Dolichol-phosphate mannosyltransferase subunit 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dolicholphosphate-mannose synthase

Species:

Leishmania major

UniProt:

Q4Q256_LEIMA

TriTrypDb:

LmjF.36.0220 , LMJLV39_360007500 , LMJSD75_360007300

Length:

262

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005635	nuclear envelope	4	2
GO:0005783	endoplasmic reticulum	5	12
GO:0005789	endoplasmic reticulum membrane	4	2
GO:0016020	membrane	2	10
GO:0031090	organelle membrane	3	2
GO:0031967	organelle envelope	3	2
GO:0031975	envelope	2	2
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4Q256

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q256

Function

Biological processes
Term	Name	Level	Count
GO:0006066	alcohol metabolic process	3	2
GO:0006486	protein glycosylation	4	12
GO:0006493	protein O-linked glycosylation	5	2
GO:0006497	protein lipidation	5	2
GO:0006505	GPI anchor metabolic process	6	2
GO:0006506	GPI anchor biosynthetic process	6	2
GO:0006629	lipid metabolic process	3	2
GO:0006643	membrane lipid metabolic process	4	2
GO:0006644	phospholipid metabolic process	4	2
GO:0006650	glycerophospholipid metabolic process	5	2
GO:0006661	phosphatidylinositol biosynthetic process	6	2
GO:0006664	glycolipid metabolic process	5	2
GO:0006720	isoprenoid metabolic process	4	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0008610	lipid biosynthetic process	4	2
GO:0008654	phospholipid biosynthetic process	5	2
GO:0009058	biosynthetic process	2	2
GO:0009247	glycolipid biosynthetic process	5	2
GO:0009987	cellular process	1	2
GO:0016093	polyprenol metabolic process	4	2
GO:0019348	dolichol metabolic process	5	2
GO:0019538	protein metabolic process	3	12
GO:0019637	organophosphate metabolic process	3	2
GO:0035268	protein mannosylation	4	2
GO:0035269	protein O-linked mannosylation	5	2
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0043413	macromolecule glycosylation	3	12
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	2
GO:0044255	cellular lipid metabolic process	3	2
GO:0044281	small molecule metabolic process	2	2
GO:0045017	glycerolipid biosynthetic process	4	2
GO:0046467	membrane lipid biosynthetic process	4	2
GO:0046474	glycerophospholipid biosynthetic process	5	2
GO:0046486	glycerolipid metabolic process	4	2
GO:0046488	phosphatidylinositol metabolic process	6	2
GO:0070085	glycosylation	2	12
GO:0071704	organic substance metabolic process	2	12
GO:0090407	organophosphate biosynthetic process	4	2
GO:0097502	mannosylation	3	2
GO:1901135	carbohydrate derivative metabolic process	3	2
GO:1901137	carbohydrate derivative biosynthetic process	4	2
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901576	organic substance biosynthetic process	3	2
GO:1901615	organic hydroxy compound metabolic process	3	2
GO:1903509	liposaccharide metabolic process	4	2

