LeishMANIAdb
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Putative mitochondrial carrier protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative mitochondrial carrier protein
Gene product:
mitochondrial carrier protein, putative
Species:
Leishmania major
UniProt:
Q4Q227_LEIMA
TriTrypDb:
LmjF.36.0510 , LMJLV39_360010500 * , LMJSD75_360010400
Length:
755

Annotations

LeishMANIAdb annotations

Appears to fold into two separate 6TM-6TM transporter domains. Each is homologous to an individual mitochondrial CoA transporter. Localization: Mitochondrial (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005743 mitochondrial inner membrane 5 10
GO:0016020 membrane 2 12
GO:0019866 organelle inner membrane 4 10
GO:0031090 organelle membrane 3 10
GO:0031966 mitochondrial membrane 4 10
GO:0110165 cellular anatomical entity 1 12

Expansion

Sequence features

Q4Q227
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q227

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 12
GO:0009987 cellular process 1 12
GO:0051179 localization 1 12
GO:0051234 establishment of localization 2 12
GO:0055085 transmembrane transport 2 12
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 240 244 PF00656 0.528
CLV_C14_Caspase3-7 390 394 PF00656 0.525
CLV_MEL_PAP_1 631 637 PF00089 0.525
CLV_NRD_NRD_1 289 291 PF00675 0.353
CLV_NRD_NRD_1 379 381 PF00675 0.276
CLV_NRD_NRD_1 386 388 PF00675 0.276
CLV_NRD_NRD_1 435 437 PF00675 0.487
CLV_NRD_NRD_1 599 601 PF00675 0.363
CLV_NRD_NRD_1 697 699 PF00675 0.408
CLV_PCSK_KEX2_1 288 290 PF00082 0.362
CLV_PCSK_KEX2_1 378 380 PF00082 0.276
CLV_PCSK_KEX2_1 386 388 PF00082 0.276
CLV_PCSK_KEX2_1 434 436 PF00082 0.487
CLV_PCSK_KEX2_1 599 601 PF00082 0.381
CLV_PCSK_KEX2_1 665 667 PF00082 0.371
CLV_PCSK_PC1ET2_1 288 290 PF00082 0.362
CLV_PCSK_PC1ET2_1 434 436 PF00082 0.501
CLV_PCSK_PC1ET2_1 665 667 PF00082 0.411
CLV_PCSK_PC7_1 595 601 PF00082 0.381
CLV_PCSK_SKI1_1 100 104 PF00082 0.621
CLV_PCSK_SKI1_1 138 142 PF00082 0.641
CLV_PCSK_SKI1_1 172 176 PF00082 0.276
CLV_PCSK_SKI1_1 234 238 PF00082 0.645
CLV_PCSK_SKI1_1 250 254 PF00082 0.616
CLV_PCSK_SKI1_1 299 303 PF00082 0.361
CLV_PCSK_SKI1_1 734 738 PF00082 0.426
CLV_PCSK_SKI1_1 746 750 PF00082 0.501
DEG_Nend_Nbox_1 1 3 PF02207 0.528
DEG_ODPH_VHL_1 165 177 PF01847 0.328
DEG_SPOP_SBC_1 264 268 PF00917 0.449
DEG_SPOP_SBC_1 282 286 PF00917 0.562
DOC_AGCK_PIF_2 625 630 PF00069 0.287
DOC_ANK_TNKS_1 238 245 PF00023 0.525
DOC_ANK_TNKS_1 598 605 PF00023 0.581
DOC_CKS1_1 382 387 PF01111 0.517
