General transcription factor IIH subunit 4

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TFIIH basal transcription factor subunit, putative

Species:

Leishmania major

UniProt:

Q4Q1Z6_LEIMA

TriTrypDb:

LmjF.36.0800 , LMJLV39_360013700 , LMJSD75_360013700

Length:

626

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000439	transcription factor TFIIH core complex	4	12
GO:0005654	nucleoplasm	2	2
GO:0005667	transcription regulator complex	2	12
GO:0005675	transcription factor TFIIH holo complex	4	2
GO:0032806	carboxy-terminal domain protein kinase complex	3	2
GO:0032991	protein-containing complex	1	12
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	2
GO:0090575	RNA polymerase II transcription regulator complex	3	12
GO:0110165	cellular anatomical entity	1	2
GO:0140513	nuclear protein-containing complex	2	12
GO:1902494	catalytic complex	2	2
GO:1902554	serine/threonine protein kinase complex	6	2
GO:1902911	protein kinase complex	5	2
GO:1990234	transferase complex	3	2

Expansion

Sequence features

Q4Q1Z6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1Z6

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006281	DNA repair	5	12
GO:0006289	nucleotide-excision repair	6	12
GO:0006355	regulation of DNA-templated transcription	6	2
GO:0006357	regulation of transcription by RNA polymerase II	7	2
GO:0006468	protein phosphorylation	5	2
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	12
GO:0006950	response to stress	2	12
GO:0006974	DNA damage response	4	12
GO:0008152	metabolic process	1	12
GO:0009889	regulation of biosynthetic process	4	2
GO:0009987	cellular process	1	12
GO:0010468	regulation of gene expression	5	2
GO:0010556	regulation of macromolecule biosynthetic process	5	2
GO:0016310	phosphorylation	5	2
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	2
GO:0019222	regulation of metabolic process	3	2
GO:0019538	protein metabolic process	3	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031326	regulation of cellular biosynthetic process	5	2
GO:0033554	cellular response to stress	3	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	2
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0050896	response to stimulus	1	12
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051252	regulation of RNA metabolic process	5	2
GO:0051716	cellular response to stimulus	2	12
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0070816	obsolete phosphorylation of RNA polymerase II C-terminal domain	6	2
GO:0071704	organic substance metabolic process	2	12
GO:0080090	regulation of primary metabolic process	4	2
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1903506	regulation of nucleic acid-templated transcription	7	2
GO:2001141	regulation of RNA biosynthetic process	6	2

