VP11

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

VP11

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q223_LEIMA

TriTrypDb:

LmjF.36.0537

Length:

210

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4Q223

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q223

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	117	121	PF00656	0.640
CLV_C14_Caspase3-7	15	19	PF00656	0.473
CLV_PCSK_SKI1_1	119	123	PF00082	0.381
CLV_PCSK_SKI1_1	133	137	PF00082	0.242
CLV_PCSK_SKI1_1	174	178	PF00082	0.401
CLV_PCSK_SKI1_1	187	191	PF00082	0.416
CLV_PCSK_SKI1_1	87	91	PF00082	0.414
DEG_APCC_DBOX_1	149	157	PF00400	0.506
DOC_MAPK_gen_1	167	177	PF00069	0.587
DOC_MAPK_MEF2A_6	59	66	PF00069	0.625
DOC_MAPK_NFAT4_5	59	67	PF00069	0.627
DOC_PP1_RVXF_1	172	178	PF00149	0.595
DOC_USP7_MATH_1	113	117	PF00917	0.644
DOC_USP7_MATH_1	8	12	PF00917	0.551
DOC_WW_Pin1_4	4	9	PF00397	0.362
LIG_14-3-3_CanoR_1	26	32	PF00244	0.402
LIG_14-3-3_CanoR_1	55	63	PF00244	0.588
LIG_BIR_II_1	1	5	PF00653	0.540
LIG_BRCT_BRCA1_1	164	168	PF00533	0.566
LIG_FHA_1	155	161	PF00498	0.608
LIG_FHA_2	188	194	PF00498	0.557
LIG_FHA_2	28	34	PF00498	0.504
LIG_FHA_2	68	74	PF00498	0.678
LIG_LIR_Gen_1	165	176	PF02991	0.489
LIG_LIR_Nem_3	165	171	PF02991	0.488
LIG_NRBOX	48	54	PF00104	0.402
LIG_SH2_CRK	107	111	PF00017	0.697
LIG_SH2_CRK	202	206	PF00017	0.578
LIG_SH2_GRB2like	201	204	PF00017	0.566
LIG_SH2_STAP1	107	111	PF00017	0.697
LIG_SH2_STAP1	172	176	PF00017	0.501
LIG_SH2_STAP1	31	35	PF00017	0.248
LIG_SH2_STAT5	76	79	PF00017	0.620
LIG_SUMO_SIM_par_1	33	40	PF11976	0.346
LIG_SUMO_SIM_par_1	45	51	PF11976	0.282
LIG_WW_1	104	107	PF00397	0.678
MOD_CK1_1	134	140	PF00069	0.645
MOD_CK1_1	14	20	PF00069	0.510
MOD_CK1_1	37	43	PF00069	0.288
MOD_CK1_1	7	13	PF00069	0.503
MOD_CK2_1	27	33	PF00069	0.508
MOD_CK2_1	6	12	PF00069	0.508
MOD_GSK3_1	127	134	PF00069	0.563
MOD_GSK3_1	14	21	PF00069	0.462
MOD_GSK3_1	27	34	PF00069	0.423
MOD_GSK3_1	4	11	PF00069	0.484
MOD_N-GLC_1	18	23	PF02516	0.717
MOD_NEK2_1	136	141	PF00069	0.580
MOD_NEK2_1	176	181	PF00069	0.636
MOD_NEK2_1	53	58	PF00069	0.442
MOD_PIKK_1	12	18	PF00454	0.570
MOD_PK_1	131	137	PF00069	0.503
MOD_PKA_2	54	60	PF00069	0.545
MOD_PKA_2	67	73	PF00069	0.593
MOD_Plk_4	31	37	PF00069	0.294
MOD_ProDKin_1	4	10	PF00069	0.363
MOD_SUMO_rev_2	179	189	PF00179	0.596
TRG_ENDOCYTIC_2	107	110	PF00928	0.701
TRG_ENDOCYTIC_2	172	175	PF00928	0.500
TRG_ENDOCYTIC_2	202	205	PF00928	0.548
TRG_ER_diArg_1	85	88	PF00400	0.627
TRG_ER_diArg_1	99	102	PF00400	0.680
TRG_Pf-PMV_PEXEL_1	87	91	PF00026	0.341

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Z6	Leptomonas seymouri	77%	100%
A0A0S4JAJ7	Bodo saltans	33%	100%
A0A1X0P877	Trypanosomatidae	51%	100%
A0A3R7MV99	Trypanosoma rangeli	49%	100%
A0A3S7XAD3	Leishmania donovani	98%	100%
A4HNR3	Leishmania braziliensis	88%	100%
A4ICT2	Leishmania infantum	98%	100%
D0A2M3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9ASH2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%