Calponin-homology (CH) domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q251_LEIMA

TriTrypDb:

LmjF.36.0270 , LMJLV39_360008000 , LMJSD75_360007800

Length:

817

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q251

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q251

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	223	225	PF00675	0.607
CLV_NRD_NRD_1	238	240	PF00675	0.723
CLV_NRD_NRD_1	254	256	PF00675	0.558
CLV_NRD_NRD_1	265	267	PF00675	0.483
CLV_NRD_NRD_1	32	34	PF00675	0.675
CLV_NRD_NRD_1	46	48	PF00675	0.501
CLV_NRD_NRD_1	498	500	PF00675	0.433
CLV_NRD_NRD_1	644	646	PF00675	0.623
CLV_NRD_NRD_1	659	661	PF00675	0.547
CLV_NRD_NRD_1	673	675	PF00675	0.730
CLV_NRD_NRD_1	685	687	PF00675	0.458
CLV_NRD_NRD_1	736	738	PF00675	0.445
CLV_NRD_NRD_1	741	743	PF00675	0.495
CLV_NRD_NRD_1	763	765	PF00675	0.365
CLV_NRD_NRD_1	802	804	PF00675	0.483
CLV_NRD_NRD_1	811	813	PF00675	0.546
CLV_PCSK_KEX2_1	223	225	PF00082	0.704
CLV_PCSK_KEX2_1	238	240	PF00082	0.509
CLV_PCSK_KEX2_1	253	255	PF00082	0.756
CLV_PCSK_KEX2_1	265	267	PF00082	0.476
CLV_PCSK_KEX2_1	32	34	PF00082	0.574
CLV_PCSK_KEX2_1	498	500	PF00082	0.433
CLV_PCSK_KEX2_1	644	646	PF00082	0.626
CLV_PCSK_KEX2_1	659	661	PF00082	0.643
CLV_PCSK_KEX2_1	673	675	PF00082	0.598
CLV_PCSK_KEX2_1	685	687	PF00082	0.416
CLV_PCSK_KEX2_1	736	738	PF00082	0.433
CLV_PCSK_KEX2_1	740	742	PF00082	0.499
CLV_PCSK_KEX2_1	763	765	PF00082	0.396
CLV_PCSK_KEX2_1	802	804	PF00082	0.474
CLV_PCSK_KEX2_1	811	813	PF00082	0.509
CLV_PCSK_PC7_1	736	742	PF00082	0.450
CLV_PCSK_SKI1_1	158	162	PF00082	0.657
CLV_PCSK_SKI1_1	223	227	PF00082	0.562
CLV_PCSK_SKI1_1	589	593	PF00082	0.760
CLV_PCSK_SKI1_1	640	644	PF00082	0.689
CLV_PCSK_SKI1_1	755	759	PF00082	0.477
DEG_APCC_DBOX_1	24	32	PF00400	0.607
DEG_APCC_DBOX_1	268	276	PF00400	0.357
DEG_APCC_DBOX_1	762	770	PF00400	0.410
DEG_COP1_1	476	483	PF00400	0.424
DEG_MDM2_SWIB_1	431	438	PF02201	0.422
DEG_SPOP_SBC_1	619	623	PF00917	0.578
DEG_SPOP_SBC_1	665	669	PF00917	0.662
DOC_ANK_TNKS_1	575	582	PF00023	0.433
DOC_MAPK_gen_1	326	336	PF00069	0.392
DOC_MAPK_gen_1	545	551	PF00069	0.586
DOC_MAPK_gen_1	562	571	PF00069	0.253
DOC_MAPK_gen_1	69	77	PF00069	0.483
DOC_MAPK_gen_1	763	771	PF00069	0.449
