Dihydrouridine synthase domain protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dihydrouridine synthase domain protein-like protein

Species:

Leishmania major

UniProt:

Q4Q231_LEIMA

TriTrypDb:

LmjF.36.0470 , LMJLV39_360010100 , LMJSD75_360010000

Length:

455

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4Q231

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q231

Function

Biological processes
Term	Name	Level	Count
GO:0002943	tRNA dihydrouridine synthesis	7	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006396	RNA processing	6	2
GO:0006399	tRNA metabolic process	7	2
GO:0006400	tRNA modification	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008033	tRNA processing	8	2
GO:0008152	metabolic process	1	2
GO:0009451	RNA modification	5	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034660	ncRNA metabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0016491	oxidoreductase activity	2	11
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	11
GO:0017150	tRNA dihydrouridine synthase activity	5	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0050660	flavin adenine dinucleotide binding	4	11
GO:0097159	organic cyclic compound binding	2	11
GO:0106413	dihydrouridine synthase activity	4	11
GO:0140098	catalytic activity, acting on RNA	3	11
GO:0140101	catalytic activity, acting on a tRNA	4	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	283	287	PF00656	0.541
CLV_NRD_NRD_1	313	315	PF00675	0.277
CLV_NRD_NRD_1	423	425	PF00675	0.650
CLV_NRD_NRD_1	6	8	PF00675	0.709
CLV_PCSK_FUR_1	4	8	PF00082	0.473
CLV_PCSK_KEX2_1	169	171	PF00082	0.360
CLV_PCSK_KEX2_1	197	199	PF00082	0.269
CLV_PCSK_KEX2_1	4	6	PF00082	0.474
CLV_PCSK_KEX2_1	425	427	PF00082	0.708
CLV_PCSK_KEX2_1	93	95	PF00082	0.245
CLV_PCSK_PC1ET2_1	169	171	PF00082	0.360
CLV_PCSK_PC1ET2_1	197	199	PF00082	0.305
CLV_PCSK_PC1ET2_1	425	427	PF00082	0.708
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.255
CLV_PCSK_SKI1_1	120	124	PF00082	0.332
CLV_PCSK_SKI1_1	219	223	PF00082	0.341
CLV_PCSK_SKI1_1	303	307	PF00082	0.295
CLV_PCSK_SKI1_1	345	349	PF00082	0.380
CLV_PCSK_SKI1_1	355	359	PF00082	0.384
CLV_PCSK_SKI1_1	373	377	PF00082	0.529
CLV_PCSK_SKI1_1	61	65	PF00082	0.337
CLV_Separin_Metazoa	259	263	PF03568	0.560
CLV_Separin_Metazoa	68	72	PF03568	0.393
DEG_Nend_UBRbox_2	1	3	PF02207	0.698
DEG_SCF_FBW7_2	75	81	PF00400	0.560
DEG_SPOP_SBC_1	447	451	PF00917	0.511
DOC_CKS1_1	226	231	PF01111	0.533
DOC_CKS1_1	75	80	PF01111	0.560
DOC_CKS1_1	98	103	PF01111	0.481
DOC_CYCLIN_RxL_1	342	351	PF00134	0.426
