Eukaryotic translation initiation factor 3 subunit L

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

eukaryotic translation initiation factor 3 subunit l

Species:

Leishmania major

UniProt:

Q4Q253_LEIMA

TriTrypDb:

LmjF.36.0250 , LMJLV39_360007800 , LMJSD75_360007600

Length:

633

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005852	eukaryotic translation initiation factor 3 complex	2	12
GO:0016020	membrane	2	3
GO:0016282	eukaryotic 43S preinitiation complex	4	6
GO:0032991	protein-containing complex	1	12
GO:0033290	eukaryotic 48S preinitiation complex	4	6
GO:0070993	translation preinitiation complex	3	6
GO:0110165	cellular anatomical entity	1	3
GO:1990904	ribonucleoprotein complex	2	6

Expansion

Sequence features

Q4Q253

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q253

Function

Biological processes
Term	Name	Level	Count
GO:0001732	formation of cytoplasmic translation initiation complex	7	6
GO:0006413	translational initiation	3	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	6
GO:0016043	cellular component organization	3	6
GO:0022607	cellular component assembly	4	6
GO:0022618	ribonucleoprotein complex assembly	6	6
GO:0043933	protein-containing complex organization	4	6
GO:0044237	cellular metabolic process	2	2
GO:0065003	protein-containing complex assembly	5	6
GO:0071826	ribonucleoprotein complex subunit organization	5	6
GO:0071840	cellular component organization or biogenesis	2	6