Molecular functions
Term	Name	Level	Count
GO:0000030	mannosyltransferase activity	5	12
GO:0003824	catalytic activity	1	12
GO:0004582	dolichyl-phosphate beta-D-mannosyltransferase activity	6	12
GO:0016740	transferase activity	2	12
GO:0016757	glycosyltransferase activity	3	12
GO:0016758	hexosyltransferase activity	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	139	141	PF00675	0.209
CLV_NRD_NRD_1	21	23	PF00675	0.312
CLV_PCSK_KEX2_1	139	141	PF00082	0.209
CLV_PCSK_KEX2_1	172	174	PF00082	0.312
CLV_PCSK_KEX2_1	21	23	PF00082	0.251
CLV_PCSK_PC1ET2_1	172	174	PF00082	0.312
CLV_PCSK_SKI1_1	151	155	PF00082	0.209
CLV_PCSK_SKI1_1	184	188	PF00082	0.238
CLV_PCSK_SKI1_1	21	25	PF00082	0.219
CLV_PCSK_SKI1_1	218	222	PF00082	0.366
DEG_Nend_UBRbox_3	1	3	PF02207	0.568
DOC_MAPK_gen_1	234	243	PF00069	0.425
DOC_MAPK_MEF2A_6	124	131	PF00069	0.414
DOC_MAPK_MEF2A_6	184	191	PF00069	0.422
DOC_MAPK_MEF2A_6	237	245	PF00069	0.499
DOC_MAPK_NFAT4_5	184	192	PF00069	0.432
DOC_PP1_RVXF_1	138	145	PF00149	0.419
DOC_USP7_UBL2_3	214	218	PF12436	0.514
LIG_14-3-3_CanoR_1	139	145	PF00244	0.409
LIG_14-3-3_CanoR_1	151	157	PF00244	0.512
LIG_14-3-3_CanoR_1	69	75	PF00244	0.412
LIG_14-3-3_CanoR_1	84	92	PF00244	0.399
LIG_APCC_ABBA_1	62	67	PF00400	0.409
LIG_BRCT_BRCA1_1	160	164	PF00533	0.409
LIG_FHA_1	214	220	PF00498	0.562
LIG_FHA_1	32	38	PF00498	0.482
LIG_FHA_2	153	159	PF00498	0.457
LIG_FHA_2	207	213	PF00498	0.552
LIG_HCF-1_HBM_1	225	228	PF13415	0.461
LIG_LIR_Nem_3	161	166	PF02991	0.452
LIG_LIR_Nem_3	225	231	PF02991	0.572
LIG_LIR_Nem_3	87	93	PF02991	0.457
LIG_MLH1_MIPbox_1	160	164	PF16413	0.419
LIG_PDZ_Class_1	257	262	PF00595	0.416
LIG_REV1ctd_RIR_1	161	171	PF16727	0.419
LIG_SH2_CRK	258	262	PF00017	0.334
LIG_SH2_CRK	3	7	PF00017	0.419
LIG_SH2_CRK	90	94	PF00017	0.512
LIG_SH2_PTP2	240	243	PF00017	0.370
LIG_SH2_SRC	223	226	PF00017	0.491
LIG_SH2_STAP1	228	232	PF00017	0.489
LIG_SH2_STAP1	3	7	PF00017	0.419
LIG_SH2_STAT5	223	226	PF00017	0.464
LIG_SH2_STAT5	231	234	PF00017	0.493
LIG_SH2_STAT5	240	243	PF00017	0.362
LIG_SH2_STAT5	252	255	PF00017	0.391
LIG_SUMO_SIM_par_1	38	44	PF11976	0.410
LIG_TYR_ITIM	238	243	PF00017	0.358
MOD_CK1_1	213	219	PF00069	0.366
MOD_CK2_1	206	212	PF00069	0.440
MOD_GlcNHglycan	160	163	PF01048	0.289
MOD_GlcNHglycan	76	79	PF01048	0.244
MOD_GlcNHglycan	86	89	PF01048	0.244
MOD_GSK3_1	154	161	PF00069	0.283
MOD_GSK3_1	206	213	PF00069	0.439
MOD_GSK3_1	43	50	PF00069	0.244
MOD_LATS_1	138	144	PF00433	0.244
MOD_NEK2_1	1	6	PF00069	0.391
MOD_NEK2_1	257	262	PF00069	0.564
MOD_NEK2_1	83	88	PF00069	0.338
MOD_PIKK_1	31	37	PF00454	0.360
MOD_PKA_2	68	74	PF00069	0.280
MOD_PKA_2	83	89	PF00069	0.280
MOD_Plk_4	1	7	PF00069	0.244
TRG_DiLeu_BaLyEn_6	137	142	PF01217	0.388
TRG_DiLeu_BaLyEn_6	144	149	PF01217	0.317
TRG_DiLeu_BaLyEn_6	15	20	PF01217	0.244
TRG_ENDOCYTIC_2	240	243	PF00928	0.381
TRG_ENDOCYTIC_2	258	261	PF00928	0.551
TRG_ENDOCYTIC_2	3	6	PF00928	0.259
TRG_ENDOCYTIC_2	90	93	PF00928	0.312
TRG_ER_diArg_1	139	141	PF00400	0.244
TRG_ER_diArg_1	20	22	PF00400	0.391

