Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q1Z9_LEIMA

TriTrypDb:

LmjF.36.0770 , LMJLV39_360013400 , LMJSD75_360013300

Length:

437

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q1Z9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1Z9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	3	7	PF00656	0.552
CLV_NRD_NRD_1	102	104	PF00675	0.589
CLV_NRD_NRD_1	298	300	PF00675	0.541
CLV_NRD_NRD_1	330	332	PF00675	0.612
CLV_NRD_NRD_1	410	412	PF00675	0.774
CLV_NRD_NRD_1	420	422	PF00675	0.631
CLV_PCSK_FUR_1	100	104	PF00082	0.514
CLV_PCSK_KEX2_1	100	102	PF00082	0.599
CLV_PCSK_KEX2_1	330	332	PF00082	0.598
CLV_PCSK_KEX2_1	420	422	PF00082	0.650
CLV_PCSK_SKI1_1	154	158	PF00082	0.560
CLV_PCSK_SKI1_1	281	285	PF00082	0.496
DEG_SPOP_SBC_1	121	125	PF00917	0.496
DEG_SPOP_SBC_1	178	182	PF00917	0.528
DEG_SPOP_SBC_1	372	376	PF00917	0.605
DEG_SPOP_SBC_1	397	401	PF00917	0.578
DOC_CKS1_1	203	208	PF01111	0.544
DOC_CKS1_1	60	65	PF01111	0.528
DOC_CYCLIN_yCln2_LP_2	329	335	PF00134	0.660
DOC_MAPK_HePTP_8	19	31	PF00069	0.421
DOC_MAPK_MEF2A_6	22	31	PF00069	0.438
DOC_PP2B_LxvP_1	248	251	PF13499	0.671
DOC_PP4_FxxP_1	23	26	PF00568	0.341
DOC_USP7_MATH_1	114	118	PF00917	0.658
DOC_USP7_MATH_1	121	125	PF00917	0.721
DOC_USP7_MATH_1	141	145	PF00917	0.436
DOC_USP7_MATH_1	179	183	PF00917	0.705
DOC_USP7_MATH_1	187	191	PF00917	0.636
DOC_USP7_MATH_1	228	232	PF00917	0.596
DOC_USP7_MATH_1	252	256	PF00917	0.770
DOC_USP7_MATH_1	267	271	PF00917	0.805
DOC_USP7_MATH_1	305	309	PF00917	0.603
DOC_USP7_MATH_1	371	375	PF00917	0.765
DOC_USP7_MATH_1	377	381	PF00917	0.529
DOC_USP7_MATH_1	398	402	PF00917	0.562
DOC_USP7_MATH_1	403	407	PF00917	0.630
DOC_WW_Pin1_4	109	114	PF00397	0.715
DOC_WW_Pin1_4	202	207	PF00397	0.692
DOC_WW_Pin1_4	375	380	PF00397	0.715
DOC_WW_Pin1_4	59	64	PF00397	0.522
LIG_14-3-3_CanoR_1	120	127	PF00244	0.594
LIG_14-3-3_CanoR_1	61	71	PF00244	0.448
LIG_Actin_WH2_2	320	336	PF00022	0.659
LIG_BIR_II_1	1	5	PF00653	0.562
LIG_FHA_1	178	184	PF00498	0.627
LIG_FHA_2	1	7	PF00498	0.470
LIG_FHA_2	165	171	PF00498	0.728
LIG_FHA_2	203	209	PF00498	0.510
LIG_FHA_2	63	69	PF00498	0.403
LIG_FHA_2	8	14	PF00498	0.320
LIG_Integrin_RGD_1	103	105	PF01839	0.452
LIG_LIR_Gen_1	193	203	PF02991	0.573
LIG_LIR_Nem_3	151	156	PF02991	0.445
LIG_LIR_Nem_3	193	198	PF02991	0.573
LIG_LIR_Nem_3	231	237	PF02991	0.570
LIG_LIR_Nem_3	6	11	PF02991	0.375
LIG_NRBOX	14	20	PF00104	0.445
LIG_SH2_CRK	153	157	PF00017	0.431
LIG_SH2_SRC	11	14	PF00017	0.454
LIG_SH2_STAT5	11	14	PF00017	0.331
LIG_SH3_3	107	113	PF00018	0.671
LIG_SH3_3	244	250	PF00018	0.627
LIG_SH3_3	329	335	PF00018	0.538
LIG_SUMO_SIM_anti_2	13	19	PF11976	0.446
LIG_SUMO_SIM_par_1	25	30	PF11976	0.563
LIG_TRAF2_1	207	210	PF00917	0.474
LIG_TRAF2_1	30	33	PF00917	0.501
LIG_TRAF2_1	65	68	PF00917	0.477
LIG_ULM_U2AF65_1	420	425	PF00076	0.685
LIG_WRC_WIRS_1	5	10	PF05994	0.398
LIG_WW_3	294	298	PF00397	0.589
MOD_CK1_1	159	165	PF00069	0.596
MOD_CK1_1	182	188	PF00069	0.782
MOD_CK1_1	190	196	PF00069	0.638
MOD_CK1_1	336	342	PF00069	0.638
MOD_CK1_1	401	407	PF00069	0.718
MOD_CK1_1	7	13	PF00069	0.355
MOD_CK2_1	185	191	PF00069	0.676
MOD_CK2_1	202	208	PF00069	0.424
MOD_CK2_1	27	33	PF00069	0.452
MOD_CK2_1	274	280	PF00069	0.668
MOD_CK2_1	62	68	PF00069	0.400
MOD_GlcNHglycan	116	119	PF01048	0.599
MOD_GlcNHglycan	129	132	PF01048	0.574
MOD_GlcNHglycan	187	190	PF01048	0.580
MOD_GlcNHglycan	269	272	PF01048	0.722
MOD_GlcNHglycan	307	310	PF01048	0.727
MOD_GlcNHglycan	335	338	PF01048	0.642
MOD_GlcNHglycan	363	366	PF01048	0.692
MOD_GlcNHglycan	375	378	PF01048	0.602
MOD_GlcNHglycan	41	44	PF01048	0.555
MOD_GlcNHglycan	80	83	PF01048	0.391
MOD_GSK3_1	123	130	PF00069	0.655
MOD_GSK3_1	156	163	PF00069	0.561
MOD_GSK3_1	178	185	PF00069	0.666
MOD_GSK3_1	187	194	PF00069	0.745
MOD_GSK3_1	35	42	PF00069	0.624
MOD_GSK3_1	361	368	PF00069	0.724
MOD_GSK3_1	371	378	PF00069	0.753
MOD_GSK3_1	397	404	PF00069	0.729
MOD_N-GLC_1	121	126	PF02516	0.711
MOD_N-GLC_1	39	44	PF02516	0.717
MOD_N-GLC_2	359	361	PF02516	0.599
MOD_NEK2_1	80	85	PF00069	0.399
MOD_NEK2_2	141	146	PF00069	0.392
MOD_NEK2_2	228	233	PF00069	0.405
MOD_PIKK_1	221	227	PF00454	0.529
MOD_PIKK_1	398	404	PF00454	0.641
MOD_PKA_1	411	417	PF00069	0.698
MOD_PKA_2	274	280	PF00069	0.498
MOD_PKA_2	333	339	PF00069	0.575
MOD_PKB_1	348	356	PF00069	0.529
MOD_Plk_1	27	33	PF00069	0.494
MOD_Plk_2-3	191	197	PF00069	0.569
MOD_Plk_4	148	154	PF00069	0.550
MOD_Plk_4	228	234	PF00069	0.458
MOD_Plk_4	243	249	PF00069	0.712
MOD_Plk_4	319	325	PF00069	0.619
MOD_Plk_4	342	348	PF00069	0.535
MOD_Plk_4	7	13	PF00069	0.406
MOD_ProDKin_1	109	115	PF00069	0.718
MOD_ProDKin_1	202	208	PF00069	0.685
MOD_ProDKin_1	375	381	PF00069	0.715
MOD_ProDKin_1	59	65	PF00069	0.524
TRG_DiLeu_BaEn_1	210	215	PF01217	0.513
TRG_DiLeu_BaEn_1	280	285	PF01217	0.637
TRG_DiLeu_BaLyEn_6	66	71	PF01217	0.449
TRG_ENDOCYTIC_2	153	156	PF00928	0.428
TRG_ER_diArg_1	100	103	PF00400	0.504
TRG_ER_diArg_1	296	299	PF00400	0.609
TRG_ER_diArg_1	329	331	PF00400	0.612
TRG_ER_diArg_1	347	350	PF00400	0.390
TRG_ER_diArg_1	420	423	PF00400	0.693
TRG_ER_diArg_1	88	91	PF00400	0.406

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFS7	Leptomonas seymouri	44%	98%
A0A1X0P881	Trypanosomatidae	28%	94%
A0A3Q8IFT7	Leishmania donovani	89%	100%
A0A422NK60	Trypanosoma rangeli	28%	100%
A4HNT7	Leishmania braziliensis	68%	100%
A4ICQ7	Leishmania infantum	90%	100%
D0A2Q4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9ASJ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
V5BZW6	Trypanosoma cruzi	28%	100%