Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q249_LEIMA

TriTrypDb:

LmjF.36.0290 , LMJLV39_360008200 , LMJSD75_360008000

Length:

316

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4Q249

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q249

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	102	104	PF00675	0.604
CLV_NRD_NRD_1	125	127	PF00675	0.577
CLV_NRD_NRD_1	138	140	PF00675	0.629
CLV_NRD_NRD_1	205	207	PF00675	0.687
CLV_NRD_NRD_1	3	5	PF00675	0.480
CLV_NRD_NRD_1	54	56	PF00675	0.585
CLV_NRD_NRD_1	94	96	PF00675	0.696
CLV_PCSK_FUR_1	123	127	PF00082	0.533
CLV_PCSK_KEX2_1	102	104	PF00082	0.604
CLV_PCSK_KEX2_1	125	127	PF00082	0.577
CLV_PCSK_KEX2_1	138	140	PF00082	0.629
CLV_PCSK_KEX2_1	2	4	PF00082	0.489
CLV_PCSK_KEX2_1	204	206	PF00082	0.687
CLV_PCSK_KEX2_1	54	56	PF00082	0.585
CLV_PCSK_KEX2_1	94	96	PF00082	0.696
CLV_PCSK_PC7_1	98	104	PF00082	0.685
CLV_PCSK_SKI1_1	236	240	PF00082	0.735
CLV_PCSK_SKI1_1	55	59	PF00082	0.523
DEG_MDM2_SWIB_1	300	308	PF02201	0.391
DEG_Nend_UBRbox_1	1	4	PF02207	0.723
DOC_CYCLIN_yCln2_LP_2	251	254	PF00134	0.587
DOC_MAPK_gen_1	102	111	PF00069	0.463
DOC_MAPK_gen_1	54	60	PF00069	0.325
DOC_MAPK_MEF2A_6	166	173	PF00069	0.407
DOC_PP2B_LxvP_1	251	254	PF13499	0.587
DOC_PP4_FxxP_1	35	38	PF00568	0.555
DOC_USP7_MATH_1	142	146	PF00917	0.540
DOC_USP7_MATH_1	194	198	PF00917	0.499
DOC_USP7_MATH_1	306	310	PF00917	0.558
DOC_WW_Pin1_4	214	219	PF00397	0.537
DOC_WW_Pin1_4	34	39	PF00397	0.469
LIG_14-3-3_CanoR_1	102	108	PF00244	0.416
LIG_14-3-3_CanoR_1	206	216	PF00244	0.480
LIG_Actin_WH2_2	221	238	PF00022	0.449
LIG_AP2alpha_2	242	244	PF02296	0.467
LIG_APCC_ABBA_1	216	221	PF00400	0.602
LIG_EH1_1	11	19	PF00400	0.440
LIG_eIF4E_1	13	19	PF01652	0.514
LIG_FHA_1	104	110	PF00498	0.358
LIG_FHA_1	208	214	PF00498	0.488
LIG_FHA_1	254	260	PF00498	0.548
LIG_FHA_1	294	300	PF00498	0.432
LIG_FHA_2	158	164	PF00498	0.496
LIG_FHA_2	66	72	PF00498	0.490
LIG_GBD_Chelix_1	18	26	PF00786	0.382
LIG_LIR_Apic_2	135	140	PF02991	0.506
LIG_LIR_Gen_1	273	280	PF02991	0.521
LIG_LIR_Nem_3	241	247	PF02991	0.560
LIG_LIR_Nem_3	273	277	PF02991	0.476
LIG_LIR_Nem_3	309	313	PF02991	0.726
LIG_LIR_Nem_3	31	35	PF02991	0.466
LIG_MYND_1	249	253	PF01753	0.594
LIG_NRBOX	17	23	PF00104	0.497
LIG_Pex14_1	240	244	PF04695	0.484
LIG_Pex14_2	300	304	PF04695	0.412
LIG_PTB_Apo_2	258	265	PF02174	0.477
LIG_PTB_Phospho_1	258	264	PF10480	0.482
LIG_SH2_CRK	274	278	PF00017	0.545
LIG_SH2_NCK_1	127	131	PF00017	0.479
LIG_SH2_SRC	113	116	PF00017	0.491
LIG_SH2_STAP1	155	159	PF00017	0.409
LIG_SH2_STAT5	174	177	PF00017	0.368
LIG_SH2_STAT5	264	267	PF00017	0.467
LIG_SH2_STAT5	274	277	PF00017	0.477
LIG_SH3_3	240	246	PF00018	0.469
LIG_SH3_3	256	262	PF00018	0.430
LIG_TRAF2_1	145	148	PF00917	0.510
LIG_TYR_ITIM	272	277	PF00017	0.545
LIG_TYR_ITIM	308	313	PF00017	0.664
LIG_WW_3	252	256	PF00397	0.519
MOD_CDK_SPxK_1	214	220	PF00069	0.540
MOD_CK1_1	157	163	PF00069	0.409
MOD_CK1_1	62	68	PF00069	0.452
MOD_CK2_1	142	148	PF00069	0.543
MOD_CK2_1	157	163	PF00069	0.374
MOD_CK2_1	194	200	PF00069	0.420
MOD_CK2_1	34	40	PF00069	0.461
MOD_Cter_Amidation	52	55	PF01082	0.593
MOD_GlcNHglycan	7	10	PF01048	0.501
MOD_GSK3_1	155	162	PF00069	0.442
MOD_GSK3_1	219	226	PF00069	0.609
MOD_GSK3_1	24	31	PF00069	0.381
MOD_N-GLC_1	65	70	PF02516	0.629
MOD_NEK2_1	24	29	PF00069	0.400
MOD_NEK2_1	272	277	PF00069	0.457
MOD_NEK2_1	280	285	PF00069	0.458
MOD_NEK2_1	300	305	PF00069	0.263
MOD_NEK2_1	59	64	PF00069	0.418
MOD_NEK2_2	231	236	PF00069	0.531
MOD_PIKK_1	207	213	PF00454	0.467
MOD_PKA_2	219	225	PF00069	0.536
MOD_PKB_1	190	198	PF00069	0.446
MOD_Plk_2-3	87	93	PF00069	0.532
MOD_Plk_4	272	278	PF00069	0.541
MOD_Plk_4	306	312	PF00069	0.640
MOD_Plk_4	59	65	PF00069	0.414
MOD_ProDKin_1	214	220	PF00069	0.540
MOD_ProDKin_1	34	40	PF00069	0.462
TRG_DiLeu_BaEn_3	91	97	PF01217	0.506
TRG_ENDOCYTIC_2	274	277	PF00928	0.477
TRG_ENDOCYTIC_2	310	313	PF00928	0.723
TRG_ER_diArg_1	1	4	PF00400	0.726
TRG_ER_diArg_1	102	104	PF00400	0.404
TRG_ER_diArg_1	122	125	PF00400	0.355
TRG_ER_diArg_1	137	139	PF00400	0.396
TRG_ER_diArg_1	181	184	PF00400	0.431
TRG_ER_diArg_1	203	206	PF00400	0.507
TRG_ER_diArg_1	54	56	PF00400	0.385
TRG_ER_diArg_1	94	96	PF00400	0.496
TRG_Pf-PMV_PEXEL_1	184	189	PF00026	0.668

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Z7	Leptomonas seymouri	47%	99%
A0A3S7XAG8	Leishmania donovani	94%	100%
A4HNN7	Leishmania braziliensis	77%	100%
A4ICV8	Leishmania infantum	94%	100%
E9ASE6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%