_1	752	754	PF00400	0.371
TRG_ER_diArg_1	825	828	PF00400	0.481
TRG_Pf-PMV_PEXEL_1	10	14	PF00026	0.441
TRG_Pf-PMV_PEXEL_1	160	164	PF00026	0.371
TRG_Pf-PMV_PEXEL_1	545	549	PF00026	0.371
TRG_Pf-PMV_PEXEL_1	620	624	PF00026	0.356

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9M7	Leptomonas seymouri	32%	95%
A0A0N1IJN8	Leptomonas seymouri	27%	83%
A0A0N1PBS6	Leptomonas seymouri	96%	100%
A0A0S4JLF0	Bodo saltans	23%	100%
A0A0S4JM05	Bodo saltans	90%	100%
A0A0S4JP20	Bodo saltans	33%	85%
A0A1X0NQW1	Trypanosomatidae	22%	100%
A0A1X0NY54	Trypanosomatidae	30%	94%
A0A1X0P8A5	Trypanosomatidae	23%	100%
A0A1X0P8P3	Trypanosomatidae	93%	100%
A0A3Q8IFJ7	Leishmania donovani	27%	100%
A0A3Q8IIX7	Leishmania donovani	100%	100%
A0A3R7MX75	Trypanosoma rangeli	30%	95%
A0A3R7NHC0	Trypanosoma rangeli	92%	100%
A0A3S7WZE0	Leishmania donovani	31%	95%
A0A3S7XAE9	Leishmania donovani	21%	100%
A0A422NBH6	Trypanosoma rangeli	24%	100%
A0A422P279	Trypanosoma rangeli	24%	100%
A0SXL6	Callithrix jacchus	61%	98%
A1A0T0	Bifidobacterium adolescentis (strain ATCC 15703 / DSM 20083 / NCTC 11814 / E194a)	26%	100%
A1AVJ7	Ruthia magnifica subsp. Calyptogena magnifica	25%	100%
A2R994	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	26%	98%
A3DMV6	Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1)	31%	100%
A3MSN3	Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1)	30%	100%
A4FUD3	Bos taurus	37%	87%
A4HEB0	Leishmania braziliensis	31%	95%
A4HKL0	Leishmania braziliensis	28%	100%
A4HNM7	Leishmania braziliensis	98%	100%
A4HNR7	Leishmania braziliensis	22%	100%
A4I1Q6	Leishmania infantum	30%	95%
A4I843	Leishmania infantum	28%	100%
A4ICS8	Leishmania infantum	21%	100%
A4ICW8	Leishmania infantum	100%	100%
A4SUV8	Polynucleobacter asymbioticus (strain DSM 18221 / CIP 109841 / QLW-P1DMWA-1)	26%	100%
A4YCV9	Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)	33%	100%
A5CF23	Orientia tsutsugamushi (strain Boryong)	24%	100%
A5DI11	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	61%	100%
A5IHR7	Legionella pneumophila (strain Corby)	26%	100%
A5IZ33	Mycoplasmopsis agalactiae (strain NCTC 10123 / CIP 59.7 / PG2)	27%	100%
A5USJ2	Roseiflexus sp. (strain RS-1)	26%	100%
A6LEJ3	Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / CIP 104284 / JCM 5825 / NCTC 11152)	27%	100%
A6Q1M7	Nitratiruptor sp. (strain SB155-2)	26%	100%
A7HWQ8	Parvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966)	27%	100%
A7Z0N4	Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / LMG 26770 / FZB42)	25%	100%
A8F0P0	Rickettsia massiliae (strain Mtu5)	27%	100%
A8F981	Bacillus pumilus (strain SAFR-032)	26%	100%
A8GMA0	Rickettsia akari (strain Hartford)	26%	100%
A8GV17	Rickettsia bellii (strain OSU 85-389)	26%	100%
A8LM45	Dinoroseobacter shibae (strain DSM 16493 / NCIMB 14021 / DFL 12)	27%	100%
A8PXR7	Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)	24%	100%
B1MW21	Leuconostoc citreum (strain KM20)	25%	100%
B1XSP8	Polynucleobacter necessarius subsp. necessarius (strain STIR1)	26%	100%
B2GIL1	Kocuria rhizophila (strain ATCC 9341 / DSM 348 / NBRC 103217 / DC2201)	26%	100%
