PDZ domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q238_LEIMA

TriTrypDb:

LmjF.36.0400 , LMJLV39_360009400 , LMJSD75_360009200

Length:

446

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q238

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q238

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	43	45	PF00675	0.704
CLV_NRD_NRD_1	7	9	PF00675	0.543
CLV_NRD_NRD_1	88	90	PF00675	0.605
CLV_PCSK_KEX2_1	7	9	PF00082	0.641
CLV_PCSK_KEX2_1	88	90	PF00082	0.605
CLV_PCSK_SKI1_1	310	314	PF00082	0.613
CLV_PCSK_SKI1_1	439	443	PF00082	0.509
CLV_Separin_Metazoa	175	179	PF03568	0.479
DEG_SPOP_SBC_1	63	67	PF00917	0.816
DOC_CKS1_1	408	413	PF01111	0.522
DOC_MAPK_DCC_7	326	335	PF00069	0.608
DOC_MAPK_MEF2A_6	326	335	PF00069	0.608
DOC_MIT_MIM_1	261	270	PF04212	0.568
DOC_SPAK_OSR1_1	8	12	PF12202	0.633
DOC_USP7_MATH_1	118	122	PF00917	0.541
DOC_USP7_MATH_1	187	191	PF00917	0.541
DOC_USP7_MATH_1	63	67	PF00917	0.708
DOC_WW_Pin1_4	280	285	PF00397	0.705
DOC_WW_Pin1_4	321	326	PF00397	0.788
DOC_WW_Pin1_4	346	351	PF00397	0.826
DOC_WW_Pin1_4	407	412	PF00397	0.525
LIG_14-3-3_CanoR_1	108	116	PF00244	0.546
LIG_14-3-3_CanoR_1	120	126	PF00244	0.536
LIG_14-3-3_CanoR_1	316	325	PF00244	0.746
LIG_14-3-3_CanoR_1	339	347	PF00244	0.728
LIG_14-3-3_CanoR_1	439	446	PF00244	0.591
LIG_14-3-3_CanoR_1	88	94	PF00244	0.608
LIG_Actin_WH2_2	233	250	PF00022	0.553
LIG_AP2alpha_2	432	434	PF02296	0.612
LIG_CtBP_PxDLS_1	303	307	PF00389	0.555
LIG_FHA_1	111	117	PF00498	0.636
LIG_FHA_1	124	130	PF00498	0.385
LIG_FHA_1	213	219	PF00498	0.625
LIG_FHA_1	281	287	PF00498	0.628
LIG_FHA_1	326	332	PF00498	0.684
LIG_FHA_2	122	128	PF00498	0.510
LIG_FHA_2	168	174	PF00498	0.525
LIG_FHA_2	254	260	PF00498	0.644
LIG_FHA_2	360	366	PF00498	0.580
LIG_FHA_2	427	433	PF00498	0.592
LIG_Integrin_isoDGR_2	435	437	PF01839	0.637
LIG_LIR_Gen_1	211	221	PF02991	0.471
LIG_LIR_Gen_1	232	242	PF02991	0.669
LIG_LIR_Nem_3	211	217	PF02991	0.473
LIG_LIR_Nem_3	232	237	PF02991	0.682
LIG_LIR_Nem_3	429	434	PF02991	0.599
LIG_PTB_Apo_2	3	10	PF02174	0.514
LIG_Rb_LxCxE_1	245	262	PF01857	0.619
LIG_RPA_C_Fungi	388	400	PF08784	0.567
LIG_SH2_STAP1	125	129	PF00017	0.532
LIG_SH2_STAP1	214	218	PF00017	0.627
LIG_SH2_STAT5	125	128	PF00017	0.509
LIG_SH2_STAT5	21	24	PF00017	0.499
LIG_SH2_STAT5	214	217	PF00017	0.630
LIG_SH3_1	344	350	PF00018	0.595
LIG_SH3_3	295	301	PF00018	0.708
LIG_SH3_3	344	350	PF00018	0.712
LIG_SH3_3	352	358	PF00018	0.683
LIG_SH3_3	405	411	PF00018	0.530
LIG_SH3_3	94	100	PF00018	0.609
LIG_SUMO_SIM_anti_2	172	180	PF11976	0.531
LIG_SUMO_SIM_anti_2	24	30	PF11976	0.522
LIG_SUMO_SIM_par_1	20	27	PF11976	0.522
LIG_SUMO_SIM_par_1	302	307	PF11976	0.551
LIG_TRAF2_1	170	173	PF00917	0.629
