LeishMANIAdb
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Mitochondrial inner membrane protease subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Mitochondrial inner membrane protease subunit
Gene product:
mitochondrial inner membrane signal peptidase, putative
Species:
Leishmania major
UniProt:
Q4Q258_LEIMA
TriTrypDb:
LmjF.36.0200 , LMJLV39_360007300 , LMJSD75_360007100
Length:
225

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 8
GO:0032991 protein-containing complex 1 2
GO:0042720 mitochondrial inner membrane peptidase complex 3 2
GO:0098796 membrane protein complex 2 2
GO:0098798 mitochondrial protein-containing complex 2 2
GO:0098800 inner mitochondrial membrane protein complex 3 2
GO:0110165 cellular anatomical entity 1 8
GO:1902494 catalytic complex 2 2
GO:0005743 mitochondrial inner membrane 5 1
GO:0019866 organelle inner membrane 4 1
GO:0031090 organelle membrane 3 1
GO:0031966 mitochondrial membrane 4 1

Expansion

Sequence features

Q4Q258
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q258

Function

Biological processes
Term Name Level Count
GO:0006465 signal peptide processing 5 12
GO:0006508 proteolysis 4 12
GO:0006518 peptide metabolic process 4 12
GO:0006627 protein processing involved in protein targeting to mitochondrion 7 2
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0016485 protein processing 5 12
GO:0019538 protein metabolic process 3 12
GO:0034982 mitochondrial protein processing 6 2
GO:0043170 macromolecule metabolic process 3 12
GO:0043603 amide metabolic process 3 12
GO:0044238 primary metabolic process 2 12
GO:0051604 protein maturation 4 12
GO:0071704 organic substance metabolic process 2 12
GO:1901564 organonitrogen compound metabolic process 3 12
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0004175 endopeptidase activity 4 12
GO:0004252 serine-type endopeptidase activity 5 12
GO:0008233 peptidase activity 3 12
GO:0008236 serine-type peptidase activity 4 12
GO:0016787 hydrolase activity 2 12
GO:0017171 serine hydrolase activity 3 12
GO:0140096 catalytic activity, acting on a protein 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 133 137 PF00656 0.298
CLV_NRD_NRD_1 187 189 PF00675 0.411
CLV_NRD_NRD_1 63 65 PF00675 0.411
CLV_PCSK_KEX2_1 187 189 PF00082 0.411
CLV_PCSK_KEX2_1 63 65 PF00082 0.411
CLV_PCSK_KEX2_1 89 91 PF00082 0.266
CLV_PCSK_PC1ET2_1 89 91 PF00082 0.266
CLV_PCSK_SKI1_1 90 94 PF00082 0.309
DOC_CYCLIN_RxL_1 195 204 PF00134 0.360
DOC_MAPK_gen_1 187 194 PF00069 0.385
DOC_MAPK_MEF2A_6 64 73 PF00069 0.405
DOC_PP4_FxxP_1 66 69 PF00568 0.411
DOC_USP7_MATH_1 167 171 PF00917 0.352
DOC_USP7_MATH_1 219 223 PF00917 0.740
DOC_USP7_UBL2_3 89 93 PF12436 0.393
DOC_WW_Pin1_4 115 120 PF00397 0.427
DOC_WW_Pin1_4 205 210 PF00397 0.522
LIG_14-3-3_CanoR_1 11 19 PF00244 0.498
