EamA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

EamA-like transporter family, putative

Species:

Leishmania major

UniProt:

Q4Q209_LEIMA

TriTrypDb:

LmjF.36.0670 , LMJLV39_360012400 , LMJSD75_360012300

Length:

463

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 3, no: 7
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	11
GO:0000139	Golgi membrane	5	2
GO:0031090	organelle membrane	3	2
GO:0098588	bounding membrane of organelle	4	2

Expansion

Sequence features

Q4Q209

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q209

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	4
GO:0009987	cellular process	1	3
GO:0051179	localization	1	4
GO:0051234	establishment of localization	2	4
GO:0055085	transmembrane transport	2	3
GO:0008643	carbohydrate transport	5	1
GO:0071702	organic substance transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	4
GO:0022857	transmembrane transporter activity	2	4
GO:0005338	nucleotide-sugar transmembrane transporter activity	4	2
GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity	5	2
GO:0015932	nucleobase-containing compound transmembrane transporter activity	3	2
GO:1901505	carbohydrate derivative transmembrane transporter activity	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	35	39	PF00656	0.294
CLV_NRD_NRD_1	100	102	PF00675	0.430
CLV_NRD_NRD_1	432	434	PF00675	0.361
CLV_PCSK_KEX2_1	100	102	PF00082	0.399
CLV_PCSK_KEX2_1	444	446	PF00082	0.400
CLV_PCSK_PC1ET2_1	444	446	PF00082	0.306
CLV_PCSK_SKI1_1	368	372	PF00082	0.272
DOC_CDC14_PxL_1	243	251	PF14671	0.480
DOC_CYCLIN_RxL_1	198	209	PF00134	0.390
DOC_MAPK_DCC_7	242	251	PF00069	0.466
DOC_MAPK_gen_1	433	442	PF00069	0.538
DOC_MAPK_MEF2A_6	242	251	PF00069	0.473
DOC_MAPK_MEF2A_6	332	339	PF00069	0.376
DOC_PP1_RVXF_1	199	206	PF00149	0.336
DOC_PP2B_LxvP_1	311	314	PF13499	0.364
DOC_PP2B_LxvP_1	377	380	PF13499	0.316
DOC_PP4_FxxP_1	40	43	PF00568	0.427
DOC_PP4_FxxP_1	61	64	PF00568	0.248
DOC_USP7_MATH_1	4	8	PF00917	0.550
DOC_USP7_MATH_1	74	78	PF00917	0.232
DOC_WW_Pin1_4	119	124	PF00397	0.550
DOC_WW_Pin1_4	212	217	PF00397	0.331
LIG_14-3-3_CanoR_1	368	373	PF00244	0.304
LIG_14-3-3_CanoR_1	56	62	PF00244	0.316
LIG_Actin_WH2_2	16	31	PF00022	0.350
LIG_Actin_WH2_2	352	370	PF00022	0.397
LIG_BIR_II_1	1	5	PF00653	0.438
LIG_BIR_III_2	3	7	PF00653	0.322
LIG_BIR_III_3	1	5	PF00653	0.369
LIG_BRCT_BRCA1_1	340	344	PF00533	0.402
LIG_BRCT_BRCA1_1	36	40	PF00533	0.376
LIG_BRCT_BRCA1_1	6	10	PF00533	0.391
