Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q243_LEIMA

TriTrypDb:

LmjF.36.0350 , LMJLV39_360008800 , LMJSD75_360008600

Length:

503

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q243

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q243

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.615
CLV_NRD_NRD_1	248	250	PF00675	0.572
CLV_NRD_NRD_1	251	253	PF00675	0.543
CLV_NRD_NRD_1	290	292	PF00675	0.477
CLV_NRD_NRD_1	304	306	PF00675	0.343
CLV_NRD_NRD_1	308	310	PF00675	0.317
CLV_NRD_NRD_1	360	362	PF00675	0.563
CLV_NRD_NRD_1	411	413	PF00675	0.475
CLV_NRD_NRD_1	429	431	PF00675	0.405
CLV_NRD_NRD_1	47	49	PF00675	0.634
CLV_NRD_NRD_1	486	488	PF00675	0.469
CLV_NRD_NRD_1	89	91	PF00675	0.583
CLV_PCSK_FUR_1	249	253	PF00082	0.536
CLV_PCSK_FUR_1	427	431	PF00082	0.553
CLV_PCSK_FUR_1	45	49	PF00082	0.635
CLV_PCSK_KEX2_1	222	224	PF00082	0.382
CLV_PCSK_KEX2_1	248	250	PF00082	0.692
CLV_PCSK_KEX2_1	251	253	PF00082	0.685
CLV_PCSK_KEX2_1	290	292	PF00082	0.473
CLV_PCSK_KEX2_1	308	310	PF00082	0.322
CLV_PCSK_KEX2_1	360	362	PF00082	0.563
CLV_PCSK_KEX2_1	411	413	PF00082	0.475
CLV_PCSK_KEX2_1	429	431	PF00082	0.405
CLV_PCSK_KEX2_1	47	49	PF00082	0.634
CLV_PCSK_PC1ET2_1	222	224	PF00082	0.382
CLV_PCSK_SKI1_1	170	174	PF00082	0.607
CLV_PCSK_SKI1_1	214	218	PF00082	0.616
CLV_PCSK_SKI1_1	239	243	PF00082	0.565
CLV_PCSK_SKI1_1	342	346	PF00082	0.528
CLV_PCSK_SKI1_1	59	63	PF00082	0.656
DEG_Nend_UBRbox_3	1	3	PF02207	0.702
DOC_CYCLIN_RxL_1	164	177	PF00134	0.623
DOC_MAPK_gen_1	293	302	PF00069	0.426
DOC_PP1_RVXF_1	212	218	PF00149	0.511
DOC_PP1_RVXF_1	242	248	PF00149	0.526
DOC_PP2B_LxvP_1	216	219	PF13499	0.505
DOC_PP2B_LxvP_1	264	267	PF13499	0.549
DOC_PP2B_LxvP_1	51	54	PF13499	0.668
DOC_PP4_FxxP_1	62	65	PF00568	0.657
DOC_USP7_MATH_1	110	114	PF00917	0.649
DOC_USP7_MATH_1	158	162	PF00917	0.561
DOC_USP7_MATH_1	21	25	PF00917	0.549
DOC_USP7_MATH_1	368	372	PF00917	0.629
DOC_USP7_MATH_1	376	380	PF00917	0.527
DOC_USP7_MATH_1	82	86	PF00917	0.611
DOC_WW_Pin1_4	154	159	PF00397	0.786
DOC_WW_Pin1_4	198	203	PF00397	0.581
DOC_WW_Pin1_4	332	337	PF00397	0.544
DOC_WW_Pin1_4	7	12	PF00397	0.535
LIG_14-3-3_CanoR_1	104	109	PF00244	0.552
LIG_14-3-3_CanoR_1	255	263	PF00244	0.564
LIG_14-3-3_CanoR_1	360	365	PF00244	0.510
LIG_14-3-3_CanoR_1	411	419	PF00244	0.484
LIG_14-3-3_CanoR_1	47	52	PF00244	0.640
LIG_14-3-3_CanoR_1	5	13	PF00244	0.664
LIG_Actin_WH2_2	256	274	PF00022	0.509
LIG_Actin_WH2_2	395	413	PF00022	0.386
LIG_BRCT_BRCA1_1	403	407	PF00533	0.442
LIG_CaM_IQ_9	282	297	PF13499	0.490
