Zinc_finger_protein_-_putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc finger protein family member, putative

Species:

Leishmania major

UniProt:

Q4Q1Z2_LEIMA

TriTrypDb:

LmjF.36.0840 , LMJLV39_360014100 , LMJSD75_360014100

Length:

784

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q1Z2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1Z2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	441	445	PF00656	0.663
CLV_C14_Caspase3-7	520	524	PF00656	0.586
CLV_C14_Caspase3-7	750	754	PF00656	0.709
CLV_NRD_NRD_1	404	406	PF00675	0.643
CLV_NRD_NRD_1	487	489	PF00675	0.621
CLV_NRD_NRD_1	565	567	PF00675	0.561
CLV_PCSK_FUR_1	243	247	PF00082	0.480
CLV_PCSK_FUR_1	402	406	PF00082	0.564
CLV_PCSK_KEX2_1	245	247	PF00082	0.502
CLV_PCSK_KEX2_1	404	406	PF00082	0.603
CLV_PCSK_KEX2_1	487	489	PF00082	0.621
CLV_PCSK_KEX2_1	565	567	PF00082	0.561
CLV_PCSK_PC1ET2_1	245	247	PF00082	0.578
CLV_PCSK_SKI1_1	342	346	PF00082	0.408
CLV_PCSK_SKI1_1	719	723	PF00082	0.702
CLV_PCSK_SKI1_1	746	750	PF00082	0.685
CLV_Separin_Metazoa	408	412	PF03568	0.497
DEG_Nend_Nbox_1	1	3	PF02207	0.679
DEG_SPOP_SBC_1	668	672	PF00917	0.704
DEG_SPOP_SBC_1	702	706	PF00917	0.686
DEG_SPOP_SBC_1	752	756	PF00917	0.633
DOC_CKS1_1	124	129	PF01111	0.450
DOC_CKS1_1	548	553	PF01111	0.613
DOC_CKS1_1	713	718	PF01111	0.704
DOC_CYCLIN_RxL_1	339	348	PF00134	0.414
DOC_CYCLIN_yCln2_LP_2	119	125	PF00134	0.506
DOC_MAPK_gen_1	277	287	PF00069	0.383
DOC_MAPK_gen_1	350	357	PF00069	0.404
DOC_MAPK_gen_1	400	409	PF00069	0.530
DOC_MAPK_gen_1	562	570	PF00069	0.570
DOC_MAPK_gen_1	89	98	PF00069	0.566
DOC_MAPK_MEF2A_6	220	227	PF00069	0.374
DOC_MAPK_MEF2A_6	350	359	PF00069	0.477
DOC_PP2B_LxvP_1	119	122	PF13499	0.520
DOC_PP4_FxxP_1	140	143	PF00568	0.460
DOC_USP7_MATH_1	226	230	PF00917	0.350
DOC_USP7_MATH_1	424	428	PF00917	0.576
DOC_USP7_MATH_1	481	485	PF00917	0.660
DOC_USP7_MATH_1	514	518	PF00917	0.595
DOC_USP7_MATH_1	522	526	PF00917	0.615
DOC_USP7_MATH_1	57	61	PF00917	0.627
DOC_USP7_MATH_1	694	698	PF00917	0.663
DOC_USP7_MATH_1	702	706	PF00917	0.623
DOC_USP7_MATH_1	737	741	PF00917	0.654
DOC_USP7_MATH_1	744	748	PF00917	0.640
DOC_USP7_MATH_1	752	756	PF00917	0.551
DOC_WW_Pin1_4	123	128	PF00397	0.453
DOC_WW_Pin1_4	389	394	PF00397	0.547
DOC_WW_Pin1_4	5	10	PF00397	0.619
DOC_WW_Pin1_4	547	552	PF00397	0.624
DOC_WW_Pin1_4	569	574	PF00397	0.600
