MYND-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q239_LEIMA

TriTrypDb:

LmjF.36.0390 , LMJLV39_360009200 , LMJSD75_360009000

Length:

663

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4Q239

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q239

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	29	33	PF00656	0.680
CLV_C14_Caspase3-7	39	43	PF00656	0.698
CLV_C14_Caspase3-7	50	54	PF00656	0.673
CLV_C14_Caspase3-7	546	550	PF00656	0.634
CLV_C14_Caspase3-7	55	59	PF00656	0.736
CLV_NRD_NRD_1	16	18	PF00675	0.820
CLV_NRD_NRD_1	266	268	PF00675	0.424
CLV_NRD_NRD_1	457	459	PF00675	0.368
CLV_NRD_NRD_1	502	504	PF00675	0.566
CLV_NRD_NRD_1	555	557	PF00675	0.704
CLV_PCSK_KEX2_1	128	130	PF00082	0.474
CLV_PCSK_KEX2_1	15	17	PF00082	0.747
CLV_PCSK_KEX2_1	157	159	PF00082	0.513
CLV_PCSK_KEX2_1	266	268	PF00082	0.424
CLV_PCSK_KEX2_1	4	6	PF00082	0.755
CLV_PCSK_KEX2_1	457	459	PF00082	0.351
CLV_PCSK_KEX2_1	502	504	PF00082	0.521
CLV_PCSK_KEX2_1	520	522	PF00082	0.503
CLV_PCSK_KEX2_1	553	555	PF00082	0.600
CLV_PCSK_KEX2_1	614	616	PF00082	0.543
CLV_PCSK_PC1ET2_1	128	130	PF00082	0.546
CLV_PCSK_PC1ET2_1	157	159	PF00082	0.569
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.684
CLV_PCSK_PC1ET2_1	520	522	PF00082	0.599
CLV_PCSK_PC1ET2_1	553	555	PF00082	0.597
CLV_PCSK_PC1ET2_1	614	616	PF00082	0.573
CLV_PCSK_PC7_1	153	159	PF00082	0.428
CLV_PCSK_SKI1_1	118	122	PF00082	0.540
CLV_PCSK_SKI1_1	266	270	PF00082	0.447
CLV_PCSK_SKI1_1	385	389	PF00082	0.586
CLV_PCSK_SKI1_1	534	538	PF00082	0.431
DEG_APCC_DBOX_1	625	633	PF00400	0.587
DEG_SPOP_SBC_1	437	441	PF00917	0.491
DOC_CDC14_PxL_1	104	112	PF14671	0.584
DOC_CDC14_PxL_1	410	418	PF14671	0.555
DOC_CYCLIN_RxL_1	115	126	PF00134	0.522
DOC_MAPK_DCC_7	576	584	PF00069	0.670
DOC_MAPK_gen_1	502	510	PF00069	0.518
DOC_MAPK_gen_1	553	561	PF00069	0.687
DOC_MAPK_gen_1	99	107	PF00069	0.644
DOC_MAPK_MEF2A_6	176	185	PF00069	0.381
DOC_MAPK_MEF2A_6	345	352	PF00069	0.800
DOC_MAPK_MEF2A_6	576	584	PF00069	0.670
DOC_MAPK_MEF2A_6	589	596	PF00069	0.657
DOC_MAPK_MEF2A_6	638	646	PF00069	0.506
DOC_PP1_RVXF_1	116	122	PF00149	0.527
DOC_PP1_RVXF_1	383	390	PF00149	0.496
DOC_PP1_RVXF_1	503	510	PF00149	0.533
DOC_PP2B_LxvP_1	594	597	PF13499	0.566
DOC_PP4_FxxP_1	537	540	PF00568	0.573
DOC_PP4_FxxP_1	97	100	PF00568	0.498
DOC_USP7_MATH_1	20	24	PF00917	0.666
DOC_USP7_MATH_1	303	307	PF00917	0.705
DOC_USP7_MATH_1	36	40	PF00917	0.738
DOC_USP7_MATH_1	360	364	PF00917	0.700
DOC_USP7_MATH_1	371	375	PF00917	0.756
DOC_USP7_MATH_1	437	441	PF00917	0.509
DOC_USP7_MATH_1	486	490	PF00917	0.462
DOC_USP7_UBL2_3	349	353	PF12436	0.649
DOC_WW_Pin1_4	287	292	PF00397	0.718
DOC_WW_Pin1_4	62	67	PF00397	0.797
DOC_WW_Pin1_4	657	662	PF00397	0.645
LIG_14-3-3_CanoR_1	134	139	PF00244	0.521
LIG_14-3-3_CanoR_1	172	176	PF00244	0.479
LIG_14-3-3_CanoR_1	554	561	PF00244	0.585
LIG_14-3-3_CanoR_1	61	66	PF00244	0.784