DOC_CYCLIN_yCln2_LP_2	98	104	PF00134	0.505
DOC_MAPK_gen_1	194	203	PF00069	0.457
DOC_MAPK_gen_1	4	12	PF00069	0.465
DOC_MAPK_HePTP_8	191	203	PF00069	0.527
DOC_MAPK_MEF2A_6	120	127	PF00069	0.542
DOC_MAPK_MEF2A_6	194	203	PF00069	0.439
DOC_MAPK_MEF2A_6	4	12	PF00069	0.465
DOC_MAPK_NFAT4_5	120	128	PF00069	0.541
DOC_PP1_RVXF_1	343	350	PF00149	0.484
DOC_USP7_MATH_1	184	188	PF00917	0.544
DOC_USP7_MATH_1	320	324	PF00917	0.573
DOC_USP7_MATH_1	431	435	PF00917	0.702
DOC_USP7_UBL2_3	89	93	PF12436	0.455
DOC_WW_Pin1_4	225	230	PF00397	0.513
DOC_WW_Pin1_4	240	245	PF00397	0.404
DOC_WW_Pin1_4	34	39	PF00397	0.567
DOC_WW_Pin1_4	74	79	PF00397	0.560
DOC_WW_Pin1_4	97	102	PF00397	0.481
LIG_14-3-3_CanoR_1	115	119	PF00244	0.393
LIG_14-3-3_CanoR_1	198	204	PF00244	0.466
LIG_14-3-3_CanoR_1	353	358	PF00244	0.470
LIG_14-3-3_CanoR_1	7	13	PF00244	0.630
LIG_AP2alpha_2	86	88	PF02296	0.505
LIG_APCC_ABBA_1	375	380	PF00400	0.523
LIG_BRCT_BRCA1_1	36	40	PF00533	0.560
LIG_FHA_1	24	30	PF00498	0.258
LIG_FHA_1	410	416	PF00498	0.605
LIG_FHA_1	52	58	PF00498	0.507
LIG_FHA_1	93	99	PF00498	0.505
LIG_FHA_2	397	403	PF00498	0.487
LIG_GBD_Chelix_1	199	207	PF00786	0.341
LIG_LIR_Gen_1	356	365	PF02991	0.401
LIG_LIR_Gen_1	391	400	PF02991	0.458
LIG_LIR_Nem_3	267	273	PF02991	0.537
LIG_LIR_Nem_3	346	352	PF02991	0.375
LIG_LIR_Nem_3	356	361	PF02991	0.333
LIG_LIR_Nem_3	366	372	PF02991	0.201
LIG_LIR_Nem_3	37	43	PF02991	0.536
LIG_LIR_Nem_3	391	396	PF02991	0.412
LIG_LIR_Nem_3	81	85	PF02991	0.452
LIG_LYPXL_yS_3	72	75	PF13949	0.541
LIG_PCNA_PIPBox_1	341	350	PF02747	0.466
LIG_PTB_Apo_2	357	364	PF02174	0.478
LIG_PTB_Phospho_1	357	363	PF10480	0.482
LIG_SH2_CRK	354	358	PF00017	0.393
LIG_SH2_NCK_1	254	258	PF00017	0.466
LIG_SH2_STAP1	254	258	PF00017	0.466
LIG_SH2_STAP1	339	343	PF00017	0.534
LIG_SH2_STAP1	350	354	PF00017	0.309
LIG_SH2_STAP1	389	393	PF00017	0.375
LIG_SH2_STAT3	108	111	PF00017	0.393
LIG_SH2_STAT5	82	85	PF00017	0.516
LIG_SH3_3	124	130	PF00018	0.481
LIG_SH3_3	226	232	PF00018	0.525
LIG_SH3_3	32	38	PF00018	0.541
LIG_SH3_3	67	73	PF00018	0.541
LIG_SH3_3	98	104	PF00018	0.534
LIG_SUMO_SIM_anti_2	412	418	PF11976	0.489
LIG_SUMO_SIM_par_1	8	14	PF11976	0.451
LIG_SUMO_SIM_par_1	94	100	PF11976	0.505
LIG_TRAF2_1	399	402	PF00917	0.404
LIG_TRAF2_1	433	436	PF00917	0.681
LIG_TYR_ITIM	352	357	PF00017	0.479
LIG_TYR_ITIM	70	75	PF00017	0.541
MOD_CDK_SPxxK_3	240	247	PF00069	0.541
MOD_CDK_SPxxK_3	34	41	PF00069	0.560
MOD_CK1_1	202	208	PF00069	0.484
MOD_CK1_1	225	231	PF00069	0.484
MOD_CK1_1	280	286	PF00069	0.466
MOD_CK2_1	186	192	PF00069	0.477
MOD_CK2_1	396	402	PF00069	0.428