DOC_CKS1_1 548 553 PF01111 0.429
DOC_CYCLIN_RxL_1 468 478 PF00134 0.242
DOC_MAPK_MEF2A_6 186 193 PF00069 0.518
DOC_MAPK_MEF2A_6 46 54 PF00069 0.434
DOC_PP1_RVXF_1 170 176 PF00149 0.476
DOC_PP1_RVXF_1 230 236 PF00149 0.342
DOC_PP1_RVXF_1 689 696 PF00149 0.685
DOC_PP2B_LxvP_1 473 476 PF13499 0.242
DOC_PP2B_LxvP_1 50 53 PF13499 0.439
DOC_PP2B_LxvP_1 67 70 PF13499 0.456
DOC_PP2B_LxvP_1 737 740 PF13499 0.720
DOC_PP4_FxxP_1 21 24 PF00568 0.423
DOC_USP7_MATH_1 102 106 PF00917 0.439
DOC_USP7_MATH_1 22 26 PF00917 0.593
DOC_USP7_MATH_1 27 31 PF00917 0.572
DOC_USP7_MATH_1 281 285 PF00917 0.490
DOC_USP7_MATH_1 325 329 PF00917 0.328
DOC_USP7_MATH_1 42 46 PF00917 0.544
DOC_USP7_MATH_1 560 564 PF00917 0.383
DOC_USP7_MATH_1 583 587 PF00917 0.562
DOC_USP7_UBL2_3 491 495 PF12436 0.581
DOC_WW_Pin1_4 20 25 PF00397 0.485
DOC_WW_Pin1_4 242 247 PF00397 0.486
DOC_WW_Pin1_4 381 386 PF00397 0.501
DOC_WW_Pin1_4 505 510 PF00397 0.537
DOC_WW_Pin1_4 547 552 PF00397 0.359
DOC_WW_Pin1_4 59 64 PF00397 0.431
DOC_WW_Pin1_4 686 691 PF00397 0.708
LIG_14-3-3_CanoR_1 100 110 PF00244 0.470
LIG_14-3-3_CanoR_1 181 186 PF00244 0.470
LIG_14-3-3_CanoR_1 250 255 PF00244 0.397
LIG_14-3-3_CanoR_1 283 291 PF00244 0.542
LIG_14-3-3_CanoR_1 31 40 PF00244 0.582
LIG_14-3-3_CanoR_1 386 392 PF00244 0.577
LIG_14-3-3_CanoR_1 542 552 PF00244 0.356
LIG_Actin_WH2_1 170 188 PF00022 0.517
LIG_AP2alpha_1 532 536 PF02296 0.317
LIG_BRCT_BRCA1_1 224 228 PF00533 0.369
LIG_BRCT_BRCA1_1 294 298 PF00533 0.534
LIG_BRCT_BRCA1_1 473 477 PF00533 0.475
LIG_BRCT_BRCA1_1 5 9 PF00533 0.560
LIG_BRCT_BRCA1_1 707 711 PF00533 0.605
LIG_Clathr_ClatBox_1 110 114 PF01394 0.500
LIG_deltaCOP1_diTrp_1 89 95 PF00928 0.383
LIG_DLG_GKlike_1 181 189 PF00625 0.524
LIG_EH1_1 426 434 PF00400 0.344
LIG_FHA_1 139 145 PF00498 0.486
LIG_FHA_1 15 21 PF00498 0.424
LIG_FHA_1 268 274 PF00498 0.348
LIG_FHA_1 369 375 PF00498 0.321
LIG_FHA_1 441 447 PF00498 0.514
LIG_FHA_1 564 570 PF00498 0.376
LIG_FHA_1 647 653 PF00498 0.387
LIG_FHA_1 656 662 PF00498 0.315
LIG_FHA_1 678 684 PF00498 0.702
LIG_FHA_1 708 714 PF00498 0.511
LIG_FHA_1 79 85 PF00498 0.472
LIG_FHA_2 34 40 PF00498 0.543
LIG_FHA_2 426 432 PF00498 0.328
LIG_FHA_2 453 459 PF00498 0.317
LIG_FHA_2 54 60 PF00498 0.454
LIG_FHA_2 726 732 PF00498 0.658
LIG_FXI_DFP_1 110 114 PF00024 0.700
LIG_Integrin_RGD_1 751 753 PF01839 0.514
LIG_LIR_Gen_1 116 124 PF02991 0.470
LIG_LIR_Gen_1 222 229 PF02991 0.277
LIG_LIR_Gen_1 328 335 PF02991 0.276
LIG_LIR_Gen_1 353 362 PF02991 0.355
LIG_LIR_Gen_1 469 480 PF02991 0.363
