Mitochondrial inner membrane protease subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial inner membrane signal peptidase, putative

Species:

Leishmania major

UniProt:

Q4Q258_LEIMA

TriTrypDb:

LmjF.36.0200 , LMJLV39_360007300 , LMJSD75_360007100

Length:

225

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0032991	protein-containing complex	1	2
GO:0042720	mitochondrial inner membrane peptidase complex	3	2
GO:0098796	membrane protein complex	2	2
GO:0098798	mitochondrial protein-containing complex	2	2
GO:0098800	inner mitochondrial membrane protein complex	3	2
GO:0110165	cellular anatomical entity	1	8
GO:1902494	catalytic complex	2	2
GO:0005743	mitochondrial inner membrane	5	1
GO:0019866	organelle inner membrane	4	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1

Expansion

Sequence features

Q4Q258

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q258

Function

Biological processes
Term	Name	Level	Count
GO:0006465	signal peptide processing	5	12
GO:0006508	proteolysis	4	12
GO:0006518	peptide metabolic process	4	12
GO:0006627	protein processing involved in protein targeting to mitochondrion	7	2
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0016485	protein processing	5	12
GO:0019538	protein metabolic process	3	12
GO:0034982	mitochondrial protein processing	6	2
GO:0043170	macromolecule metabolic process	3	12
GO:0043603	amide metabolic process	3	12
GO:0044238	primary metabolic process	2	12
GO:0051604	protein maturation	4	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004175	endopeptidase activity	4	12
GO:0004252	serine-type endopeptidase activity	5	12
GO:0008233	peptidase activity	3	12
GO:0008236	serine-type peptidase activity	4	12
GO:0016787	hydrolase activity	2	12
GO:0017171	serine hydrolase activity	3	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	133	137	PF00656	0.298
CLV_NRD_NRD_1	187	189	PF00675	0.411
CLV_NRD_NRD_1	63	65	PF00675	0.411
CLV_PCSK_KEX2_1	187	189	PF00082	0.411
CLV_PCSK_KEX2_1	63	65	PF00082	0.411
CLV_PCSK_KEX2_1	89	91	PF00082	0.266
CLV_PCSK_PC1ET2_1	89	91	PF00082	0.266
CLV_PCSK_SKI1_1	90	94	PF00082	0.309
DOC_CYCLIN_RxL_1	195	204	PF00134	0.360
DOC_MAPK_gen_1	187	194	PF00069	0.385
DOC_MAPK_MEF2A_6	64	73	PF00069	0.405
DOC_PP4_FxxP_1	66	69	PF00568	0.411
DOC_USP7_MATH_1	167	171	PF00917	0.352
DOC_USP7_MATH_1	219	223	PF00917	0.740
DOC_USP7_UBL2_3	89	93	PF12436	0.393
DOC_WW_Pin1_4	115	120	PF00397	0.427
DOC_WW_Pin1_4	205	210	PF00397	0.522
LIG_14-3-3_CanoR_1	11	19	PF00244	0.498
LIG_14-3-3_CanoR_1	151	155	PF00244	0.331
LIG_BRCT_BRCA1_1	180	184	PF00533	0.411
LIG_FHA_2	123	129	PF00498	0.464
LIG_FHA_2	131	137	PF00498	0.291
