Putative SET domain protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SET domain protein, putative

Species:

Leishmania major

UniProt:

Q4Q257_LEIMA

TriTrypDb:

LmjF.36.0210 , LMJLV39_360007400 , LMJSD75_360007200

Length:

473

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q257

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q257

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	2
GO:0032259	methylation	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016740	transferase activity	2	11
GO:0000166	nucleotide binding	3	1
GO:0005488	binding	1	1
GO:0005524	ATP binding	5	1
GO:0008168	methyltransferase activity	4	2
GO:0008716	D-alanine-D-alanine ligase activity	5	1
GO:0016741	transferase activity, transferring one-carbon groups	3	2
GO:0016874	ligase activity	2	1
GO:0016879	ligase activity, forming carbon-nitrogen bonds	3	1
GO:0016881	acid-amino acid ligase activity	4	1
GO:0017076	purine nucleotide binding	4	1
GO:0030554	adenyl nucleotide binding	5	1
GO:0032553	ribonucleotide binding	3	1
GO:0032555	purine ribonucleotide binding	4	1
GO:0032559	adenyl ribonucleotide binding	5	1
GO:0035639	purine ribonucleoside triphosphate binding	4	1
GO:0036094	small molecule binding	2	1
GO:0043167	ion binding	2	1
GO:0043168	anion binding	3	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:0097367	carbohydrate derivative binding	2	1
GO:1901265	nucleoside phosphate binding	3	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	157	161	PF00656	0.537
CLV_NRD_NRD_1	130	132	PF00675	0.516
CLV_NRD_NRD_1	297	299	PF00675	0.510
CLV_NRD_NRD_1	314	316	PF00675	0.591
CLV_NRD_NRD_1	326	328	PF00675	0.283
CLV_NRD_NRD_1	462	464	PF00675	0.501
CLV_PCSK_KEX2_1	130	132	PF00082	0.469
CLV_PCSK_KEX2_1	462	464	PF00082	0.427
CLV_PCSK_SKI1_1	233	237	PF00082	0.425
CLV_PCSK_SKI1_1	358	362	PF00082	0.308
CLV_PCSK_SKI1_1	469	473	PF00082	0.613
CLV_PCSK_SKI1_1	95	99	PF00082	0.430
DEG_APCC_KENBOX_2	249	253	PF00400	0.463
DEG_SCF_FBW7_2	300	307	PF00400	0.387
DOC_CYCLIN_yCln2_LP_2	136	142	PF00134	0.373
DOC_CYCLIN_yCln2_LP_2	99	105	PF00134	0.406
DOC_MAPK_gen_1	135	142	PF00069	0.520
DOC_MAPK_gen_1	324	333	PF00069	0.507
DOC_MAPK_MEF2A_6	185	193	PF00069	0.469
DOC_PP1_RVXF_1	173	180	PF00149	0.394
DOC_PP2B_LxvP_1	136	139	PF13499	0.460
DOC_PP4_FxxP_1	397	400	PF00568	0.562
DOC_USP7_MATH_1	194	198	PF00917	0.487
DOC_USP7_MATH_1	206	210	PF00917	0.571
DOC_USP7_MATH_1	229	233	PF00917	0.440
DOC_USP7_MATH_1	366	370	PF00917	0.539
DOC_USP7_MATH_1	52	56	PF00917	0.549
DOC_USP7_UBL2_3	324	328	PF12436	0.562
DOC_WW_Pin1_4	13	18	PF00397	0.598
DOC_WW_Pin1_4	300	305	PF00397	0.474
DOC_WW_Pin1_4	50	55	PF00397	0.542
LIG_14-3-3_CanoR_1	143	151	PF00244	0.555
LIG_14-3-3_CanoR_1	153	159	PF00244	0.385
LIG_14-3-3_CanoR_1	442	452	PF00244	0.535
LIG_14-3-3_CanoR_1	95	100	PF00244	0.455
LIG_APCC_ABBA_1	308	313	PF00400	0.585
LIG_BIR_II_1	1	5	PF00653	0.558
LIG_BIR_III_4	70	74	PF00653	0.439
LIG_BRCT_BRCA1_1	29	33	PF00533	0.508
LIG_BRCT_BRCA1_1	99	103	PF00533	0.296
LIG_EH1_1	102	110	PF00400	0.486
LIG_EH1_1	186	194	PF00400	0.430
LIG_eIF4E_1	101	107	PF01652	0.447
LIG_FHA_1	143	149	PF00498	0.523
LIG_FHA_1	303	309	PF00498	0.591
LIG_FHA_1	321	327	PF00498	0.513