LIG_LIR_Gen_1 529 538 PF02991 0.344
LIG_LIR_Gen_1 550 560 PF02991 0.362
LIG_LIR_Gen_1 89 98 PF02991 0.374
LIG_LIR_LC3C_4 120 124 PF02991 0.517
LIG_LIR_Nem_3 116 122 PF02991 0.418
LIG_LIR_Nem_3 187 193 PF02991 0.570
LIG_LIR_Nem_3 222 226 PF02991 0.277
LIG_LIR_Nem_3 309 314 PF02991 0.355
LIG_LIR_Nem_3 328 332 PF02991 0.163
LIG_LIR_Nem_3 353 357 PF02991 0.347
LIG_LIR_Nem_3 469 475 PF02991 0.397
LIG_LIR_Nem_3 529 533 PF02991 0.348
LIG_LIR_Nem_3 534 539 PF02991 0.291
LIG_LIR_Nem_3 550 555 PF02991 0.337
LIG_LIR_Nem_3 586 590 PF02991 0.495
LIG_LIR_Nem_3 639 643 PF02991 0.383
LIG_LIR_Nem_3 89 95 PF02991 0.372
LIG_LRP6_Inhibitor_1 412 418 PF00058 0.328
LIG_PCNA_yPIPBox_3 729 737 PF02747 0.685
LIG_Pex14_1 607 611 PF04695 0.449
LIG_Pex14_2 147 151 PF04695 0.276
LIG_Pex14_2 532 536 PF04695 0.316
LIG_Pex14_2 587 591 PF04695 0.562
LIG_Pex14_2 711 715 PF04695 0.537
LIG_Pex14_2 738 742 PF04695 0.646
LIG_Rb_LxCxE_1 89 112 PF01857 0.475
LIG_SH2_CRK 119 123 PF00017 0.508
LIG_SH2_CRK 218 222 PF00017 0.328
LIG_SH2_CRK 311 315 PF00017 0.381
LIG_SH2_CRK 354 358 PF00017 0.362
LIG_SH2_CRK 388 392 PF00017 0.468
LIG_SH2_CRK 409 413 PF00017 0.328
LIG_SH2_CRK 502 506 PF00017 0.525
LIG_SH2_CRK 525 529 PF00017 0.328
LIG_SH2_CRK 628 632 PF00017 0.325
LIG_SH2_CRK 675 679 PF00017 0.650
LIG_SH2_GRB2like 552 555 PF00017 0.381
LIG_SH2_NCK_1 218 222 PF00017 0.328
LIG_SH2_NCK_1 294 298 PF00017 0.525
LIG_SH2_NCK_1 545 549 PF00017 0.444
LIG_SH2_STAP1 119 123 PF00017 0.489
LIG_SH2_STAP1 294 298 PF00017 0.525
LIG_SH2_STAP1 388 392 PF00017 0.553
LIG_SH2_STAP1 441 445 PF00017 0.464
LIG_SH2_STAP1 545 549 PF00017 0.444
LIG_SH2_STAP1 552 556 PF00017 0.362
LIG_SH2_STAT5 190 193 PF00017 0.547
LIG_SH2_STAT5 338 341 PF00017 0.301
LIG_SH2_STAT5 530 533 PF00017 0.363
LIG_SH2_STAT5 552 555 PF00017 0.362
LIG_SH2_STAT5 590 593 PF00017 0.538
LIG_SH2_STAT5 611 614 PF00017 0.447
LIG_SH2_STAT5 630 633 PF00017 0.205
LIG_SH3_3 161 167 PF00018 0.339
LIG_SH3_3 451 457 PF00018 0.401
LIG_SH3_3 545 551 PF00018 0.437
LIG_SUMO_SIM_anti_2 120 125 PF11976 0.525
LIG_SUMO_SIM_anti_2 47 53 PF11976 0.464
LIG_SUMO_SIM_par_1 452 458 PF11976 0.381
LIG_TRAF2_1 45 48 PF00917 0.499
LIG_TYR_ITIM 216 221 PF00017 0.328
LIG_TYR_ITIM 500 505 PF00017 0.581
LIG_TYR_ITIM 523 528 PF00017 0.328
LIG_TYR_ITIM 543 548 PF00017 0.233
LIG_TYR_ITIM 673 678 PF00017 0.650
LIG_WRC_WIRS_1 148 153 PF05994 0.362
LIG_WRC_WIRS_1 223 228 PF05994 0.276
LIG_WRC_WIRS_1 584 589 PF05994 0.537
LIG_WRC_WIRS_1 739 744 PF05994 0.703
MOD_CDK_SPK_2 381 386 PF00069 0.525
MOD_CDK_SPK_2 686 691 PF00069 0.708