LIG_TRAF2_1	262	265	PF00917	0.661
LIG_TRAF2_1	413	416	PF00917	0.575
LIG_TYR_ITIM	92	97	PF00017	0.616
MOD_CDK_SPK_2	321	326	PF00069	0.803
MOD_CK1_1	110	116	PF00069	0.542
MOD_CK1_1	121	127	PF00069	0.536
MOD_CK1_1	200	206	PF00069	0.623
MOD_CK1_1	212	218	PF00069	0.294
MOD_CK1_1	272	278	PF00069	0.701
MOD_CK1_1	314	320	PF00069	0.709
MOD_CK2_1	121	127	PF00069	0.477
MOD_CK2_1	167	173	PF00069	0.527
MOD_CK2_1	255	261	PF00069	0.642
MOD_CK2_1	359	365	PF00069	0.703
MOD_DYRK1A_RPxSP_1	321	325	PF00069	0.733
MOD_DYRK1A_RPxSP_1	346	350	PF00069	0.590
MOD_GlcNHglycan	139	142	PF01048	0.530
MOD_GlcNHglycan	14	17	PF01048	0.538
MOD_GlcNHglycan	316	319	PF01048	0.695
MOD_GlcNHglycan	339	342	PF01048	0.819
MOD_GlcNHglycan	386	389	PF01048	0.553
MOD_GlcNHglycan	59	62	PF01048	0.731
MOD_GSK3_1	208	215	PF00069	0.627
MOD_GSK3_1	255	262	PF00069	0.612
MOD_GSK3_1	269	276	PF00069	0.601
MOD_GSK3_1	321	328	PF00069	0.808
MOD_GSK3_1	335	342	PF00069	0.583
MOD_GSK3_1	403	410	PF00069	0.626
MOD_GSK3_1	53	60	PF00069	0.741
MOD_GSK3_1	64	71	PF00069	0.648
MOD_N-GLC_1	314	319	PF02516	0.804
MOD_N-GLC_1	33	38	PF02516	0.534
MOD_NEK2_1	12	17	PF00069	0.531
MOD_NEK2_1	137	142	PF00069	0.468
MOD_NEK2_1	181	186	PF00069	0.519
MOD_NEK2_1	210	215	PF00069	0.521
MOD_NEK2_1	304	309	PF00069	0.691
MOD_NEK2_1	335	340	PF00069	0.803
MOD_OFUCOSY	13	18	PF10250	0.504
MOD_PIKK_1	148	154	PF00454	0.544
MOD_PIKK_1	200	206	PF00454	0.564
MOD_PIKK_1	304	310	PF00454	0.802
MOD_PIKK_1	319	325	PF00454	0.751
MOD_PIKK_1	87	93	PF00454	0.648
MOD_PKA_2	107	113	PF00069	0.521
MOD_PKA_2	345	351	PF00069	0.772
MOD_PKA_2	87	93	PF00069	0.631
MOD_PKB_1	437	445	PF00069	0.524
MOD_Plk_1	118	124	PF00069	0.536
MOD_Plk_2-3	259	265	PF00069	0.591
MOD_Plk_4	110	116	PF00069	0.542
MOD_Plk_4	162	168	PF00069	0.447
MOD_Plk_4	17	23	PF00069	0.508
MOD_Plk_4	24	30	PF00069	0.536
MOD_Plk_4	269	275	PF00069	0.604
MOD_ProDKin_1	280	286	PF00069	0.706
MOD_ProDKin_1	321	327	PF00069	0.791
MOD_ProDKin_1	346	352	PF00069	0.828
MOD_ProDKin_1	407	413	PF00069	0.523
MOD_SUMO_for_1	39	42	PF00179	0.587
MOD_SUMO_rev_2	127	132	PF00179	0.643
TRG_ENDOCYTIC_2	214	217	PF00928	0.630
TRG_ENDOCYTIC_2	234	237	PF00928	0.346
TRG_ENDOCYTIC_2	431	434	PF00928	0.612
TRG_ENDOCYTIC_2	94	97	PF00928	0.619
TRG_ER_diArg_1	437	440	PF00400	0.530
TRG_ER_diArg_1	7	9	PF00400	0.641
TRG_Pf-PMV_PEXEL_1	194	198	PF00026	0.519
TRG_Pf-PMV_PEXEL_1	361	365	PF00026	0.668
TRG_Pf-PMV_PEXEL_1	439	444	PF00026	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0I6	Leptomonas seymouri	57%	94%
A0A3S5H814	Leishmania donovani	91%	100%
A4HNP8	Leishmania braziliensis	78%	100%
A4ICU7	Leishmania infantum	91%	100%
E9ASF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%