Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q1Z1_LEIMA

TriTrypDb:

LmjF.36.0850 , LMJLV39_360014200 , LMJSD75_360014200

Length:

888

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q1Z1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1Z1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	300	304	PF00656	0.668
CLV_C14_Caspase3-7	524	528	PF00656	0.697
CLV_C14_Caspase3-7	561	565	PF00656	0.823
CLV_C14_Caspase3-7	620	624	PF00656	0.722
CLV_NRD_NRD_1	187	189	PF00675	0.463
CLV_NRD_NRD_1	206	208	PF00675	0.629
CLV_NRD_NRD_1	358	360	PF00675	0.585
CLV_NRD_NRD_1	402	404	PF00675	0.840
CLV_NRD_NRD_1	405	407	PF00675	0.806
CLV_NRD_NRD_1	416	418	PF00675	0.555
CLV_NRD_NRD_1	515	517	PF00675	0.757
CLV_NRD_NRD_1	534	536	PF00675	0.529
CLV_NRD_NRD_1	582	584	PF00675	0.832
CLV_NRD_NRD_1	68	70	PF00675	0.755
CLV_NRD_NRD_1	811	813	PF00675	0.627
CLV_PCSK_FUR_1	356	360	PF00082	0.578
CLV_PCSK_FUR_1	403	407	PF00082	0.619
CLV_PCSK_KEX2_1	159	161	PF00082	0.681
CLV_PCSK_KEX2_1	187	189	PF00082	0.463
CLV_PCSK_KEX2_1	206	208	PF00082	0.629
CLV_PCSK_KEX2_1	358	360	PF00082	0.691
CLV_PCSK_KEX2_1	402	404	PF00082	0.840
CLV_PCSK_KEX2_1	405	407	PF00082	0.806
CLV_PCSK_KEX2_1	416	418	PF00082	0.555
CLV_PCSK_KEX2_1	515	517	PF00082	0.757
CLV_PCSK_KEX2_1	533	535	PF00082	0.544
CLV_PCSK_KEX2_1	582	584	PF00082	0.832
CLV_PCSK_KEX2_1	68	70	PF00082	0.601
CLV_PCSK_KEX2_1	811	813	PF00082	0.627
CLV_PCSK_PC1ET2_1	159	161	PF00082	0.681
CLV_PCSK_SKI1_1	136	140	PF00082	0.692
CLV_PCSK_SKI1_1	188	192	PF00082	0.453
CLV_PCSK_SKI1_1	384	388	PF00082	0.563
CLV_PCSK_SKI1_1	417	421	PF00082	0.597
CLV_PCSK_SKI1_1	48	52	PF00082	0.686
CLV_PCSK_SKI1_1	555	559	PF00082	0.762
CLV_PCSK_SKI1_1	632	636	PF00082	0.749
CLV_PCSK_SKI1_1	697	701	PF00082	0.662
CLV_PCSK_SKI1_1	828	832	PF00082	0.447
CLV_PCSK_SKI1_1	864	868	PF00082	0.526
DEG_APCC_DBOX_1	309	317	PF00400	0.727
DEG_APCC_DBOX_1	383	391	PF00400	0.572
DEG_APCC_DBOX_1	416	424	PF00400	0.688
DEG_Nend_Nbox_1	1	3	PF02207	0.830
DEG_SCF_FBW7_1	725	732	PF00400	0.685
DEG_SCF_FBW7_1	744	751	PF00400	0.732
DEG_SPOP_SBC_1	95	99	PF00917	0.609
DOC_CKS1_1	281	286	PF01111	0.694
DOC_CKS1_1	745	750	PF01111	0.652
DOC_CYCLIN_RxL_1	140	154	PF00134	0.676
DOC_CYCLIN_RxL_1	694	704	PF00134	0.607
DOC_MAPK_gen_1	543	552	PF00069	0.608
DOC_MAPK_gen_1	695	702	PF00069	0.608
DOC_MAPK_gen_1	845	854	PF00069	0.394
DOC_MAPK_MEF2A_6	384	392	PF00069	0.577
DOC_PP4_FxxP_1	121	124	PF00568	0.689
DOC_PP4_FxxP_1	806	809	PF00568	0.640