LIG_deltaCOP1_diTrp_1	327	334	PF00928	0.255
LIG_FHA_1	106	112	PF00498	0.657
LIG_FHA_1	23	29	PF00498	0.344
LIG_FHA_1	252	258	PF00498	0.461
LIG_FHA_1	359	365	PF00498	0.470
LIG_FHA_1	369	375	PF00498	0.316
LIG_FHA_1	391	397	PF00498	0.175
LIG_FHA_1	74	80	PF00498	0.357
LIG_FHA_2	174	180	PF00498	0.529
LIG_FHA_2	447	453	PF00498	0.596
LIG_LIR_Apic_2	115	120	PF02991	0.544
LIG_LIR_Apic_2	124	129	PF02991	0.260
LIG_LIR_Apic_2	37	43	PF02991	0.411
LIG_LIR_Apic_2	60	64	PF02991	0.268
LIG_LIR_Gen_1	145	155	PF02991	0.291
LIG_LIR_Gen_1	159	169	PF02991	0.266
LIG_LIR_Gen_1	384	395	PF02991	0.219
LIG_LIR_Gen_1	7	18	PF02991	0.333
LIG_LIR_Nem_3	145	151	PF02991	0.308
LIG_LIR_Nem_3	159	165	PF02991	0.266
LIG_LIR_Nem_3	167	171	PF02991	0.293
LIG_LIR_Nem_3	384	390	PF02991	0.330
LIG_LIR_Nem_3	393	398	PF02991	0.248
LIG_LIR_Nem_3	66	72	PF02991	0.271
LIG_LIR_Nem_3	7	13	PF02991	0.442
LIG_LIR_Nem_3	85	91	PF02991	0.441
LIG_MLH1_MIPbox_1	340	344	PF16413	0.300
LIG_NRBOX	194	200	PF00104	0.284
LIG_NRBOX	217	223	PF00104	0.371
LIG_NRBOX	335	341	PF00104	0.232
LIG_NRBOX	373	379	PF00104	0.300
LIG_Pex14_1	409	413	PF04695	0.554
LIG_Pex14_2	383	387	PF04695	0.303
LIG_Pex14_2	405	409	PF04695	0.393
LIG_Pex14_2	61	65	PF04695	0.259
LIG_PTB_Apo_2	399	406	PF02174	0.371
LIG_SH2_CRK	117	121	PF00017	0.578
LIG_SH2_CRK	148	152	PF00017	0.259
LIG_SH2_CRK	232	236	PF00017	0.247
LIG_SH2_CRK	244	248	PF00017	0.445
LIG_SH2_NCK_1	148	152	PF00017	0.270
LIG_SH2_PTP2	91	94	PF00017	0.487
LIG_SH2_SRC	315	318	PF00017	0.313
LIG_SH2_STAP1	148	152	PF00017	0.270
LIG_SH2_STAP1	315	319	PF00017	0.319
LIG_SH2_STAT5	168	171	PF00017	0.269
LIG_SH2_STAT5	338	341	PF00017	0.282
LIG_SH2_STAT5	355	358	PF00017	0.543
LIG_SH2_STAT5	91	94	PF00017	0.513
LIG_SH3_1	117	123	PF00018	0.541
LIG_SH3_3	117	123	PF00018	0.531
LIG_SUMO_SIM_anti_2	263	268	PF11976	0.332
LIG_SUMO_SIM_anti_2	75	83	PF11976	0.280
LIG_SUMO_SIM_par_1	360	366	PF11976	0.539
LIG_SUMO_SIM_par_1	79	85	PF11976	0.255
LIG_TRAF2_1	284	287	PF00917	0.346
LIG_TYR_ITIM	146	151	PF00017	0.269
LIG_TYR_ITIM	166	171	PF00017	0.164
LIG_TYR_ITIM	313	318	PF00017	0.347
LIG_UBA3_1	240	245	PF00899	0.477
LIG_WRC_WIRS_1	58	63	PF05994	0.293
MOD_CK1_1	446	452	PF00069	0.721
MOD_CK2_1	173	179	PF00069	0.506
MOD_CK2_1	281	287	PF00069	0.256
MOD_CK2_1	378	384	PF00069	0.323
MOD_CK2_1	446	452	PF00069	0.589
MOD_GlcNHglycan	129	132	PF01048	0.342
MOD_GlcNHglycan	286	291	PF01048	0.633
MOD_GlcNHglycan	340	343	PF01048	0.336
MOD_GlcNHglycan	356	359	PF01048	0.266