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003743	translation initiation factor activity	4	12
GO:0005488	binding	1	12
GO:0008135	translation factor activity, RNA binding	3	12
GO:0045182	translation regulator activity	1	12
GO:0090079	translation regulator activity, nucleic acid binding	2	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	116	120	PF00656	0.613
CLV_C14_Caspase3-7	251	255	PF00656	0.625
CLV_C14_Caspase3-7	391	395	PF00656	0.617
CLV_MEL_PAP_1	318	324	PF00089	0.425
CLV_NRD_NRD_1	117	119	PF00675	0.614
CLV_NRD_NRD_1	351	353	PF00675	0.353
CLV_NRD_NRD_1	361	363	PF00675	0.407
CLV_NRD_NRD_1	395	397	PF00675	0.332
CLV_NRD_NRD_1	452	454	PF00675	0.336
CLV_NRD_NRD_1	561	563	PF00675	0.582
CLV_NRD_NRD_1	576	578	PF00675	0.599
CLV_NRD_NRD_1	585	587	PF00675	0.644
CLV_PCSK_KEX2_1	117	119	PF00082	0.614
CLV_PCSK_KEX2_1	351	353	PF00082	0.353
CLV_PCSK_KEX2_1	361	363	PF00082	0.407
CLV_PCSK_KEX2_1	452	454	PF00082	0.345
CLV_PCSK_KEX2_1	561	563	PF00082	0.600
CLV_PCSK_KEX2_1	576	578	PF00082	0.589
CLV_PCSK_KEX2_1	584	586	PF00082	0.657
CLV_PCSK_PC1ET2_1	561	563	PF00082	0.677
CLV_PCSK_PC1ET2_1	576	578	PF00082	0.709
CLV_PCSK_PC1ET2_1	584	586	PF00082	0.820
CLV_PCSK_PC7_1	113	119	PF00082	0.589
CLV_PCSK_PC7_1	581	587	PF00082	0.781
CLV_PCSK_SKI1_1	177	181	PF00082	0.418
CLV_PCSK_SKI1_1	316	320	PF00082	0.332
CLV_PCSK_SKI1_1	352	356	PF00082	0.425
CLV_PCSK_SKI1_1	417	421	PF00082	0.369
CLV_PCSK_SKI1_1	426	430	PF00082	0.315
CLV_PCSK_SKI1_1	81	85	PF00082	0.471
CLV_PCSK_SKI1_1	89	93	PF00082	0.431
DEG_APCC_DBOX_1	315	323	PF00400	0.545
DEG_SPOP_SBC_1	515	519	PF00917	0.625
DOC_CKS1_1	30	35	PF01111	0.579
DOC_CYCLIN_RxL_1	174	182	PF00134	0.432
DOC_CYCLIN_yClb3_PxF_3	29	35	PF00134	0.449
DOC_CYCLIN_yClb5_NLxxxL_5	384	393	PF00134	0.625
DOC_CYCLIN_yClb5_NLxxxL_5	475	482	PF00134	0.625
DOC_CYCLIN_yCln2_LP_2	14	17	PF00134	0.463
DOC_MAPK_gen_1	289	296	PF00069	0.600
DOC_MAPK_gen_1	351	358	PF00069	0.582
DOC_MAPK_MEF2A_6	147	154	PF00069	0.481
DOC_MAPK_MEF2A_6	289	296	PF00069	0.597
DOC_MAPK_MEF2A_6	351	358	PF00069	0.625
DOC_PP2B_LxvP_1	14	17	PF13499	0.463
DOC_PP2B_LxvP_1	428	431	PF13499	0.532
DOC_USP7_MATH_1	243	247	PF00917	0.619
DOC_USP7_MATH_1	603	607	PF00917	0.632
DOC_USP7_MATH_1	62	66	PF00917	0.449
DOC_USP7_MATH_1	622	626	PF00917	0.673
DOC_USP7_UBL2_3	545	549	PF12436	0.666
DOC_WW_Pin1_4	29	34	PF00397	0.577
DOC_WW_Pin1_4	320	325	PF00397	0.614
DOC_WW_Pin1_4	421	426	PF00397	0.521
DOC_WW_Pin1_4	433	438	PF00397	0.521
DOC_WW_Pin1_4	70	75	PF00397	0.510
LIG_14-3-3_CanoR_1	351	357	PF00244	0.545
LIG_14-3-3_CanoR_1	69	74	PF00244	0.508
LIG_14-3-3_CanoR_1	77	83	PF00244	0.467
LIG_Actin_WH2_2	535	550	PF00022	0.757
LIG_AP2alpha_1	416	420	PF02296	0.576
LIG_BIR_III_4	190	194	PF00653	0.555
LIG_BRCT_BRCA1_1	157	161	PF00533	0.514
LIG_BRCT_BRCA1_1	171	175	PF00533	0.480
LIG_BRCT_BRCA1_1	346	350	PF00533	0.532
LIG_BRCT_BRCA1_1	423	427	PF00533	0.521
LIG_BRCT_BRCA1_1	518	522	PF00533	0.588
LIG_BRCT_BRCA1_1	535	539	PF00533	0.608
LIG_BRCT_BRCA1_1	624	628	PF00533	0.770
LIG_BRCT_BRCA1_2	171	177	PF00533	0.521