LIG_CaM_NSCaTE_8	70	77	PF13499	0.527
LIG_Clathr_ClatBox_1	397	401	PF01394	0.441
LIG_eIF4E_1	210	216	PF01652	0.520
LIG_FHA_1	117	123	PF00498	0.528
LIG_FHA_1	148	154	PF00498	0.540
LIG_FHA_1	210	216	PF00498	0.419
LIG_FHA_1	232	238	PF00498	0.522
LIG_FHA_1	360	366	PF00498	0.606
LIG_FHA_1	401	407	PF00498	0.434
LIG_FHA_1	445	451	PF00498	0.532
LIG_FHA_1	474	480	PF00498	0.370
LIG_FHA_2	129	135	PF00498	0.612
LIG_FHA_2	177	183	PF00498	0.444
LIG_FHA_2	319	325	PF00498	0.415
LIG_LIR_Gen_1	257	267	PF02991	0.525
LIG_LIR_Gen_1	313	320	PF02991	0.468
LIG_LIR_Gen_1	404	415	PF02991	0.407
LIG_LIR_Gen_1	466	473	PF02991	0.429
LIG_LIR_Nem_3	205	210	PF02991	0.593
LIG_LIR_Nem_3	257	263	PF02991	0.536
LIG_LIR_Nem_3	301	307	PF02991	0.448
LIG_LIR_Nem_3	313	319	PF02991	0.358
LIG_LIR_Nem_3	404	410	PF02991	0.386
LIG_LIR_Nem_3	466	472	PF02991	0.434
LIG_MAD2	115	123	PF02301	0.595
LIG_Pex14_2	217	221	PF04695	0.577
LIG_PTB_Apo_2	472	479	PF02174	0.415
LIG_PTB_Phospho_1	472	478	PF10480	0.410
LIG_SH2_CRK	210	214	PF00017	0.522
LIG_SH2_CRK	304	308	PF00017	0.443
LIG_SH2_CRK	469	473	PF00017	0.365
LIG_SH2_STAP1	373	377	PF00017	0.608
LIG_SH2_STAP1	469	473	PF00017	0.365
LIG_SH2_STAT5	478	481	PF00017	0.402
LIG_SH2_STAT5	60	63	PF00017	0.613
LIG_SH3_1	162	168	PF00018	0.629
LIG_SH3_2	165	170	PF14604	0.642
LIG_SH3_3	15	21	PF00018	0.658
LIG_SH3_3	162	168	PF00018	0.665
LIG_SH3_3	330	336	PF00018	0.516
LIG_TYR_ITIM	302	307	PF00017	0.446
LIG_UBA3_1	216	222	PF00899	0.504
MOD_CDK_SPK_2	154	159	PF00069	0.644
MOD_CDK_SPK_2	198	203	PF00069	0.580
MOD_CDK_SPxxK_3	332	339	PF00069	0.542
MOD_CK1_1	149	155	PF00069	0.734
MOD_CK1_1	188	194	PF00069	0.628
MOD_CK1_1	198	204	PF00069	0.502
MOD_CK1_1	363	369	PF00069	0.505
MOD_CK1_1	372	378	PF00069	0.463
MOD_CK1_1	93	99	PF00069	0.619
MOD_CK2_1	176	182	PF00069	0.452
MOD_CK2_1	318	324	PF00069	0.413
MOD_DYRK1A_RPxSP_1	332	336	PF00069	0.548
MOD_GlcNHglycan	108	111	PF01048	0.637
MOD_GlcNHglycan	187	190	PF01048	0.621
MOD_GlcNHglycan	192	195	PF01048	0.579
MOD_GlcNHglycan	23	26	PF01048	0.554
MOD_GlcNHglycan	366	369	PF01048	0.585
MOD_GlcNHglycan	403	406	PF01048	0.435
MOD_GlcNHglycan	412	415	PF01048	0.406
MOD_GlcNHglycan	7	10	PF01048	0.650
MOD_GSK3_1	106	113	PF00069	0.533
MOD_GSK3_1	147	154	PF00069	0.625
MOD_GSK3_1	250	257	PF00069	0.529
MOD_GSK3_1	3	10	PF00069	0.650
MOD_GSK3_1	359	366	PF00069	0.597
MOD_GSK3_1	368	375	PF00069	0.517
MOD_GSK3_1	473	480	PF00069	0.418
MOD_GSK3_1	60	67	PF00069	0.655
MOD_GSK3_1	80	87	PF00069	0.489
MOD_GSK3_1	92	99	PF00069	0.564