DOC_MAPK_MEF2A_6	565	573	PF00069	0.349
DOC_PP1_RVXF_1	69	75	PF00149	0.496
DOC_PP1_RVXF_1	762	769	PF00149	0.345
DOC_PP1_SILK_1	669	674	PF00149	0.625
DOC_PP2B_LxvP_1	389	392	PF13499	0.478
DOC_PP4_FxxP_1	519	522	PF00568	0.464
DOC_SPAK_OSR1_1	467	471	PF12202	0.317
DOC_USP7_MATH_1	127	131	PF00917	0.624
DOC_USP7_MATH_1	153	157	PF00917	0.643
DOC_USP7_MATH_1	194	198	PF00917	0.726
DOC_USP7_MATH_1	246	250	PF00917	0.613
DOC_USP7_MATH_1	344	348	PF00917	0.453
DOC_USP7_MATH_1	439	443	PF00917	0.583
DOC_USP7_MATH_1	497	501	PF00917	0.427
DOC_USP7_MATH_1	535	539	PF00917	0.545
DOC_USP7_MATH_1	606	610	PF00917	0.632
DOC_USP7_MATH_1	619	623	PF00917	0.493
DOC_USP7_MATH_1	627	631	PF00917	0.569
DOC_USP7_MATH_1	652	656	PF00917	0.674
DOC_USP7_MATH_1	663	667	PF00917	0.655
DOC_USP7_MATH_1	705	709	PF00917	0.458
DOC_USP7_UBL2_3	754	758	PF12436	0.461
DOC_WW_Pin1_4	110	115	PF00397	0.735
DOC_WW_Pin1_4	125	130	PF00397	0.588
DOC_WW_Pin1_4	162	167	PF00397	0.682
DOC_WW_Pin1_4	223	228	PF00397	0.592
DOC_WW_Pin1_4	244	249	PF00397	0.633
DOC_WW_Pin1_4	31	36	PF00397	0.590
DOC_WW_Pin1_4	345	350	PF00397	0.531
DOC_WW_Pin1_4	361	366	PF00397	0.333
DOC_WW_Pin1_4	370	375	PF00397	0.621
DOC_WW_Pin1_4	509	514	PF00397	0.444
DOC_WW_Pin1_4	579	584	PF00397	0.583
DOC_WW_Pin1_4	601	606	PF00397	0.620
DOC_WW_Pin1_4	631	636	PF00397	0.691
DOC_WW_Pin1_4	647	652	PF00397	0.502
DOC_WW_Pin1_4	654	659	PF00397	0.554
LIG_14-3-3_CanoR_1	121	125	PF00244	0.649
LIG_14-3-3_CanoR_1	326	332	PF00244	0.476
LIG_14-3-3_CanoR_1	358	364	PF00244	0.532
LIG_14-3-3_CanoR_1	40	49	PF00244	0.537
LIG_14-3-3_CanoR_1	430	436	PF00244	0.284
LIG_14-3-3_CanoR_1	55	63	PF00244	0.500
LIG_14-3-3_CanoR_1	644	648	PF00244	0.617
LIG_14-3-3_CanoR_1	701	709	PF00244	0.433
LIG_14-3-3_CanoR_1	740	746	PF00244	0.504
LIG_Actin_WH2_2	17	34	PF00022	0.562
LIG_Actin_WH2_2	333	348	PF00022	0.456
LIG_BRCT_BRCA1_1	707	711	PF00533	0.396
LIG_BRCT_BRCA1_1	87	91	PF00533	0.602
LIG_FHA_1	131	137	PF00498	0.688
LIG_FHA_1	138	144	PF00498	0.618
LIG_FHA_1	373	379	PF00498	0.454
LIG_FHA_1	432	438	PF00498	0.275
LIG_FHA_1	531	537	PF00498	0.475
LIG_FHA_1	542	548	PF00498	0.403
LIG_FHA_1	80	86	PF00498	0.562
LIG_FHA_2	308	314	PF00498	0.515
LIG_FHA_2	328	334	PF00498	0.457
LIG_FHA_2	349	355	PF00498	0.539