DOC_WW_Pin1_4	656	661	PF00397	0.723
DOC_WW_Pin1_4	712	717	PF00397	0.707
LIG_14-3-3_CanoR_1	201	205	PF00244	0.413
LIG_14-3-3_CanoR_1	309	314	PF00244	0.374
LIG_14-3-3_CanoR_1	488	494	PF00244	0.632
LIG_14-3-3_CanoR_1	502	512	PF00244	0.438
LIG_14-3-3_CanoR_1	691	699	PF00244	0.543
LIG_14-3-3_CanoR_1	746	752	PF00244	0.714
LIG_BIR_III_2	394	398	PF00653	0.461
LIG_BRCT_BRCA1_1	190	194	PF00533	0.404
LIG_BRCT_BRCA1_1	228	232	PF00533	0.361
LIG_BRCT_BRCA1_1	508	512	PF00533	0.556
LIG_BRCT_BRCA1_1	524	528	PF00533	0.623
LIG_BRCT_BRCA1_1	654	658	PF00533	0.666
LIG_BRCT_BRCA1_2	228	234	PF00533	0.357
LIG_Clathr_ClatBox_1	663	667	PF01394	0.695
LIG_deltaCOP1_diTrp_1	653	658	PF00928	0.667
LIG_FHA_1	209	215	PF00498	0.397
LIG_FHA_1	231	237	PF00498	0.379
LIG_FHA_1	269	275	PF00498	0.588
LIG_FHA_1	316	322	PF00498	0.431
LIG_FHA_1	598	604	PF00498	0.562
LIG_FHA_1	659	665	PF00498	0.628
LIG_FHA_2	183	189	PF00498	0.428
LIG_FHA_2	318	324	PF00498	0.399
LIG_FHA_2	439	445	PF00498	0.631
LIG_FHA_2	637	643	PF00498	0.592
LIG_IBAR_NPY_1	513	515	PF08397	0.588
LIG_Integrin_isoDGR_2	87	89	PF01839	0.670
LIG_LIR_Apic_2	20	25	PF02991	0.674
LIG_LIR_Apic_2	697	702	PF02991	0.685
LIG_LIR_Gen_1	209	219	PF02991	0.474
LIG_LIR_Gen_1	288	299	PF02991	0.424
LIG_LIR_Gen_1	300	311	PF02991	0.377
LIG_LIR_Gen_1	385	393	PF02991	0.423
LIG_LIR_Gen_1	525	532	PF02991	0.677
LIG_LIR_Nem_3	16	22	PF02991	0.641
LIG_LIR_Nem_3	209	215	PF02991	0.397
LIG_LIR_Nem_3	288	294	PF02991	0.421
LIG_LIR_Nem_3	300	306	PF02991	0.384
LIG_LIR_Nem_3	509	515	PF02991	0.573
LIG_LIR_Nem_3	525	531	PF02991	0.634
LIG_PALB2_WD40_1	298	306	PF16756	0.394
LIG_Pex14_2	299	303	PF04695	0.394
LIG_Pex14_2	652	656	PF04695	0.671
LIG_PTB_Apo_2	305	312	PF02174	0.395
LIG_SH2_CRK	22	26	PF00017	0.752
LIG_SH2_CRK	515	519	PF00017	0.672
LIG_SH2_CRK	621	625	PF00017	0.715
LIG_SH2_NCK_1	22	26	PF00017	0.786
LIG_SH2_PTP2	237	240	PF00017	0.507
LIG_SH2_PTP2	699	702	PF00017	0.639
LIG_SH2_SRC	22	25	PF00017	0.669
LIG_SH2_SRC	237	240	PF00017	0.507
LIG_SH2_SRC	699	702	PF00017	0.639
LIG_SH2_STAP1	104	108	PF00017	0.551
LIG_SH2_STAP1	19	23	PF00017	0.685
LIG_SH2_STAT3	104	107	PF00017	0.677
LIG_SH2_STAT5	181	184	PF00017	0.487
LIG_SH2_STAT5	237	240	PF00017	0.621
LIG_SH2_STAT5	28	31	PF00017	0.629
LIG_SH2_STAT5	310	313	PF00017	0.386
LIG_SH2_STAT5	379	382	PF00017	0.357
