ER membrane protein complex subunit 3

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Integral membrane protein DUF106, putative

Species:

Leishmania major

UniProt:

Q4Q242_LEIMA

TriTrypDb:

LmjF.36.0360 , LMJLV39_360008900 , LMJSD75_360008700

Length:

259

Annotations

LeishMANIAdb annotations

A very conserved component of the ER translocon. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	2
GO:0072546	EMC complex	3	2
GO:0098796	membrane protein complex	2	2
GO:0140534	endoplasmic reticulum protein-containing complex	2	2
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4Q242

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q242

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	249	251	PF00082	0.631
CLV_PCSK_KEX2_1	257	259	PF00082	0.722
CLV_PCSK_PC1ET2_1	249	251	PF00082	0.631
CLV_PCSK_PC1ET2_1	257	259	PF00082	0.722
CLV_PCSK_SKI1_1	214	218	PF00082	0.514
CLV_PCSK_SKI1_1	249	253	PF00082	0.602
CLV_PCSK_SKI1_1	60	64	PF00082	0.457
DOC_CYCLIN_RxL_1	57	65	PF00134	0.272
DOC_MAPK_DCC_7	14	24	PF00069	0.357
DOC_MAPK_FxFP_2	138	141	PF00069	0.552
DOC_MAPK_MEF2A_6	14	23	PF00069	0.382
DOC_MAPK_MEF2A_6	32	39	PF00069	0.241
DOC_PP2B_PxIxI_1	19	25	PF00149	0.335
DOC_PP4_FxxP_1	138	141	PF00568	0.552
DOC_USP7_MATH_1	203	207	PF00917	0.517
DOC_WW_Pin1_4	38	43	PF00397	0.246
DOC_WW_Pin1_4	67	72	PF00397	0.272
LIG_14-3-3_CanoR_1	60	69	PF00244	0.260
LIG_BRCT_BRCA1_1	126	130	PF00533	0.300
LIG_BRCT_BRCA1_1	142	146	PF00533	0.447
LIG_BRCT_BRCA1_1	167	171	PF00533	0.300
LIG_EH1_1	32	40	PF00400	0.408
LIG_LIR_Gen_1	15	24	PF02991	0.300
LIG_LIR_Gen_1	211	219	PF02991	0.353
LIG_LIR_Nem_3	127	133	PF02991	0.290
LIG_LIR_Nem_3	15	19	PF02991	0.300
LIG_LIR_Nem_3	168	173	PF02991	0.300
LIG_LIR_Nem_3	211	215	PF02991	0.321
LIG_MLH1_MIPbox_1	126	130	PF16413	0.300
LIG_MLH1_MIPbox_1	167	171	PF16413	0.300
LIG_NRBOX	179	185	PF00104	0.303
LIG_NRP_CendR_1	257	259	PF00754	0.746
LIG_PCNA_PIPBox_1	122	131	PF02747	0.300
LIG_Pex14_2	129	133	PF04695	0.300
LIG_Pex14_2	212	216	PF04695	0.377
LIG_PTB_Apo_2	157	164	PF02174	0.533
LIG_PTB_Phospho_1	157	163	PF10480	0.533
LIG_SH2_CRK	58	62	PF00017	0.259
LIG_SH2_GRB2like	234	237	PF00017	0.351
LIG_SH2_NCK_1	234	238	PF00017	0.362
LIG_SH2_PTP2	34	37	PF00017	0.408
LIG_SH2_SRC	234	237	PF00017	0.375
LIG_SH2_STAT5	128	131	PF00017	0.300
LIG_SH2_STAT5	163	166	PF00017	0.291
LIG_SH2_STAT5	170	173	PF00017	0.280
LIG_SH2_STAT5	34	37	PF00017	0.408
LIG_SH3_3	14	20	PF00018	0.300
LIG_SH3_3	39	45	PF00018	0.325
LIG_SH3_3	89	95	PF00018	0.336
LIG_SUMO_SIM_anti_2	155	160	PF11976	0.533
LIG_UBA3_1	105	110	PF00899	0.274
LIG_UBA3_1	81	88	PF00899	0.352
MOD_CDC14_SPxK_1	41	44	PF00782	0.325
MOD_CDK_SPxK_1	38	44	PF00069	0.325
MOD_GlcNHglycan	130	133	PF01048	0.295
MOD_GlcNHglycan	174	177	PF01048	0.420
MOD_GlcNHglycan	194	197	PF01048	0.666
MOD_GlcNHglycan	205	208	PF01048	0.631
MOD_GlcNHglycan	64	67	PF01048	0.515
MOD_GSK3_1	124	131	PF00069	0.309
MOD_GSK3_1	188	195	PF00069	0.457
MOD_N-GLC_1	192	197	PF02516	0.637
MOD_NEK2_1	124	129	PF00069	0.332
MOD_NEK2_1	172	177	PF00069	0.307
MOD_NEK2_1	62	67	PF00069	0.320
MOD_PIKK_1	244	250	PF00454	0.452
MOD_Plk_1	192	198	PF00069	0.440
MOD_Plk_4	124	130	PF00069	0.320
MOD_Plk_4	165	171	PF00069	0.290
MOD_Plk_4	33	39	PF00069	0.336
MOD_ProDKin_1	38	44	PF00069	0.246
MOD_ProDKin_1	67	73	PF00069	0.272
MOD_SUMO_for_1	86	89	PF00179	0.348
TRG_DiLeu_BaEn_1	4	9	PF01217	0.533
TRG_DiLeu_BaLyEn_6	17	22	PF01217	0.300
TRG_ENDOCYTIC_2	170	173	PF00928	0.300
TRG_ENDOCYTIC_2	34	37	PF00928	0.300
TRG_ENDOCYTIC_2	58	61	PF00928	0.259
TRG_NLS_MonoExtN_4	246	253	PF00514	0.441
TRG_Pf-PMV_PEXEL_1	152	157	PF00026	0.325

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P702	Leptomonas seymouri	78%	100%
A0A0S4JI82	Bodo saltans	52%	100%
A0A1X0P9P9	Trypanosomatidae	62%	100%
A0A3S7XAB1	Leishmania donovani	99%	100%
A0A422P2C0	Trypanosoma rangeli	59%	100%
A4HNP4	Leishmania braziliensis	88%	100%
A4ICV1	Leishmania infantum	99%	100%
A7A082	Saccharomyces cerevisiae (strain YJM789)	30%	100%
B3LQQ2	Saccharomyces cerevisiae (strain RM11-1a)	28%	100%
B5VLV9	Saccharomyces cerevisiae (strain AWRI1631)	28%	100%
D0A2K0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9ASF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
P36039	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
Q3ZCB8	Bos taurus	33%	99%
Q54YN3	Dictyostelium discoideum	30%	82%
Q5R7C1	Pongo abelii	34%	99%
Q5U2V8	Rattus norvegicus	33%	99%
Q7SXW4	Danio rerio	35%	99%
Q99KI3	Mus musculus	33%	99%
Q9P0I2	Homo sapiens	34%	99%
Q9P787	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	100%
V5DRR4	Trypanosoma cruzi	61%	100%