TFIIS central domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q250_LEIMA

TriTrypDb:

LmjF.36.0280 , LMJLV39_360008100 , LMJSD75_360007900

Length:

252

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q250

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q250

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006351	DNA-templated transcription	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0032774	RNA biosynthetic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0097659	nucleic acid-templated transcription	6	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	132	134	PF00675	0.683
CLV_NRD_NRD_1	163	165	PF00675	0.500
CLV_NRD_NRD_1	187	189	PF00675	0.453
CLV_NRD_NRD_1	20	22	PF00675	0.369
CLV_NRD_NRD_1	88	90	PF00675	0.381
CLV_PCSK_KEX2_1	156	158	PF00082	0.542
CLV_PCSK_KEX2_1	165	167	PF00082	0.455
CLV_PCSK_KEX2_1	187	189	PF00082	0.453
CLV_PCSK_KEX2_1	20	22	PF00082	0.369
CLV_PCSK_KEX2_1	88	90	PF00082	0.381
CLV_PCSK_PC1ET2_1	156	158	PF00082	0.542
CLV_PCSK_PC1ET2_1	165	167	PF00082	0.455
DEG_SPOP_SBC_1	56	60	PF00917	0.614
DOC_CYCLIN_yClb5_NLxxxL_5	120	126	PF00134	0.439
DOC_MAPK_gen_1	187	193	PF00069	0.464
DOC_MAPK_gen_1	20	26	PF00069	0.365
DOC_MAPK_MEF2A_6	65	74	PF00069	0.467
DOC_USP7_MATH_1	149	153	PF00917	0.586
DOC_USP7_MATH_1	197	201	PF00917	0.567
DOC_USP7_MATH_1	244	248	PF00917	0.629
DOC_USP7_MATH_1	56	60	PF00917	0.614
DOC_WW_Pin1_4	58	63	PF00397	0.450
LIG_14-3-3_CanoR_1	88	98	PF00244	0.434
LIG_BIR_II_1	1	5	PF00653	0.429
LIG_BIR_III_1	1	5	PF00653	0.429
LIG_BIR_III_3	1	5	PF00653	0.429
LIG_BRCT_BRCA1_1	43	47	PF00533	0.475
LIG_FHA_1	40	46	PF00498	0.477
LIG_FHA_1	9	15	PF00498	0.400
LIG_FHA_2	102	108	PF00498	0.415
LIG_FHA_2	169	175	PF00498	0.615
LIG_FHA_2	243	249	PF00498	0.650
LIG_GBD_Chelix_1	66	74	PF00786	0.462
LIG_Pex14_2	207	211	PF04695	0.521
LIG_SH2_STAP1	90	94	PF00017	0.397
LIG_SH2_STAT3	90	93	PF00017	0.474
LIG_TRAF2_1	104	107	PF00917	0.431
LIG_UBA3_1	112	120	PF00899	0.398
LIG_UBA3_1	69	76	PF00899	0.401
MOD_CDK_SPxxK_3	58	65	PF00069	0.438
MOD_CK1_1	200	206	PF00069	0.702
MOD_CK1_1	218	224	PF00069	0.473
MOD_CK1_1	239	245	PF00069	0.570
MOD_CK1_1	54	60	PF00069	0.560
MOD_CK2_1	101	107	PF00069	0.437
MOD_CK2_1	135	141	PF00069	0.504
MOD_CK2_1	218	224	PF00069	0.576
MOD_CK2_1	225	231	PF00069	0.622
MOD_GlcNHglycan	122	125	PF01048	0.377
MOD_GlcNHglycan	137	140	PF01048	0.513
MOD_GlcNHglycan	201	205	PF01048	0.612
MOD_GlcNHglycan	227	230	PF01048	0.720
MOD_GlcNHglycan	5	8	PF01048	0.532
MOD_GlcNHglycan	54	57	PF01048	0.587
MOD_GlcNHglycan	83	86	PF01048	0.493
MOD_GSK3_1	155	162	PF00069	0.605
MOD_GSK3_1	174	181	PF00069	0.422
MOD_GSK3_1	211	218	PF00069	0.527
MOD_GSK3_1	244	251	PF00069	0.618
MOD_GSK3_1	35	42	PF00069	0.511
MOD_GSK3_1	48	55	PF00069	0.586
MOD_GSK3_1	8	15	PF00069	0.468
MOD_N-GLC_1	101	106	PF02516	0.430
MOD_N-GLC_1	120	125	PF02516	0.434
MOD_N-GLC_2	213	215	PF02516	0.473
MOD_NEK2_1	14	19	PF00069	0.478
MOD_NEK2_1	159	164	PF00069	0.673
MOD_NEK2_1	178	183	PF00069	0.354
MOD_NEK2_1	211	216	PF00069	0.564
MOD_NEK2_1	24	29	PF00069	0.448
MOD_NEK2_1	52	57	PF00069	0.579
MOD_NEK2_1	8	13	PF00069	0.482
MOD_PIKK_1	127	133	PF00454	0.501
MOD_PIKK_1	149	155	PF00454	0.410
MOD_PIKK_1	24	30	PF00454	0.371
MOD_PIKK_1	39	45	PF00454	0.459
MOD_PIKK_1	89	95	PF00454	0.428
MOD_PKA_2	224	230	PF00069	0.720
MOD_PKB_1	166	174	PF00069	0.588
MOD_Plk_1	173	179	PF00069	0.510
MOD_Plk_1	233	239	PF00069	0.588
MOD_Plk_2-3	141	147	PF00069	0.516
MOD_Plk_4	14	20	PF00069	0.375
MOD_ProDKin_1	58	64	PF00069	0.440
MOD_SUMO_rev_2	130	135	PF00179	0.569
MOD_SUMO_rev_2	58	67	PF00179	0.467
TRG_ER_diArg_1	163	166	PF00400	0.525
TRG_ER_diArg_1	186	188	PF00400	0.472
TRG_ER_diArg_1	19	21	PF00400	0.384
TRG_ER_diArg_1	88	90	PF00400	0.381
TRG_NLS_MonoExtC_3	163	168	PF00514	0.503

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7E0	Leptomonas seymouri	62%	100%
A0A3Q8IVQ2	Leishmania donovani	93%	88%
A4HNN6	Leishmania braziliensis	79%	100%
A4ICV9	Leishmania infantum	95%	100%
E9ASE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%