MOD_CDK_SPxK_1 381 387 PF00069 0.501
MOD_CK1_1 25 31 PF00069 0.547
MOD_CK1_1 3 9 PF00069 0.584
MOD_CK1_1 41 47 PF00069 0.418
MOD_CK1_1 563 569 PF00069 0.477
MOD_CK1_1 586 592 PF00069 0.534
MOD_CK1_1 655 661 PF00069 0.446
MOD_CK1_1 682 688 PF00069 0.697
MOD_CK1_1 689 695 PF00069 0.707
MOD_CK1_1 707 713 PF00069 0.508
MOD_CK1_1 747 753 PF00069 0.752
MOD_CK2_1 102 108 PF00069 0.449
MOD_CK2_1 181 187 PF00069 0.557
MOD_CK2_1 242 248 PF00069 0.451
MOD_CK2_1 41 47 PF00069 0.521
MOD_CK2_1 452 458 PF00069 0.395
MOD_CK2_1 53 59 PF00069 0.418
MOD_CK2_1 65 71 PF00069 0.450
MOD_CK2_1 9 15 PF00069 0.527
MOD_Cter_Amidation 286 289 PF01082 0.362
MOD_GlcNHglycan 11 14 PF01048 0.750
MOD_GlcNHglycan 114 118 PF01048 0.705
MOD_GlcNHglycan 257 260 PF01048 0.358
MOD_GlcNHglycan 285 288 PF01048 0.362
MOD_GlcNHglycan 294 297 PF01048 0.329
MOD_GlcNHglycan 368 371 PF01048 0.336
MOD_GlcNHglycan 38 43 PF01048 0.716
MOD_GlcNHglycan 492 495 PF01048 0.344
MOD_GlcNHglycan 513 516 PF01048 0.347
MOD_GlcNHglycan 649 652 PF01048 0.449
MOD_GSK3_1 1 8 PF00069 0.579
MOD_GSK3_1 113 120 PF00069 0.468
MOD_GSK3_1 177 184 PF00069 0.503
MOD_GSK3_1 22 29 PF00069 0.525
MOD_GSK3_1 263 270 PF00069 0.397
MOD_GSK3_1 340 347 PF00069 0.457
MOD_GSK3_1 38 45 PF00069 0.475
MOD_GSK3_1 441 448 PF00069 0.455
MOD_GSK3_1 486 493 PF00069 0.524
MOD_GSK3_1 511 518 PF00069 0.528
MOD_GSK3_1 543 550 PF00069 0.361
MOD_GSK3_1 560 567 PF00069 0.344
MOD_GSK3_1 678 685 PF00069 0.691
MOD_GSK3_1 700 707 PF00069 0.558
MOD_GSK3_1 738 745 PF00069 0.707
MOD_GSK3_1 747 754 PF00069 0.681
MOD_GSK3_1 9 16 PF00069 0.559
MOD_N-GLC_1 25 30 PF02516 0.781
MOD_NEK2_1 1 6 PF00069 0.557
MOD_NEK2_1 147 152 PF00069 0.387
MOD_NEK2_1 199 204 PF00069 0.549
MOD_NEK2_1 228 233 PF00069 0.332
MOD_NEK2_1 235 240 PF00069 0.423
MOD_NEK2_1 366 371 PF00069 0.443
MOD_NEK2_1 40 45 PF00069 0.584
MOD_NEK2_1 511 516 PF00069 0.514
MOD_NEK2_1 543 548 PF00069 0.385
MOD_NEK2_1 564 569 PF00069 0.390
MOD_NEK2_1 574 579 PF00069 0.479
MOD_NEK2_1 652 657 PF00069 0.449
MOD_NEK2_1 678 683 PF00069 0.609
MOD_NEK2_1 702 707 PF00069 0.582
MOD_NEK2_1 711 716 PF00069 0.548
MOD_NEK2_1 742 747 PF00069 0.685
MOD_NEK2_1 9 14 PF00069 0.540
MOD_NEK2_2 306 311 PF00069 0.501
MOD_NEK2_2 331 336 PF00069 0.337
MOD_NEK2_2 394 399 PF00069 0.537
MOD_NEK2_2 90 95 PF00069 0.473
MOD_PK_1 387 393 PF00069 0.581
MOD_PKA_1 386 392 PF00069 0.498
MOD_PKA_1 434 440 PF00069 0.362
MOD_PKA_2 282 288 PF00069 0.553
MOD_PKA_2 386 392 PF00069 0.577
MOD_PKA_2 434 440 PF00069 0.360
MOD_Plk_1 117 123 PF00069 0.452