LIG_Clathr_ClatBox_1	482	486	PF01394	0.607
LIG_FHA_1	234	240	PF00498	0.571
LIG_FHA_1	275	281	PF00498	0.597
LIG_FHA_1	353	359	PF00498	0.607
LIG_FHA_1	388	394	PF00498	0.625
LIG_FHA_1	506	512	PF00498	0.599
LIG_FHA_1	622	628	PF00498	0.823
LIG_FHA_2	195	201	PF00498	0.607
LIG_FHA_2	302	308	PF00498	0.632
LIG_FHA_2	408	414	PF00498	0.582
LIG_FHA_2	479	485	PF00498	0.542
LIG_FHA_2	551	557	PF00498	0.632
LIG_FHA_2	90	96	PF00498	0.602
LIG_Integrin_isoDGR_2	359	361	PF01839	0.407
LIG_LIR_Apic_2	207	211	PF02991	0.607
LIG_LIR_Apic_2	237	243	PF02991	0.588
LIG_LIR_Gen_1	103	111	PF02991	0.454
LIG_LIR_Gen_1	128	139	PF02991	0.562
LIG_LIR_Gen_1	168	179	PF02991	0.420
LIG_LIR_Gen_1	197	205	PF02991	0.555
LIG_LIR_Gen_1	217	226	PF02991	0.523
LIG_LIR_Gen_1	227	235	PF02991	0.585
LIG_LIR_Gen_1	281	292	PF02991	0.638
LIG_LIR_Gen_1	298	308	PF02991	0.452
LIG_LIR_Gen_1	336	343	PF02991	0.532
LIG_LIR_Gen_1	370	381	PF02991	0.532
LIG_LIR_Gen_1	424	432	PF02991	0.521
LIG_LIR_Gen_1	519	526	PF02991	0.607
LIG_LIR_Gen_1	84	94	PF02991	0.741
LIG_LIR_Nem_3	103	108	PF02991	0.458
LIG_LIR_Nem_3	128	134	PF02991	0.463
LIG_LIR_Nem_3	148	152	PF02991	0.532
LIG_LIR_Nem_3	168	174	PF02991	0.214
LIG_LIR_Nem_3	192	198	PF02991	0.393
LIG_LIR_Nem_3	217	222	PF02991	0.523
LIG_LIR_Nem_3	227	233	PF02991	0.585
LIG_LIR_Nem_3	27	31	PF02991	0.455
LIG_LIR_Nem_3	281	287	PF02991	0.605
LIG_LIR_Nem_3	298	303	PF02991	0.449
LIG_LIR_Nem_3	32	38	PF02991	0.428
LIG_LIR_Nem_3	328	333	PF02991	0.540
LIG_LIR_Nem_3	336	340	PF02991	0.498
LIG_LIR_Nem_3	370	376	PF02991	0.521
LIG_LIR_Nem_3	413	419	PF02991	0.524
LIG_LIR_Nem_3	424	430	PF02991	0.519
LIG_LIR_Nem_3	486	492	PF02991	0.567
LIG_LIR_Nem_3	519	525	PF02991	0.600
LIG_LIR_Nem_3	536	542	PF02991	0.459
LIG_MYND_1	12	16	PF01753	0.474
LIG_NRBOX	291	297	PF00104	0.582
LIG_NRBOX	478	484	PF00104	0.607
LIG_PCNA_yPIPBox_3	255	263	PF02747	0.625
LIG_PCNA_yPIPBox_3	289	300	PF02747	0.557
LIG_PCNA_yPIPBox_3	75	87	PF02747	0.478
LIG_Pex14_2	416	420	PF04695	0.529
LIG_REV1ctd_RIR_1	105	113	PF16727	0.478
LIG_SH2_CRK	171	175	PF00017	0.395
LIG_SH2_CRK	230	234	PF00017	0.607
LIG_SH2_CRK	284	288	PF00017	0.636
LIG_SH2_CRK	300	304	PF00017	0.489
LIG_SH2_CRK	373	377	PF00017	0.582
LIG_SH2_CRK	489	493	PF00017	0.624
LIG_SH2_GRB2like	471	474	PF00017	0.607
LIG_SH2_NCK_1	208	212	PF00017	0.607
LIG_SH2_NCK_1	284	288	PF00017	0.607
LIG_SH2_SRC	284	287	PF00017	0.625
LIG_SH2_SRC	392	395	PF00017	0.625
LIG_SH2_SRC	4	7	PF00017	0.467
LIG_SH2_STAP1	127	131	PF00017	0.465
LIG_SH2_STAP1	171	175	PF00017	0.515
LIG_SH2_STAP1	198	202	PF00017	0.607
LIG_SH2_STAT3	127	130	PF00017	0.492
LIG_SH2_STAT5	31	34	PF00017	0.544
LIG_SH2_STAT5	337	340	PF00017	0.529
LIG_SH2_STAT5	375	378	PF00017	0.607
LIG_SH2_STAT5	392	395	PF00017	0.607
LIG_SH2_STAT5	467	470	PF00017	0.545
LIG_SH3_3	183	189	PF00018	0.631
LIG_SH3_3	259	265	PF00018	0.581
LIG_SH3_3	27	33	PF00018	0.452
LIG_SUMO_SIM_anti_2	528	536	PF11976	0.563
LIG_SUMO_SIM_par_1	46	53	PF11976	0.541
LIG_SUMO_SIM_par_1	480	487	PF11976	0.534
LIG_TYR_ITIM	169	174	PF00017	0.478
LIG_TYR_ITIM	228	233	PF00017	0.607
LIG_UBA3_1	201	206	PF00899	0.625