LIG_FHA_2	362	368	PF00498	0.608
LIG_FHA_2	7	13	PF00498	0.561
LIG_FHA_2	701	707	PF00498	0.378
LIG_GBD_Chelix_1	16	24	PF00786	0.558
LIG_GBD_Chelix_1	228	236	PF00786	0.587
LIG_Integrin_RGD_1	562	564	PF01839	0.427
LIG_LIR_Apic_2	205	211	PF02991	0.623
LIG_LIR_Apic_2	442	447	PF02991	0.483
LIG_LIR_Apic_2	715	721	PF02991	0.430
LIG_LIR_Gen_1	379	389	PF02991	0.459
LIG_LIR_Gen_1	767	776	PF02991	0.471
LIG_LIR_Nem_3	379	384	PF02991	0.444
LIG_LIR_Nem_3	412	416	PF02991	0.546
LIG_LIR_Nem_3	434	438	PF02991	0.278
LIG_LIR_Nem_3	482	487	PF02991	0.433
LIG_LIR_Nem_3	58	63	PF02991	0.496
LIG_LIR_Nem_3	767	771	PF02991	0.459
LIG_MYND_1	513	517	PF01753	0.419
LIG_NRBOX	491	497	PF00104	0.342
LIG_NRBOX	568	574	PF00104	0.538
LIG_Pex14_1	208	212	PF04695	0.622
LIG_Pex14_2	431	435	PF04695	0.431
LIG_Pex14_2	87	91	PF04695	0.645
LIG_RPA_C_Fungi	494	506	PF08784	0.294
LIG_SH2_CRK	413	417	PF00017	0.487
LIG_SH2_CRK	444	448	PF00017	0.504
LIG_SH2_NCK_1	14	18	PF00017	0.570
LIG_SH2_NCK_1	413	417	PF00017	0.537
LIG_SH2_NCK_1	702	706	PF00017	0.424
LIG_SH2_SRC	388	391	PF00017	0.457
LIG_SH2_SRC	413	416	PF00017	0.541
LIG_SH2_STAP1	338	342	PF00017	0.439
LIG_SH2_STAT5	233	236	PF00017	0.522
LIG_SH2_STAT5	271	274	PF00017	0.352
LIG_SH2_STAT5	369	372	PF00017	0.651
LIG_SH2_STAT5	388	391	PF00017	0.276
LIG_SH2_STAT5	702	705	PF00017	0.371
LIG_SH2_STAT5	733	736	PF00017	0.428
LIG_SH2_STAT5	805	808	PF00017	0.544
LIG_SH3_1	645	651	PF00018	0.609
LIG_SH3_3	212	218	PF00018	0.489
LIG_SH3_3	285	291	PF00018	0.565
LIG_SH3_3	412	418	PF00018	0.535
LIG_SH3_3	580	586	PF00018	0.477
LIG_SH3_3	645	651	PF00018	0.707
LIG_SUMO_SIM_anti_2	778	784	PF11976	0.324
LIG_SUMO_SIM_par_1	276	282	PF11976	0.465
LIG_SUMO_SIM_par_1	547	556	PF11976	0.331
LIG_SUMO_SIM_par_1	778	784	PF11976	0.324
LIG_TRAF2_1	351	354	PF00917	0.545
LIG_TRAF2_1	364	367	PF00917	0.474
LIG_TRAF2_1	391	394	PF00917	0.482
LIG_WRC_WIRS_1	536	541	PF05994	0.428
MOD_CDC14_SPxK_1	165	168	PF00782	0.560
MOD_CDC14_SPxK_1	657	660	PF00782	0.537
MOD_CDK_SPK_2	654	659	PF00069	0.618
MOD_CDK_SPxK_1	162	168	PF00069	0.559
MOD_CDK_SPxK_1	601	607	PF00069	0.686
MOD_CDK_SPxK_1	654	660	PF00069	0.543
MOD_CDK_SPxxK_3	110	117	PF00069	0.624
MOD_CDK_SPxxK_3	223	230	PF00069	0.604