B2RLZ4	Porphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / CIP 103683 / JCM 12257 / NCTC 11834 / 2561)	27%	100%
B3EP64	Chlorobium phaeobacteroides (strain BS1)	26%	100%
B3QZH4	Phytoplasma mali (strain AT)	26%	100%
B5ELX6	Acidithiobacillus ferrooxidans (strain ATCC 53993 / BNL-5-31)	25%	100%
B7J464	Acidithiobacillus ferrooxidans (strain ATCC 23270 / DSM 14882 / CIP 104768 / NCIMB 8455)	25%	100%
B8DTV6	Bifidobacterium animalis subsp. lactis (strain AD011)	26%	100%
B9DKV7	Staphylococcus carnosus (strain TM300)	26%	100%
C3PMH0	Rickettsia africae (strain ESF-5)	27%	100%
C4K1P6	Rickettsia peacockii (strain Rustic)	27%	100%
C4YJQ8	Candida albicans (strain WO-1)	61%	100%
C9ZKB0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	95%
D0A2I0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	92%	100%
D0A2M7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
D0AAB0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	87%
D3E3N9	Methanobrevibacter ruminantium (strain ATCC 35063 / DSM 1093 / JCM 13430 / OCM 146 / M1)	32%	100%
E9ASD6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
E9ASH6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	100%
E9AXU0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	95%
E9B301	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
F4JWP9	Arabidopsis thaliana	38%	87%
O08810	Mus musculus	37%	87%
O14460	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	63%	100%
O23755	Beta vulgaris	63%	100%
O59521	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	31%	100%
O74945	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	84%
O83464	Treponema pallidum (strain Nichols)	26%	100%
O94316	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	86%
P05197	Rattus norvegicus	62%	98%
P09445	Cricetulus griseus	61%	98%
P13060	Drosophila melanogaster	62%	100%
P13639	Homo sapiens	62%	98%
P15112	Dictyostelium discoideum	63%	100%
P28996	Parachlorella kessleri	62%	100%
P29691	Caenorhabditis elegans	63%	99%
P32324	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	62%	100%
P36048	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	84%
P41084	Rickettsia prowazekii (strain Madrid E)	25%	100%
P58252	Mus musculus	62%	98%
P61877	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	33%	100%
P61878	Pyrococcus woesei	33%	100%
P80868	Bacillus subtilis (strain 168)	25%	100%
Q01W89	Solibacter usitatus (strain Ellin6076)	26%	100%
Q04ED6	Oenococcus oeni (strain ATCC BAA-331 / PSU-1)	26%	100%
Q06193	Entamoeba histolytica	61%	100%
Q10W80	Trichodesmium erythraeum (strain IMS101)	24%	100%
Q123W3	Polaromonas sp. (strain JS666 / ATCC BAA-500)	28%	100%
Q15029	Homo sapiens	37%	87%
Q17152	Blastocystis hominis	57%	97%
Q1HPK6	Bombyx mori	62%	100%
Q1RHC3	Rickettsia bellii (strain RML369-C)	26%	100%
Q1WVA0	Ligilactobacillus salivarius (strain UCC118)	25%	100%
Q23716	Cryptosporidium parvum	59%	100%
Q2IJ93	Anaeromyxobacter dehalogenans (strain 2CP-C)	25%	100%
Q2YB00	Nitrosospira multiformis (strain ATCC 25196 / NCIMB 11849 / C 71)	26%	100%
