Phosphatidylinositol-4-phosphate 5-kinase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatidylinositol-4-phosphate 5-kinase-like protein

Species:

Leishmania major

UniProt:

Q4Q241_LEIMA

TriTrypDb:

LmjF.36.0370 , LMJLV39_360009000 , LMJSD75_360008800

Length:

455

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	2
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q241

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q241

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	2
GO:0006644	phospholipid metabolic process	4	2
GO:0006650	glycerophospholipid metabolic process	5	2
GO:0006661	phosphatidylinositol biosynthetic process	6	2
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0008152	metabolic process	1	12
GO:0008610	lipid biosynthetic process	4	2
GO:0008654	phospholipid biosynthetic process	5	2
GO:0009058	biosynthetic process	2	2
GO:0009987	cellular process	1	12
GO:0016310	phosphorylation	5	12
GO:0019637	organophosphate metabolic process	3	2
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044255	cellular lipid metabolic process	3	2
GO:0045017	glycerolipid biosynthetic process	4	2
GO:0046474	glycerophospholipid biosynthetic process	5	2
GO:0046486	glycerolipid metabolic process	4	2
GO:0046488	phosphatidylinositol metabolic process	6	2
GO:0046854	phosphatidylinositol phosphate biosynthetic process	7	2
GO:0071704	organic substance metabolic process	2	2
GO:0090407	organophosphate biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016301	kinase activity	4	12
GO:0016307	phosphatidylinositol phosphate kinase activity	5	12
GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity	6	2
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	292	294	PF00675	0.373
CLV_PCSK_KEX2_1	241	243	PF00082	0.372
CLV_PCSK_KEX2_1	294	296	PF00082	0.395
CLV_PCSK_PC1ET2_1	241	243	PF00082	0.239
CLV_PCSK_PC1ET2_1	294	296	PF00082	0.399
CLV_PCSK_PC7_1	290	296	PF00082	0.291
CLV_PCSK_SKI1_1	12	16	PF00082	0.414
CLV_PCSK_SKI1_1	135	139	PF00082	0.381
CLV_PCSK_SKI1_1	242	246	PF00082	0.226
CLV_PCSK_SKI1_1	280	284	PF00082	0.257
CLV_PCSK_SKI1_1	372	376	PF00082	0.202
CLV_PCSK_SKI1_1	416	420	PF00082	0.262
CLV_PCSK_SKI1_1	56	60	PF00082	0.530
CLV_PCSK_SKI1_1	97	101	PF00082	0.288
CLV_Separin_Metazoa	299	303	PF03568	0.265
DEG_APCC_DBOX_1	371	379	PF00400	0.187
DEG_SPOP_SBC_1	342	346	PF00917	0.280
DEG_SPOP_SBC_1	350	354	PF00917	0.234
DEG_SPOP_SBC_1	37	41	PF00917	0.455
DOC_MAPK_gen_1	77	85	PF00069	0.550
DOC_MAPK_HePTP_8	170	182	PF00069	0.292
DOC_MAPK_MEF2A_6	173	182	PF00069	0.257
DOC_MAPK_MEF2A_6	77	85	PF00069	0.569
DOC_MAPK_NFAT4_5	173	181	PF00069	0.262
DOC_PP1_RVXF_1	282	288	PF00149	0.237
DOC_PP1_RVXF_1	414	421	PF00149	0.291
DOC_PP2B_LxvP_1	69	72	PF13499	0.439
DOC_PP4_FxxP_1	286	289	PF00568	0.399
DOC_USP7_MATH_1	165	169	PF00917	0.382
DOC_USP7_MATH_1	351	355	PF00917	0.326
DOC_USP7_MATH_1	36	40	PF00917	0.507
DOC_USP7_MATH_1	363	367	PF00917	0.160
DOC_USP7_MATH_1	43	47	PF00917	0.469
DOC_USP7_MATH_1	52	56	PF00917	0.439
DOC_USP7_UBL2_3	205	209	PF12436	0.273
DOC_USP7_UBL2_3	237	241	PF12436	0.213
LIG_14-3-3_CanoR_1	12	19	PF00244	0.573
LIG_14-3-3_CanoR_1	157	162	PF00244	0.333
LIG_14-3-3_CanoR_1	24	31	PF00244	0.454
LIG_14-3-3_CanoR_1	358	363	PF00244	0.425
LIG_14-3-3_CanoR_1	372	381	PF00244	0.269
LIG_14-3-3_CanoR_1	436	441	PF00244	0.398
LIG_14-3-3_CanoR_1	68	72	PF00244	0.411
LIG_14-3-3_CanoR_1	84	92	PF00244	0.499
LIG_Actin_WH2_1	293	310	PF00022	0.291
LIG_Actin_WH2_2	10	26	PF00022	0.422
LIG_Actin_WH2_2	294	310	PF00022	0.291
LIG_AP2alpha_1	192	196	PF02296	0.247
LIG_BIR_III_4	270	274	PF00653	0.388
LIG_BRCT_BRCA1_1	410	414	PF00533	0.213
LIG_BRCT_BRCA1_2	410	416	PF00533	0.213
LIG_CSL_BTD_1	286	289	PF09270	0.335
LIG_DLG_GKlike_1	436	443	PF00625	0.399
LIG_FHA_1	134	140	PF00498	0.271
LIG_FHA_1	141	147	PF00498	0.406
LIG_FHA_1	158	164	PF00498	0.190
LIG_FHA_1	196	202	PF00498	0.187