LIG_14-3-3_CanoR_1	76	83	PF00244	0.803
LIG_BIR_II_1	1	5	PF00653	0.767
LIG_BRCT_BRCA1_1	401	405	PF00533	0.578
LIG_CaM_IQ_9	618	633	PF13499	0.448
LIG_Clathr_ClatBox_1	528	532	PF01394	0.491
LIG_CtBP_PxDLS_1	591	595	PF00389	0.650
LIG_eIF4E_1	650	656	PF01652	0.489
LIG_FHA_1	253	259	PF00498	0.634
LIG_FHA_1	502	508	PF00498	0.547
LIG_FHA_1	510	516	PF00498	0.471
LIG_FHA_1	543	549	PF00498	0.474
LIG_FHA_1	78	84	PF00498	0.724
LIG_FHA_2	29	35	PF00498	0.774
LIG_FHA_2	443	449	PF00498	0.503
LIG_FHA_2	544	550	PF00498	0.732
LIG_FHA_2	599	605	PF00498	0.666
LIG_FHA_2	622	628	PF00498	0.493
LIG_FHA_2	7	13	PF00498	0.675
LIG_Integrin_isoDGR_2	166	168	PF01839	0.381
LIG_LIR_Apic_2	94	100	PF02991	0.523
LIG_LIR_Gen_1	445	454	PF02991	0.505
LIG_LIR_Gen_1	651	661	PF02991	0.485
LIG_LIR_Nem_3	101	107	PF02991	0.480
LIG_LIR_Nem_3	137	143	PF02991	0.398
LIG_LIR_Nem_3	445	450	PF02991	0.514
LIG_LIR_Nem_3	455	459	PF02991	0.489
LIG_LIR_Nem_3	651	656	PF02991	0.493
LIG_MYND_2	216	220	PF01753	0.287
LIG_NRBOX	449	455	PF00104	0.501
LIG_PCNA_yPIPBox_3	571	581	PF02747	0.640
LIG_Pex14_1	649	653	PF04695	0.482
LIG_Pex14_2	459	463	PF04695	0.433
LIG_Rb_pABgroove_1	190	198	PF01858	0.381
LIG_RPA_C_Fungi	453	465	PF08784	0.490
LIG_SH2_CRK	196	200	PF00017	0.428
LIG_SH2_CRK	653	657	PF00017	0.551
LIG_SH2_PTP2	104	107	PF00017	0.638
LIG_SH2_STAP1	617	621	PF00017	0.573
LIG_SH2_STAT3	156	159	PF00017	0.431
LIG_SH2_STAT5	104	107	PF00017	0.593
LIG_SH2_STAT5	140	143	PF00017	0.357
LIG_SH2_STAT5	273	276	PF00017	0.403
LIG_SH2_STAT5	535	538	PF00017	0.420
LIG_SH3_1	511	517	PF00018	0.519
LIG_SH3_2	106	111	PF14604	0.578
LIG_SH3_2	344	349	PF14604	0.722
LIG_SH3_3	103	109	PF00018	0.597
LIG_SH3_3	200	206	PF00018	0.499
LIG_SH3_3	255	261	PF00018	0.497
LIG_SH3_3	288	294	PF00018	0.578
LIG_SH3_3	333	339	PF00018	0.627
LIG_SH3_3	341	347	PF00018	0.600
LIG_SH3_3	511	517	PF00018	0.475
LIG_SH3_3	545	551	PF00018	0.693
LIG_SH3_3	585	591	PF00018	0.551
LIG_SH3_3	634	640	PF00018	0.564
LIG_SH3_3	641	647	PF00018	0.505
LIG_SH3_3	655	661	PF00018	0.514
LIG_SUMO_SIM_par_1	217	223	PF11976	0.512
LIG_SUMO_SIM_par_1	526	532	PF11976	0.474
LIG_TRAF2_1	11	14	PF00917	0.671
LIG_TYR_ITIM	138	143	PF00017	0.416
LIG_TYR_ITIM	194	199	PF00017	0.414
LIG_UBA3_1	120	128	PF00899	0.518
LIG_WRC_WIRS_1	453	458	PF05994	0.486
MOD_CDK_SPxK_1	62	68	PF00069	0.562
MOD_CK1_1	19	25	PF00069	0.651
MOD_CK1_1	231	237	PF00069	0.501
MOD_CK1_1	26	32	PF00069	0.624
MOD_CK1_1	3	9	PF00069	0.689
MOD_CK1_1	363	369	PF00069	0.506
MOD_CK1_1	38	44	PF00069	0.516
MOD_CK1_1	45	51	PF00069	0.480
MOD_CK1_1	54	60	PF00069	0.659
MOD_CK2_1	442	448	PF00069	0.495
MOD_CK2_1	49	55	PF00069	0.708
MOD_CK2_1	554	560	PF00069	0.566
MOD_CK2_1	598	604	PF00069	0.558
MOD_CK2_1	621	627	PF00069	0.574
MOD_DYRK1A_RPxSP_1	657	661	PF00069	0.432
MOD_GlcNHglycan	177	180	PF01048	0.481
MOD_GlcNHglycan	18	21	PF01048	0.724