Q3JV86	Burkholderia pseudomallei (strain 1710b)	24%	100%
Q3SYU2	Bos taurus	61%	98%
Q4A8T7	Mesomycoplasma hyopneumoniae (strain 7448)	26%	100%
Q4AAQ6	Mesomycoplasma hyopneumoniae (strain J / ATCC 25934 / NCTC 10110)	26%	100%
Q4Q219	Leishmania major	22%	100%
Q4Q555	Leishmania major	27%	100%
Q4Q9N1	Leishmania major	30%	95%
Q5A0M4	Candida albicans (strain SC5314 / ATCC MYA-2876)	61%	100%
Q5F3X4	Gallus gallus	37%	87%
Q5FM92	Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM)	25%	100%
Q5R6E0	Pongo abelii	37%	87%
Q5R8Z3	Pongo abelii	62%	98%
Q5WZL5	Legionella pneumophila (strain Lens)	27%	100%
Q601W8	Mesomycoplasma hyopneumoniae (strain 232)	26%	100%
Q62HK4	Burkholderia mallei (strain ATCC 23344)	24%	100%
Q63WJ7	Burkholderia pseudomallei (strain K96243)	24%	100%
Q660H9	Borrelia garinii subsp. bavariensis (strain ATCC BAA-2496 / DSM 23469 / PBi)	23%	100%
Q6BJ25	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	62%	100%
Q6BPD3	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	26%	100%
Q6CPQ9	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	61%	100%
Q6CRY5	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	24%	100%
Q6FLG2	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	27%	100%
Q6FYA7	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	61%	100%
Q6KHS5	Mycoplasma mobile (strain ATCC 43663 / 163K / NCTC 11711)	28%	100%
Q73R08	Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)	26%	100%
Q74M52	Nanoarchaeum equitans (strain Kin4-M)	32%	100%
Q754C8	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	61%	100%
Q7MTL1	Porphyromonas gingivalis (strain ATCC BAA-308 / W83)	27%	100%
Q7NAV3	Mycoplasma gallisepticum (strain R(low / passage 15 / clone 2))	28%	100%
Q7VJ85	Helicobacter hepaticus (strain ATCC 51449 / 3B1)	26%	100%
Q7Z2Z2	Homo sapiens	28%	75%
Q874B9	Komagataella pastoris	62%	100%
Q875S0	Lachancea kluyveri (strain ATCC 58438 / CBS 3082 / BCRC 21498 / NBRC 1685 / JCM 7257 / NCYC 543 / NRRL Y-12651)	61%	100%
Q875Z2	Naumovozyma castellii (strain ATCC 76901 / BCRC 22586 / CBS 4309 / NBRC 1992 / NRRL Y-12630)	62%	100%
Q88XY8	Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)	26%	100%
Q8C0D5	Mus musculus	28%	75%
Q8KTB0	Rickettsia bellii	26%	100%
Q8KTB6	Rickettsia montanensis	27%	100%
Q8KTB7	Rickettsia rhipicephali	27%	100%
Q8KTB9	Rickettsia parkeri	27%	100%
Q8SQT7	Encephalitozoon cuniculi (strain GB-M1)	41%	99%
Q8TXJ4	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	33%	67%
Q90705	Gallus gallus	62%	98%
Q92J93	Rickettsia conorii (strain ATCC VR-613 / Malish 7)	27%	100%
Q96X45	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	62%	100%
Q975H5	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	33%	100%
Q98QD8	Mycoplasmopsis pulmonis (strain UAB CTIP)	29%	100%
Q9ASR1	Arabidopsis thaliana	61%	100%
Q9HWD2	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	26%	100%
Q9LNC5	Arabidopsis thaliana	39%	86%
Q9V1Z8	Pyrococcus abyssi (strain GE5 / Orsay)	33%	100%
V5AW74	Trypanosoma cruzi	27%	88%
V5BGQ2	Trypanosoma cruzi	23%	98%
V5BI00	Trypanosoma cruzi	30%	95%
V5DRS6	Trypanosoma cruzi	92%	100%