Eukaryotic initiation factor 4E

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Eukaryotic translation initiation factor 4E type 5, putative

Species:

Leishmania major

UniProt:

Q4Q217_LEIMA

TriTrypDb:

LmjF.36.0590 , LMJLV39_360011600 , LMJSD75_360011500

Length:

219

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0016281	eukaryotic translation initiation factor 4F complex	2	3
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0032991	protein-containing complex	1	3
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q217

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q217

PDB structure(s): 7kcj_A , 7kcj_B

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000339	RNA cap binding	5	3
GO:0000340	RNA 7-methylguanosine cap binding	6	3
GO:0003676	nucleic acid binding	3	21
GO:0003723	RNA binding	4	21
GO:0003743	translation initiation factor activity	4	21
GO:0005488	binding	1	21
GO:0008135	translation factor activity, RNA binding	3	21
GO:0045182	translation regulator activity	1	21
GO:0090079	translation regulator activity, nucleic acid binding	2	21
GO:0097159	organic cyclic compound binding	2	21
GO:1901363	heterocyclic compound binding	2	21

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	2	6	PF00082	0.643
CLV_PCSK_SKI1_1	200	204	PF00082	0.611
DEG_Nend_UBRbox_1	1	4	PF02207	0.591
DOC_MAPK_gen_1	13	20	PF00069	0.315
DOC_PP1_RVXF_1	45	51	PF00149	0.510
DOC_PP2B_LxvP_1	102	105	PF13499	0.559
DOC_USP7_MATH_1	141	145	PF00917	0.553
DOC_USP7_MATH_1	180	184	PF00917	0.562
DOC_USP7_MATH_1	187	191	PF00917	0.491
DOC_USP7_MATH_1	209	213	PF00917	0.791
DOC_USP7_MATH_1	4	8	PF00917	0.480
DOC_USP7_MATH_1	92	96	PF00917	0.556
DOC_WW_Pin1_4	207	212	PF00397	0.618
LIG_deltaCOP1_diTrp_1	14	20	PF00928	0.530
LIG_FHA_1	43	49	PF00498	0.546
LIG_FHA_1	7	13	PF00498	0.507
LIG_FHA_2	120	126	PF00498	0.461
LIG_FHA_2	50	56	PF00498	0.479
LIG_GBD_Chelix_1	166	174	PF00786	0.400
LIG_LIR_Gen_1	14	24	PF02991	0.467
LIG_LIR_Gen_1	55	65	PF02991	0.491
LIG_LIR_Nem_3	14	20	PF02991	0.499
LIG_LIR_Nem_3	87	91	PF02991	0.481
LIG_MAD2	201	209	PF02301	0.502
LIG_Pex14_1	16	20	PF04695	0.491
LIG_PTB_Apo_2	27	34	PF02174	0.467
LIG_PTB_Phospho_1	27	33	PF10480	0.467
LIG_SH2_NCK_1	184	188	PF00017	0.401
LIG_SH3_3	208	214	PF00018	0.749
LIG_TRAF2_1	40	43	PF00917	0.502
LIG_TRAF2_1	53	56	PF00917	0.450
LIG_UBA3_1	97	103	PF00899	0.531
LIG_WRC_WIRS_1	17	22	PF05994	0.467
LIG_WW_1	85	88	PF00397	0.559
MOD_CK1_1	158	164	PF00069	0.522
MOD_CK1_1	210	216	PF00069	0.574
MOD_CK2_1	119	125	PF00069	0.487
MOD_CK2_1	49	55	PF00069	0.472
MOD_GlcNHglycan	2	5	PF01048	0.675
MOD_GlcNHglycan	6	9	PF01048	0.614
MOD_GSK3_1	141	148	PF00069	0.547
MOD_GSK3_1	2	9	PF00069	0.657
MOD_GSK3_1	203	210	PF00069	0.727
MOD_GSK3_1	56	63	PF00069	0.512
MOD_N-GLC_1	92	97	PF02516	0.313
MOD_NEK2_1	119	124	PF00069	0.549
MOD_NEK2_1	157	162	PF00069	0.566
MOD_NEK2_1	203	208	PF00069	0.788
MOD_NEK2_1	57	62	PF00069	0.444
MOD_NEK2_1	6	11	PF00069	0.504
MOD_NEK2_1	72	77	PF00069	0.526
MOD_PIKK_1	42	48	PF00454	0.541
MOD_PKA_2	141	147	PF00069	0.495
MOD_Plk_1	187	193	PF00069	0.531
MOD_Plk_2-3	84	90	PF00069	0.546
MOD_Plk_4	16	22	PF00069	0.456
MOD_Plk_4	72	78	PF00069	0.463
MOD_ProDKin_1	207	213	PF00069	0.617
MOD_SUMO_rev_2	125	133	PF00179	0.539
TRG_DiLeu_BaLyEn_6	19	24	PF01217	0.467

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5E4	Leptomonas seymouri	31%	100%
A0A0N1ILF7	Leptomonas seymouri	81%	100%
A0A0S4IN32	Bodo saltans	32%	100%
A0A0S4IZ31	Bodo saltans	41%	100%
A0A1X0NSI0	Trypanosomatidae	35%	100%
A0A1X0P9L6	Trypanosomatidae	51%	100%
A0A3S7WZL5	Leishmania donovani	33%	100%
A0A3S7XAF1	Leishmania donovani	98%	100%
A0A422P286	Trypanosoma rangeli	46%	100%
A4HEN3	Leishmania braziliensis	32%	100%
A4HNR9	Leishmania braziliensis	94%	100%
A4I1W1	Leishmania infantum	33%	100%
A4ICS5	Leishmania infantum	98%	100%
C9ZS59	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
D0A2M9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9ASH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
E9AY06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
Q4Q9G7	Leishmania major	34%	100%
V5BZH5	Trypanosoma cruzi	34%	100%