Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q226_LEIMA

TriTrypDb:

LmjF.36.0520 , LMJLV39_360010600 , LMJSD75_360010500

Length:

444

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q226

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q226

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	431	435	PF00656	0.448
CLV_NRD_NRD_1	162	164	PF00675	0.510
CLV_NRD_NRD_1	199	201	PF00675	0.489
CLV_NRD_NRD_1	229	231	PF00675	0.574
CLV_NRD_NRD_1	321	323	PF00675	0.519
CLV_NRD_NRD_1	334	336	PF00675	0.501
CLV_NRD_NRD_1	402	404	PF00675	0.472
CLV_NRD_NRD_1	93	95	PF00675	0.742
CLV_PCSK_KEX2_1	150	152	PF00082	0.456
CLV_PCSK_KEX2_1	229	231	PF00082	0.462
CLV_PCSK_KEX2_1	334	336	PF00082	0.488
CLV_PCSK_KEX2_1	402	404	PF00082	0.472
CLV_PCSK_KEX2_1	423	425	PF00082	0.512
CLV_PCSK_PC1ET2_1	150	152	PF00082	0.456
CLV_PCSK_PC1ET2_1	423	425	PF00082	0.546
CLV_PCSK_SKI1_1	164	168	PF00082	0.530
CLV_PCSK_SKI1_1	372	376	PF00082	0.623
CLV_PCSK_SKI1_1	85	89	PF00082	0.678
DEG_Nend_UBRbox_2	1	3	PF02207	0.519
DOC_MAPK_gen_1	200	207	PF00069	0.403
DOC_MAPK_MEF2A_6	108	117	PF00069	0.504
DOC_PP1_RVXF_1	161	168	PF00149	0.449
DOC_PP1_RVXF_1	313	320	PF00149	0.400
DOC_PP2B_PxIxI_1	328	334	PF00149	0.561
DOC_PP4_FxxP_1	167	170	PF00568	0.479
DOC_PP4_FxxP_1	268	271	PF00568	0.423
DOC_USP7_MATH_1	159	163	PF00917	0.553
DOC_USP7_MATH_1	21	25	PF00917	0.514
DOC_USP7_MATH_1	428	432	PF00917	0.447
DOC_WW_Pin1_4	85	90	PF00397	0.594
LIG_14-3-3_CanoR_1	200	208	PF00244	0.347
LIG_14-3-3_CanoR_1	293	299	PF00244	0.556
LIG_14-3-3_CanoR_1	315	320	PF00244	0.520
LIG_14-3-3_CanoR_1	322	331	PF00244	0.611
LIG_14-3-3_CanoR_1	98	104	PF00244	0.564
LIG_Actin_WH2_2	125	143	PF00022	0.396
LIG_Actin_WH2_2	22	40	PF00022	0.518
LIG_Actin_WH2_2	376	394	PF00022	0.478
LIG_APCC_ABBA_1	234	239	PF00400	0.422
LIG_Clathr_ClatBox_1	380	384	PF01394	0.490
LIG_EH1_1	206	214	PF00400	0.394
LIG_FHA_1	134	140	PF00498	0.418
LIG_FHA_1	222	228	PF00498	0.405
LIG_FHA_1	271	277	PF00498	0.468
LIG_FHA_1	319	325	PF00498	0.662
LIG_FHA_2	265	271	PF00498	0.447
LIG_FHA_2	399	405	PF00498	0.376
LIG_GBD_Chelix_1	10	18	PF00786	0.445
LIG_LIR_Apic_2	266	271	PF02991	0.488
LIG_LIR_Gen_1	128	134	PF02991	0.355
LIG_LIR_Gen_1	244	255	PF02991	0.400
LIG_LIR_Nem_3	128	133	PF02991	0.381
LIG_LIR_Nem_3	231	237	PF02991	0.458
LIG_LIR_Nem_3	240	246	PF02991	0.343
LIG_LIR_Nem_3	281	286	PF02991	0.594
LIG_NRBOX	128	134	PF00104	0.404
LIG_Pex14_2	247	251	PF04695	0.463
LIG_Pex14_2	264	268	PF04695	0.346
LIG_PTB_Apo_2	306	313	PF02174	0.512
LIG_PTB_Phospho_1	306	312	PF10480	0.517
LIG_Rb_LxCxE_1	249	267	PF01857	0.432
LIG_SH2_CRK	283	287	PF00017	0.562
LIG_SH2_SRC	269	272	PF00017	0.468
LIG_SH2_STAP1	243	247	PF00017	0.384
LIG_SH2_STAP1	312	316	PF00017	0.590
LIG_SH2_STAP1	415	419	PF00017	0.456
LIG_SH2_STAT5	243	246	PF00017	0.408
LIG_SH2_STAT5	283	286	PF00017	0.467
LIG_SH2_STAT5	362	365	PF00017	0.448
LIG_SH3_3	215	221	PF00018	0.532
LIG_SH3_3	26	32	PF00018	0.470