LIG_FHA_1	402	408	PF00498	0.425
LIG_FHA_1	439	445	PF00498	0.273
LIG_FHA_2	274	280	PF00498	0.257
LIG_FHA_2	351	357	PF00498	0.291
LIG_FHA_2	375	381	PF00498	0.399
LIG_LIR_Apic_2	109	114	PF02991	0.369
LIG_LIR_Apic_2	283	289	PF02991	0.399
LIG_LIR_Gen_1	303	312	PF02991	0.276
LIG_LIR_Gen_1	314	323	PF02991	0.232
LIG_LIR_Gen_1	439	448	PF02991	0.391
LIG_LIR_Gen_1	91	99	PF02991	0.424
LIG_LIR_Nem_3	303	307	PF02991	0.275
LIG_LIR_Nem_3	314	318	PF02991	0.246
LIG_LIR_Nem_3	392	398	PF02991	0.239
LIG_LIR_Nem_3	439	443	PF02991	0.317
LIG_LIR_Nem_3	91	96	PF02991	0.267
LIG_LYPXL_yS_3	221	224	PF13949	0.265
LIG_Pex14_2	107	111	PF04695	0.341
LIG_Pex14_2	192	196	PF04695	0.260
LIG_REV1ctd_RIR_1	412	420	PF16727	0.317
LIG_SH2_CRK	175	179	PF00017	0.399
LIG_SH2_CRK	304	308	PF00017	0.297
LIG_SH2_CRK	315	319	PF00017	0.212
LIG_SH2_PTP2	395	398	PF00017	0.257
LIG_SH2_STAP1	159	163	PF00017	0.236
LIG_SH2_STAP1	315	319	PF00017	0.265
LIG_SH2_STAP1	433	437	PF00017	0.319
LIG_SH2_STAT5	159	162	PF00017	0.288
LIG_SH2_STAT5	188	191	PF00017	0.285
LIG_SH2_STAT5	395	398	PF00017	0.257
LIG_SH2_STAT5	405	408	PF00017	0.257
LIG_SH3_3	99	105	PF00018	0.356
LIG_SH3_4	237	244	PF00018	0.187
LIG_SUMO_SIM_par_1	142	148	PF11976	0.317
LIG_SUMO_SIM_par_1	397	404	PF11976	0.399
LIG_TRAF2_1	145	148	PF00917	0.351
LIG_TYR_ITIM	219	224	PF00017	0.265
LIG_UBA3_1	137	142	PF00899	0.373
LIG_WRC_WIRS_1	385	390	PF05994	0.291
LIG_WRC_WIRS_1	437	442	PF05994	0.399
LIG_WRC_WIRS_1	92	97	PF05994	0.434
MOD_CK1_1	181	187	PF00069	0.416
MOD_CK1_1	366	372	PF00069	0.192
MOD_CK2_1	109	115	PF00069	0.439
MOD_CK2_1	142	148	PF00069	0.299
MOD_CK2_1	224	230	PF00069	0.404
MOD_CK2_1	350	356	PF00069	0.421
MOD_CK2_1	374	380	PF00069	0.431
MOD_CK2_1	436	442	PF00069	0.363
MOD_CK2_1	47	53	PF00069	0.584
MOD_GlcNHglycan	226	229	PF01048	0.291
MOD_GlcNHglycan	260	263	PF01048	0.418
MOD_GlcNHglycan	345	348	PF01048	0.384
MOD_GlcNHglycan	353	356	PF01048	0.247
MOD_GlcNHglycan	368	371	PF01048	0.250
MOD_GlcNHglycan	410	413	PF01048	0.213
MOD_GlcNHglycan	45	48	PF01048	0.505
MOD_GlcNHglycan	61	66	PF01048	0.415
MOD_GlcNHglycan	9	12	PF01048	0.434
MOD_GSK3_1	157	164	PF00069	0.281
MOD_GSK3_1	336	343	PF00069	0.318
MOD_GSK3_1	366	373	PF00069	0.414
MOD_GSK3_1	43	50	PF00069	0.562
MOD_GSK3_1	67	74	PF00069	0.531
MOD_LATS_1	278	284	PF00433	0.399
MOD_N-GLC_1	340	345	PF02516	0.363
MOD_NEK2_1	131	136	PF00069	0.257
MOD_NEK2_1	140	145	PF00069	0.257
MOD_NEK2_1	161	166	PF00069	0.383
MOD_NEK2_1	178	183	PF00069	0.314
MOD_NEK2_1	224	229	PF00069	0.291
MOD_NEK2_1	23	28	PF00069	0.369
MOD_NEK2_1	313	318	PF00069	0.269
MOD_NEK2_1	374	379	PF00069	0.187
MOD_NEK2_1	414	419	PF00069	0.299
MOD_NMyristoyl	1	7	PF02799	0.557
MOD_PIKK_1	124	130	PF00454	0.399
MOD_PIKK_1	250	256	PF00454	0.370
MOD_PIKK_1	38	44	PF00454	0.566
MOD_PK_1	142	148	PF00069	0.317
MOD_PKA_1	408	414	PF00069	0.242
MOD_PKA_2	23	29	PF00069	0.493
MOD_PKA_2	258	264	PF00069	0.452
MOD_PKA_2	265	271	PF00069	0.215
MOD_PKA_2	328	334	PF00069	0.295
MOD_PKA_2	67	73	PF00069	0.468
MOD_PKA_2	83	89	PF00069	0.300
MOD_Plk_1	109	115	PF00069	0.421
MOD_Plk_1	280	286	PF00069	0.263
MOD_Plk_1	313	319	PF00069	0.257
MOD_Plk_1	61	67	PF00069	0.437
MOD_Plk_2-3	109	115	PF00069	0.432
MOD_Plk_4	133	139	PF00069	0.370
MOD_Plk_4	166	172	PF00069	0.257
MOD_Plk_4	197	203	PF00069	0.391
MOD_Plk_4	313	319	PF00069	0.257
MOD_Plk_4	414	420	PF00069	0.273
MOD_SUMO_for_1	118	121	PF00179	0.329
MOD_SUMO_for_1	448	451	PF00179	0.453
MOD_SUMO_for_1	58	61	PF00179	0.419
TRG_DiLeu_BaEn_1	148	153	PF01217	0.257
TRG_DiLeu_BaEn_4	185	191	PF01217	0.265
TRG_ENDOCYTIC_2	175	178	PF00928	0.351
TRG_ENDOCYTIC_2	221	224	PF00928	0.249
TRG_ENDOCYTIC_2	304	307	PF00928	0.282
TRG_ENDOCYTIC_2	315	318	PF00928	0.230
TRG_ENDOCYTIC_2	395	398	PF00928	0.257
TRG_ER_diArg_1	293	296	PF00400	0.399
TRG_NLS_MonoExtC_3	292	298	PF00514	0.393
TRG_NLS_MonoExtN_4	290	297	PF00514	0.341
TRG_Pf-PMV_PEXEL_1	294	298	PF00026	0.361