MOD_N-GLC_1	369	374	PF02516	0.564
MOD_N-GLC_1	473	478	PF02516	0.412
MOD_N-GLC_2	475	477	PF02516	0.409
MOD_NEK2_1	148	153	PF00069	0.754
MOD_NEK2_1	176	181	PF00069	0.482
MOD_NEK2_1	185	190	PF00069	0.658
MOD_NEK2_1	364	369	PF00069	0.508
MOD_NEK2_1	400	405	PF00069	0.439
MOD_NEK2_1	410	415	PF00069	0.394
MOD_NEK2_1	423	428	PF00069	0.429
MOD_NEK2_1	449	454	PF00069	0.551
MOD_NEK2_1	473	478	PF00069	0.412
MOD_NEK2_2	209	214	PF00069	0.458
MOD_NEK2_2	70	75	PF00069	0.572
MOD_PIKK_1	163	169	PF00454	0.617
MOD_PIKK_1	318	324	PF00454	0.441
MOD_PK_1	354	360	PF00069	0.541
MOD_PKA_1	360	366	PF00069	0.496
MOD_PKA_1	47	53	PF00069	0.628
MOD_PKA_1	90	96	PF00069	0.565
MOD_PKA_2	163	169	PF00069	0.615
MOD_PKA_2	21	27	PF00069	0.560
MOD_PKA_2	250	256	PF00069	0.510
MOD_PKA_2	359	365	PF00069	0.580
MOD_PKA_2	410	416	PF00069	0.474
MOD_PKA_2	47	53	PF00069	0.628
MOD_PKB_1	104	112	PF00069	0.553
MOD_PKB_1	352	360	PF00069	0.535
MOD_PKB_1	45	53	PF00069	0.674
MOD_PKB_1	88	96	PF00069	0.558
MOD_Plk_1	176	182	PF00069	0.452
MOD_Plk_1	32	38	PF00069	0.541
MOD_Plk_1	369	375	PF00069	0.582
MOD_Plk_1	473	479	PF00069	0.418
MOD_Plk_4	256	262	PF00069	0.578
MOD_Plk_4	360	366	PF00069	0.496
MOD_Plk_4	393	399	PF00069	0.441
MOD_Plk_4	464	470	PF00069	0.423
MOD_Plk_4	478	484	PF00069	0.330
MOD_Plk_4	96	102	PF00069	0.678
MOD_ProDKin_1	154	160	PF00069	0.788
MOD_ProDKin_1	198	204	PF00069	0.577
MOD_ProDKin_1	332	338	PF00069	0.541
MOD_ProDKin_1	7	13	PF00069	0.534
MOD_SUMO_rev_2	182	188	PF00179	0.525
MOD_SUMO_rev_2	481	489	PF00179	0.449
TRG_DiLeu_BaLyEn_6	211	216	PF01217	0.517
TRG_ENDOCYTIC_2	210	213	PF00928	0.524
TRG_ENDOCYTIC_2	304	307	PF00928	0.444
TRG_ENDOCYTIC_2	469	472	PF00928	0.411
TRG_ER_diArg_1	162	165	PF00400	0.623
TRG_ER_diArg_1	19	22	PF00400	0.560
TRG_ER_diArg_1	247	249	PF00400	0.588
TRG_ER_diArg_1	289	291	PF00400	0.498
TRG_ER_diArg_1	293	296	PF00400	0.440
TRG_ER_diArg_1	307	309	PF00400	0.282
TRG_ER_diArg_1	352	355	PF00400	0.544
TRG_ER_diArg_1	410	412	PF00400	0.470
TRG_ER_diArg_1	427	430	PF00400	0.414
TRG_ER_diArg_1	45	48	PF00400	0.652
TRG_ER_diArg_1	450	453	PF00400	0.556
TRG_ER_diArg_1	493	496	PF00400	0.492
TRG_NLS_Bipartite_1	290	309	PF00514	0.441
TRG_NLS_MonoExtC_3	304	309	PF00514	0.451
TRG_NLS_MonoExtN_4	219	226	PF00514	0.378
TRG_Pf-PMV_PEXEL_1	170	175	PF00026	0.627

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IJS5	Leishmania donovani	90%	100%
A4HNP3	Leishmania braziliensis	61%	100%
A4ICV2	Leishmania infantum	90%	100%
E9ASF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%