LIG_UBA3_1	258	263	PF00899	0.607
LIG_UBA3_1	461	469	PF00899	0.607
LIG_UBA3_1	492	496	PF00899	0.545
LIG_UBA3_1	546	551	PF00899	0.677
LIG_WRC_WIRS_1	170	175	PF05994	0.410
MOD_CDC14_SPxK_1	436	439	PF00782	0.600
MOD_CDK_SPK_2	421	426	PF00069	0.521
MOD_CDK_SPK_2	70	75	PF00069	0.510
MOD_CDK_SPxK_1	433	439	PF00069	0.600
MOD_CDK_SPxxK_3	70	77	PF00069	0.508
MOD_CK1_1	301	307	PF00069	0.590
MOD_CK1_1	407	413	PF00069	0.599
MOD_CK1_1	433	439	PF00069	0.588
MOD_CK1_1	63	69	PF00069	0.466
MOD_CK1_1	73	79	PF00069	0.487
MOD_CK2_1	194	200	PF00069	0.589
MOD_CK2_1	301	307	PF00069	0.607
MOD_CK2_1	407	413	PF00069	0.555
MOD_CK2_1	478	484	PF00069	0.542
MOD_CK2_1	515	521	PF00069	0.632
MOD_CMANNOS	213	216	PF00535	0.332
MOD_Cter_Amidation	359	362	PF01082	0.407
MOD_GlcNHglycan	280	283	PF01048	0.380
MOD_GlcNHglycan	300	303	PF01048	0.342
MOD_GlcNHglycan	601	604	PF01048	0.800
MOD_GSK3_1	274	281	PF00069	0.599
MOD_GSK3_1	388	395	PF00069	0.612
MOD_GSK3_1	426	433	PF00069	0.604
MOD_GSK3_1	599	606	PF00069	0.626
MOD_GSK3_1	65	72	PF00069	0.567
MOD_GSK3_1	75	82	PF00069	0.567
MOD_N-GLC_1	182	187	PF02516	0.624
MOD_N-GLC_1	387	392	PF02516	0.332
MOD_N-GLC_1	564	569	PF02516	0.665
MOD_N-GLC_1	603	608	PF02516	0.811
MOD_NEK2_1	126	131	PF00069	0.565
MOD_NEK2_1	169	174	PF00069	0.513
MOD_NEK2_1	478	483	PF00069	0.512
MOD_NEK2_1	564	569	PF00069	0.665
MOD_NEK2_2	325	330	PF00069	0.582
MOD_PIKK_1	126	132	PF00454	0.502
MOD_PIKK_1	550	556	PF00454	0.603
MOD_PIKK_1	76	82	PF00454	0.628
MOD_PKA_1	361	367	PF00069	0.532
MOD_PKA_2	361	367	PF00069	0.562
MOD_PKA_2	404	410	PF00069	0.582
MOD_PKA_2	604	610	PF00069	0.687
MOD_PKA_2	76	82	PF00069	0.481
MOD_Plk_1	182	188	PF00069	0.600
MOD_Plk_1	243	249	PF00069	0.571
MOD_Plk_1	253	259	PF00069	0.582
MOD_Plk_1	387	393	PF00069	0.545
MOD_Plk_1	63	69	PF00069	0.466
MOD_Plk_4	169	175	PF00069	0.410
MOD_Plk_4	224	230	PF00069	0.521
MOD_Plk_4	325	331	PF00069	0.528
MOD_Plk_4	388	394	PF00069	0.548
MOD_Plk_4	478	484	PF00069	0.521
MOD_ProDKin_1	29	35	PF00069	0.578
MOD_ProDKin_1	320	326	PF00069	0.614
MOD_ProDKin_1	421	427	PF00069	0.521
MOD_ProDKin_1	433	439	PF00069	0.521
MOD_ProDKin_1	70	76	PF00069	0.508
TRG_DiLeu_BaEn_1	244	249	PF01217	0.562
TRG_DiLeu_BaLyEn_6	254	259	PF01217	0.581
TRG_DiLeu_LyEn_5	244	249	PF01217	0.607
TRG_ENDOCYTIC_2	105	108	PF00928	0.473
TRG_ENDOCYTIC_2	171	174	PF00928	0.393
TRG_ENDOCYTIC_2	176	179	PF00928	0.408
TRG_ENDOCYTIC_2	198	201	PF00928	0.607
TRG_ENDOCYTIC_2	230	233	PF00928	0.586
TRG_ENDOCYTIC_2	284	287	PF00928	0.636
TRG_ENDOCYTIC_2	300	303	PF00928	0.489
TRG_ENDOCYTIC_2	337	340	PF00928	0.534
TRG_ENDOCYTIC_2	373	376	PF00928	0.545
TRG_ENDOCYTIC_2	467	470	PF00928	0.545
TRG_ENDOCYTIC_2	489	492	PF00928	0.604
TRG_ER_diArg_1	350	352	PF00400	0.553
TRG_ER_diArg_1	361	363	PF00400	0.568
TRG_ER_diArg_1	451	453	PF00400	0.545
TRG_ER_diArg_1	497	500	PF00400	0.563
TRG_ER_diArg_1	585	587	PF00400	0.756
TRG_NES_CRM1_1	217	231	PF08389	0.532
TRG_NES_CRM1_1	460	472	PF08389	0.548
TRG_NLS_MonoExtN_4	581	588	PF00514	0.784
TRG_Pf-PMV_PEXEL_1	247	251	PF00026	0.407
TRG_Pf-PMV_PEXEL_1	500	505	PF00026	0.332