Molecular functions
Term	Name	Level	Count
GO:0001671	ATPase activator activity	3	12
GO:0003676	nucleic acid binding	3	2
GO:0003677	DNA binding	4	2
GO:0003690	double-stranded DNA binding	5	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:0098772	molecular function regulator activity	1	12
GO:0140677	molecular function activator activity	2	12
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	541	545	PF00656	0.629
CLV_NRD_NRD_1	112	114	PF00675	0.524
CLV_NRD_NRD_1	26	28	PF00675	0.455
CLV_NRD_NRD_1	269	271	PF00675	0.269
CLV_NRD_NRD_1	373	375	PF00675	0.366
CLV_NRD_NRD_1	419	421	PF00675	0.284
CLV_NRD_NRD_1	475	477	PF00675	0.322
CLV_NRD_NRD_1	498	500	PF00675	0.626
CLV_NRD_NRD_1	529	531	PF00675	0.614
CLV_NRD_NRD_1	567	569	PF00675	0.413
CLV_PCSK_KEX2_1	112	114	PF00082	0.521
CLV_PCSK_KEX2_1	224	226	PF00082	0.511
CLV_PCSK_KEX2_1	25	27	PF00082	0.458
CLV_PCSK_KEX2_1	419	421	PF00082	0.284
CLV_PCSK_KEX2_1	498	500	PF00082	0.577
CLV_PCSK_KEX2_1	529	531	PF00082	0.617
CLV_PCSK_KEX2_1	567	569	PF00082	0.400
CLV_PCSK_PC1ET2_1	224	226	PF00082	0.511
CLV_PCSK_SKI1_1	182	186	PF00082	0.523
CLV_PCSK_SKI1_1	224	228	PF00082	0.410
CLV_PCSK_SKI1_1	250	254	PF00082	0.395
CLV_PCSK_SKI1_1	27	31	PF00082	0.443
CLV_PCSK_SKI1_1	271	275	PF00082	0.346
CLV_PCSK_SKI1_1	299	303	PF00082	0.337
CLV_PCSK_SKI1_1	322	326	PF00082	0.335
CLV_PCSK_SKI1_1	477	481	PF00082	0.419
CLV_PCSK_SKI1_1	568	572	PF00082	0.435
CLV_PCSK_SKI1_1	587	591	PF00082	0.319
DEG_APCC_DBOX_1	181	189	PF00400	0.508
DOC_CKS1_1	202	207	PF01111	0.381
DOC_CKS1_1	260	265	PF01111	0.292
DOC_CYCLIN_RxL_1	177	186	PF00134	0.451
DOC_CYCLIN_RxL_1	296	304	PF00134	0.362
DOC_MAPK_FxFP_2	342	345	PF00069	0.367
DOC_PP1_RVXF_1	24	31	PF00149	0.446
DOC_PP1_RVXF_1	320	327	PF00149	0.413
DOC_PP1_RVXF_1	565	572	PF00149	0.418
DOC_PP2B_LxvP_1	549	552	PF13499	0.488
DOC_PP2B_LxvP_1	620	623	PF13499	0.442
DOC_PP2B_LxvP_1	72	75	PF13499	0.476
DOC_PP4_FxxP_1	196	199	PF00568	0.601
DOC_PP4_FxxP_1	342	345	PF00568	0.367
DOC_USP7_MATH_1	132	136	PF00917	0.540
DOC_USP7_MATH_1	492	496	PF00917	0.317
DOC_USP7_MATH_1	510	514	PF00917	0.619
DOC_USP7_MATH_1	518	522	PF00917	0.619
DOC_WW_Pin1_4	201	206	PF00397	0.471
DOC_WW_Pin1_4	259	264	PF00397	0.313
DOC_WW_Pin1_4	271	276	PF00397	0.413
DOC_WW_Pin1_4	377	382	PF00397	0.297
DOC_WW_Pin1_4	508	513	PF00397	0.626
DOC_WW_Pin1_4	524	529	PF00397	0.447
LIG_14-3-3_CanoR_1	134	143	PF00244	0.538
LIG_14-3-3_CanoR_1	166	170	PF00244	0.509
LIG_14-3-3_CanoR_1	182	192	PF00244	0.553
LIG_14-3-3_CanoR_1	218	227	PF00244	0.447
LIG_14-3-3_CanoR_1	27	37	PF00244	0.439
LIG_14-3-3_CanoR_1	359	367	PF00244	0.280
LIG_14-3-3_CanoR_1	468	472	PF00244	0.249
LIG_14-3-3_CanoR_1	476	485	PF00244	0.292
LIG_14-3-3_CanoR_1	486	491	PF00244	0.336
LIG_14-3-3_CanoR_1	579	589	PF00244	0.489
LIG_Actin_WH2_2	213	230	PF00022	0.427
LIG_APCC_ABBAyCdc20_2	26	32	PF00400	0.444
LIG_BIR_III_4	178	182	PF00653	0.325
LIG_BRCT_BRCA1_1	136	140	PF00533	0.629
LIG_BRCT_BRCA1_1	157	161	PF00533	0.388
