BZIP domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Afadin- and alpha -actinin-Binding, putative

Species:

Leishmania major

UniProt:

Q4Q254_LEIMA

TriTrypDb:

LmjF.36.0240 , LMJLV39_360007700 , LMJSD75_360007500

Length:

224

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q254

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q254

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	103	107	PF00656	0.391
CLV_C14_Caspase3-7	25	29	PF00656	0.459
CLV_NRD_NRD_1	138	140	PF00675	0.437
CLV_NRD_NRD_1	183	185	PF00675	0.509
CLV_NRD_NRD_1	187	189	PF00675	0.392
CLV_PCSK_KEX2_1	138	140	PF00082	0.424
CLV_PCSK_KEX2_1	156	158	PF00082	0.508
CLV_PCSK_KEX2_1	183	185	PF00082	0.462
CLV_PCSK_PC1ET2_1	156	158	PF00082	0.593
CLV_PCSK_SKI1_1	189	193	PF00082	0.420
DEG_Nend_Nbox_1	1	3	PF02207	0.664
DEG_SPOP_SBC_1	23	27	PF00917	0.509
DOC_CYCLIN_RxL_1	183	196	PF00134	0.416
DOC_USP7_MATH_1	113	117	PF00917	0.521
DOC_WW_Pin1_4	63	68	PF00397	0.658
DOC_WW_Pin1_4	94	99	PF00397	0.428
LIG_14-3-3_CanoR_1	124	128	PF00244	0.527
LIG_14-3-3_CanoR_1	17	22	PF00244	0.726
LIG_14-3-3_CanoR_1	174	178	PF00244	0.479
LIG_14-3-3_CanoR_1	58	67	PF00244	0.615
LIG_Actin_WH2_2	152	169	PF00022	0.434
LIG_BRCT_BRCA1_1	96	100	PF00533	0.436
LIG_eIF4E_1	104	110	PF01652	0.482
LIG_eIF4E_1	87	93	PF01652	0.501
LIG_FHA_2	124	130	PF00498	0.570
LIG_FHA_2	194	200	PF00498	0.494
LIG_FHA_2	23	29	PF00498	0.625
LIG_LIR_Nem_3	83	89	PF02991	0.442
LIG_MYND_1	94	98	PF01753	0.423
LIG_SH2_STAP1	104	108	PF00017	0.415
LIG_SH3_2	67	72	PF14604	0.597
LIG_SH3_3	61	67	PF00018	0.672
LIG_SH3_3	8	14	PF00018	0.667
LIG_SUMO_SIM_anti_2	105	112	PF11976	0.392
MOD_CK1_1	173	179	PF00069	0.444
MOD_CK2_1	193	199	PF00069	0.493
MOD_CK2_1	41	47	PF00069	0.548
MOD_CK2_1	63	69	PF00069	0.651
MOD_DYRK1A_RPxSP_1	63	67	PF00069	0.726
MOD_GlcNHglycan	115	118	PF01048	0.520
MOD_GlcNHglycan	120	123	PF01048	0.580
MOD_GSK3_1	41	48	PF00069	0.559
MOD_GSK3_1	59	66	PF00069	0.708
MOD_N-GLC_1	211	216	PF02516	0.446
MOD_NEK2_1	100	105	PF00069	0.448
MOD_NEK2_1	193	198	PF00069	0.399
MOD_PKA_2	123	129	PF00069	0.503
MOD_PKA_2	173	179	PF00069	0.453
MOD_PKA_2	41	47	PF00069	0.650
MOD_PKA_2	57	63	PF00069	0.624
MOD_Plk_1	211	217	PF00069	0.446
MOD_Plk_4	17	23	PF00069	0.644
MOD_Plk_4	88	94	PF00069	0.519
MOD_ProDKin_1	63	69	PF00069	0.657
MOD_ProDKin_1	94	100	PF00069	0.424
MOD_SUMO_for_1	155	158	PF00179	0.448
TRG_DiLeu_BaEn_1	88	93	PF01217	0.494
TRG_ER_diArg_1	51	54	PF00400	0.603
TRG_NES_CRM1_1	140	154	PF08389	0.307
TRG_Pf-PMV_PEXEL_1	139	143	PF00026	0.489

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5U6	Leptomonas seymouri	62%	98%
A0A1X0P8P1	Trypanosomatidae	38%	97%
A0A3Q8IQF0	Leishmania donovani	96%	100%
A0A422P2B9	Trypanosoma rangeli	41%	98%
A4HNN2	Leishmania braziliensis	80%	100%
A4ICW3	Leishmania infantum	96%	100%
E9ASE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%