J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR-repeat-containing chaperone protein DNAJ, putative

Species:

Leishmania major

UniProt:

Q4Q200_LEIMA

TriTrypDb:

LmjF.36.0760 , LMJLV39_360013300 , LMJSD75_360013200

Length:

855

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q200

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q200

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	365	369	PF00656	0.707
CLV_C14_Caspase3-7	476	480	PF00656	0.282
CLV_NRD_NRD_1	194	196	PF00675	0.748
CLV_NRD_NRD_1	349	351	PF00675	0.644
CLV_NRD_NRD_1	389	391	PF00675	0.597
CLV_NRD_NRD_1	651	653	PF00675	0.378
CLV_NRD_NRD_1	721	723	PF00675	0.568
CLV_NRD_NRD_1	767	769	PF00675	0.646
CLV_NRD_NRD_1	96	98	PF00675	0.791
CLV_NRD_NRD_1	99	101	PF00675	0.771
CLV_PCSK_FUR_1	97	101	PF00082	0.782
CLV_PCSK_KEX2_1	349	351	PF00082	0.644
CLV_PCSK_KEX2_1	389	391	PF00082	0.586
CLV_PCSK_KEX2_1	502	504	PF00082	0.518
CLV_PCSK_KEX2_1	514	516	PF00082	0.532
CLV_PCSK_KEX2_1	651	653	PF00082	0.378
CLV_PCSK_KEX2_1	721	723	PF00082	0.568
CLV_PCSK_KEX2_1	767	769	PF00082	0.646
CLV_PCSK_KEX2_1	96	98	PF00082	0.791
CLV_PCSK_KEX2_1	99	101	PF00082	0.771
CLV_PCSK_PC1ET2_1	502	504	PF00082	0.518
CLV_PCSK_PC1ET2_1	514	516	PF00082	0.532
CLV_PCSK_SKI1_1	310	314	PF00082	0.373
CLV_PCSK_SKI1_1	393	397	PF00082	0.553
CLV_PCSK_SKI1_1	401	405	PF00082	0.501
CLV_PCSK_SKI1_1	435	439	PF00082	0.498
CLV_PCSK_SKI1_1	464	468	PF00082	0.542
CLV_PCSK_SKI1_1	489	493	PF00082	0.376
CLV_PCSK_SKI1_1	629	633	PF00082	0.457
CLV_PCSK_SKI1_1	668	672	PF00082	0.591
CLV_PCSK_SKI1_1	722	726	PF00082	0.574
CLV_PCSK_SKI1_1	821	825	PF00082	0.411
CLV_PCSK_SKI1_1	9	13	PF00082	0.742
DEG_APCC_DBOX_1	653	661	PF00400	0.515
DEG_APCC_DBOX_1	99	107	PF00400	0.767
DEG_SPOP_SBC_1	376	380	PF00917	0.666
DOC_CDC14_PxL_1	481	489	PF14671	0.507
DOC_CYCLIN_RxL_1	500	510	PF00134	0.533
DOC_CYCLIN_RxL_1	779	787	PF00134	0.505
DOC_CYCLIN_yCln2_LP_2	7	13	PF00134	0.766
DOC_MAPK_gen_1	349	356	PF00069	0.439
DOC_MAPK_gen_1	651	659	PF00069	0.436
DOC_MAPK_gen_1	848	855	PF00069	0.582
DOC_MAPK_MEF2A_6	651	659	PF00069	0.454
DOC_PP2B_LxvP_1	437	440	PF13499	0.476
DOC_PP4_FxxP_1	214	217	PF00568	0.745
DOC_USP7_MATH_1	151	155	PF00917	0.807
DOC_USP7_MATH_1	17	21	PF00917	0.649
DOC_USP7_MATH_1	178	182	PF00917	0.754
DOC_USP7_MATH_1	221	225	PF00917	0.691
DOC_USP7_MATH_1	345	349	PF00917	0.613
DOC_USP7_MATH_1	375	379	PF00917	0.705
DOC_USP7_MATH_1	46	50	PF00917	0.714
DOC_USP7_MATH_1	592	596	PF00917	0.483
DOC_USP7_MATH_1	672	676	PF00917	0.567
DOC_USP7_MATH_1	735	739	PF00917	0.708
DOC_USP7_MATH_1	744	748	PF00917	0.693
DOC_USP7_UBL2_3	725	729	PF12436	0.595
DOC_USP7_UBL2_3	804	808	PF12436	0.442
DOC_WW_Pin1_4	119	124	PF00397	0.692
DOC_WW_Pin1_4	152	157	PF00397	0.716
DOC_WW_Pin1_4	186	191	PF00397	0.759
DOC_WW_Pin1_4	217	222	PF00397	0.736
DOC_WW_Pin1_4	363	368	PF00397	0.777
DOC_WW_Pin1_4	40	45	PF00397	0.771
DOC_WW_Pin1_4	639	644	PF00397	0.537
DOC_WW_Pin1_4	702	707	PF00397	0.564
DOC_WW_Pin1_4	731	736	PF00397	0.769
DOC_WW_Pin1_4	756	761	PF00397	0.766
DOC_WW_Pin1_4	81	86	PF00397	0.772
DOC_WW_Pin1_4	823	828	PF00397	0.442
LIG_14-3-3_CanoR_1	132	138	PF00244	0.670
LIG_14-3-3_CanoR_1	3	8	PF00244	0.756
LIG_14-3-3_CanoR_1	349	355	PF00244	0.709
LIG_14-3-3_CanoR_1	393	403	PF00244	0.573
LIG_14-3-3_CanoR_1	527	537	PF00244	0.501
LIG_14-3-3_CanoR_1	753	762	PF00244	0.759
LIG_14-3-3_CanoR_1	99	104	PF00244	0.801
LIG_BIR_III_4	630	634	PF00653	0.333
LIG_BRCT_BRCA1_1	110	114	PF00533	0.758
LIG_BRCT_BRCA1_1	737	741	PF00533	0.758
LIG_deltaCOP1_diTrp_1	271	281	PF00928	0.460
LIG_FHA_1	126	132	PF00498	0.728
LIG_FHA_1	170	176	PF00498	0.735
LIG_FHA_1	231	237	PF00498	0.593
LIG_FHA_1	259	265	PF00498	0.496
LIG_FHA_1	349	355	PF00498	0.659
LIG_FHA_1	56	62	PF00498	0.747
LIG_FHA_1	562	568	PF00498	0.310
LIG_FHA_1	596	602	PF00498	0.402
LIG_FHA_1	678	684	PF00498	0.635
LIG_FHA_1	697	703	PF00498	0.504
LIG_FHA_1	776	782	PF00498	0.516
LIG_FHA_2	134	140	PF00498	0.472
LIG_FHA_2	257	263	PF00498	0.533
LIG_FHA_2	474	480	PF00498	0.352
LIG_FHA_2	824	830	PF00498	0.442
LIG_GSK3_LRP6_1	217	223	PF00069	0.735
LIG_LIR_Apic_2	212	217	PF02991	0.742
LIG_LIR_Apic_2	441	445	PF02991	0.540
LIG_LIR_Gen_1	415	424	PF02991	0.485
LIG_LIR_Gen_1	449	458	PF02991	0.426
LIG_LIR_Gen_1	550	558	PF02991	0.408
LIG_LIR_Nem_3	284	288	PF02991	0.458
LIG_LIR_Nem_3	415	421	PF02991	0.474
LIG_LIR_Nem_3	449	453	PF02991	0.418
LIG_LIR_Nem_3	471	477	PF02991	0.496
LIG_LIR_Nem_3	482	487	PF02991	0.421
LIG_LIR_Nem_3	490	495	PF02991	0.297
LIG_LIR_Nem_3	550	555	PF02991	0.528
LIG_LIR_Nem_3	796	800	PF02991	0.623
LIG_LIR_Nem_3	834	840	PF02991	0.342
LIG_LYPXL_S_1	483	487	PF13949	0.502
LIG_LYPXL_yS_3	484	487	PF13949	0.503
LIG_PDZ_Class_2	850	855	PF00595	0.591
LIG_Pex14_2	281	285	PF04695	0.460
LIG_SH2_CRK	442	446	PF00017	0.533
LIG_SH2_CRK	844	848	PF00017	0.327
LIG_SH2_NCK_1	315	319	PF00017	0.464
LIG_SH2_NCK_1	690	694	PF00017	0.511
LIG_SH2_SRC	287	290	PF00017	0.417
LIG_SH2_SRC	690	693	PF00017	0.519
LIG_SH2_STAP1	260	264	PF00017	0.404
LIG_SH2_STAP1	315	319	PF00017	0.445
LIG_SH2_STAP1	597	601	PF00017	0.400
LIG_SH2_STAP1	690	694	PF00017	0.511
LIG_SH2_STAT3	664	667	PF00017	0.556
LIG_SH2_STAT5	260	263	PF00017	0.485
LIG_SH2_STAT5	287	290	PF00017	0.392
LIG_SH2_STAT5	296	299	PF00017	0.404