MOD_Plk_1 441 447 PF00069 0.495
MOD_Plk_4 117 123 PF00069 0.488
MOD_Plk_4 160 166 PF00069 0.328
MOD_Plk_4 208 214 PF00069 0.396
MOD_Plk_4 306 312 PF00069 0.498
MOD_Plk_4 314 320 PF00069 0.312
MOD_Plk_4 387 393 PF00069 0.580
MOD_Plk_4 441 447 PF00069 0.495
MOD_Plk_4 515 521 PF00069 0.449
MOD_Plk_4 53 59 PF00069 0.411
MOD_Plk_4 564 570 PF00069 0.437
MOD_Plk_4 586 592 PF00069 0.489
MOD_Plk_4 602 608 PF00069 0.476
MOD_Plk_4 610 616 PF00069 0.368
MOD_Plk_4 636 642 PF00069 0.406
MOD_Plk_4 652 658 PF00069 0.386
MOD_Plk_4 682 688 PF00069 0.656
MOD_Plk_4 744 750 PF00069 0.695
MOD_ProDKin_1 20 26 PF00069 0.486
MOD_ProDKin_1 242 248 PF00069 0.482
MOD_ProDKin_1 381 387 PF00069 0.501
MOD_ProDKin_1 505 511 PF00069 0.537
MOD_ProDKin_1 547 553 PF00069 0.352
MOD_ProDKin_1 59 65 PF00069 0.428
MOD_ProDKin_1 686 692 PF00069 0.706
TRG_DiLeu_BaEn_1 118 123 PF01217 0.497
TRG_DiLeu_BaEn_1 71 76 PF01217 0.436
TRG_DiLeu_BaEn_2 142 148 PF01217 0.325
TRG_ENDOCYTIC_2 119 122 PF00928 0.458
TRG_ENDOCYTIC_2 190 193 PF00928 0.535
TRG_ENDOCYTIC_2 218 221 PF00928 0.328
TRG_ENDOCYTIC_2 223 226 PF00928 0.276
TRG_ENDOCYTIC_2 311 314 PF00928 0.381
TRG_ENDOCYTIC_2 354 357 PF00928 0.356
TRG_ENDOCYTIC_2 388 391 PF00928 0.476
TRG_ENDOCYTIC_2 409 412 PF00928 0.328
TRG_ENDOCYTIC_2 502 505 PF00928 0.562
TRG_ENDOCYTIC_2 525 528 PF00928 0.328
TRG_ENDOCYTIC_2 530 533 PF00928 0.328
TRG_ENDOCYTIC_2 545 548 PF00928 0.230
TRG_ENDOCYTIC_2 552 555 PF00928 0.362
TRG_ENDOCYTIC_2 590 593 PF00928 0.477
TRG_ENDOCYTIC_2 611 614 PF00928 0.437
TRG_ENDOCYTIC_2 628 631 PF00928 0.185
TRG_ENDOCYTIC_2 675 678 PF00928 0.635
TRG_ENDOCYTIC_2 697 700 PF00928 0.603
TRG_ER_diArg_1 276 279 PF00400 0.477
TRG_ER_diArg_1 289 291 PF00400 0.480
TRG_ER_diArg_1 377 380 PF00400 0.476
TRG_ER_diArg_1 385 387 PF00400 0.476
TRG_ER_diArg_1 435 438 PF00400 0.302
TRG_ER_diArg_1 575 578 PF00400 0.562
TRG_NES_CRM1_1 478 490 PF08389 0.517
TRG_NLS_MonoExtC_3 287 292 PF00514 0.553
TRG_NLS_MonoExtC_3 433 438 PF00514 0.317

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I5T6 Leptomonas seymouri 76% 100%
A0A0S4JI73 Bodo saltans 45% 100%
A0A1X0P8K0 Trypanosomatidae 53% 100%
A0A3Q8IVR2 Leishmania donovani 97% 100%
A0A422P2C2 Trypanosoma rangeli 54% 100%
A4HNQ9 Leishmania braziliensis 85% 100%
A4ICT6 Leishmania infantum 97% 100%
D0A2L7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 48% 100%
E9ASG8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
V5BV54 Trypanosoma cruzi 56% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS