Putative GPI transamidase component Tta2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GPI transamidase component Tta2, putative

Species:

Leishmania major

UniProt:

Q4Q211_LEIMA

TriTrypDb:

LmjF.36.0650 , LMJLV39_360012200 , LMJSD75_360012100

Length:

494

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005635	nuclear envelope	4	2
GO:0005783	endoplasmic reticulum	5	2
GO:0008303	caspase complex	5	2
GO:0031967	organelle envelope	3	2
GO:0031975	envelope	2	2
GO:0032991	protein-containing complex	1	2
GO:0042765	GPI-anchor transamidase complex	3	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0098796	membrane protein complex	2	2
GO:0110165	cellular anatomical entity	1	10
GO:0140534	endoplasmic reticulum protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1905368	peptidase complex	3	2
GO:1905369	endopeptidase complex	4	2
GO:0016020	membrane	2	8

Expansion

Sequence features

Q4Q211

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q211

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0003923	GPI-anchor transamidase activity	6	2
GO:0004175	endopeptidase activity	4	2
GO:0004197	cysteine-type endopeptidase activity	5	2
GO:0008233	peptidase activity	3	2
GO:0008234	cysteine-type peptidase activity	4	2
GO:0016787	hydrolase activity	2	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	157	161	PF00656	0.472
CLV_NRD_NRD_1	214	216	PF00675	0.364
CLV_PCSK_KEX2_1	214	216	PF00082	0.362
CLV_PCSK_KEX2_1	492	494	PF00082	0.552
CLV_PCSK_PC1ET2_1	492	494	PF00082	0.573
CLV_PCSK_SKI1_1	21	25	PF00082	0.325
CLV_PCSK_SKI1_1	214	218	PF00082	0.453
CLV_PCSK_SKI1_1	253	257	PF00082	0.521
CLV_PCSK_SKI1_1	351	355	PF00082	0.303
CLV_PCSK_SKI1_1	37	41	PF00082	0.262
CLV_PCSK_SKI1_1	391	395	PF00082	0.456
CLV_PCSK_SKI1_1	399	403	PF00082	0.418
CLV_PCSK_SKI1_1	91	95	PF00082	0.735
DEG_APCC_DBOX_1	350	358	PF00400	0.532
DEG_MDM2_SWIB_1	457	465	PF02201	0.447
DEG_ODPH_VHL_1	244	256	PF01847	0.443
DEG_ODPH_VHL_1	317	329	PF01847	0.596
DEG_SPOP_SBC_1	189	193	PF00917	0.324
DEG_SPOP_SBC_1	337	341	PF00917	0.663
DOC_CDC14_PxL_1	315	323	PF14671	0.586
DOC_CKS1_1	92	97	PF01111	0.483
DOC_CYCLIN_RxL_1	296	305	PF00134	0.675
DOC_CYCLIN_yCln2_LP_2	23	29	PF00134	0.331
DOC_CYCLIN_yCln2_LP_2	321	327	PF00134	0.568
DOC_CYCLIN_yCln2_LP_2	369	375	PF00134	0.636
DOC_CYCLIN_yCln2_LP_2	411	417	PF00134	0.373
DOC_MAPK_DCC_7	408	417	PF00069	0.562
DOC_MAPK_DCC_7	91	100	PF00069	0.537
DOC_MAPK_gen_1	408	417	PF00069	0.538
DOC_MAPK_MEF2A_6	21	30	PF00069	0.501
DOC_MAPK_MEF2A_6	408	417	PF00069	0.517
DOC_MAPK_MEF2A_6	91	100	PF00069	0.537
DOC_MAPK_RevD_3	200	215	PF00069	0.442
DOC_PP1_RVXF_1	251	257	PF00149	0.330
DOC_PP2B_LxvP_1	243	246	PF13499	0.496
DOC_PP2B_LxvP_1	286	289	PF13499	0.654
DOC_PP2B_LxvP_1	301	304	PF13499	0.561
DOC_PP2B_LxvP_1	321	324	PF13499	0.394
DOC_PP2B_LxvP_1	369	372	PF13499	0.581
DOC_PP2B_LxvP_1	411	414	PF13499	0.373
DOC_USP7_MATH_1	337	341	PF00917	0.647
DOC_USP7_MATH_1	387	391	PF00917	0.645
DOC_USP7_MATH_1	57	61	PF00917	0.490
DOC_USP7_MATH_1	76	80	PF00917	0.469
DOC_WW_Pin1_4	401	406	PF00397	0.682
DOC_WW_Pin1_4	483	488	PF00397	0.749
DOC_WW_Pin1_4	50	55	PF00397	0.516
DOC_WW_Pin1_4	91	96	PF00397	0.492
LIG_14-3-3_CanoR_1	16	20	PF00244	0.658
LIG_14-3-3_CanoR_1	169	178	PF00244	0.562
LIG_14-3-3_CanoR_1	214	222	PF00244	0.598
LIG_14-3-3_CanoR_1	282	287	PF00244	0.625
LIG_14-3-3_CanoR_1	335	344	PF00244	0.678
LIG_14-3-3_CanoR_1	366	372	PF00244	0.610
LIG_14-3-3_CanoR_1	399	404	PF00244	0.639
LIG_14-3-3_CanoR_1	44	48	PF00244	0.441
LIG_AP_GAE_1	120	126	PF02883	0.441
LIG_BRCT_BRCA1_1	279	283	PF00533	0.685
LIG_BRCT_BRCA1_1	361	365	PF00533	0.565
LIG_eIF4E_1	406	412	PF01652	0.679
LIG_EVH1_2	96	100	PF00568	0.492
LIG_FHA_1	150	156	PF00498	0.374
LIG_FHA_1	161	167	PF00498	0.470
LIG_FHA_1	172	178	PF00498	0.323
LIG_FHA_1	204	210	PF00498	0.355
LIG_FHA_1	274	280	PF00498	0.551
LIG_FHA_1	31	37	PF00498	0.368
LIG_FHA_1	390	396	PF00498	0.671
LIG_FHA_1	461	467	PF00498	0.439
LIG_FHA_2	109	115	PF00498	0.355
LIG_FHA_2	15	21	PF00498	0.697
LIG_FHA_2	196	202	PF00498	0.435
LIG_FHA_2	392	398	PF00498	0.682
LIG_HP1_1	240	244	PF01393	0.441
LIG_LIR_Apic_2	285	290	PF02991	0.617
LIG_LIR_Gen_1	120	131	PF02991	0.469
LIG_LIR_Gen_1	198	207	PF02991	0.463
LIG_LIR_Gen_1	234	244	PF02991	0.381
LIG_LIR_Gen_1	280	290	PF02991	0.701
LIG_LIR_Gen_1	370	381	PF02991	0.587
LIG_LIR_Gen_1	404	414	PF02991	0.592
LIG_LIR_Nem_3	110	115	PF02991	0.420
LIG_LIR_Nem_3	120	126	PF02991	0.440
LIG_LIR_Nem_3	198	203	PF02991	0.461
LIG_LIR_Nem_3	234	239	PF02991	0.377
LIG_LIR_Nem_3	280	286	PF02991	0.679
LIG_LIR_Nem_3	370	376	PF02991	0.573
LIG_LIR_Nem_3	402	406	PF02991	0.617
LIG_Pex14_1	137	141	PF04695	0.426
LIG_Pex14_2	30	34	PF04695	0.447
LIG_Pex14_2	428	432	PF04695	0.335
LIG_Pex14_2	457	461	PF04695	0.335
LIG_RPA_C_Fungi	164	176	PF08784	0.452
LIG_SH2_CRK	269	273	PF00017	0.480
LIG_SH2_CRK	373	377	PF00017	0.479
LIG_SH2_CRK	382	386	PF00017	0.484
LIG_SH2_CRK	406	410	PF00017	0.579
LIG_SH2_NCK_1	287	291	PF00017	0.500
LIG_SH2_SRC	287	290	PF00017	0.572
LIG_SH2_STAP1	179	183	PF00017	0.389
LIG_SH2_STAP1	269	273	PF00017	0.414
LIG_SH2_STAP1	275	279	PF00017	0.497
LIG_SH2_STAP1	462	466	PF00017	0.523
LIG_SH2_STAT3	129	132	PF00017	0.595
LIG_SH2_STAT3	297	300	PF00017	0.596
LIG_SH2_STAT3	333	336	PF00017	0.607
LIG_SH2_STAT5	130	133	PF00017	0.462
LIG_SH2_STAT5	138	141	PF00017	0.415
LIG_SH2_STAT5	273	276	PF00017	0.429
LIG_SH2_STAT5	297	300	PF00017	0.484
LIG_SH2_STAT5	333	336	PF00017	0.574
LIG_SH2_STAT5	373	376	PF00017	0.481
LIG_SH2_STAT5	406	409	PF00017	0.567
LIG_SH2_STAT5	462	465	PF00017	0.512
LIG_SH2_STAT5	50	53	PF00017	0.696
LIG_SH2_STAT5	81	84	PF00017	0.720
LIG_SH3_3	180	186	PF00018	0.335
LIG_SH3_3	324	330	PF00018	0.471
LIG_SH3_3	51	57	PF00018	0.646
LIG_SH3_3	90	96	PF00018	0.663
LIG_SUMO_SIM_anti_2	201	206	PF11976	0.434
LIG_SUMO_SIM_anti_2	359	365	PF11976	0.480
LIG_SUMO_SIM_par_1	185	194	PF11976	0.487
LIG_SUMO_SIM_par_1	201	206	PF11976	0.237