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYX9	Leptomonas seymouri	83%	100%
A0A0S4KKX1	Bodo saltans	66%	100%
A0A1X0P8C1	Trypanosomatidae	68%	100%
A0A3Q8IGV1	Leishmania donovani	96%	100%
A0A422P2H6	Trypanosoma rangeli	64%	100%
A0QZ12	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	33%	99%
A1ADA6	Escherichia coli O1:K1 / APEC	27%	81%
A4HNN0	Leishmania braziliensis	81%	100%
A4ICW5	Leishmania infantum	96%	100%
A4WAM4	Enterobacter sp. (strain 638)	26%	80%
A5GFZ5	Sus scrofa	33%	100%
A7ZP72	Escherichia coli O139:H28 (strain E24377A / ETEC)	25%	81%
A8A2C1	Escherichia coli O9:H4 (strain HS)	26%	81%
B1IXT3	Escherichia coli (strain ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks)	26%	81%
B1LLK8	Escherichia coli (strain SMS-3-5 / SECEC)	26%	81%
B1X8W7	Escherichia coli (strain K12 / DH10B)	26%	81%
B4ETL6	Proteus mirabilis (strain HI4320)	26%	80%
B5YX45	Escherichia coli O157:H7 (strain EC4115 / EHEC)	26%	81%
B6I7J7	Escherichia coli (strain SE11)	26%	81%
B7LAR9	Escherichia coli (strain 55989 / EAEC)	26%	81%
B7LM77	Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CCUG 18766 / IAM 14443 / JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73)	25%	80%
B7M5T6	Escherichia coli O8 (strain IAI1)	25%	81%
B7MG21	Escherichia coli O45:K1 (strain S88 / ExPEC)	27%	81%
B7MXT5	Escherichia coli O81 (strain ED1a)	27%	81%
B7N5L9	Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)	26%	81%
B7NNT3	Escherichia coli O7:K1 (strain IAI39 / ExPEC)	27%	81%
B7UFR6	Escherichia coli O127:H6 (strain E2348/69 / EPEC)	27%	81%
C3KAD3	Pseudomonas fluorescens (strain SBW25)	31%	77%
C4ZU96	Escherichia coli (strain K12 / MC4100 / BW2952)	26%	81%
C5CBV8	Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230)	33%	100%
D0A2I4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	100%
E9ASD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
O14466	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	100%
O60762	Homo sapiens	33%	100%
O70152	Mus musculus	34%	100%
P14020	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	47%	98%
P54856	Ustilago maydis (strain 521 / FGSC 9021)	54%	89%
P77757	Escherichia coli (strain K12)	26%	81%
Q0T2M9	Shigella flexneri serotype 5b (strain 8401)	26%	81%
Q0TFI8	Escherichia coli O6:K15:H31 (strain 536 / UPEC)	27%	81%
Q1JQ93	Bos taurus	34%	100%
Q1R9G1	Escherichia coli (strain UTI89 / UPEC)	27%	81%
Q31YK3	Shigella boydii serotype 4 (strain Sb227)	26%	81%
Q32DT4	Shigella dysenteriae serotype 1 (strain Sd197)	26%	81%
Q3YZV2	Shigella sonnei (strain Ss046)	26%	81%
Q4KC83	Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)	30%	77%
Q4ZSZ3	Pseudomonas syringae pv. syringae (strain B728a)	29%	78%
Q54LP3	Dictyostelium discoideum	32%	100%
Q7UC63	Shigella flexneri	26%	81%
Q8FFM2	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	27%	81%
Q8XDZ5	Escherichia coli O157:H7	26%	81%
Q9LM93	Arabidopsis thaliana	33%	100%
Q9VIU7	Drosophila melanogaster	32%	100%
Q9WU83	Cricetulus griseus	35%	98%
V5C000	Trypanosoma cruzi	64%	100%