LIG_SH2_STAT5	442	445	PF00017	0.570
LIG_SH2_STAT5	528	531	PF00017	0.479
LIG_SH2_STAT5	557	560	PF00017	0.552
LIG_SH2_STAT5	597	600	PF00017	0.405
LIG_SH2_STAT5	615	618	PF00017	0.287
LIG_SH2_STAT5	658	661	PF00017	0.449
LIG_SH2_STAT5	79	82	PF00017	0.797
LIG_SH3_1	82	88	PF00018	0.795
LIG_SH3_2	86	91	PF14604	0.744
LIG_SH3_3	215	221	PF00018	0.674
LIG_SH3_3	788	794	PF00018	0.673
LIG_SH3_3	80	86	PF00018	0.761
LIG_SH3_CIN85_PxpxPR_1	86	91	PF14604	0.744
LIG_SUMO_SIM_anti_2	353	360	PF11976	0.462
LIG_SUMO_SIM_par_1	434	441	PF11976	0.574
LIG_SUMO_SIM_par_1	694	699	PF11976	0.274
LIG_SUMO_SIM_par_1	9	14	PF11976	0.763
LIG_TRAF2_1	123	126	PF00917	0.639
LIG_TRAF2_1	143	146	PF00917	0.521
LIG_TRAF2_1	147	150	PF00917	0.696
LIG_TRAF2_1	405	408	PF00917	0.567
LIG_TYR_ITIM	842	847	PF00017	0.351
LIG_UBA3_1	458	465	PF00899	0.480
LIG_WRC_WIRS_1	282	287	PF05994	0.475
LIG_WW_3	88	92	PF00397	0.762
MOD_CDK_SPK_2	731	736	PF00069	0.766
MOD_CDK_SPxxK_3	823	830	PF00069	0.424
MOD_CK1_1	102	108	PF00069	0.700
MOD_CK1_1	110	116	PF00069	0.675
MOD_CK1_1	181	187	PF00069	0.730
MOD_CK1_1	220	226	PF00069	0.742
MOD_CK1_1	348	354	PF00069	0.653
MOD_CK1_1	49	55	PF00069	0.597
MOD_CK1_1	595	601	PF00069	0.480
MOD_CK1_1	705	711	PF00069	0.345
MOD_CK1_1	742	748	PF00069	0.746
MOD_CK1_1	756	762	PF00069	0.756
MOD_CK1_1	81	87	PF00069	0.795
MOD_CK2_1	119	125	PF00069	0.768
MOD_CK2_1	152	158	PF00069	0.807
MOD_CK2_1	256	262	PF00069	0.531
MOD_CK2_1	376	382	PF00069	0.689
MOD_CK2_1	394	400	PF00069	0.571
MOD_CK2_1	465	471	PF00069	0.457
MOD_CK2_1	59	65	PF00069	0.793
MOD_CK2_1	742	748	PF00069	0.762
MOD_CK2_1	823	829	PF00069	0.442
MOD_GlcNHglycan	110	113	PF01048	0.724
MOD_GlcNHglycan	139	143	PF01048	0.743
MOD_GlcNHglycan	180	183	PF01048	0.728
MOD_GlcNHglycan	29	32	PF01048	0.792
MOD_GlcNHglycan	343	346	PF01048	0.678
MOD_GlcNHglycan	379	382	PF01048	0.603
MOD_GlcNHglycan	544	547	PF01048	0.383
MOD_GlcNHglycan	594	597	PF01048	0.453
MOD_GlcNHglycan	636	639	PF01048	0.496
MOD_GlcNHglycan	674	677	PF01048	0.644
MOD_GlcNHglycan	741	744	PF01048	0.721
MOD_GlcNHglycan	755	758	PF01048	0.726
MOD_GlcNHglycan	770	773	PF01048	0.579
MOD_GlcNHglycan	849	853	PF01048	0.568
MOD_GSK3_1	11	18	PF00069	0.728
MOD_GSK3_1	158	165	PF00069	0.717
MOD_GSK3_1	205	212	PF00069	0.722
MOD_GSK3_1	217	224	PF00069	0.651
MOD_GSK3_1	341	348	PF00069	0.672
MOD_GSK3_1	352	359	PF00069	0.692
MOD_GSK3_1	40	47	PF00069	0.751
MOD_GSK3_1	473	480	PF00069	0.360
MOD_GSK3_1	55	62	PF00069	0.681
MOD_GSK3_1	705	712	PF00069	0.475
MOD_GSK3_1	724	731	PF00069	0.641
MOD_GSK3_1	735	742	PF00069	0.794
MOD_GSK3_1	74	81	PF00069	0.740
MOD_GSK3_1	95	102	PF00069	0.740
MOD_N-GLC_1	108	113	PF02516	0.790