LIG_FHA_2	97	103	PF00498	0.228
LIG_LIR_Apic_2	204	209	PF02991	0.479
LIG_LIR_Gen_1	107	117	PF02991	0.328
LIG_LIR_Gen_1	17	27	PF02991	0.414
LIG_LIR_Gen_1	170	178	PF02991	0.283
LIG_LIR_Gen_1	50	59	PF02991	0.281
LIG_LIR_Nem_3	107	112	PF02991	0.311
LIG_LIR_Nem_3	13	18	PF02991	0.439
LIG_LIR_Nem_3	142	148	PF02991	0.411
LIG_LIR_Nem_3	170	175	PF02991	0.283
LIG_LIR_Nem_3	50	54	PF02991	0.298
LIG_MYND_1	44	48	PF01753	0.266
LIG_SH2_CRK	117	121	PF00017	0.331
LIG_SH2_CRK	57	61	PF00017	0.300
LIG_SH2_NCK_1	117	121	PF00017	0.221
LIG_SH2_PTP2	109	112	PF00017	0.375
LIG_SH2_SRC	109	112	PF00017	0.375
LIG_SH2_STAT5	109	112	PF00017	0.375
LIG_SH2_STAT5	145	148	PF00017	0.373
LIG_SH2_STAT5	51	54	PF00017	0.281
LIG_SH2_STAT5	57	60	PF00017	0.281
LIG_SH3_2	215	220	PF14604	0.549
LIG_SH3_3	212	218	PF00018	0.566
LIG_SH3_3	50	56	PF00018	0.200
LIG_SH3_CIN85_PxpxPR_1	215	220	PF14604	0.549
LIG_SUMO_SIM_anti_2	74	80	PF11976	0.329
LIG_TYR_ITIM	55	60	PF00017	0.325
LIG_WW_3	217	221	PF00397	0.645
MOD_CK1_1	183	189	PF00069	0.279
MOD_CK1_1	208	214	PF00069	0.425
MOD_CK1_1	31	37	PF00069	0.277
MOD_CK1_1	96	102	PF00069	0.295
MOD_CK2_1	96	102	PF00069	0.251
MOD_CMANNOS	3	6	PF00535	0.455
MOD_GlcNHglycan	7	10	PF01048	0.403
MOD_GSK3_1	130	137	PF00069	0.364
MOD_GSK3_1	201	208	PF00069	0.432
MOD_GSK3_1	38	45	PF00069	0.281
MOD_GSK3_1	79	86	PF00069	0.293
MOD_GSK3_1	92	99	PF00069	0.256
MOD_N-GLC_1	178	183	PF02516	0.373
MOD_N-GLC_1	71	76	PF02516	0.416
MOD_NEK2_2	150	155	PF00069	0.287
MOD_PIKK_1	10	16	PF00454	0.332
MOD_PIKK_1	167	173	PF00454	0.411
MOD_PIKK_1	219	225	PF00454	0.598
MOD_PIKK_1	96	102	PF00454	0.200
MOD_PKA_2	10	16	PF00069	0.544
MOD_PKA_2	150	156	PF00069	0.418
MOD_PKA_2	219	225	PF00069	0.723
MOD_Plk_1	83	89	PF00069	0.293
MOD_Plk_2-3	130	136	PF00069	0.373
MOD_Plk_4	201	207	PF00069	0.411
MOD_Plk_4	38	44	PF00069	0.309
MOD_Plk_4	55	61	PF00069	0.327
MOD_ProDKin_1	115	121	PF00069	0.427
MOD_ProDKin_1	205	211	PF00069	0.527
MOD_SUMO_rev_2	176	181	PF00179	0.393
TRG_DiLeu_BaEn_2	49	55	PF01217	0.411
TRG_ENDOCYTIC_2	109	112	PF00928	0.378
TRG_ENDOCYTIC_2	15	18	PF00928	0.431
TRG_ENDOCYTIC_2	51	54	PF00928	0.288
TRG_ENDOCYTIC_2	57	60	PF00928	0.296
TRG_ER_diArg_1	62	64	PF00400	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5U2	Leptomonas seymouri	67%	100%
A0A0S4KL01	Bodo saltans	33%	100%
A0A1X0P9C8	Trypanosomatidae	45%	100%
A0A3Q8IK39	Leishmania donovani	92%	100%
A0A3R7N3L4	Trypanosoma rangeli	41%	100%
A4HNM8	Leishmania braziliensis	83%	100%
A4ICW7	Leishmania infantum	92%	100%
D0A2I2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9ASD7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BA41	Trypanosoma cruzi	44%	100%