Transcription initiation factor IIE subunit beta

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

transcription factor IIa, putative

Species:

Leishmania major

UniProt:

Q4Q235_LEIMA

TriTrypDb:

LmjF.36.0430 , LMJLV39_360009700 , LMJSD75_360009600

Length:

290

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0005667	transcription regulator complex	2	1
GO:0005672	transcription factor TFIIA complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0090575	RNA polymerase II transcription regulator complex	3	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

Q4Q235

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q235

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006352	DNA-templated transcription initiation	6	1
GO:0006367	transcription initiation at RNA polymerase II promoter	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0032774	RNA biosynthetic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	197	201	PF00656	0.487
CLV_MEL_PAP_1	43	49	PF00089	0.463
CLV_NRD_NRD_1	288	290	PF00675	0.628
CLV_PCSK_FUR_1	286	290	PF00082	0.695
CLV_PCSK_KEX2_1	288	290	PF00082	0.573
CLV_PCSK_SKI1_1	40	44	PF00082	0.470
DEG_APCC_DBOX_1	103	111	PF00400	0.481
DEG_APCC_DBOX_1	263	271	PF00400	0.585
DEG_SCF_FBW7_1	164	170	PF00400	0.631
DEG_SCF_FBW7_2	131	138	PF00400	0.584
DEG_SPOP_SBC_1	179	183	PF00917	0.632
DOC_CKS1_1	164	169	PF01111	0.549
DOC_CYCLIN_yCln2_LP_2	187	193	PF00134	0.715
DOC_MAPK_gen_1	71	81	PF00069	0.638
DOC_PP2B_LxvP_1	187	190	PF13499	0.717
DOC_PP4_FxxP_1	206	209	PF00568	0.532
DOC_PP4_FxxP_1	65	68	PF00568	0.668
DOC_USP7_MATH_1	157	161	PF00917	0.569
DOC_USP7_MATH_1	179	183	PF00917	0.632
DOC_USP7_MATH_1	19	23	PF00917	0.706
DOC_USP7_MATH_1	210	214	PF00917	0.505
DOC_WW_Pin1_4	131	136	PF00397	0.589
DOC_WW_Pin1_4	163	168	PF00397	0.474
DOC_WW_Pin1_4	215	220	PF00397	0.720
DOC_WW_Pin1_4	51	56	PF00397	0.510
DOC_WW_Pin1_4	66	71	PF00397	0.631
DOC_WW_Pin1_4	98	103	PF00397	0.674
LIG_14-3-3_CanoR_1	104	108	PF00244	0.416
LIG_14-3-3_CanoR_1	46	52	PF00244	0.462
LIG_14-3-3_CanoR_1	71	81	PF00244	0.556
LIG_BRCT_BRCA1_1	16	20	PF00533	0.471
LIG_deltaCOP1_diTrp_1	138	145	PF00928	0.492
LIG_FHA_1	236	242	PF00498	0.465
LIG_FHA_1	243	249	PF00498	0.445
LIG_FHA_1	48	54	PF00498	0.692
LIG_FHA_1	57	63	PF00498	0.523
LIG_FHA_2	181	187	PF00498	0.705
LIG_FHA_2	216	222	PF00498	0.571
LIG_LIR_Apic_2	203	209	PF02991	0.499
LIG_LIR_Gen_1	234	244	PF02991	0.474
LIG_LIR_Gen_1	261	270	PF02991	0.504
LIG_LIR_Gen_1	89	99	PF02991	0.441
LIG_LIR_Nem_3	106	111	PF02991	0.571
LIG_LIR_Nem_3	139	145	PF02991	0.429