MOD_N-GLC_1	119	124	PF02516	0.448
MOD_N-GLC_1	616	621	PF02516	0.410
MOD_N-GLC_1	65	70	PF02516	0.618
MOD_NEK2_1	1	6	PF00069	0.763
MOD_NEK2_1	133	138	PF00069	0.564
MOD_NEK2_1	162	167	PF00069	0.797
MOD_NEK2_1	169	174	PF00069	0.680
MOD_NEK2_1	281	286	PF00069	0.450
MOD_NEK2_1	413	418	PF00069	0.524
MOD_NEK2_1	473	478	PF00069	0.376
MOD_NEK2_1	487	492	PF00069	0.397
MOD_NEK2_1	55	60	PF00069	0.739
MOD_NEK2_1	784	789	PF00069	0.499
MOD_NEK2_2	127	132	PF00069	0.729
MOD_PIKK_1	528	534	PF00454	0.482
MOD_PIKK_1	658	664	PF00454	0.397
MOD_PIKK_1	709	715	PF00454	0.521
MOD_PKA_1	389	395	PF00069	0.397
MOD_PKA_1	99	105	PF00069	0.770
MOD_PKA_2	2	8	PF00069	0.730
MOD_PKA_2	336	342	PF00069	0.591
MOD_PKA_2	348	354	PF00069	0.553
MOD_PKA_2	389	395	PF00069	0.607
MOD_PKA_2	567	573	PF00069	0.480
MOD_PKA_2	95	101	PF00069	0.774
MOD_PKB_1	751	759	PF00069	0.809
MOD_PKB_1	97	105	PF00069	0.774
MOD_Plk_1	158	164	PF00069	0.781
MOD_Plk_1	209	215	PF00069	0.526
MOD_Plk_1	616	622	PF00069	0.411
MOD_Plk_4	110	116	PF00069	0.633
MOD_Plk_4	164	170	PF00069	0.740
MOD_Plk_4	336	342	PF00069	0.381
MOD_Plk_4	352	358	PF00069	0.591
MOD_Plk_4	413	419	PF00069	0.553
MOD_Plk_4	487	493	PF00069	0.444
MOD_Plk_4	74	80	PF00069	0.750
MOD_Plk_4	784	790	PF00069	0.589
MOD_ProDKin_1	119	125	PF00069	0.688
MOD_ProDKin_1	152	158	PF00069	0.715
MOD_ProDKin_1	186	192	PF00069	0.761
MOD_ProDKin_1	217	223	PF00069	0.735
MOD_ProDKin_1	363	369	PF00069	0.776
MOD_ProDKin_1	40	46	PF00069	0.767
MOD_ProDKin_1	639	645	PF00069	0.535
MOD_ProDKin_1	702	708	PF00069	0.571
MOD_ProDKin_1	731	737	PF00069	0.770
MOD_ProDKin_1	756	762	PF00069	0.761
MOD_ProDKin_1	81	87	PF00069	0.772
MOD_ProDKin_1	823	829	PF00069	0.442
MOD_SUMO_for_1	143	146	PF00179	0.683
MOD_SUMO_for_1	395	398	PF00179	0.352
MOD_SUMO_rev_2	51	61	PF00179	0.741
MOD_SUMO_rev_2	703	712	PF00179	0.613
MOD_SUMO_rev_2	796	806	PF00179	0.632
TRG_DiLeu_BaLyEn_6	390	395	PF01217	0.643
TRG_ENDOCYTIC_2	327	330	PF00928	0.482
TRG_ENDOCYTIC_2	484	487	PF00928	0.431
TRG_ENDOCYTIC_2	844	847	PF00928	0.327
TRG_ER_diArg_1	651	654	PF00400	0.409
TRG_ER_diArg_1	96	99	PF00400	0.786
TRG_Pf-PMV_PEXEL_1	393	398	PF00026	0.607
TRG_Pf-PMV_PEXEL_1	465	469	PF00026	0.514
TRG_Pf-PMV_PEXEL_1	599	604	PF00026	0.462

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I741	Leptomonas seymouri	47%	71%
A0A0S4JSA3	Bodo saltans	26%	88%
A0A3S7XAG9	Leishmania donovani	93%	100%
A4HNT6	Leishmania braziliensis	72%	100%
A4ICQ8	Leishmania infantum	93%	100%
D0A2Q0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	88%
E9ASJ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5DRP2	Trypanosoma cruzi	29%	100%