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDA7	Leptomonas seymouri	79%	100%
A0A0S4KNQ8	Bodo saltans	34%	100%
A0A1X0P8D7	Trypanosomatidae	53%	100%
A0A3Q8IIN0	Leishmania donovani	98%	100%
A0A3R7KQY4	Trypanosoma rangeli	53%	100%
A4HNN3	Leishmania braziliensis	96%	100%
A4ICW2	Leishmania infantum	98%	100%
A5A6M4	Pan troglodytes	25%	100%
A7SDW5	Nematostella vectensis	24%	100%
A8PHP4	Brugia malayi	22%	100%
A8X419	Caenorhabditis briggsae	23%	100%
A9VCY6	Monosiga brevicollis	25%	100%
B0WR18	Culex quinquefasciatus	22%	100%
B3M7W0	Drosophila ananassae	24%	100%
B3NH71	Drosophila erecta	24%	100%
B4GR63	Drosophila persimilis	25%	100%
B4HFJ3	Drosophila sechellia	24%	100%
B4IWN1	Drosophila grimshawi	23%	100%
B4KZ45	Drosophila mojavensis	24%	100%
B4LEJ0	Drosophila virilis	24%	100%
B4MX71	Drosophila willistoni	23%	100%
B4PG99	Drosophila yakuba	24%	100%
B4QR64	Drosophila simulans	24%	100%
D0A2I7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9ASE2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
P0CN56	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	23%	100%
P0CN57	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	23%	100%
Q16FL6	Aedes aegypti	22%	100%
Q2M0S3	Drosophila pseudoobscura pseudoobscura	25%	100%
Q3ZCK1	Bos taurus	25%	100%
Q4PF85	Ustilago maydis (strain 521 / FGSC 9021)	22%	95%
Q5F428	Gallus gallus	25%	100%
Q6CAE9	Yarrowia lipolytica (strain CLIB 122 / E 150)	24%	100%
Q6P878	Xenopus tropicalis	25%	100%
Q7Q5Y8	Anopheles gambiae	24%	100%
Q7T2A5	Danio rerio	25%	100%
Q8AVJ0	Xenopus laevis	24%	100%
Q8QZY1	Mus musculus	25%	100%
Q95QW0	Caenorhabditis elegans	24%	100%
Q9VTU4	Drosophila melanogaster	24%	100%
Q9Y262	Homo sapiens	25%	100%
V5BV76	Trypanosoma cruzi	52%	100%