MOD_CDK_SPxxK_3	647	654	PF00069	0.611
MOD_CK1_1	120	126	PF00069	0.688
MOD_CK1_1	130	136	PF00069	0.566
MOD_CK1_1	137	143	PF00069	0.525
MOD_CK1_1	203	209	PF00069	0.661
MOD_CK1_1	213	219	PF00069	0.731
MOD_CK1_1	347	353	PF00069	0.586
MOD_CK1_1	476	482	PF00069	0.427
MOD_CK1_1	538	544	PF00069	0.472
MOD_CK1_1	550	556	PF00069	0.417
MOD_CK1_1	621	627	PF00069	0.665
MOD_CK1_1	666	672	PF00069	0.746
MOD_CK1_1	753	759	PF00069	0.328
MOD_CK2_1	276	282	PF00069	0.463
MOD_CK2_1	307	313	PF00069	0.490
MOD_CK2_1	327	333	PF00069	0.513
MOD_CK2_1	348	354	PF00069	0.536
MOD_CK2_1	361	367	PF00069	0.399
MOD_CK2_1	497	503	PF00069	0.424
MOD_CK2_1	62	68	PF00069	0.649
MOD_Cter_Amidation	683	686	PF01082	0.430
MOD_DYRK1A_RPxSP_1	654	658	PF00069	0.617
MOD_GlcNHglycan	130	133	PF01048	0.604
MOD_GlcNHglycan	136	139	PF01048	0.558
MOD_GlcNHglycan	202	205	PF01048	0.641
MOD_GlcNHglycan	212	215	PF01048	0.611
MOD_GlcNHglycan	248	251	PF01048	0.782
MOD_GlcNHglycan	499	502	PF01048	0.432
MOD_GlcNHglycan	533	536	PF01048	0.373
MOD_GlcNHglycan	589	592	PF01048	0.590
MOD_GlcNHglycan	608	611	PF01048	0.520
MOD_GlcNHglycan	627	630	PF01048	0.584
MOD_GlcNHglycan	645	648	PF01048	0.686
MOD_GlcNHglycan	668	671	PF01048	0.744
MOD_GlcNHglycan	755	758	PF01048	0.329
MOD_GSK3_1	106	113	PF00069	0.688
MOD_GSK3_1	115	122	PF00069	0.700
MOD_GSK3_1	127	134	PF00069	0.605
MOD_GSK3_1	194	201	PF00069	0.660
MOD_GSK3_1	344	351	PF00069	0.498
MOD_GSK3_1	372	379	PF00069	0.466
MOD_GSK3_1	469	476	PF00069	0.404
MOD_GSK3_1	531	538	PF00069	0.475
MOD_GSK3_1	587	594	PF00069	0.643
MOD_GSK3_1	618	625	PF00069	0.615
MOD_GSK3_1	627	634	PF00069	0.621
MOD_GSK3_1	643	650	PF00069	0.618
MOD_GSK3_1	749	756	PF00069	0.493
MOD_GSK3_1	75	82	PF00069	0.578
MOD_N-GLC_1	138	143	PF02516	0.691
MOD_N-GLC_1	299	304	PF02516	0.425
MOD_N-GLC_1	530	535	PF02516	0.382
MOD_NEK2_1	299	304	PF00069	0.479
MOD_NEK2_1	307	312	PF00069	0.456
MOD_NEK2_1	384	389	PF00069	0.466
MOD_NEK2_1	41	46	PF00069	0.503
MOD_NEK2_1	431	436	PF00069	0.307
MOD_NEK2_1	643	648	PF00069	0.616
MOD_NEK2_2	153	158	PF00069	0.646
MOD_NEK2_2	376	381	PF00069	0.444
MOD_NEK2_2	439	444	PF00069	0.461
MOD_PIKK_1	151	157	PF00454	0.690
MOD_PKA_1	253	259	PF00069	0.652
MOD_PKA_1	741	747	PF00069	0.497