LIG_14-3-3_CanoR_1 151 155 PF00244 0.331
LIG_BRCT_BRCA1_1 180 184 PF00533 0.411
LIG_FHA_2 123 129 PF00498 0.464
LIG_FHA_2 131 137 PF00498 0.291
LIG_FHA_2 97 103 PF00498 0.228
LIG_LIR_Apic_2 204 209 PF02991 0.479
LIG_LIR_Gen_1 107 117 PF02991 0.328
LIG_LIR_Gen_1 17 27 PF02991 0.414
LIG_LIR_Gen_1 170 178 PF02991 0.283
LIG_LIR_Gen_1 50 59 PF02991 0.281
LIG_LIR_Nem_3 107 112 PF02991 0.311
LIG_LIR_Nem_3 13 18 PF02991 0.439
LIG_LIR_Nem_3 142 148 PF02991 0.411
LIG_LIR_Nem_3 170 175 PF02991 0.283
LIG_LIR_Nem_3 50 54 PF02991 0.298
LIG_MYND_1 44 48 PF01753 0.266
LIG_SH2_CRK 117 121 PF00017 0.331
LIG_SH2_CRK 57 61 PF00017 0.300
LIG_SH2_NCK_1 117 121 PF00017 0.221
LIG_SH2_PTP2 109 112 PF00017 0.375
LIG_SH2_SRC 109 112 PF00017 0.375
LIG_SH2_STAT5 109 112 PF00017 0.375
LIG_SH2_STAT5 145 148 PF00017 0.373
LIG_SH2_STAT5 51 54 PF00017 0.281
LIG_SH2_STAT5 57 60 PF00017 0.281
LIG_SH3_2 215 220 PF14604 0.549
LIG_SH3_3 212 218 PF00018 0.566
LIG_SH3_3 50 56 PF00018 0.200
LIG_SH3_CIN85_PxpxPR_1 215 220 PF14604 0.549
LIG_SUMO_SIM_anti_2 74 80 PF11976 0.329
LIG_TYR_ITIM 55 60 PF00017 0.325
LIG_WW_3 217 221 PF00397 0.645
MOD_CK1_1 183 189 PF00069 0.279
MOD_CK1_1 208 214 PF00069 0.425
MOD_CK1_1 31 37 PF00069 0.277
MOD_CK1_1 96 102 PF00069 0.295
MOD_CK2_1 96 102 PF00069 0.251
MOD_CMANNOS 3 6 PF00535 0.455
MOD_GlcNHglycan 7 10 PF01048 0.403
MOD_GSK3_1 130 137 PF00069 0.364
MOD_GSK3_1 201 208 PF00069 0.432
MOD_GSK3_1 38 45 PF00069 0.281
MOD_GSK3_1 79 86 PF00069 0.293
MOD_GSK3_1 92 99 PF00069 0.256
MOD_N-GLC_1 178 183 PF02516 0.373
MOD_N-GLC_1 71 76 PF02516 0.416
MOD_NEK2_2 150 155 PF00069 0.287
MOD_PIKK_1 10 16 PF00454 0.332
MOD_PIKK_1 167 173 PF00454 0.411
MOD_PIKK_1 219 225 PF00454 0.598
MOD_PIKK_1 96 102 PF00454 0.200
MOD_PKA_2 10 16 PF00069 0.544
MOD_PKA_2 150 156 PF00069 0.418
MOD_PKA_2 219 225 PF00069 0.723
MOD_Plk_1 83 89 PF00069 0.293
MOD_Plk_2-3 130 136 PF00069 0.373
MOD_Plk_4 201 207 PF00069 0.411
MOD_Plk_4 38 44 PF00069 0.309
MOD_Plk_4 55 61 PF00069 0.327
MOD_ProDKin_1 115 121 PF00069 0.427
MOD_ProDKin_1 205 211 PF00069 0.527
MOD_SUMO_rev_2 176 181 PF00179 0.393
TRG_DiLeu_BaEn_2 49 55 PF01217 0.411
TRG_ENDOCYTIC_2 109 112 PF00928 0.378
TRG_ENDOCYTIC_2 15 18 PF00928 0.431
TRG_ENDOCYTIC_2 51 54 PF00928 0.288
TRG_ENDOCYTIC_2 57 60 PF00928 0.296
TRG_ER_diArg_1 62 64 PF00400 0.411

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I5U2 Leptomonas seymouri 67% 100%
A0A0S4KL01 Bodo saltans 33% 100%
A0A1X0P9C8 Trypanosomatidae 45% 100%
A0A3Q8IK39 Leishmania donovani 92% 100%
A0A3R7N3L4 Trypanosoma rangeli 41% 100%
A4HNM8 Leishmania braziliensis 83% 100%
A4ICW7 Leishmania infantum 92% 100%
D0A2I2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 100%
E9ASD7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
V5BA41 Trypanosoma cruzi 44% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS