Enriched in surface-labeled proteome protein 14

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Enriched in surface-labeled proteome protein 18

Species:

Leishmania major

UniProt:

Q4Q210_LEIMA

TriTrypDb:

LmjF.36.0660 , LMJLV39_360012300 , LMJSD75_360012200

Length:

202

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 6, no: 3
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005768	endosome	7	2
GO:0009986	cell surface	2	2
GO:0031410	cytoplasmic vesicle	6	2
GO:0031982	vesicle	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0097708	intracellular vesicle	5	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q210

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q210

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	114	116	PF00675	0.473
CLV_PCSK_KEX2_1	113	115	PF00082	0.510
CLV_PCSK_SKI1_1	17	21	PF00082	0.575
CLV_PCSK_SKI1_1	57	61	PF00082	0.577
CLV_PCSK_SKI1_1	6	10	PF00082	0.526
DEG_APCC_DBOX_1	153	161	PF00400	0.343
DEG_SPOP_SBC_1	59	63	PF00917	0.611
DOC_CDC14_PxL_1	157	165	PF14671	0.421
DOC_MAPK_MEF2A_6	158	165	PF00069	0.427
DOC_PP2B_LxvP_1	163	166	PF13499	0.477
DOC_WW_Pin1_4	61	66	PF00397	0.741
DOC_WW_Pin1_4	89	94	PF00397	0.500
LIG_14-3-3_CanoR_1	113	119	PF00244	0.562
LIG_14-3-3_CanoR_1	57	66	PF00244	0.672
LIG_BRCT_BRCA1_1	15	19	PF00533	0.468
LIG_eIF4E_1	175	181	PF01652	0.376
LIG_FHA_1	114	120	PF00498	0.485
LIG_FHA_1	54	60	PF00498	0.732
LIG_GBD_Chelix_1	24	32	PF00786	0.502
LIG_LIR_Gen_1	117	128	PF02991	0.581
LIG_LIR_Gen_1	172	181	PF02991	0.456
LIG_LIR_Nem_3	117	123	PF02991	0.611
LIG_LIR_Nem_3	172	178	PF02991	0.345
LIG_MLH1_MIPbox_1	15	19	PF16413	0.468
LIG_NBox_RRM_1	19	29	PF00076	0.449
LIG_Pex14_2	9	13	PF04695	0.544
LIG_SH2_STAT5	18	21	PF00017	0.549
LIG_SH2_STAT5	85	88	PF00017	0.470
LIG_SH3_2	90	95	PF14604	0.457
LIG_SH3_3	87	93	PF00018	0.462
LIG_SUMO_SIM_par_1	26	31	PF11976	0.397
LIG_SUMO_SIM_par_1	70	76	PF11976	0.453
LIG_TRAF2_1	73	76	PF00917	0.580
LIG_TYR_ITIM	118	123	PF00017	0.571
MOD_CDC14_SPxK_1	92	95	PF00782	0.485
MOD_CDK_SPxK_1	89	95	PF00069	0.501
MOD_CK1_1	33	39	PF00069	0.704
MOD_CK2_1	104	110	PF00069	0.537
MOD_CK2_1	70	76	PF00069	0.555
MOD_GlcNHglycan	171	174	PF01048	0.449
MOD_GlcNHglycan	32	35	PF01048	0.605
MOD_GlcNHglycan	47	50	PF01048	0.770
MOD_GSK3_1	102	109	PF00069	0.608
MOD_GSK3_1	114	121	PF00069	0.483
MOD_GSK3_1	33	40	PF00069	0.604
MOD_GSK3_1	53	60	PF00069	0.531
MOD_GSK3_1	61	68	PF00069	0.691
MOD_GSK3_1	9	16	PF00069	0.592
MOD_N-GLC_1	52	57	PF02516	0.700
MOD_NEK2_1	145	150	PF00069	0.461
MOD_NEK2_1	28	33	PF00069	0.569
MOD_NEK2_1	37	42	PF00069	0.613
MOD_NEK2_1	9	14	PF00069	0.515
MOD_NEK2_2	174	179	PF00069	0.398
MOD_PK_1	114	120	PF00069	0.394
MOD_PKA_1	113	119	PF00069	0.508
MOD_PKA_2	102	108	PF00069	0.551
MOD_PKA_2	113	119	PF00069	0.567
MOD_PKB_1	41	49	PF00069	0.541
MOD_Plk_4	114	120	PF00069	0.540
MOD_Plk_4	123	129	PF00069	0.349
MOD_Plk_4	145	151	PF00069	0.421
MOD_ProDKin_1	61	67	PF00069	0.739
MOD_ProDKin_1	89	95	PF00069	0.501
MOD_SUMO_rev_2	76	84	PF00179	0.431
TRG_DiLeu_BaEn_1	176	181	PF01217	0.473
TRG_DiLeu_BaLyEn_6	192	197	PF01217	0.478
TRG_ENDOCYTIC_2	120	123	PF00928	0.575
TRG_ENDOCYTIC_2	175	178	PF00928	0.330
TRG_ER_diArg_1	112	115	PF00400	0.528
TRG_ER_diArg_1	193	196	PF00400	0.547
TRG_Pf-PMV_PEXEL_1	195	199	PF00026	0.461
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.475

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8L4	Leptomonas seymouri	50%	97%
A0A1X0P888	Trypanosomatidae	26%	100%
A0A3R7NU99	Trypanosoma rangeli	29%	100%
A0A3S7XAF9	Leishmania donovani	88%	100%
A4HNS6	Leishmania braziliensis	75%	100%
A4ICR8	Leishmania infantum	87%	100%
D0A2N6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9ASI6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%