LIG_LIR_Nem_3	234	240	PF02991	0.474
LIG_LIR_Nem_3	261	265	PF02991	0.490
LIG_LIR_Nem_3	89	94	PF02991	0.462
LIG_MYND_1	131	135	PF01753	0.586
LIG_SH2_CRK	177	181	PF00017	0.704
LIG_SH2_NCK_1	177	181	PF00017	0.704
LIG_SH2_SRC	188	191	PF00017	0.712
LIG_SH2_STAT5	105	108	PF00017	0.651
LIG_SH2_STAT5	188	191	PF00017	0.710
LIG_SH2_STAT5	262	265	PF00017	0.479
LIG_SH3_2	99	104	PF14604	0.667
LIG_SH3_3	161	167	PF00018	0.529
LIG_SH3_3	50	56	PF00018	0.687
LIG_SH3_3	96	102	PF00018	0.683
LIG_SUMO_SIM_par_1	234	243	PF11976	0.542
LIG_SUMO_SIM_par_1	48	54	PF11976	0.458
LIG_TRAF2_1	135	138	PF00917	0.586
LIG_TYR_ITIM	260	265	PF00017	0.487
MOD_CDC14_SPxK_1	101	104	PF00782	0.661
MOD_CDK_SPK_2	131	136	PF00069	0.589
MOD_CDK_SPK_2	66	71	PF00069	0.675
MOD_CDK_SPxK_1	98	104	PF00069	0.669
MOD_CK1_1	100	106	PF00069	0.662
MOD_CK1_1	160	166	PF00069	0.587
MOD_CK1_1	182	188	PF00069	0.693
MOD_CK1_1	274	280	PF00069	0.683
MOD_CK1_1	54	60	PF00069	0.494
MOD_CK1_1	69	75	PF00069	0.614
MOD_CK2_1	180	186	PF00069	0.701
MOD_CK2_1	215	221	PF00069	0.715
MOD_GlcNHglycan	16	19	PF01048	0.549
MOD_GlcNHglycan	194	199	PF01048	0.638
MOD_GlcNHglycan	25	28	PF01048	0.448
MOD_GlcNHglycan	273	276	PF01048	0.457
MOD_GlcNHglycan	83	86	PF01048	0.672
MOD_GSK3_1	163	170	PF00069	0.547
MOD_GSK3_1	178	185	PF00069	0.486
MOD_GSK3_1	19	26	PF00069	0.708
MOD_GSK3_1	45	52	PF00069	0.463
MOD_GSK3_1	54	61	PF00069	0.403
MOD_GSK3_1	77	84	PF00069	0.641
MOD_NEK2_1	220	225	PF00069	0.662
MOD_NEK2_1	58	63	PF00069	0.653
MOD_NEK2_1	77	82	PF00069	0.355
MOD_NEK2_1	86	91	PF00069	0.532
MOD_OFUCOSY	16	23	PF10250	0.471
MOD_PIKK_1	210	216	PF00454	0.504
MOD_PIKK_1	274	280	PF00454	0.637
MOD_PKA_2	103	109	PF00069	0.588
MOD_PKA_2	113	119	PF00069	0.452
MOD_PKA_2	45	51	PF00069	0.461
MOD_PKA_2	77	83	PF00069	0.561
MOD_Plk_1	220	226	PF00069	0.656
MOD_Plk_1	235	241	PF00069	0.541
MOD_Plk_4	103	109	PF00069	0.471
MOD_Plk_4	242	248	PF00069	0.538
MOD_Plk_4	58	64	PF00069	0.654
MOD_Plk_4	77	83	PF00069	0.356
MOD_Plk_4	86	92	PF00069	0.530
MOD_ProDKin_1	131	137	PF00069	0.586
MOD_ProDKin_1	163	169	PF00069	0.481
MOD_ProDKin_1	215	221	PF00069	0.715
MOD_ProDKin_1	51	57	PF00069	0.506
MOD_ProDKin_1	66	72	PF00069	0.630
MOD_ProDKin_1	98	104	PF00069	0.669
TRG_DiLeu_BaEn_1	236	241	PF01217	0.533
TRG_ENDOCYTIC_2	177	180	PF00928	0.705
TRG_ENDOCYTIC_2	230	233	PF00928	0.568
TRG_ENDOCYTIC_2	262	265	PF00928	0.483
TRG_ER_diArg_1	263	266	PF00400	0.553

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P9A1	Trypanosomatidae	34%	100%
A0A3S7XAA2	Leishmania donovani	89%	100%
A4ICU4	Leishmania infantum	89%	100%