LIG_SH2_STAT5	549	552	PF00017	0.697
LIG_SH2_STAT5	699	702	PF00017	0.639
LIG_SH3_3	121	127	PF00018	0.453
LIG_SH3_3	140	146	PF00018	0.361
LIG_SH3_3	220	226	PF00018	0.417
LIG_SH3_3	318	324	PF00018	0.399
LIG_SH3_3	621	627	PF00018	0.660
LIG_SUMO_SIM_par_1	121	126	PF11976	0.403
LIG_SUMO_SIM_par_1	566	572	PF11976	0.577
LIG_TRAF2_1	160	163	PF00917	0.379
LIG_TRAF2_1	451	454	PF00917	0.622
LIG_TRFH_1	311	315	PF08558	0.394
MOD_CDK_SPxxK_3	712	719	PF00069	0.707
MOD_CK1_1	13	19	PF00069	0.619
MOD_CK1_1	208	214	PF00069	0.476
MOD_CK1_1	328	334	PF00069	0.402
MOD_CK1_1	480	486	PF00069	0.656
MOD_CK1_1	506	512	PF00069	0.557
MOD_CK1_1	517	523	PF00069	0.603
MOD_CK1_1	558	564	PF00069	0.754
MOD_CK1_1	572	578	PF00069	0.613
MOD_CK1_1	669	675	PF00069	0.708
MOD_CK1_1	695	701	PF00069	0.686
MOD_CK1_1	704	710	PF00069	0.597
MOD_CK1_1	723	729	PF00069	0.496
MOD_CK1_1	736	742	PF00069	0.564
MOD_CK1_1	747	753	PF00069	0.600
MOD_CK1_1	754	760	PF00069	0.521
MOD_CK1_1	764	770	PF00069	0.529
MOD_CK2_1	107	113	PF00069	0.500
MOD_CK2_1	182	188	PF00069	0.465
MOD_CK2_1	433	439	PF00069	0.539
MOD_CK2_1	636	642	PF00069	0.556
MOD_CMANNOS	278	281	PF00535	0.405
MOD_GlcNHglycan	12	15	PF01048	0.611
MOD_GlcNHglycan	135	138	PF01048	0.495
MOD_GlcNHglycan	426	429	PF01048	0.516
MOD_GlcNHglycan	435	438	PF01048	0.619
MOD_GlcNHglycan	479	482	PF01048	0.790
MOD_GlcNHglycan	48	51	PF01048	0.588
MOD_GlcNHglycan	491	494	PF01048	0.515
MOD_GlcNHglycan	536	539	PF01048	0.752
MOD_GlcNHglycan	574	577	PF01048	0.700
MOD_GlcNHglycan	636	639	PF01048	0.561
MOD_GlcNHglycan	735	738	PF01048	0.650
MOD_GlcNHglycan	746	749	PF01048	0.606
MOD_GlcNHglycan	77	80	PF01048	0.605
MOD_GSK3_1	126	133	PF00069	0.415
MOD_GSK3_1	13	20	PF00069	0.617
MOD_GSK3_1	226	233	PF00069	0.353
MOD_GSK3_1	473	480	PF00069	0.645
MOD_GSK3_1	543	550	PF00069	0.693
MOD_GSK3_1	57	64	PF00069	0.589
MOD_GSK3_1	652	659	PF00069	0.766
MOD_GSK3_1	666	673	PF00069	0.623
MOD_GSK3_1	690	697	PF00069	0.611
MOD_GSK3_1	701	708	PF00069	0.652
MOD_GSK3_1	719	726	PF00069	0.514
MOD_GSK3_1	733	740	PF00069	0.550
MOD_GSK3_1	747	754	PF00069	0.566
MOD_GSK3_1	763	770	PF00069	0.542
MOD_N-GLC_1	10	15	PF02516	0.579
MOD_N-GLC_1	481	486	PF02516	0.621
MOD_N-GLC_1	489	494	PF02516	0.615
MOD_N-GLC_1	543	548	PF02516	0.624
MOD_N-GLC_1	675	680	PF02516	0.724
MOD_N-GLC_1	695	700	PF02516	0.480
MOD_N-GLC_1	723	728	PF02516	0.619
