Conserved NUDIX hydrolase protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mutt-Nudix-related hydrolase 5, putative

Species:

Leishmania major

UniProt:

Q4Q248_LEIMA

TriTrypDb:

LmjF.36.0300 , LMJLV39_360008300 , LMJSD75_360008100

Length:

332

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q248

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q248

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006163	purine nucleotide metabolic process	5	2
GO:0006195	purine nucleotide catabolic process	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006753	nucleoside phosphate metabolic process	4	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009117	nucleotide metabolic process	5	2
GO:0009150	purine ribonucleotide metabolic process	6	2
GO:0009154	purine ribonucleotide catabolic process	6	2
GO:0009166	nucleotide catabolic process	6	2
GO:0009259	ribonucleotide metabolic process	5	2
GO:0009261	ribonucleotide catabolic process	5	2
GO:0009987	cellular process	1	2
GO:0015936	coenzyme A metabolic process	6	2
GO:0015938	coenzyme A catabolic process	7	2
GO:0019439	aromatic compound catabolic process	4	2
GO:0019637	organophosphate metabolic process	3	2
GO:0019693	ribose phosphate metabolic process	4	2
GO:0033865	nucleoside bisphosphate metabolic process	5	2
GO:0033869	nucleoside bisphosphate catabolic process	6	2
GO:0033875	ribonucleoside bisphosphate metabolic process	6	2
GO:0034031	ribonucleoside bisphosphate catabolic process	7	2
GO:0034032	purine nucleoside bisphosphate metabolic process	5	2
GO:0034034	purine nucleoside bisphosphate catabolic process	6	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034655	nucleobase-containing compound catabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0044270	cellular nitrogen compound catabolic process	4	2
GO:0044281	small molecule metabolic process	2	2
GO:0046434	organophosphate catabolic process	4	2
GO:0046483	heterocycle metabolic process	3	2
GO:0046700	heterocycle catabolic process	4	2
GO:0055086	nucleobase-containing small molecule metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0072521	purine-containing compound metabolic process	4	2
GO:0072523	purine-containing compound catabolic process	5	2
GO:1901135	carbohydrate derivative metabolic process	3	2
GO:1901136	carbohydrate derivative catabolic process	4	2
GO:1901292	nucleoside phosphate catabolic process	5	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901361	organic cyclic compound catabolic process	4	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901565	organonitrogen compound catabolic process	4	2
GO:1901575	organic substance catabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0003986	acetyl-CoA hydrolase activity	6	2
GO:0010945	CoA pyrophosphatase activity	6	12
GO:0016289	CoA hydrolase activity	5	2
GO:0016462	pyrophosphatase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0016790	thiolester hydrolase activity	4	2
GO:0016817	hydrolase activity, acting on acid anhydrides	3	12
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	23	25	PF00675	0.541
CLV_NRD_NRD_1	48	50	PF00675	0.388
CLV_PCSK_FUR_1	21	25	PF00082	0.542
CLV_PCSK_KEX2_1	118	120	PF00082	0.289
CLV_PCSK_KEX2_1	21	23	PF00082	0.672
CLV_PCSK_KEX2_1	48	50	PF00082	0.386
CLV_PCSK_PC1ET2_1	118	120	PF00082	0.289
CLV_PCSK_PC7_1	18	24	PF00082	0.536
CLV_PCSK_SKI1_1	119	123	PF00082	0.400
CLV_PCSK_SKI1_1	222	226	PF00082	0.470
CLV_PCSK_SKI1_1	227	231	PF00082	0.440
CLV_PCSK_SKI1_1	295	299	PF00082	0.383
CLV_PCSK_SKI1_1	48	52	PF00082	0.321
DEG_APCC_DBOX_1	148	156	PF00400	0.417
DEG_Nend_UBRbox_4	1	3	PF02207	0.524
DEG_SCF_FBW7_1	168	173	PF00400	0.302
DOC_CKS1_1	315	320	PF01111	0.583
DOC_CYCLIN_RxL_1	46	57	PF00134	0.423
DOC_MAPK_FxFP_2	10	13	PF00069	0.536
DOC_MAPK_MEF2A_6	179	186	PF00069	0.312
DOC_MAPK_MEF2A_6	92	100	PF00069	0.340
DOC_PP1_RVXF_1	47	54	PF00149	0.384
DOC_PP4_FxxP_1	10	13	PF00568	0.536
DOC_PP4_FxxP_1	241	244	PF00568	0.492
DOC_USP7_MATH_1	54	58	PF00917	0.448