LIG_BRCT_BRCA1_1	222	226	PF00533	0.502
LIG_BRCT_BRCA1_1	379	383	PF00533	0.320
LIG_BRCT_BRCA1_1	395	399	PF00533	0.395
LIG_BRCT_BRCA1_1	518	522	PF00533	0.702
LIG_CaM_IQ_9	105	121	PF13499	0.521
LIG_CtBP_PxDLS_1	394	398	PF00389	0.395
LIG_FHA_1	230	236	PF00498	0.438
LIG_FHA_1	237	243	PF00498	0.475
LIG_FHA_1	319	325	PF00498	0.414
LIG_FHA_1	336	342	PF00498	0.456
LIG_FHA_1	421	427	PF00498	0.453
LIG_FHA_1	538	544	PF00498	0.684
LIG_FHA_1	546	552	PF00498	0.505
LIG_FHA_1	588	594	PF00498	0.519
LIG_FHA_2	13	19	PF00498	0.433
LIG_FHA_2	202	208	PF00498	0.663
LIG_FHA_2	539	545	PF00498	0.713
LIG_LIR_Apic_2	170	176	PF02991	0.558
LIG_LIR_Gen_1	137	146	PF02991	0.606
LIG_LIR_Gen_1	279	285	PF02991	0.457
LIG_LIR_Gen_1	606	617	PF02991	0.377
LIG_LIR_LC3C_4	547	551	PF02991	0.521
LIG_LIR_Nem_3	137	143	PF02991	0.552
LIG_LIR_Nem_3	279	283	PF02991	0.457
LIG_LIR_Nem_3	429	435	PF02991	0.269
LIG_LIR_Nem_3	606	612	PF02991	0.377
LIG_LIR_Nem_3	614	620	PF02991	0.351
LIG_LYPXL_S_1	366	370	PF13949	0.284
LIG_LYPXL_yS_3	367	370	PF13949	0.284
LIG_MAD2	27	35	PF02301	0.440
LIG_NRBOX	126	132	PF00104	0.597
LIG_NRBOX	324	330	PF00104	0.284
LIG_PCNA_PIPBox_1	586	595	PF02747	0.537
LIG_PCNA_yPIPBox_3	245	253	PF02747	0.364
LIG_PCNA_yPIPBox_3	288	301	PF02747	0.337
LIG_PCNA_yPIPBox_3	579	593	PF02747	0.538
LIG_SH2_CRK	609	613	PF00017	0.404
LIG_SH2_GRB2like	437	440	PF00017	0.201
LIG_SH2_SRC	101	104	PF00017	0.499
LIG_SH2_STAP1	101	105	PF00017	0.332
LIG_SH2_STAP1	437	441	PF00017	0.395
LIG_SH2_STAT5	340	343	PF00017	0.367
LIG_SH2_STAT5	437	440	PF00017	0.298
LIG_SH2_STAT5	592	595	PF00017	0.537
LIG_SH3_3	199	205	PF00018	0.555
LIG_SH3_3	207	213	PF00018	0.524
LIG_SH3_3	257	263	PF00018	0.376
LIG_SH3_3	317	323	PF00018	0.395
LIG_SH3_3	375	381	PF00018	0.318
LIG_SUMO_SIM_anti_2	298	304	PF11976	0.339
LIG_SUMO_SIM_anti_2	56	62	PF11976	0.521
LIG_SUMO_SIM_par_1	128	135	PF11976	0.608
LIG_SUMO_SIM_par_1	212	217	PF11976	0.539
LIG_SUMO_SIM_par_1	298	304	PF11976	0.371
LIG_SUMO_SIM_par_1	327	333	PF11976	0.337
LIG_SUMO_SIM_par_1	35	41	PF11976	0.441
LIG_SUMO_SIM_par_1	392	398	PF11976	0.395
LIG_SUMO_SIM_par_1	96	102	PF11976	0.542
LIG_TRFH_1	209	213	PF08558	0.571
LIG_TRFH_1	377	381	PF08558	0.280
LIG_TYR_ITIM	365	370	PF00017	0.328
LIG_TYR_ITIM	99	104	PF00017	0.438
LIG_WW_3	267	271	PF00397	0.269
MOD_CDC14_SPxK_1	527	530	PF00782	0.543
MOD_CDK_SPK_2	524	529	PF00069	0.546
MOD_CDK_SPxK_1	524	530	PF00069	0.545
MOD_CK1_1	155	161	PF00069	0.470
MOD_CK1_1	315	321	PF00069	0.390
MOD_CK1_1	408	414	PF00069	0.439
MOD_CK1_1	45	51	PF00069	0.608
MOD_CK1_1	511	517	PF00069	0.686
MOD_CK1_1	520	526	PF00069	0.669
MOD_CK1_1	539	545	PF00069	0.378
MOD_CK1_1	66	72	PF00069	0.647
MOD_CK1_1	82	88	PF00069	0.484
MOD_CK2_1	12	18	PF00069	0.432
MOD_CK2_1	132	138	PF00069	0.472
MOD_CK2_1	201	207	PF00069	0.468
MOD_Cter_Amidation	110	113	PF01082	0.515
MOD_GlcNHglycan	314	317	PF01048	0.382
MOD_GlcNHglycan	391	394	PF01048	0.349
MOD_GlcNHglycan	405	408	PF01048	0.366