MOD_Cter_Amidation	195	198	PF01082	0.298
MOD_DYRK1A_RPxSP_1	34	38	PF00069	0.560
MOD_GlcNHglycan	116	119	PF01048	0.346
MOD_GlcNHglycan	13	16	PF01048	0.385
MOD_GlcNHglycan	322	325	PF01048	0.653
MOD_GSK3_1	114	121	PF00069	0.546
MOD_GSK3_1	207	214	PF00069	0.454
MOD_GSK3_1	405	412	PF00069	0.541
MOD_GSK3_1	427	434	PF00069	0.701
MOD_GSK3_1	447	454	PF00069	0.707
MOD_GSK3_1	88	95	PF00069	0.487
MOD_N-GLC_1	277	282	PF02516	0.255
MOD_NEK2_1	222	227	PF00069	0.440
MOD_NEK2_1	23	28	PF00069	0.428
MOD_NEK2_1	277	282	PF00069	0.469
MOD_NEK2_1	348	353	PF00069	0.450
MOD_NEK2_1	405	410	PF00069	0.489
MOD_NEK2_1	88	93	PF00069	0.525
MOD_PIKK_1	222	228	PF00454	0.519
MOD_PK_1	155	161	PF00069	0.455
MOD_PKA_1	155	161	PF00069	0.455
MOD_PKA_1	314	320	PF00069	0.477
MOD_PKA_2	114	120	PF00069	0.393
MOD_Plk_1	104	110	PF00069	0.393
MOD_Plk_1	18	24	PF00069	0.499
MOD_Plk_1	211	217	PF00069	0.541
MOD_Plk_2-3	385	391	PF00069	0.500
MOD_Plk_2-3	81	87	PF00069	0.496
MOD_Plk_4	18	24	PF00069	0.444
MOD_Plk_4	277	283	PF00069	0.508
MOD_ProDKin_1	225	231	PF00069	0.513
MOD_ProDKin_1	240	246	PF00069	0.404
MOD_ProDKin_1	34	40	PF00069	0.567
MOD_ProDKin_1	74	80	PF00069	0.560
MOD_ProDKin_1	97	103	PF00069	0.481
MOD_SUMO_for_1	16	19	PF00179	0.477
MOD_SUMO_rev_2	283	292	PF00179	0.516
TRG_ENDOCYTIC_2	354	357	PF00928	0.401
TRG_ENDOCYTIC_2	393	396	PF00928	0.387
TRG_ENDOCYTIC_2	72	75	PF00928	0.541
TRG_ENDOCYTIC_2	85	88	PF00928	0.466
TRG_ER_diArg_1	3	6	PF00400	0.476
TRG_PTS1	452	455	PF00515	0.494

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Z1	Leptomonas seymouri	66%	100%
A0A0N1PBT7	Leptomonas seymouri	25%	89%
A0A0S4JLG1	Bodo saltans	36%	91%
A0A0S4JUA9	Bodo saltans	23%	100%
A0A1X0P8K8	Trypanosomatidae	46%	100%
A0A3Q8IJ00	Leishmania donovani	92%	100%
A0A3R7KZP3	Trypanosoma rangeli	26%	100%
A0A422P287	Trypanosoma rangeli	47%	100%
A3LUK5	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	23%	74%
A4HNQ5	Leishmania braziliensis	79%	100%
A4ICU0	Leishmania infantum	92%	100%
A5DTS1	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	23%	71%
A8NZY7	Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)	24%	67%
D0A2L3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9ASG4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
O74553	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
P53720	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
Q06063	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	21%	100%
Q32M08	Mus musculus	25%	100%
Q9D7B1	Mus musculus	28%	92%
Q9NX74	Homo sapiens	28%	92%
V5DJT2	Trypanosoma cruzi	27%	100%
V5DRQ6	Trypanosoma cruzi	49%	100%