LRRcap domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein C21orf2 homolog, putative

Species:

Leishmania major

UniProt:

Q4Q205_LEIMA

TriTrypDb:

LmjF.36.0710 , LMJLV39_360012800 , LMJSD75_360012700

Length:

259

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	10
GO:0042995	cell projection	2	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0110165	cellular anatomical entity	1	10
GO:0120025	plasma membrane bounded cell projection	3	10

Expansion

Sequence features

Q4Q205

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q205

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	132	134	PF00675	0.290
CLV_NRD_NRD_1	73	75	PF00675	0.220
CLV_PCSK_KEX2_1	138	140	PF00082	0.294
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.294
CLV_PCSK_SKI1_1	10	14	PF00082	0.564
CLV_PCSK_SKI1_1	138	142	PF00082	0.266
CLV_PCSK_SKI1_1	203	207	PF00082	0.593
CLV_PCSK_SKI1_1	214	218	PF00082	0.375
CLV_PCSK_SKI1_1	82	86	PF00082	0.240
DEG_APCC_DBOX_1	213	221	PF00400	0.515
DEG_SCF_FBW7_1	179	184	PF00400	0.550
DOC_CDC14_PxL_1	87	95	PF14671	0.427
DOC_MAPK_gen_1	42	51	PF00069	0.494
DOC_MAPK_MEF2A_6	88	95	PF00069	0.456
DOC_PP1_RVXF_1	201	208	PF00149	0.593
DOC_USP7_MATH_1	163	167	PF00917	0.687
DOC_USP7_UBL2_3	134	138	PF12436	0.494
DOC_USP7_UBL2_3	15	19	PF12436	0.438
DOC_USP7_UBL2_3	245	249	PF12436	0.539
DOC_WW_Pin1_4	157	162	PF00397	0.639
DOC_WW_Pin1_4	169	174	PF00397	0.555
DOC_WW_Pin1_4	177	182	PF00397	0.743
LIG_14-3-3_CanoR_1	139	145	PF00244	0.530
LIG_14-3-3_CanoR_1	198	207	PF00244	0.649
LIG_BRCT_BRCA1_1	203	207	PF00533	0.479
LIG_FHA_1	1	7	PF00498	0.505
LIG_FHA_1	140	146	PF00498	0.481
LIG_FHA_1	190	196	PF00498	0.763
LIG_FHA_1	249	255	PF00498	0.426
LIG_FHA_1	90	96	PF00498	0.437
LIG_FHA_2	127	133	PF00498	0.452
LIG_FHA_2	142	148	PF00498	0.507
LIG_FHA_2	192	198	PF00498	0.598
LIG_LIR_Gen_1	204	215	PF02991	0.455
LIG_LIR_Nem_3	204	210	PF02991	0.479
LIG_MYND_3	43	47	PF01753	0.478
LIG_SH2_STAT5	253	256	PF00017	0.451
LIG_SH2_STAT5	72	75	PF00017	0.422
LIG_SUMO_SIM_anti_2	219	226	PF11976	0.497
LIG_SUMO_SIM_anti_2	230	236	PF11976	0.431
LIG_SUMO_SIM_anti_2	35	41	PF11976	0.427
LIG_SUMO_SIM_anti_2	92	97	PF11976	0.456
LIG_SUMO_SIM_par_1	216	222	PF11976	0.462
LIG_TRAF2_1	194	197	PF00917	0.588
LIG_UBA3_1	67	75	PF00899	0.538
MOD_CDC14_SPxK_1	172	175	PF00782	0.582
MOD_CDK_SPK_2	157	162	PF00069	0.591
MOD_CDK_SPxK_1	169	175	PF00069	0.588
MOD_CDK_SPxxK_3	157	164	PF00069	0.595
MOD_CK1_1	189	195	PF00069	0.645
MOD_CK1_1	201	207	PF00069	0.504
MOD_CK1_1	219	225	PF00069	0.490
MOD_CK2_1	126	132	PF00069	0.410
MOD_CK2_1	141	147	PF00069	0.456
MOD_CK2_1	191	197	PF00069	0.726
MOD_GlcNHglycan	151	154	PF01048	0.589
MOD_GlcNHglycan	166	169	PF01048	0.591
MOD_GSK3_1	13	20	PF00069	0.451
MOD_GSK3_1	164	171	PF00069	0.661
MOD_GSK3_1	177	184	PF00069	0.657
MOD_GSK3_1	201	208	PF00069	0.546
MOD_N-GLC_1	198	203	PF02516	0.516
MOD_N-GLC_1	54	59	PF02516	0.294
MOD_NEK2_1	13	18	PF00069	0.365
MOD_NEK2_1	149	154	PF00069	0.524
MOD_NEK2_1	206	211	PF00069	0.528
MOD_NEK2_1	216	221	PF00069	0.483
MOD_PKA_1	138	144	PF00069	0.470
MOD_PKA_1	164	170	PF00069	0.689
MOD_PKA_2	138	144	PF00069	0.509
MOD_Plk_1	225	231	PF00069	0.446
MOD_Plk_1	35	41	PF00069	0.410
MOD_Plk_1	54	60	PF00069	0.410
MOD_Plk_1	82	88	PF00069	0.494
MOD_Plk_4	216	222	PF00069	0.406
MOD_Plk_4	91	97	PF00069	0.472
MOD_ProDKin_1	157	163	PF00069	0.638
MOD_ProDKin_1	169	175	PF00069	0.538
MOD_ProDKin_1	177	183	PF00069	0.742
MOD_SUMO_rev_2	127	136	PF00179	0.494
TRG_DiLeu_BaEn_1	230	235	PF01217	0.530
TRG_ENDOCYTIC_2	109	112	PF00928	0.444
TRG_Pf-PMV_PEXEL_1	143	147	PF00026	0.222

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7V8	Leptomonas seymouri	64%	100%
A0A0S4JS78	Bodo saltans	44%	100%
A0A3S7XAD6	Leishmania donovani	97%	100%
A4HNT1	Leishmania braziliensis	80%	100%
A4ICR3	Leishmania infantum	97%	100%
D0A2P1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	94%
E9ASJ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
O43822	Homo sapiens	33%	100%
Q8C6G1	Mus musculus	35%	100%
Q9BV99	Homo sapiens	32%	100%
V5DRP5	Trypanosoma cruzi	41%	94%