Peptidylprolyl isomerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peptidyl-prolyl cis-trans isomerase, putative

Species:

Leishmania major

UniProt:

Q4Q255_LEIMA

TriTrypDb:

LmjF.36.0230 , LMJLV39_360007600 , LMJSD75_360007400

Length:

109

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 4

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q255

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q255

Function

Biological processes
Term	Name	Level	Count
GO:0000413	protein peptidyl-prolyl isomerization	7	2
GO:0006457	protein folding	2	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018208	peptidyl-proline modification	6	2
GO:0019538	protein metabolic process	3	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044238	primary metabolic process	2	2
GO:0061077	chaperone-mediated protein folding	3	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	11
GO:0003824	catalytic activity	1	11
GO:0016853	isomerase activity	2	11
GO:0016859	cis-trans isomerase activity	3	11
GO:0140096	catalytic activity, acting on a protein	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DOC_WW_Pin1_4	12	17	PF00397	0.540
LIG_Clathr_ClatBox_1	100	104	PF01394	0.362
LIG_EH_1	44	48	PF12763	0.317
LIG_FHA_1	19	25	PF00498	0.412
LIG_FHA_1	46	52	PF00498	0.213
LIG_FHA_1	70	76	PF00498	0.436
LIG_FHA_2	38	44	PF00498	0.328
LIG_PCNA_yPIPBox_3	44	57	PF02747	0.407
LIG_SH2_SRC	81	84	PF00017	0.303
LIG_SH2_STAT5	29	32	PF00017	0.284
LIG_SUMO_SIM_anti_2	102	107	PF11976	0.304
LIG_UBA3_1	99	107	PF00899	0.302
MOD_CDK_SPK_2	12	17	PF00069	0.540
MOD_CK1_1	12	18	PF00069	0.343
MOD_Cter_Amidation	32	35	PF01082	0.284
MOD_GlcNHglycan	11	14	PF01048	0.566
MOD_GSK3_1	20	27	PF00069	0.284
MOD_NMyristoyl	1	7	PF02799	0.519
MOD_ProDKin_1	12	18	PF00069	0.414
MOD_SUMO_rev_2	39	46	PF00179	0.307
TRG_DiLeu_BaEn_1	71	76	PF01217	0.414

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTT4	Leptomonas seymouri	37%	70%
A0A0N1HUP7	Leptomonas seymouri	44%	98%
A0A0N1PEA6	Leptomonas seymouri	83%	89%
A0A0S4KLH1	Bodo saltans	72%	100%
A0A1X0NUY2	Trypanosomatidae	44%	97%
A0A1X0P8C6	Trypanosomatidae	65%	100%
A0A3Q8IB31	Leishmania donovani	40%	69%
A0A3Q8ICF9	Leishmania donovani	42%	98%
A0A3R7LCV9	Trypanosoma rangeli	66%	100%
A0A3S5H813	Leishmania donovani	96%	100%
A0A422N485	Trypanosoma rangeli	43%	97%
A4H677	Leishmania braziliensis	38%	70%
A4HNN1	Leishmania braziliensis	87%	94%
A4HUK1	Leishmania infantum	40%	69%
A4I002	Leishmania infantum	42%	98%
A4ICW4	Leishmania infantum	96%	100%
C9ZSQ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	97%
D0A2I5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AN99	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	70%
E9ASE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9AVX5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	98%
O04287	Vicia faba	56%	97%
O42123	Xenopus laevis	47%	100%
O42993	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	55%	97%
O94746	Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487)	52%	100%
P0A0W2	Neisseria meningitidis serogroup B (strain MC58)	43%	100%
P0A0W3	Neisseria meningitidis serogroup C	48%	100%
P0C1J3	Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880)	51%	100%
P0CP94	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	53%	100%
P0CP95	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	53%	100%
P0CP96	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	43%	77%
P0CP97	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	43%	77%
P0CY37	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	38%	91%
P18203	Bos taurus	51%	100%
P20080	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	41%	91%
P20081	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	50%	96%
P26883	Mus musculus	50%	100%
P26885	Homo sapiens	44%	77%
P28725	Streptomyces anulatus	36%	88%
P28870	Candida albicans (strain SC5314 / ATCC MYA-2876)	38%	88%
P32472	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	81%
P45878	Mus musculus	44%	78%
P48375	Drosophila melanogaster	51%	100%
P56989	Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491)	45%	100%
P62942	Homo sapiens	50%	100%
P62943	Oryctolagus cuniculus	50%	100%
P68106	Homo sapiens	48%	100%
P68107	Bos taurus	48%	100%
P97534	Rattus norvegicus	47%	100%
Q2U316	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	45%	94%
Q2UPT7	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	41%	81%
Q32PA9	Bos taurus	44%	78%
Q38935	Arabidopsis thaliana	40%	71%
Q38936	Arabidopsis thaliana	42%	67%
Q41649	Vicia faba	41%	72%
Q4HZB8	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	50%	98%
Q4QBK4	Leishmania major	42%	98%
Q4QHC5	Leishmania major	39%	69%
Q4W9R2	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	45%	91%
Q4WHX4	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	38%	81%
Q4WLV6	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	51%	97%
Q54SR7	Dictyostelium discoideum	42%	82%
Q554J3	Dictyostelium discoideum	45%	100%
Q5ATN7	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	43%	81%
Q62658	Rattus norvegicus	50%	100%
Q6BP84	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	40%	81%
Q6BX45	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	49%	97%
Q6CF41	Yarrowia lipolytica (strain CLIB 122 / E 150)	48%	100%
Q6CGG3	Yarrowia lipolytica (strain CLIB 122 / E 150)	34%	76%
Q6CUZ8	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	41%	78%
Q6CX30	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	52%	96%
Q6FMA3	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	49%	96%
Q6FSC1	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	44%	80%
Q6KBA8	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	54%	100%
Q6M981	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	41%	96%
Q754K8	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	49%	96%
Q8HYX6	Oryctolagus cuniculus	48%	100%
Q8LGG0	Arabidopsis thaliana	55%	97%
Q9FLB3	Arabidopsis thaliana	35%	76%
Q9Z2I2	Mus musculus	47%	100%
V5BA38	Trypanosoma cruzi	68%	100%