Zinc-finger of a C2HC-type family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc-finger of a C2HC-type, putative

Species:

Leishmania major

UniProt:

Q4Q229_LEIMA

TriTrypDb:

LmjF.36.0490 , LMJLV39_360010300 , LMJSD75_360010200

Length:

348

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q229

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q229

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	301	305	PF00656	0.613
CLV_NRD_NRD_1	128	130	PF00675	0.544
CLV_NRD_NRD_1	159	161	PF00675	0.754
CLV_NRD_NRD_1	253	255	PF00675	0.739
CLV_PCSK_KEX2_1	127	129	PF00082	0.548
CLV_PCSK_KEX2_1	159	161	PF00082	0.673
CLV_PCSK_KEX2_1	200	202	PF00082	0.557
CLV_PCSK_KEX2_1	253	255	PF00082	0.719
CLV_PCSK_KEX2_1	34	36	PF00082	0.482
CLV_PCSK_PC1ET2_1	127	129	PF00082	0.548
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.604
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.482
CLV_PCSK_SKI1_1	128	132	PF00082	0.531
CLV_PCSK_SKI1_1	197	201	PF00082	0.645
CLV_PCSK_SKI1_1	31	35	PF00082	0.461
DEG_SPOP_SBC_1	169	173	PF00917	0.707
DOC_PP4_FxxP_1	152	155	PF00568	0.772
DOC_USP7_MATH_1	195	199	PF00917	0.505
DOC_USP7_MATH_1	215	219	PF00917	0.655
DOC_USP7_MATH_1	233	237	PF00917	0.733
DOC_USP7_MATH_1	242	246	PF00917	0.766
DOC_USP7_MATH_1	56	60	PF00917	0.700
DOC_USP7_MATH_1	75	79	PF00917	0.705
DOC_USP7_UBL2_3	123	127	PF12436	0.511
DOC_USP7_UBL2_3	53	57	PF12436	0.776
DOC_WW_Pin1_4	173	178	PF00397	0.708
DOC_WW_Pin1_4	231	236	PF00397	0.544
DOC_WW_Pin1_4	295	300	PF00397	0.712
LIG_14-3-3_CanoR_1	247	257	PF00244	0.762
LIG_FHA_1	161	167	PF00498	0.705
LIG_FHA_1	250	256	PF00498	0.757
LIG_FHA_1	334	340	PF00498	0.589
LIG_FHA_1	6	12	PF00498	0.369
LIG_Integrin_RGD_1	309	311	PF01839	0.577
LIG_LIR_Gen_1	109	117	PF02991	0.444
LIG_LIR_Nem_3	109	115	PF02991	0.444
LIG_SH2_NCK_1	175	179	PF00017	0.700
LIG_SH2_STAP1	29	33	PF00017	0.426
LIG_SH2_STAT5	175	178	PF00017	0.700
LIG_SH3_3	211	217	PF00018	0.700
LIG_SH3_3	294	300	PF00018	0.810
LIG_SH3_3	37	43	PF00018	0.523
LIG_SH3_4	53	60	PF00018	0.696
MOD_CK1_1	173	179	PF00069	0.667
MOD_CK1_1	218	224	PF00069	0.592
MOD_CK1_1	249	255	PF00069	0.752
MOD_GlcNHglycan	155	158	PF01048	0.667
MOD_GlcNHglycan	17	20	PF01048	0.444
MOD_GlcNHglycan	197	200	PF01048	0.560
MOD_GlcNHglycan	235	238	PF01048	0.738
MOD_GlcNHglycan	244	247	PF01048	0.771
MOD_GlcNHglycan	248	251	PF01048	0.732
MOD_GlcNHglycan	300	303	PF01048	0.601
MOD_GlcNHglycan	63	66	PF01048	0.640
MOD_GlcNHglycan	77	80	PF01048	0.568
MOD_GSK3_1	165	172	PF00069	0.695
MOD_GSK3_1	215	222	PF00069	0.764
MOD_GSK3_1	242	249	PF00069	0.775
MOD_GSK3_1	298	305	PF00069	0.705
MOD_GSK3_1	75	82	PF00069	0.680
MOD_N-GLC_1	169	174	PF02516	0.723
MOD_N-GLC_1	262	267	PF02516	0.661
MOD_N-GLC_1	334	339	PF02516	0.602
MOD_NEK2_1	131	136	PF00069	0.551
MOD_NEK2_1	209	214	PF00069	0.690
MOD_NEK2_1	219	224	PF00069	0.456
MOD_PIKK_1	178	184	PF00454	0.626
MOD_PKA_2	246	252	PF00069	0.772
MOD_PKA_2	302	308	PF00069	0.679
MOD_PKA_2	311	317	PF00069	0.658
MOD_Plk_1	262	268	PF00069	0.660
MOD_Plk_1	334	340	PF00069	0.602
MOD_ProDKin_1	173	179	PF00069	0.706
MOD_ProDKin_1	231	237	PF00069	0.542
MOD_ProDKin_1	295	301	PF00069	0.712
TRG_ER_diArg_1	128	130	PF00400	0.637
TRG_ER_diArg_1	158	160	PF00400	0.698
TRG_ER_diArg_1	253	255	PF00400	0.744
TRG_NLS_MonoExtC_3	126	132	PF00514	0.535
TRG_Pf-PMV_PEXEL_1	330	334	PF00026	0.708
TRG_Pf-PMV_PEXEL_1	81	86	PF00026	0.611

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYW4	Leptomonas seymouri	56%	94%
A0A1X0P958	Trypanosomatidae	42%	100%
A0A3R7MA87	Trypanosoma rangeli	43%	100%
A0A3S7XAD7	Leishmania donovani	94%	100%
A4HNQ7	Leishmania braziliensis	78%	100%
A4ICT8	Leishmania infantum	95%	100%
E9ASG6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BQI1	Trypanosoma cruzi	41%	100%