MOD_PKA_2	120	126	PF00069	0.661
MOD_PKA_2	253	259	PF00069	0.607
MOD_PKA_2	497	503	PF00069	0.412
MOD_PKA_2	643	649	PF00069	0.690
MOD_PKA_2	700	706	PF00069	0.427
MOD_PKA_2	741	747	PF00069	0.497
MOD_PKA_2	810	816	PF00069	0.606
MOD_PKB_1	53	61	PF00069	0.453
MOD_Plk_1	283	289	PF00069	0.591
MOD_Plk_1	553	559	PF00069	0.414
MOD_Plk_1	705	711	PF00069	0.387
MOD_Plk_4	131	137	PF00069	0.654
MOD_Plk_4	376	382	PF00069	0.448
MOD_Plk_4	384	390	PF00069	0.403
MOD_Plk_4	439	445	PF00069	0.496
MOD_Plk_4	479	485	PF00069	0.342
MOD_Plk_4	547	553	PF00069	0.479
MOD_Plk_4	705	711	PF00069	0.489
MOD_Plk_4	741	747	PF00069	0.497
MOD_Plk_4	793	799	PF00069	0.373
MOD_ProDKin_1	110	116	PF00069	0.735
MOD_ProDKin_1	125	131	PF00069	0.590
MOD_ProDKin_1	162	168	PF00069	0.684
MOD_ProDKin_1	223	229	PF00069	0.585
MOD_ProDKin_1	244	250	PF00069	0.635
MOD_ProDKin_1	31	37	PF00069	0.586
MOD_ProDKin_1	345	351	PF00069	0.539
MOD_ProDKin_1	361	367	PF00069	0.334
MOD_ProDKin_1	370	376	PF00069	0.615
MOD_ProDKin_1	509	515	PF00069	0.445
MOD_ProDKin_1	579	585	PF00069	0.584
MOD_ProDKin_1	601	607	PF00069	0.622
MOD_ProDKin_1	631	637	PF00069	0.688
MOD_ProDKin_1	647	653	PF00069	0.506
MOD_ProDKin_1	654	660	PF00069	0.553
TRG_ENDOCYTIC_2	233	236	PF00928	0.572
TRG_ENDOCYTIC_2	413	416	PF00928	0.490
TRG_ENDOCYTIC_2	60	63	PF00928	0.647
TRG_ER_diArg_1	222	224	PF00400	0.645
TRG_ER_diArg_1	252	255	PF00400	0.661
TRG_ER_diArg_1	264	266	PF00400	0.490
TRG_ER_diArg_1	31	33	PF00400	0.560
TRG_ER_diArg_1	643	645	PF00400	0.731
TRG_ER_diArg_1	658	660	PF00400	0.477
TRG_ER_diArg_1	672	674	PF00400	0.657
TRG_ER_diArg_1	735	737	PF00400	0.436
TRG_ER_diArg_1	740	742	PF00400	0.521
TRG_ER_diArg_1	762	764	PF00400	0.416
TRG_ER_diArg_1	801	803	PF00400	0.454
TRG_ER_diArg_1	810	812	PF00400	0.508
TRG_Pf-PMV_PEXEL_1	217	221	PF00026	0.627
TRG_Pf-PMV_PEXEL_1	230	235	PF00026	0.451
TRG_Pf-PMV_PEXEL_1	329	333	PF00026	0.441
TRG_Pf-PMV_PEXEL_1	690	694	PF00026	0.429

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0J3	Leptomonas seymouri	43%	100%
A0A3Q8IIY8	Leishmania donovani	89%	100%
A0A422P2B7	Trypanosoma rangeli	32%	100%
A4HNN5	Leishmania braziliensis	72%	100%
A4ICW0	Leishmania infantum	89%	100%
E9ASE4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%