LIG_SH3_3	276	282	PF00018	0.449
LIG_SH3_3	283	289	PF00018	0.486
LIG_SH3_3	342	348	PF00018	0.710
LIG_SUMO_SIM_anti_2	376	382	PF11976	0.483
LIG_SUMO_SIM_par_1	379	384	PF11976	0.488
LIG_UBA3_1	356	360	PF00899	0.485
LIG_WRC_WIRS_1	265	270	PF05994	0.529
LIG_WRC_WIRS_1	57	62	PF05994	0.495
MOD_CK1_1	119	125	PF00069	0.421
MOD_CK1_1	318	324	PF00069	0.537
MOD_CK1_1	337	343	PF00069	0.457
MOD_CK1_1	396	402	PF00069	0.509
MOD_CK1_1	58	64	PF00069	0.760
MOD_CK2_1	352	358	PF00069	0.468
MOD_CK2_1	398	404	PF00069	0.428
MOD_Cter_Amidation	198	201	PF01082	0.499
MOD_GlcNHglycan	103	106	PF01048	0.644
MOD_GlcNHglycan	178	181	PF01048	0.418
MOD_GlcNHglycan	201	204	PF01048	0.443
MOD_GlcNHglycan	324	327	PF01048	0.684
MOD_GSK3_1	115	122	PF00069	0.379
MOD_GSK3_1	237	244	PF00069	0.501
MOD_GSK3_1	318	325	PF00069	0.631
MOD_GSK3_1	348	355	PF00069	0.506
MOD_GSK3_1	67	74	PF00069	0.679
MOD_GSK3_1	81	88	PF00069	0.564
MOD_GSK3_1	99	106	PF00069	0.722
MOD_N-GLC_1	159	164	PF02516	0.496
MOD_N-GLC_1	21	26	PF02516	0.514
MOD_NEK2_1	133	138	PF00069	0.481
MOD_NEK2_1	140	145	PF00069	0.529
MOD_NEK2_1	185	190	PF00069	0.536
MOD_NEK2_1	264	269	PF00069	0.601
MOD_NEK2_1	299	304	PF00069	0.496
MOD_NEK2_1	398	403	PF00069	0.461
MOD_NEK2_1	81	86	PF00069	0.708
MOD_NEK2_1	90	95	PF00069	0.745
MOD_NEK2_2	21	26	PF00069	0.514
MOD_NEK2_2	221	226	PF00069	0.383
MOD_NEK2_2	246	251	PF00069	0.483
MOD_OFUCOSY	100	107	PF10250	0.546
MOD_PIKK_1	119	125	PF00454	0.463
MOD_PIKK_1	270	276	PF00454	0.445
MOD_PKA_1	322	328	PF00069	0.634
MOD_PKA_1	334	340	PF00069	0.556
MOD_PKA_2	140	146	PF00069	0.471
MOD_PKA_2	199	205	PF00069	0.407
MOD_PKA_2	334	340	PF00069	0.540
MOD_Plk_1	241	247	PF00069	0.414
MOD_Plk_1	42	48	PF00069	0.568
MOD_Plk_4	125	131	PF00069	0.410
MOD_Plk_4	241	247	PF00069	0.463
MOD_Plk_4	264	270	PF00069	0.575
MOD_Plk_4	294	300	PF00069	0.487
MOD_Plk_4	315	321	PF00069	0.518
MOD_Plk_4	352	358	PF00069	0.552
MOD_ProDKin_1	85	91	PF00069	0.594
MOD_SUMO_for_1	4	7	PF00179	0.440
MOD_SUMO_for_1	429	432	PF00179	0.413
MOD_SUMO_rev_2	355	361	PF00179	0.478
MOD_SUMO_rev_2	384	394	PF00179	0.396
TRG_DiLeu_BaEn_1	376	381	PF01217	0.359
TRG_DiLeu_BaEn_1	6	11	PF01217	0.496
TRG_DiLeu_BaLyEn_6	135	140	PF01217	0.419
TRG_DiLeu_BaLyEn_6	14	19	PF01217	0.443
TRG_DiLeu_BaLyEn_6	29	34	PF01217	0.328
TRG_ENDOCYTIC_2	130	133	PF00928	0.344
TRG_ENDOCYTIC_2	283	286	PF00928	0.562
TRG_ENDOCYTIC_2	426	429	PF00928	0.496
TRG_ER_diArg_1	333	335	PF00400	0.519
TRG_ER_diArg_1	36	39	PF00400	0.411
TRG_NES_CRM1_1	28	43	PF08389	0.432
TRG_Pf-PMV_PEXEL_1	211	215	PF00026	0.438

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JPJ4	Bodo saltans	34%	86%
A0A1X0P9M8	Trypanosomatidae	36%	100%
A0A3Q8IFS3	Leishmania donovani	93%	100%
A0A422P297	Trypanosoma rangeli	36%	99%
A4HNR0	Leishmania braziliensis	72%	100%
A4ICT5	Leishmania infantum	93%	100%
D0A2L8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9ASG9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%