MOD_N-GLC_1	75	80	PF02516	0.718
MOD_NEK2_1	182	187	PF00069	0.401
MOD_NEK2_1	230	235	PF00069	0.446
MOD_NEK2_1	326	331	PF00069	0.413
MOD_NEK2_1	345	350	PF00069	0.468
MOD_NEK2_1	489	494	PF00069	0.649
MOD_NEK2_1	652	657	PF00069	0.776
MOD_NEK2_1	666	671	PF00069	0.611
MOD_NEK2_1	690	695	PF00069	0.676
MOD_NEK2_1	733	738	PF00069	0.693
MOD_NEK2_1	761	766	PF00069	0.720
MOD_NEK2_2	34	39	PF00069	0.686
MOD_OFUCOSY	364	369	PF10250	0.496
MOD_PIKK_1	636	642	PF00454	0.556
MOD_PIKK_1	705	711	PF00454	0.689
MOD_PK_1	210	216	PF00069	0.462
MOD_PK_1	351	357	PF00069	0.389
MOD_PK_1	675	681	PF00069	0.722
MOD_PKA_2	200	206	PF00069	0.467
MOD_PKA_2	534	540	PF00069	0.647
MOD_PKA_2	690	696	PF00069	0.545
MOD_PKA_2	771	777	PF00069	0.681
MOD_Plk_1	187	193	PF00069	0.482
MOD_Plk_1	208	214	PF00069	0.550
MOD_Plk_1	315	321	PF00069	0.429
MOD_Plk_1	481	487	PF00069	0.621
MOD_Plk_1	494	500	PF00069	0.639
MOD_Plk_1	652	658	PF00069	0.669
MOD_Plk_1	695	701	PF00069	0.686
MOD_Plk_2-3	317	323	PF00069	0.396
MOD_Plk_4	126	132	PF00069	0.420
MOD_Plk_4	17	23	PF00069	0.727
MOD_Plk_4	188	194	PF00069	0.497
MOD_Plk_4	226	232	PF00069	0.375
MOD_Plk_4	695	701	PF00069	0.637
MOD_Plk_4	771	777	PF00069	0.681
MOD_ProDKin_1	123	129	PF00069	0.447
MOD_ProDKin_1	389	395	PF00069	0.546
MOD_ProDKin_1	5	11	PF00069	0.619
MOD_ProDKin_1	547	553	PF00069	0.614
MOD_ProDKin_1	569	575	PF00069	0.602
MOD_ProDKin_1	656	662	PF00069	0.720
MOD_ProDKin_1	712	718	PF00069	0.705
MOD_SUMO_for_1	415	418	PF00179	0.511
MOD_SUMO_rev_2	213	222	PF00179	0.472
MOD_SUMO_rev_2	443	451	PF00179	0.682
MOD_SUMO_rev_2	558	564	PF00179	0.503
TRG_DiLeu_BaEn_4	398	404	PF01217	0.520
TRG_DiLeu_BaLyEn_6	659	664	PF01217	0.668
TRG_ENDOCYTIC_2	310	313	PF00928	0.386
TRG_ENDOCYTIC_2	379	382	PF00928	0.362
TRG_ENDOCYTIC_2	515	518	PF00928	0.597
TRG_ENDOCYTIC_2	621	624	PF00928	0.718
TRG_ER_diArg_1	402	405	PF00400	0.648
TRG_ER_diArg_1	487	489	PF00400	0.621
TRG_ER_diArg_1	564	566	PF00400	0.574
TRG_ER_diArg_1	730	733	PF00400	0.546
TRG_NLS_MonoExtN_4	243	249	PF00514	0.578
TRG_Pf-PMV_PEXEL_1	342	346	PF00026	0.408

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDN9	Leptomonas seymouri	58%	100%
A0A3S7XAM4	Leishmania donovani	93%	100%
A4HNU4	Leishmania braziliensis	81%	99%
A4ICQ0	Leishmania infantum	94%	100%
E9ASK4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%