Zinc finger protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Zinc finger protein

Gene product:

zinc finger protein family member, putative

Species:

Leishmania major

UniProt:

Q4Q202_LEIMA

TriTrypDb:

LmjF.36.0740 , LMJLV39_360013100 , LMJSD75_360013000

Length:

543

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	yes	yes: 4
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q202

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q202

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	257	261	PF00656	0.643
CLV_C14_Caspase3-7	359	363	PF00656	0.432
CLV_C14_Caspase3-7	504	508	PF00656	0.529
CLV_C14_Caspase3-7	534	538	PF00656	0.584
CLV_NRD_NRD_1	468	470	PF00675	0.501
CLV_NRD_NRD_1	504	506	PF00675	0.497
CLV_PCSK_KEX2_1	470	472	PF00082	0.456
CLV_PCSK_PC1ET2_1	470	472	PF00082	0.456
CLV_PCSK_SKI1_1	273	277	PF00082	0.425
CLV_PCSK_SKI1_1	310	314	PF00082	0.499
DOC_CDC14_PxL_1	415	423	PF14671	0.451
DOC_MAPK_gen_1	202	209	PF00069	0.454
DOC_MAPK_MEF2A_6	202	209	PF00069	0.454
DOC_MAPK_MEF2A_6	420	429	PF00069	0.429
DOC_MAPK_RevD_3	493	506	PF00069	0.452
DOC_PP2B_LxvP_1	370	373	PF13499	0.468
DOC_PP4_FxxP_1	280	283	PF00568	0.443
DOC_USP7_MATH_1	232	236	PF00917	0.733
DOC_USP7_MATH_1	340	344	PF00917	0.412
DOC_USP7_MATH_1	62	66	PF00917	0.725
DOC_USP7_UBL2_3	266	270	PF12436	0.544
DOC_USP7_UBL2_3	310	314	PF12436	0.490
DOC_USP7_UBL2_3	365	369	PF12436	0.507
DOC_USP7_UBL2_3	453	457	PF12436	0.446
DOC_USP7_UBL2_3	532	536	PF12436	0.578
DOC_WW_Pin1_4	188	193	PF00397	0.570
DOC_WW_Pin1_4	259	264	PF00397	0.680
DOC_WW_Pin1_4	279	284	PF00397	0.455
DOC_WW_Pin1_4	98	103	PF00397	0.769
LIG_14-3-3_CanoR_1	211	217	PF00244	0.512
LIG_APCC_ABBA_1	354	359	PF00400	0.424
LIG_BRCT_BRCA1_1	320	324	PF00533	0.448
LIG_BRCT_BRCA1_1	488	492	PF00533	0.437
LIG_eIF4E_1	441	447	PF01652	0.484
LIG_FHA_1	189	195	PF00498	0.520
LIG_FHA_1	199	205	PF00498	0.477
LIG_FHA_1	269	275	PF00498	0.544
LIG_FHA_1	276	282	PF00498	0.347
LIG_FHA_1	424	430	PF00498	0.420
LIG_FHA_1	520	526	PF00498	0.449
LIG_FHA_2	213	219	PF00498	0.537
LIG_FHA_2	435	441	PF00498	0.488
LIG_FHA_2	496	502	PF00498	0.451
LIG_LIR_Apic_2	278	283	PF02991	0.441
LIG_LIR_Apic_2	301	305	PF02991	0.533
LIG_LIR_Apic_2	334	340	PF02991	0.422
LIG_LIR_Gen_1	350	357	PF02991	0.425
LIG_LIR_Gen_1	489	497	PF02991	0.414
LIG_LIR_Nem_3	301	307	PF02991	0.450
LIG_LIR_Nem_3	334	339	PF02991	0.456
LIG_LIR_Nem_3	436	441	PF02991	0.447
LIG_LIR_Nem_3	489	495	PF02991	0.418
LIG_Pex14_2	364	368	PF04695	0.429
LIG_PTB_Apo_2	168	175	PF02174	0.615
LIG_SH2_CRK	337	341	PF00017	0.407
LIG_SH2_GRB2like	353	356	PF00017	0.445
LIG_SH2_STAP1	213	217	PF00017	0.528
LIG_SH2_STAP1	459	463	PF00017	0.586
LIG_SH2_STAT3	125	128	PF00017	0.684
LIG_SH2_STAT3	161	164	PF00017	0.745
LIG_SH2_STAT3	175	178	PF00017	0.523
LIG_SH2_STAT3	455	458	PF00017	0.441
LIG_SH2_STAT3	52	55	PF00017	0.741
LIG_SH2_STAT3	84	87	PF00017	0.614