DOC_USP7_MATH_2	198	204	PF00917	0.390
DOC_WW_Pin1_4	166	171	PF00397	0.406
DOC_WW_Pin1_4	178	183	PF00397	0.328
DOC_WW_Pin1_4	186	191	PF00397	0.342
DOC_WW_Pin1_4	194	199	PF00397	0.413
DOC_WW_Pin1_4	240	245	PF00397	0.441
DOC_WW_Pin1_4	253	258	PF00397	0.485
DOC_WW_Pin1_4	3	8	PF00397	0.539
DOC_WW_Pin1_4	314	319	PF00397	0.446
DOC_WW_Pin1_4	77	82	PF00397	0.553
DOC_WW_Pin1_4	98	103	PF00397	0.336
LIG_14-3-3_CanoR_1	119	124	PF00244	0.434
LIG_14-3-3_CanoR_1	227	237	PF00244	0.428
LIG_14-3-3_CanoR_1	28	36	PF00244	0.494
LIG_14-3-3_CanoR_1	9	13	PF00244	0.628
LIG_BRCT_BRCA1_1	56	60	PF00533	0.587
LIG_deltaCOP1_diTrp_1	279	287	PF00928	0.322
LIG_FHA_1	171	177	PF00498	0.490
LIG_FHA_1	179	185	PF00498	0.378
LIG_FHA_1	283	289	PF00498	0.355
LIG_FHA_1	3	9	PF00498	0.524
LIG_FHA_2	149	155	PF00498	0.289
LIG_LIR_Gen_1	160	170	PF02991	0.255
LIG_LIR_Gen_1	181	191	PF02991	0.494
LIG_LIR_Gen_1	203	214	PF02991	0.327
LIG_LIR_Nem_3	160	165	PF02991	0.291
LIG_LIR_Nem_3	181	186	PF02991	0.378
LIG_LIR_Nem_3	40	46	PF02991	0.393
LIG_Pex14_2	236	240	PF04695	0.351
LIG_Pex14_2	60	64	PF04695	0.440
LIG_SH2_NCK_1	162	166	PF00017	0.400
LIG_SH2_SRC	162	165	PF00017	0.390
LIG_SH2_STAT5	206	209	PF00017	0.341
LIG_SH2_STAT5	65	68	PF00017	0.511
LIG_SH3_2	190	195	PF14604	0.497
LIG_SH3_3	152	158	PF00018	0.453
LIG_SH3_3	187	193	PF00018	0.489
LIG_SH3_3	267	273	PF00018	0.549
LIG_SH3_3	55	61	PF00018	0.456
LIG_SUMO_SIM_par_1	197	203	PF11976	0.459
LIG_SUMO_SIM_par_1	210	215	PF11976	0.392
LIG_SUMO_SIM_par_1	95	101	PF11976	0.312
LIG_TRAF2_1	151	154	PF00917	0.289
LIG_WRC_WIRS_1	226	231	PF05994	0.544
LIG_WRC_WIRS_1	284	289	PF05994	0.381
MOD_CDC14_SPxK_1	6	9	PF00782	0.524
MOD_CDC14_SPxK_1	80	83	PF00782	0.630
MOD_CDK_SPK_2	253	258	PF00069	0.542
MOD_CDK_SPxK_1	3	9	PF00069	0.524
MOD_CDK_SPxK_1	77	83	PF00069	0.624
MOD_CK1_1	125	131	PF00069	0.446
MOD_CK1_1	215	221	PF00069	0.356
MOD_CK1_1	228	234	PF00069	0.470
MOD_CK1_1	286	292	PF00069	0.404
MOD_CK2_1	148	154	PF00069	0.312
MOD_CK2_1	157	163	PF00069	0.323
MOD_CK2_1	194	200	PF00069	0.407
MOD_GlcNHglycan	176	179	PF01048	0.455
MOD_GlcNHglycan	214	217	PF01048	0.326
MOD_GlcNHglycan	250	253	PF01048	0.508
MOD_GlcNHglycan	307	310	PF01048	0.595
MOD_GSK3_1	166	173	PF00069	0.353
MOD_GSK3_1	174	181	PF00069	0.477
MOD_GSK3_1	240	247	PF00069	0.433
MOD_GSK3_1	253	260	PF00069	0.487
MOD_GSK3_1	282	289	PF00069	0.398
MOD_GSK3_1	73	80	PF00069	0.536
MOD_GSK3_1	8	15	PF00069	0.622
MOD_GSK3_1	98	105	PF00069	0.487
MOD_N-GLC_1	70	75	PF02516	0.460
MOD_NEK2_1	112	117	PF00069	0.288
MOD_NEK2_1	207	212	PF00069	0.359
MOD_NEK2_1	214	219	PF00069	0.445
MOD_NEK2_1	26	31	PF00069	0.520
MOD_NEK2_1	327	332	PF00069	0.643
MOD_NEK2_1	8	13	PF00069	0.756
MOD_PIKK_1	37	43	PF00454	0.412
MOD_PKA_2	148	154	PF00069	0.298
MOD_PKA_2	27	33	PF00069	0.509
MOD_PKA_2	8	14	PF00069	0.545
MOD_Plk_1	128	134	PF00069	0.427
MOD_Plk_1	139	145	PF00069	0.316
MOD_Plk_4	12	18	PF00069	0.743
MOD_Plk_4	207	213	PF00069	0.255
MOD_Plk_4	244	250	PF00069	0.571
MOD_Plk_4	283	289	PF00069	0.443
MOD_ProDKin_1	166	172	PF00069	0.406
MOD_ProDKin_1	178	184	PF00069	0.325
MOD_ProDKin_1	186	192	PF00069	0.354
MOD_ProDKin_1	194	200	PF00069	0.410
MOD_ProDKin_1	240	246	PF00069	0.446
MOD_ProDKin_1	253	259	PF00069	0.482
MOD_ProDKin_1	3	9	PF00069	0.541
MOD_ProDKin_1	314	320	PF00069	0.455
MOD_ProDKin_1	77	83	PF00069	0.557
MOD_ProDKin_1	98	104	PF00069	0.351
TRG_ENDOCYTIC_2	162	165	PF00928	0.274
TRG_ENDOCYTIC_2	206	209	PF00928	0.351
TRG_ENDOCYTIC_2	226	229	PF00928	0.536
TRG_ER_diArg_1	21	24	PF00400	0.568
TRG_ER_diArg_1	47	49	PF00400	0.395

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I791	Leptomonas seymouri	59%	100%
A0A0S4JMA9	Bodo saltans	36%	100%
A0A1X0P9B8	Trypanosomatidae	45%	100%
A0A3R7N2P2	Trypanosoma rangeli	48%	100%
A0A3S7XAB7	Leishmania donovani	93%	100%
A4HNN8	Leishmania braziliensis	78%	100%
A4ICV7	Leishmania infantum	92%	100%
D0A2J1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9ASE7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BZZ8	Trypanosoma cruzi	49%	100%