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCT9	Leptomonas seymouri	23%	83%
A0A0N1PE70	Leptomonas seymouri	56%	100%
A0A0S4JRR3	Bodo saltans	40%	98%
A0A1X0P9B0	Trypanosomatidae	49%	100%
A0A1X0PB79	Trypanosomatidae	23%	95%
A0A3R7KQW9	Trypanosoma rangeli	45%	100%
A0A3S7XA92	Leishmania donovani	91%	100%
A0A422N247	Trypanosoma rangeli	23%	95%
A4HNP5	Leishmania braziliensis	66%	100%
A4ICV0	Leishmania infantum	91%	100%
C9ZM20	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	95%
D0A2K2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
D3ZSI8	Rattus norvegicus	24%	83%
E9ASF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
O13010	Sus scrofa	23%	100%
O14986	Homo sapiens	23%	84%
O60331	Homo sapiens	25%	68%
O70172	Mus musculus	23%	100%
O88370	Rattus norvegicus	24%	100%
O88377	Rattus norvegicus	24%	100%
P48426	Homo sapiens	23%	100%
P70182	Mus musculus	24%	83%
P78356	Homo sapiens	23%	100%
Q0P5F7	Bos taurus	26%	100%
Q17QS4	Bos taurus	25%	100%
Q5F356	Gallus gallus	23%	100%
Q5PQ01	Xenopus laevis	26%	100%
Q5R488	Pongo abelii	25%	100%
Q6GL14	Xenopus tropicalis	26%	100%
Q6IQE1	Danio rerio	25%	100%
Q80XI4	Mus musculus	23%	100%
Q8TBX8	Homo sapiens	25%	100%
Q91XU3	Mus musculus	24%	100%
Q99755	Homo sapiens	25%	81%
Q9M149	Arabidopsis thaliana	23%	100%
Q9R0I8	Rattus norvegicus	23%	100%
V5BA13	Trypanosoma cruzi	47%	100%
V5BV28	Trypanosoma cruzi	24%	96%