LIG_SH2_STAT3	95	98	PF00017	0.653
LIG_SH2_STAT5	173	176	PF00017	0.690
LIG_SH2_STAT5	302	305	PF00017	0.446
LIG_SH2_STAT5	345	348	PF00017	0.397
LIG_SH2_STAT5	353	356	PF00017	0.417
LIG_SH2_STAT5	60	63	PF00017	0.655
LIG_SH2_STAT5	95	98	PF00017	0.681
LIG_SH3_2	119	124	PF14604	0.682
LIG_SH3_3	108	114	PF00018	0.687
LIG_SH3_3	115	121	PF00018	0.618
LIG_SH3_3	416	422	PF00018	0.453
LIG_TRAF2_1	498	501	PF00917	0.467
LIG_TYR_ITSM	332	339	PF00017	0.424
LIG_UBA3_1	204	208	PF00899	0.410
MOD_CDK_SPK_2	279	284	PF00069	0.454
MOD_CDK_SPxxK_3	259	266	PF00069	0.571
MOD_CK1_1	131	137	PF00069	0.661
MOD_CK1_1	259	265	PF00069	0.600
MOD_CK1_1	279	285	PF00069	0.425
MOD_CK1_1	434	440	PF00069	0.515
MOD_CK1_1	465	471	PF00069	0.506
MOD_CK2_1	236	242	PF00069	0.815
MOD_CK2_1	247	253	PF00069	0.702
MOD_CK2_1	495	501	PF00069	0.439
MOD_Cter_Amidation	315	318	PF01082	0.462
MOD_GlcNHglycan	158	161	PF01048	0.717
MOD_GlcNHglycan	232	235	PF01048	0.744
MOD_GlcNHglycan	289	292	PF01048	0.481
MOD_GlcNHglycan	320	323	PF01048	0.456
MOD_GlcNHglycan	340	343	PF01048	0.487
MOD_GlcNHglycan	349	352	PF01048	0.388
MOD_GlcNHglycan	401	405	PF01048	0.521
MOD_GSK3_1	226	233	PF00069	0.683
MOD_GSK3_1	243	250	PF00069	0.596
MOD_GSK3_1	275	282	PF00069	0.440
MOD_GSK3_1	340	347	PF00069	0.432
MOD_GSK3_1	400	407	PF00069	0.522
MOD_N-GLC_1	131	136	PF02516	0.705
MOD_N-GLC_1	404	409	PF02516	0.470
MOD_NEK2_1	107	112	PF00069	0.700
MOD_NEK2_1	276	281	PF00069	0.415
MOD_NEK2_1	287	292	PF00069	0.544
MOD_NEK2_1	300	305	PF00069	0.391
MOD_NEK2_1	486	491	PF00069	0.440
MOD_NEK2_2	340	345	PF00069	0.409
MOD_NEK2_2	423	428	PF00069	0.523
MOD_OFUCOSY	484	490	PF10250	0.414
MOD_PIKK_1	113	119	PF00454	0.771
MOD_PIKK_1	47	53	PF00454	0.773
MOD_PIKK_1	78	84	PF00454	0.712
MOD_PIKK_1	93	99	PF00454	0.635
MOD_PK_1	203	209	PF00069	0.448
MOD_Plk_1	300	306	PF00069	0.459
MOD_Plk_1	404	410	PF00069	0.463
MOD_Plk_1	423	429	PF00069	0.430
MOD_Plk_4	107	113	PF00069	0.740
MOD_Plk_4	169	175	PF00069	0.595
MOD_Plk_4	276	282	PF00069	0.417
MOD_Plk_4	340	346	PF00069	0.408
MOD_ProDKin_1	188	194	PF00069	0.557
MOD_ProDKin_1	259	265	PF00069	0.677
MOD_ProDKin_1	279	285	PF00069	0.450
MOD_ProDKin_1	98	104	PF00069	0.769
MOD_SUMO_for_1	312	315	PF00179	0.500
MOD_SUMO_rev_2	239	246	PF00179	0.725
MOD_SUMO_rev_2	262	272	PF00179	0.633
MOD_SUMO_rev_2	311	319	PF00179	0.465
MOD_SUMO_rev_2	499	508	PF00179	0.489
MOD_SUMO_rev_2	528	538	PF00179	0.583
TRG_DiLeu_BaEn_2	487	493	PF01217	0.422
TRG_ENDOCYTIC_2	213	216	PF00928	0.517
TRG_ENDOCYTIC_2	336	339	PF00928	0.407
TRG_ENDOCYTIC_2	353	356	PF00928	0.417
TRG_ER_diArg_1	469	472	PF00400	0.474
TRG_NLS_MonoExtN_4	467	473	PF00514	0.467

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7W2	Leptomonas seymouri	67%	100%
A0A3S7XAD2	Leishmania donovani	96%	100%
A4HNT4	Leishmania braziliensis	84%	100%
A4ICR0	Leishmania infantum	96%	100%
E9ASJ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%