Protein CASP

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Protein CASP

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q220_LEIMA

TriTrypDb:

LmjF.36.0560 , LMJLV39_360011100 , LMJSD75_360011000

Length:

305

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q220

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q220

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.470
CLV_NRD_NRD_1	154	156	PF00675	0.463
CLV_NRD_NRD_1	166	168	PF00675	0.493
CLV_NRD_NRD_1	190	192	PF00675	0.539
CLV_NRD_NRD_1	207	209	PF00675	0.405
CLV_NRD_NRD_1	80	82	PF00675	0.499
CLV_NRD_NRD_1	94	96	PF00675	0.515
CLV_PCSK_FUR_1	208	212	PF00082	0.503
CLV_PCSK_KEX2_1	154	156	PF00082	0.401
CLV_PCSK_KEX2_1	166	168	PF00082	0.412
CLV_PCSK_KEX2_1	177	179	PF00082	0.531
CLV_PCSK_KEX2_1	190	192	PF00082	0.531
CLV_PCSK_KEX2_1	210	212	PF00082	0.406
CLV_PCSK_KEX2_1	301	303	PF00082	0.514
CLV_PCSK_KEX2_1	82	84	PF00082	0.432
CLV_PCSK_KEX2_1	94	96	PF00082	0.616
CLV_PCSK_PC1ET2_1	177	179	PF00082	0.513
CLV_PCSK_PC1ET2_1	210	212	PF00082	0.506
CLV_PCSK_PC1ET2_1	301	303	PF00082	0.442
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.468
CLV_PCSK_PC7_1	150	156	PF00082	0.405
CLV_PCSK_SKI1_1	166	170	PF00082	0.429
CLV_PCSK_SKI1_1	174	178	PF00082	0.421
CLV_PCSK_SKI1_1	301	305	PF00082	0.490
DEG_APCC_DBOX_1	80	88	PF00400	0.454
DEG_Nend_UBRbox_3	1	3	PF02207	0.437
DOC_CYCLIN_RxL_1	15	26	PF00134	0.405
DOC_CYCLIN_yCln2_LP_2	8	14	PF00134	0.438
DOC_MAPK_RevD_3	139	155	PF00069	0.510
DOC_PP2B_LxvP_1	235	238	PF13499	0.547
DOC_PP2B_LxvP_1	8	11	PF13499	0.464
DOC_PP4_FxxP_1	25	28	PF00568	0.401
DOC_USP7_MATH_1	170	174	PF00917	0.491
DOC_USP7_MATH_1	179	183	PF00917	0.438
DOC_USP7_MATH_1	55	59	PF00917	0.574
DOC_USP7_MATH_1	61	65	PF00917	0.533
DOC_USP7_UBL2_3	268	272	PF12436	0.516
DOC_WW_Pin1_4	29	34	PF00397	0.436
LIG_14-3-3_CanoR_1	116	126	PF00244	0.502
LIG_14-3-3_CanoR_1	178	184	PF00244	0.601
LIG_14-3-3_CanoR_1	226	236	PF00244	0.478
LIG_14-3-3_CanoR_1	37	41	PF00244	0.417
LIG_FHA_1	17	23	PF00498	0.477
LIG_FHA_1	178	184	PF00498	0.490
LIG_FHA_1	216	222	PF00498	0.502
LIG_FHA_1	41	47	PF00498	0.456
LIG_FHA_2	147	153	PF00498	0.532
LIG_FHA_2	264	270	PF00498	0.575
LIG_FHA_2	61	67	PF00498	0.595
LIG_LIR_Gen_1	147	156	PF02991	0.440
LIG_LIR_Gen_1	291	300	PF02991	0.478
LIG_LIR_Nem_3	147	151	PF02991	0.444
LIG_LIR_Nem_3	291	296	PF02991	0.437
LIG_MAD2	21	29	PF02301	0.403
