DUF3592 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF3592), putative

Species:

Leishmania major

UniProt:

Q4Q213_LEIMA

TriTrypDb:

LmjF.36.0630 , LMJLV39_360012000 , LMJSD75_360011900

Length:

188

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4Q213

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q213

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	158	164	PF00089	0.697
CLV_NRD_NRD_1	160	162	PF00675	0.627
CLV_NRD_NRD_1	35	37	PF00675	0.280
CLV_PCSK_FUR_1	33	37	PF00082	0.266
CLV_PCSK_KEX2_1	160	162	PF00082	0.627
CLV_PCSK_KEX2_1	35	37	PF00082	0.266
CLV_PCSK_SKI1_1	25	29	PF00082	0.326
DOC_CYCLIN_RxL_1	22	32	PF00134	0.402
DOC_PP1_RVXF_1	7	13	PF00149	0.335
DOC_USP7_MATH_1	108	112	PF00917	0.489
DOC_USP7_UBL2_3	176	180	PF12436	0.491
LIG_14-3-3_CanoR_1	169	179	PF00244	0.384
LIG_14-3-3_CanoR_1	33	42	PF00244	0.482
LIG_14-3-3_CanoR_1	56	62	PF00244	0.482
LIG_Actin_WH2_2	155	171	PF00022	0.422
LIG_EH1_1	126	134	PF00400	0.447
LIG_FHA_1	5	11	PF00498	0.296
LIG_FHA_1	97	103	PF00498	0.482
LIG_FHA_2	44	50	PF00498	0.482
LIG_LIR_LC3C_4	99	103	PF02991	0.496
LIG_LIR_Nem_3	59	64	PF02991	0.507
LIG_Pex14_2	135	139	PF04695	0.426
LIG_Pex14_2	8	12	PF04695	0.335
LIG_PTB_Apo_2	147	154	PF02174	0.400
LIG_PTB_Phospho_1	147	153	PF10480	0.397
LIG_SH2_CRK	153	157	PF00017	0.467
LIG_SH2_GRB2like	104	107	PF00017	0.482
LIG_SH2_NCK_1	105	109	PF00017	0.534
LIG_SH2_PTP2	21	24	PF00017	0.347
LIG_SH2_STAT5	18	21	PF00017	0.327
LIG_SH2_STAT5	4	7	PF00017	0.287
LIG_SH2_STAT5	61	64	PF00017	0.496
LIG_SH2_STAT5	73	76	PF00017	0.480
LIG_SH3_1	104	110	PF00018	0.482
LIG_SH3_3	104	110	PF00018	0.471
LIG_SH3_3	86	92	PF00018	0.482
LIG_WRC_WIRS_1	132	137	PF05994	0.447
LIG_WRC_WIRS_1	5	10	PF05994	0.296
MOD_CK1_1	131	137	PF00069	0.463
MOD_CK1_1	90	96	PF00069	0.564
MOD_GlcNHglycan	112	115	PF01048	0.282
MOD_GlcNHglycan	165	168	PF01048	0.707
MOD_GlcNHglycan	184	187	PF01048	0.746
MOD_GlcNHglycan	79	82	PF01048	0.282
MOD_GSK3_1	52	59	PF00069	0.562
MOD_NEK2_2	122	127	PF00069	0.509
MOD_NEK2_2	4	9	PF00069	0.296
MOD_NEK2_2	43	48	PF00069	0.482
MOD_PIKK_1	96	102	PF00454	0.488
MOD_PKA_1	35	41	PF00069	0.553
MOD_PKA_2	34	40	PF00069	0.495
MOD_PKB_1	33	41	PF00069	0.553
MOD_Plk_4	122	128	PF00069	0.496
MOD_Plk_4	131	137	PF00069	0.337
MOD_Plk_4	143	149	PF00069	0.353
MOD_Plk_4	43	49	PF00069	0.476
MOD_Plk_4	57	63	PF00069	0.509
MOD_Plk_4	90	96	PF00069	0.534
TRG_ENDOCYTIC_2	153	156	PF00928	0.449
TRG_ENDOCYTIC_2	16	19	PF00928	0.335
TRG_ENDOCYTIC_2	21	24	PF00928	0.319
TRG_ER_diArg_1	160	162	PF00400	0.427
TRG_ER_diArg_1	34	36	PF00400	0.480
TRG_Pf-PMV_PEXEL_1	25	29	PF00026	0.296

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P892	Leptomonas seymouri	88%	100%
A0A1X0P871	Trypanosomatidae	78%	100%
A0A3S7XAC1	Leishmania donovani	99%	100%
A0A422P2C4	Trypanosoma rangeli	75%	99%
A4HNS3	Leishmania braziliensis	95%	100%
A4ICS1	Leishmania infantum	99%	100%
D0A2N3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	75%	100%
E9ASI3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
V5B9Z4	Trypanosoma cruzi	76%	71%