LIG_FHA_1	74	80	PF00498	0.520
LIG_FHA_2	13	19	PF00498	0.567
LIG_FHA_2	155	161	PF00498	0.465
LIG_FHA_2	246	252	PF00498	0.524
LIG_FHA_2	283	289	PF00498	0.490
LIG_FHA_2	357	363	PF00498	0.502
LIG_FHA_2	421	427	PF00498	0.394
LIG_LIR_Apic_2	349	355	PF02991	0.534
LIG_LIR_Apic_2	361	366	PF02991	0.426
LIG_LIR_Gen_1	100	111	PF02991	0.454
LIG_LIR_Gen_1	339	348	PF02991	0.490
LIG_LIR_Gen_1	418	429	PF02991	0.518
LIG_LIR_Nem_3	100	106	PF02991	0.411
LIG_LIR_Nem_3	232	237	PF02991	0.434
LIG_LIR_Nem_3	30	36	PF02991	0.494
LIG_LIR_Nem_3	339	343	PF02991	0.490
LIG_LIR_Nem_3	359	363	PF02991	0.341
LIG_LIR_Nem_3	418	424	PF02991	0.480
LIG_LIR_Nem_3	55	60	PF02991	0.498
LIG_SH2_CRK	112	116	PF00017	0.351
LIG_SH2_CRK	57	61	PF00017	0.469
LIG_SH2_STAT5	234	237	PF00017	0.524
LIG_SH2_STAT5	64	67	PF00017	0.364
LIG_SH2_STAT5	91	94	PF00017	0.450
LIG_SH3_3	112	118	PF00018	0.462
LIG_SH3_3	259	265	PF00018	0.475
LIG_SH3_3	340	346	PF00018	0.491
LIG_SH3_3	467	473	PF00018	0.527
LIG_SUMO_SIM_anti_2	104	109	PF11976	0.486
LIG_TRAF2_1	161	164	PF00917	0.445
LIG_TYR_ITIM	110	115	PF00017	0.500
LIG_WRC_WIRS_1	421	426	PF05994	0.388
MOD_CK2_1	12	18	PF00069	0.527
MOD_CK2_1	245	251	PF00069	0.492
MOD_CK2_1	282	288	PF00069	0.535
MOD_CK2_1	289	295	PF00069	0.506
MOD_CK2_1	356	362	PF00069	0.513
MOD_GlcNHglycan	167	170	PF01048	0.439
MOD_GlcNHglycan	280	283	PF01048	0.574
MOD_GlcNHglycan	445	448	PF01048	0.520
MOD_GlcNHglycan	465	468	PF01048	0.613
MOD_GlcNHglycan	66	70	PF01048	0.646
MOD_GlcNHglycan	76	79	PF01048	0.499
MOD_GSK3_1	278	285	PF00069	0.505
MOD_GSK3_1	74	81	PF00069	0.508
MOD_GSK3_1	85	92	PF00069	0.500
MOD_N-GLC_1	181	186	PF02516	0.488
MOD_N-GLC_1	387	392	PF02516	0.276
MOD_N-GLC_2	144	146	PF02516	0.533
MOD_N-GLC_2	154	156	PF02516	0.372
MOD_N-GLC_2	29	31	PF02516	0.412
MOD_NEK2_1	1	6	PF00069	0.457
MOD_NEK2_1	162	167	PF00069	0.501
MOD_NEK2_1	289	294	PF00069	0.493
MOD_NEK2_1	320	325	PF00069	0.554
MOD_NEK2_1	356	361	PF00069	0.522
MOD_NEK2_1	89	94	PF00069	0.431
MOD_NEK2_2	194	199	PF00069	0.514
MOD_NEK2_2	425	430	PF00069	0.413
MOD_NEK2_2	78	83	PF00069	0.494
MOD_PIKK_1	1	7	PF00454	0.555
MOD_PKA_2	142	148	PF00069	0.511
MOD_Plk_1	162	168	PF00069	0.509
MOD_Plk_1	415	421	PF00069	0.496
MOD_Plk_2-3	415	421	PF00069	0.471
MOD_Plk_4	162	168	PF00069	0.455
MOD_Plk_4	289	295	PF00069	0.519
MOD_Plk_4	456	462	PF00069	0.518
MOD_Plk_4	52	58	PF00069	0.447
MOD_Plk_4	78	84	PF00069	0.402
MOD_ProDKin_1	13	19	PF00069	0.598
MOD_ProDKin_1	300	306	PF00069	0.466
MOD_ProDKin_1	50	56	PF00069	0.540
TRG_DiLeu_BaEn_4	295	301	PF01217	0.354
TRG_DiLeu_BaLyEn_6	467	472	PF01217	0.601
TRG_ENDOCYTIC_2	112	115	PF00928	0.423
TRG_ENDOCYTIC_2	421	424	PF00928	0.385
TRG_ENDOCYTIC_2	57	60	PF00928	0.481
TRG_ER_diArg_1	461	463	PF00400	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILG6	Leptomonas seymouri	65%	100%
A0A0S4KKY2	Bodo saltans	42%	100%
A0A1X0P8J8	Trypanosomatidae	42%	100%
A0A3Q8IJR2	Leishmania donovani	91%	100%
A0A3R7MWC4	Trypanosoma rangeli	28%	92%
A0A3R7P2U3	Trypanosoma rangeli	39%	100%
A4HNM9	Leishmania braziliensis	82%	100%
A4ICW6	Leishmania infantum	92%	100%
D0A2I3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9ASD8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5BQK1	Trypanosoma cruzi	38%	100%