DUF5678 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q214_LEIMA

TriTrypDb:

LmjF.36.0620 , LMJLV39_360011900 , LMJSD75_360011800

Length:

187

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Cellular components
Term	Name	Level	Count
GO:0000275	mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)	4	3
GO:0005737	cytoplasm	2	2
GO:0032991	protein-containing complex	1	3
GO:0033178	proton-transporting two-sector ATPase complex, catalytic domain	3	3
GO:0045261	proton-transporting ATP synthase complex, catalytic core F(1)	4	3
GO:0098796	membrane protein complex	2	3
GO:0098798	mitochondrial protein-containing complex	2	3
GO:0098800	inner mitochondrial membrane protein complex	3	3
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q214

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q214

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0005215	transporter activity	1	3
GO:0005216	monoatomic ion channel activity	4	3
GO:0005261	monoatomic cation channel activity	5	3
GO:0008324	monoatomic cation transmembrane transporter activity	4	3
GO:0015075	monoatomic ion transmembrane transporter activity	3	3
GO:0015078	proton transmembrane transporter activity	5	3
GO:0015252	proton channel activity	6	3
GO:0015267	channel activity	4	3
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	3
GO:0016874	ligase activity	2	3
GO:0022803	passive transmembrane transporter activity	3	3
GO:0022857	transmembrane transporter activity	2	3
GO:0022890	inorganic cation transmembrane transporter activity	4	3
GO:0046933	proton-transporting ATP synthase activity, rotational mechanism	3	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	100	102	PF00675	0.782
CLV_NRD_NRD_1	117	119	PF00675	0.619
CLV_NRD_NRD_1	6	8	PF00675	0.448
CLV_NRD_NRD_1	77	79	PF00675	0.687
CLV_PCSK_KEX2_1	100	102	PF00082	0.782
CLV_PCSK_KEX2_1	117	119	PF00082	0.634
CLV_PCSK_KEX2_1	6	8	PF00082	0.448
CLV_PCSK_KEX2_1	77	79	PF00082	0.721
CLV_PCSK_SKI1_1	100	104	PF00082	0.648
CLV_PCSK_SKI1_1	6	10	PF00082	0.444
CLV_PCSK_SKI1_1	87	91	PF00082	0.721
DEG_APCC_DBOX_1	116	124	PF00400	0.525
DEG_APCC_DBOX_1	5	13	PF00400	0.644
DOC_MAPK_gen_1	117	123	PF00069	0.589
DOC_MAPK_gen_1	6	14	PF00069	0.644
DOC_MAPK_RevD_3	63	78	PF00069	0.503
DOC_PP2B_LxvP_1	60	63	PF13499	0.482
DOC_PP4_FxxP_1	103	106	PF00568	0.464
DOC_PP4_FxxP_1	158	161	PF00568	0.529
DOC_PP4_FxxP_1	49	52	PF00568	0.470
DOC_PP4_FxxP_1	58	61	PF00568	0.441
DOC_USP7_MATH_1	73	77	PF00917	0.639
DOC_USP7_UBL2_3	150	154	PF12436	0.540
DOC_WW_Pin1_4	109	114	PF00397	0.582
DOC_WW_Pin1_4	40	45	PF00397	0.602
DOC_WW_Pin1_4	48	53	PF00397	0.507
LIG_14-3-3_CanoR_1	117	121	PF00244	0.497
LIG_14-3-3_CanoR_1	157	161	PF00244	0.532
LIG_14-3-3_CanoR_1	78	86	PF00244	0.537
LIG_14-3-3_CanoR_1	91	97	PF00244	0.442
LIG_FHA_1	138	144	PF00498	0.508
LIG_FHA_1	69	75	PF00498	0.639
LIG_LIR_Apic_2	156	161	PF02991	0.532
LIG_LIR_Apic_2	48	52	PF02991	0.471
LIG_LIR_Nem_3	131	135	PF02991	0.417
LIG_LIR_Nem_3	83	89	PF02991	0.586
LIG_LIR_Nem_3	95	99	PF02991	0.445
LIG_NRBOX	19	25	PF00104	0.285
LIG_NRBOX	8	14	PF00104	0.516
LIG_Pex14_2	90	94	PF04695	0.580
LIG_SH2_CRK	86	90	PF00017	0.580
LIG_SH2_GRB2like	135	138	PF00017	0.506
LIG_SH2_PTP2	163	166	PF00017	0.418
LIG_SH2_SRC	135	138	PF00017	0.506
LIG_SH2_STAT5	132	135	PF00017	0.414
LIG_SH2_STAT5	163	166	PF00017	0.543
LIG_SH3_3	60	66	PF00018	0.576
LIG_TRFH_1	58	62	PF08558	0.477
LIG_TYR_ITIM	133	138	PF00017	0.505
MOD_CK1_1	156	162	PF00069	0.537
MOD_CK1_1	76	82	PF00069	0.530
MOD_CK1_1	85	91	PF00069	0.524
MOD_GlcNHglycan	158	161	PF01048	0.652
MOD_GlcNHglycan	3	6	PF01048	0.455
MOD_GSK3_1	107	114	PF00069	0.462
MOD_GSK3_1	32	39	PF00069	0.517
MOD_GSK3_1	76	83	PF00069	0.496
MOD_N-GLC_1	136	141	PF02516	0.703
MOD_NEK2_1	1	6	PF00069	0.660
MOD_NEK2_1	116	121	PF00069	0.594
MOD_NEK2_1	32	37	PF00069	0.522
MOD_NEK2_1	45	50	PF00069	0.497
MOD_PKA_2	107	113	PF00069	0.481
MOD_PKA_2	116	122	PF00069	0.455
MOD_PKA_2	156	162	PF00069	0.537
MOD_PKA_2	76	82	PF00069	0.553
MOD_PKA_2	92	98	PF00069	0.432
MOD_Plk_4	111	117	PF00069	0.578
MOD_ProDKin_1	109	115	PF00069	0.584
MOD_ProDKin_1	40	46	PF00069	0.602
MOD_ProDKin_1	48	54	PF00069	0.507
MOD_SUMO_rev_2	175	180	PF00179	0.531
TRG_ENDOCYTIC_2	135	138	PF00928	0.506
TRG_ENDOCYTIC_2	155	158	PF00928	0.536
TRG_ENDOCYTIC_2	163	166	PF00928	0.460
TRG_ENDOCYTIC_2	86	89	PF00928	0.579
TRG_ER_diArg_1	116	118	PF00400	0.423
TRG_ER_diArg_1	90	93	PF00400	0.580
TRG_ER_diArg_1	99	101	PF00400	0.484
TRG_NES_CRM1_1	128	141	PF08389	0.507
TRG_Pf-PMV_PEXEL_1	7	11	PF00026	0.441

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7XAE3	Leishmania donovani	85%	70%