MOD_GlcNHglycan	410	413	PF01048	0.421
MOD_GlcNHglycan	44	47	PF01048	0.439
MOD_GlcNHglycan	513	516	PF01048	0.644
MOD_GlcNHglycan	524	527	PF01048	0.617
MOD_GlcNHglycan	61	64	PF01048	0.558
MOD_GlcNHglycan	69	72	PF01048	0.551
MOD_GlcNHglycan	7	10	PF01048	0.488
MOD_GSK3_1	152	159	PF00069	0.634
MOD_GSK3_1	311	318	PF00069	0.466
MOD_GSK3_1	330	337	PF00069	0.160
MOD_GSK3_1	37	44	PF00069	0.445
MOD_GSK3_1	389	396	PF00069	0.336
MOD_GSK3_1	506	513	PF00069	0.623
MOD_GSK3_1	516	523	PF00069	0.668
MOD_GSK3_1	533	540	PF00069	0.474
MOD_GSK3_1	587	594	PF00069	0.423
MOD_GSK3_1	59	66	PF00069	0.505
MOD_N-GLC_1	312	317	PF02516	0.309
MOD_N-GLC_1	579	584	PF02516	0.422
MOD_N-GLC_1	63	68	PF02516	0.414
MOD_NEK2_1	118	123	PF00069	0.579
MOD_NEK2_1	146	151	PF00069	0.670
MOD_NEK2_1	152	157	PF00069	0.396
MOD_NEK2_1	220	225	PF00069	0.390
MOD_NEK2_1	226	231	PF00069	0.398
MOD_NEK2_1	301	306	PF00069	0.328
MOD_NEK2_1	335	340	PF00069	0.214
MOD_NEK2_1	37	42	PF00069	0.446
MOD_NEK2_1	395	400	PF00069	0.339
MOD_NEK2_1	403	408	PF00069	0.285
MOD_NEK2_1	5	10	PF00069	0.424
MOD_NEK2_1	522	527	PF00069	0.763
MOD_NEK2_1	65	70	PF00069	0.629
MOD_PIKK_1	144	150	PF00454	0.564
MOD_PIKK_1	156	162	PF00454	0.437
MOD_PIKK_1	183	189	PF00454	0.402
MOD_PIKK_1	335	341	PF00454	0.259
MOD_PIKK_1	580	586	PF00454	0.362
MOD_PKA_2	118	124	PF00069	0.664
MOD_PKA_2	165	171	PF00069	0.506
MOD_PKA_2	358	364	PF00069	0.280
MOD_PKA_2	464	470	PF00069	0.277
MOD_Plk_1	335	341	PF00069	0.259
MOD_Plk_4	330	336	PF00069	0.439
MOD_Plk_4	422	428	PF00069	0.278
MOD_Plk_4	492	498	PF00069	0.420
MOD_Plk_4	545	551	PF00069	0.501
MOD_ProDKin_1	201	207	PF00069	0.468
MOD_ProDKin_1	259	265	PF00069	0.313
MOD_ProDKin_1	271	277	PF00069	0.413
MOD_ProDKin_1	377	383	PF00069	0.297
MOD_ProDKin_1	508	514	PF00069	0.622
MOD_ProDKin_1	524	530	PF00069	0.447
MOD_SUMO_rev_2	371	377	PF00179	0.292
TRG_DiLeu_BaEn_1	298	303	PF01217	0.337
TRG_DiLeu_BaEn_1	92	97	PF01217	0.370
TRG_DiLeu_BaLyEn_6	320	325	PF01217	0.395
TRG_DiLeu_BaLyEn_6	33	38	PF01217	0.437
TRG_DiLeu_BaLyEn_6	365	370	PF01217	0.290
TRG_DiLeu_BaLyEn_6	620	625	PF01217	0.387
TRG_ENDOCYTIC_2	101	104	PF00928	0.389
TRG_ENDOCYTIC_2	367	370	PF00928	0.291
TRG_ENDOCYTIC_2	609	612	PF00928	0.346
TRG_ER_diArg_1	24	27	PF00400	0.454
TRG_ER_diArg_1	418	420	PF00400	0.287
TRG_ER_diArg_1	497	499	PF00400	0.627
TRG_ER_diArg_1	528	530	PF00400	0.591
TRG_ER_diArg_1	567	569	PF00400	0.414
TRG_Pf-PMV_PEXEL_1	134	138	PF00026	0.462
TRG_Pf-PMV_PEXEL_1	182	187	PF00026	0.510

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7V5	Leptomonas seymouri	65%	100%
A0A0S4JS94	Bodo saltans	28%	100%
A0A1X0P966	Trypanosomatidae	42%	100%
A0A3S5H816	Leishmania donovani	94%	100%
A0A422NK89	Trypanosoma rangeli	45%	100%
A4HNU0	Leishmania braziliensis	83%	100%
A4ICQ4	Leishmania infantum	93%	100%
D0A2Q5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9ASK0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5B9Y1	Trypanosoma cruzi	44%	100%