LIG_SUMO_SIM_par_1	390	397	PF11976	0.575
LIG_TRFH_1	182	186	PF08558	0.355
LIG_TYR_ITIM	371	376	PF00017	0.486
LIG_WRC_WIRS_1	197	202	PF05994	0.480
LIG_WRC_WIRS_1	303	308	PF05994	0.585
LIG_WRC_WIRS_1	31	36	PF05994	0.408
MOD_CDC14_SPxK_1	486	489	PF00782	0.627
MOD_CDK_SPxK_1	483	489	PF00069	0.626
MOD_CDK_SPxxK_3	401	408	PF00069	0.630
MOD_CK1_1	168	174	PF00069	0.447
MOD_CK1_1	196	202	PF00069	0.480
MOD_CK1_1	404	410	PF00069	0.591
MOD_CK1_1	43	49	PF00069	0.383
MOD_CK2_1	102	108	PF00069	0.370
MOD_CK2_1	14	20	PF00069	0.651
MOD_CK2_1	195	201	PF00069	0.435
MOD_CK2_1	84	90	PF00069	0.690
MOD_GlcNHglycan	120	123	PF01048	0.550
MOD_GlcNHglycan	156	159	PF01048	0.422
MOD_GlcNHglycan	171	174	PF01048	0.237
MOD_GlcNHglycan	217	220	PF01048	0.506
MOD_GlcNHglycan	483	486	PF01048	0.670
MOD_GlcNHglycan	78	81	PF01048	0.677
MOD_GlcNHglycan	82	85	PF01048	0.682
MOD_GSK3_1	165	172	PF00069	0.383
MOD_GSK3_1	189	196	PF00069	0.447
MOD_GSK3_1	273	280	PF00069	0.458
MOD_GSK3_1	381	388	PF00069	0.429
MOD_GSK3_1	39	46	PF00069	0.579
MOD_GSK3_1	479	486	PF00069	0.622
MOD_GSK3_1	76	83	PF00069	0.705
MOD_GSK3_1	98	105	PF00069	0.480
MOD_NEK2_1	100	105	PF00069	0.477
MOD_NEK2_1	154	159	PF00069	0.397
MOD_NEK2_1	188	193	PF00069	0.408
MOD_NEK2_1	203	208	PF00069	0.233
MOD_NEK2_1	30	35	PF00069	0.447
MOD_NEK2_1	338	343	PF00069	0.642
MOD_NEK2_1	381	386	PF00069	0.391
MOD_NEK2_1	40	45	PF00069	0.541
MOD_NEK2_1	424	429	PF00069	0.366
MOD_NEK2_1	434	439	PF00069	0.498
MOD_NEK2_1	488	493	PF00069	0.757
MOD_PIKK_1	191	197	PF00454	0.246
MOD_PIKK_1	246	252	PF00454	0.508
MOD_PIKK_1	84	90	PF00454	0.660
MOD_PKA_2	118	124	PF00069	0.535
MOD_PKA_2	15	21	PF00069	0.519
MOD_PKA_2	168	174	PF00069	0.447
MOD_PKA_2	43	49	PF00069	0.575
MOD_PKA_2	434	440	PF00069	0.583
MOD_PKA_2	488	494	PF00069	0.743
MOD_Plk_1	107	113	PF00069	0.560
MOD_Plk_1	424	430	PF00069	0.480
MOD_Plk_2-3	108	114	PF00069	0.535
MOD_Plk_4	282	288	PF00069	0.509
MOD_Plk_4	329	335	PF00069	0.468
MOD_Plk_4	359	365	PF00069	0.456
MOD_Plk_4	424	430	PF00069	0.408
MOD_ProDKin_1	401	407	PF00069	0.622
MOD_ProDKin_1	483	489	PF00069	0.709
MOD_ProDKin_1	50	56	PF00069	0.658
MOD_ProDKin_1	91	97	PF00069	0.622
TRG_DiLeu_BaLyEn_6	18	23	PF01217	0.593
TRG_DiLeu_BaLyEn_6	407	412	PF01217	0.642
TRG_ENDOCYTIC_2	138	141	PF00928	0.456
TRG_ENDOCYTIC_2	179	182	PF00928	0.408
TRG_ENDOCYTIC_2	269	272	PF00928	0.456
TRG_ENDOCYTIC_2	373	376	PF00928	0.407
TRG_ENDOCYTIC_2	382	385	PF00928	0.324
TRG_ENDOCYTIC_2	406	409	PF00928	0.556
TRG_ENDOCYTIC_2	462	465	PF00928	0.489
TRG_ER_diArg_1	408	411	PF00400	0.603

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1Y0	Leptomonas seymouri	64%	96%
A0A1X0P8I4	Trypanosomatidae	37%	100%
A0A3Q8IIQ8	Leishmania donovani	93%	100%
A0A422P255	Trypanosoma rangeli	37%	100%
A4HNS5	Leishmania braziliensis	80%	100%
A4ICR9	Leishmania infantum	93%	100%
D0A2N5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9ASI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BZX2	Trypanosoma cruzi	37%	100%