MOD_GlcNHglycan	44	47	PF01048	0.679
MOD_GlcNHglycan	6	9	PF01048	0.581
MOD_GSK3_1	30	37	PF00069	0.341
MOD_GSK3_1	354	361	PF00069	0.537
MOD_GSK3_1	38	45	PF00069	0.395
MOD_GSK3_1	443	450	PF00069	0.625
MOD_N-GLC_1	299	304	PF02516	0.604
MOD_N-GLC_1	368	373	PF02516	0.290
MOD_N-GLC_2	346	348	PF02516	0.281
MOD_N-GLC_2	423	425	PF02516	0.276
MOD_NEK2_1	134	139	PF00069	0.263
MOD_NEK2_1	144	149	PF00069	0.288
MOD_NEK2_1	155	160	PF00069	0.332
MOD_NEK2_1	19	24	PF00069	0.320
MOD_NEK2_1	205	210	PF00069	0.490
MOD_NEK2_1	262	267	PF00069	0.326
MOD_NEK2_1	288	293	PF00069	0.386
MOD_NEK2_1	363	368	PF00069	0.276
MOD_NEK2_1	57	62	PF00069	0.358
MOD_NEK2_1	82	87	PF00069	0.380
MOD_NEK2_1	96	101	PF00069	0.467
MOD_OFUCOSY	73	78	PF10250	0.232
MOD_PIKK_1	63	69	PF00454	0.327
MOD_PKA_2	173	179	PF00069	0.529
MOD_PKA_2	325	331	PF00069	0.361
MOD_PKA_2	446	452	PF00069	0.705
MOD_PKA_2	96	102	PF00069	0.585
MOD_PKB_1	445	453	PF00069	0.576
MOD_Plk_1	299	305	PF00069	0.391
MOD_Plk_1	368	374	PF00069	0.302
MOD_Plk_1	447	453	PF00069	0.606
MOD_Plk_1	74	80	PF00069	0.232
MOD_Plk_4	121	127	PF00069	0.450
MOD_Plk_4	134	140	PF00069	0.213
MOD_Plk_4	147	153	PF00069	0.238
MOD_Plk_4	156	162	PF00069	0.272
MOD_Plk_4	262	268	PF00069	0.320
MOD_Plk_4	348	354	PF00069	0.375
MOD_Plk_4	358	364	PF00069	0.496
MOD_Plk_4	368	374	PF00069	0.331
MOD_Plk_4	378	384	PF00069	0.374
MOD_Plk_4	82	88	PF00069	0.316
MOD_ProDKin_1	119	125	PF00069	0.542
MOD_ProDKin_1	212	218	PF00069	0.326
MOD_SUMO_for_1	440	443	PF00179	0.555
MOD_SUMO_rev_2	327	334	PF00179	0.292
TRG_DiLeu_BaEn_1	75	80	PF01217	0.364
TRG_DiLeu_BaEn_2	329	335	PF01217	0.255
TRG_DiLeu_BaLyEn_6	236	241	PF01217	0.508
TRG_DiLeu_BaLyEn_6	53	58	PF01217	0.294
TRG_ENDOCYTIC_2	148	151	PF00928	0.264
TRG_ENDOCYTIC_2	152	155	PF00928	0.246
TRG_ENDOCYTIC_2	168	171	PF00928	0.204
TRG_ENDOCYTIC_2	232	235	PF00928	0.256
TRG_ENDOCYTIC_2	315	318	PF00928	0.338
TRG_ER_diArg_1	94	97	PF00400	0.502
TRG_Pf-PMV_PEXEL_1	201	206	PF00026	0.517

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAC3	Leptomonas seymouri	62%	99%
A0A0S4JLV3	Bodo saltans	32%	100%
A0A0S4JVX5	Bodo saltans	33%	100%
A0A1X0P938	Trypanosomatidae	48%	100%
A0A3Q8INC1	Leishmania donovani	93%	100%
A0A3R7N2L5	Trypanosoma rangeli	48%	100%
A4HNS7	Leishmania braziliensis	72%	100%
A4ICR7	Leishmania infantum	93%	100%
E9ASI7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q5RFT1	Pongo abelii	31%	100%
Q5RKH7	Rattus norvegicus	31%	100%
Q8N357	Homo sapiens	31%	100%
Q8VE96	Mus musculus	30%	100%