LIG_SH2_PTP2	293	296	PF00017	0.473
LIG_SH2_STAP1	18	22	PF00017	0.470
LIG_SH2_STAP1	65	69	PF00017	0.557
LIG_SH2_STAP1	99	103	PF00017	0.572
LIG_SH2_STAT5	148	151	PF00017	0.536
LIG_SH2_STAT5	157	160	PF00017	0.555
LIG_SH2_STAT5	18	21	PF00017	0.472
LIG_SH2_STAT5	293	296	PF00017	0.473
LIG_SH3_3	27	33	PF00018	0.416
LIG_TRFH_1	25	29	PF08558	0.400
LIG_UBA3_1	259	268	PF00899	0.468
MOD_CK1_1	117	123	PF00069	0.502
MOD_CK1_1	182	188	PF00069	0.474
MOD_CK2_1	182	188	PF00069	0.517
MOD_CK2_1	210	216	PF00069	0.538
MOD_CK2_1	227	233	PF00069	0.482
MOD_CK2_1	263	269	PF00069	0.575
MOD_CK2_1	98	104	PF00069	0.585
MOD_GlcNHglycan	108	112	PF01048	0.556
MOD_GlcNHglycan	119	122	PF01048	0.491
MOD_GlcNHglycan	2	5	PF01048	0.427
MOD_GlcNHglycan	281	284	PF01048	0.627
MOD_GSK3_1	227	234	PF00069	0.502
MOD_GSK3_1	36	43	PF00069	0.458
MOD_GSK3_1	50	57	PF00069	0.621
MOD_N-GLC_1	139	144	PF02516	0.498
MOD_N-GLC_1	170	175	PF02516	0.486
MOD_N-GLC_1	76	81	PF02516	0.492
MOD_NEK2_1	244	249	PF00069	0.671
MOD_NEK2_1	263	268	PF00069	0.520
MOD_NEK2_1	50	55	PF00069	0.663
MOD_NEK2_1	60	65	PF00069	0.624
MOD_NEK2_2	16	21	PF00069	0.468
MOD_PIKK_1	128	134	PF00454	0.485
MOD_PIKK_1	182	188	PF00454	0.522
MOD_PIKK_1	215	221	PF00454	0.445
MOD_PKA_1	177	183	PF00069	0.510
MOD_PKA_1	210	216	PF00069	0.582
MOD_PKA_2	117	123	PF00069	0.459
MOD_PKA_2	177	183	PF00069	0.538
MOD_PKA_2	210	216	PF00069	0.582
MOD_PKA_2	36	42	PF00069	0.412
MOD_Plk_1	146	152	PF00069	0.473
MOD_Plk_1	263	269	PF00069	0.458
MOD_Plk_1	76	82	PF00069	0.528
MOD_Plk_4	36	42	PF00069	0.482
MOD_ProDKin_1	29	35	PF00069	0.437
MOD_SUMO_rev_2	173	179	PF00179	0.567
TRG_DiLeu_BaEn_1	217	222	PF01217	0.518
TRG_DiLeu_BaEn_2	239	245	PF01217	0.426
TRG_DiLeu_BaEn_4	291	297	PF01217	0.437
TRG_ENDOCYTIC_2	148	151	PF00928	0.412
TRG_ENDOCYTIC_2	293	296	PF00928	0.439
TRG_ER_diArg_1	115	118	PF00400	0.542
TRG_ER_diArg_1	165	167	PF00400	0.523
TRG_ER_diArg_1	189	191	PF00400	0.629
TRG_ER_diArg_1	80	83	PF00400	0.497
TRG_Pf-PMV_PEXEL_1	167	172	PF00026	0.490
TRG_Pf-PMV_PEXEL_1	226	231	PF00026	0.457

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Y9	Leptomonas seymouri	60%	100%
A0A1X0P948	Trypanosomatidae	28%	100%
A0A3S7XAJ5	Leishmania donovani	85%	99%
A4HNR6	Leishmania braziliensis	81%	100%
A4ICS9	Leishmania infantum	85%	99%
D0A2M6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9ASH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%