MOD_GlcNHglycan	22	25	PF01048	0.718
MOD_GlcNHglycan	275	278	PF01048	0.506
MOD_GlcNHglycan	331	334	PF01048	0.576
MOD_GlcNHglycan	440	443	PF01048	0.434
MOD_GlcNHglycan	45	48	PF01048	0.630
MOD_GlcNHglycan	585	588	PF01048	0.648
MOD_GlcNHglycan	633	636	PF01048	0.610
MOD_GlcNHglycan	69	72	PF01048	0.588
MOD_GSK3_1	15	22	PF00069	0.638
MOD_GSK3_1	171	178	PF00069	0.556
MOD_GSK3_1	225	232	PF00069	0.489
MOD_GSK3_1	23	30	PF00069	0.606
MOD_GSK3_1	269	276	PF00069	0.388
MOD_GSK3_1	34	41	PF00069	0.509
MOD_GSK3_1	43	50	PF00069	0.596
MOD_GSK3_1	438	445	PF00069	0.512
MOD_GSK3_1	56	63	PF00069	0.716
MOD_NEK2_1	195	200	PF00069	0.509
MOD_NEK2_1	229	234	PF00069	0.512
MOD_NEK2_1	372	377	PF00069	0.729
MOD_NEK2_1	388	393	PF00069	0.577
MOD_NEK2_1	436	441	PF00069	0.435
MOD_NEK2_1	621	626	PF00069	0.600
MOD_NEK2_2	373	378	PF00069	0.700
MOD_NEK2_2	442	447	PF00069	0.522
MOD_NEK2_2	452	457	PF00069	0.449
MOD_PIKK_1	229	235	PF00454	0.555
MOD_PIKK_1	488	494	PF00454	0.426
MOD_PIKK_1	77	83	PF00454	0.729
MOD_PK_1	259	265	PF00069	0.507
MOD_PKA_1	15	21	PF00069	0.679
MOD_PKA_1	554	560	PF00069	0.495
MOD_PKA_2	15	21	PF00069	0.756
MOD_PKA_2	171	177	PF00069	0.481
MOD_PKA_2	303	309	PF00069	0.743
MOD_PKA_2	501	507	PF00069	0.581
MOD_PKA_2	554	560	PF00069	0.582
MOD_PKA_2	60	66	PF00069	0.749
MOD_PKA_2	67	73	PF00069	0.790
MOD_PKA_2	75	81	PF00069	0.777
MOD_Plk_1	543	549	PF00069	0.735
MOD_Plk_1	604	610	PF00069	0.635
MOD_Plk_4	225	231	PF00069	0.465
MOD_Plk_4	269	275	PF00069	0.386
MOD_Plk_4	388	394	PF00069	0.538
MOD_Plk_4	442	448	PF00069	0.477
MOD_ProDKin_1	287	293	PF00069	0.721
MOD_ProDKin_1	62	68	PF00069	0.800
MOD_ProDKin_1	657	663	PF00069	0.651
MOD_SUMO_for_1	268	271	PF00179	0.436
MOD_SUMO_for_1	613	616	PF00179	0.405
TRG_DiLeu_BaEn_1	428	433	PF01217	0.495
TRG_DiLeu_BaLyEn_6	511	516	PF01217	0.519
TRG_ENDOCYTIC_2	104	107	PF00928	0.602
TRG_ENDOCYTIC_2	140	143	PF00928	0.374
TRG_ENDOCYTIC_2	196	199	PF00928	0.402
TRG_ENDOCYTIC_2	653	656	PF00928	0.482
TRG_ER_diArg_1	15	17	PF00400	0.815
TRG_ER_diArg_1	266	268	PF00400	0.468
TRG_ER_diArg_1	456	458	PF00400	0.376
TRG_ER_diArg_1	502	505	PF00400	0.570
TRG_ER_diArg_1	554	556	PF00400	0.677
TRG_NES_CRM1_1	112	126	PF08389	0.477
TRG_NES_CRM1_1	506	518	PF08389	0.422
TRG_NES_CRM1_1	563	575	PF08389	0.639
TRG_NLS_MonoCore_2	552	557	PF00514	0.706
TRG_NLS_MonoExtC_3	552	558	PF00514	0.644
TRG_NLS_MonoExtN_4	551	557	PF00514	0.641

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Z4	Leptomonas seymouri	67%	100%
A0A0S4JPG4	Bodo saltans	30%	100%
A0A1X0P8L9	Trypanosomatidae	40%	100%
A0A3S7XAH7	Leishmania donovani	96%	100%
A0A422P299	Trypanosoma rangeli	40%	100%
A4HNP7	Leishmania braziliensis	87%	99%
A4ICU8	Leishmania infantum	96%	100%
D0A2K5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	99%
E9ASF6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BZZ1	Trypanosoma cruzi	41%	100%