DOC_SPAK_OSR1_1	837	841	PF12202	0.573
DOC_USP7_MATH_1	106	110	PF00917	0.617
DOC_USP7_MATH_1	221	225	PF00917	0.720
DOC_USP7_MATH_1	229	233	PF00917	0.663
DOC_USP7_MATH_1	237	241	PF00917	0.546
DOC_USP7_MATH_1	471	475	PF00917	0.695
DOC_USP7_MATH_1	538	542	PF00917	0.668
DOC_USP7_MATH_1	559	563	PF00917	0.782
DOC_USP7_MATH_1	605	609	PF00917	0.721
DOC_USP7_MATH_1	708	712	PF00917	0.755
DOC_USP7_MATH_1	714	718	PF00917	0.801
DOC_USP7_MATH_1	729	733	PF00917	0.609
DOC_USP7_MATH_1	95	99	PF00917	0.815
DOC_USP7_UBL2_3	48	52	PF12436	0.729
DOC_WW_Pin1_4	15	20	PF00397	0.685
DOC_WW_Pin1_4	280	285	PF00397	0.776
DOC_WW_Pin1_4	326	331	PF00397	0.763
DOC_WW_Pin1_4	411	416	PF00397	0.754
DOC_WW_Pin1_4	450	455	PF00397	0.777
DOC_WW_Pin1_4	534	539	PF00397	0.840
DOC_WW_Pin1_4	555	560	PF00397	0.766
DOC_WW_Pin1_4	585	590	PF00397	0.821
DOC_WW_Pin1_4	686	691	PF00397	0.650
DOC_WW_Pin1_4	725	730	PF00397	0.792
DOC_WW_Pin1_4	744	749	PF00397	0.811
DOC_WW_Pin1_4	750	755	PF00397	0.768
LIG_14-3-3_CanoR_1	127	134	PF00244	0.645
LIG_14-3-3_CanoR_1	178	186	PF00244	0.601
LIG_14-3-3_CanoR_1	187	191	PF00244	0.534
LIG_14-3-3_CanoR_1	192	198	PF00244	0.458
LIG_14-3-3_CanoR_1	23	29	PF00244	0.823
LIG_14-3-3_CanoR_1	448	456	PF00244	0.540
LIG_14-3-3_CanoR_1	712	720	PF00244	0.712
LIG_14-3-3_CanoR_1	749	754	PF00244	0.693
LIG_14-3-3_CanoR_1	811	819	PF00244	0.560
LIG_14-3-3_CanoR_1	828	836	PF00244	0.446
LIG_Actin_WH2_2	176	194	PF00022	0.675
LIG_APCC_ABBA_1	880	885	PF00400	0.349
LIG_BIR_III_4	630	634	PF00653	0.742
LIG_BRCT_BRCA1_1	673	677	PF00533	0.618
LIG_BRCT_BRCA1_1	92	96	PF00533	0.742
LIG_EVH1_1	736	740	PF00568	0.814
LIG_FHA_1	100	106	PF00498	0.730
LIG_FHA_1	133	139	PF00498	0.688
LIG_FHA_1	281	287	PF00498	0.709
LIG_FHA_1	395	401	PF00498	0.564
LIG_FHA_1	424	430	PF00498	0.557
LIG_FHA_1	457	463	PF00498	0.572
LIG_FHA_1	487	493	PF00498	0.659
LIG_FHA_1	49	55	PF00498	0.633
LIG_FHA_1	502	508	PF00498	0.402
LIG_FHA_1	572	578	PF00498	0.780
LIG_FHA_1	640	646	PF00498	0.761
LIG_FHA_1	694	700	PF00498	0.824
LIG_FHA_1	720	726	PF00498	0.670
LIG_FHA_1	745	751	PF00498	0.671
LIG_FHA_1	77	83	PF00498	0.719
LIG_FHA_1	825	831	PF00498	0.475
LIG_FHA_2	2	8	PF00498	0.701
LIG_FHA_2	33	39	PF00498	0.706
LIG_FHA_2	625	631	PF00498	0.622
LIG_FHA_2	648	654	PF00498	0.775
LIG_FHA_2	673	679	PF00498	0.668
LIG_GBD_Chelix_1	175	183	PF00786	0.435
LIG_GBD_Chelix_1	316	324	PF00786	0.724
LIG_LIR_Apic_2	120	124	PF02991	0.690
LIG_LIR_Apic_2	733	739	PF02991	0.814
LIG_LIR_Apic_2	803	809	PF02991	0.650
LIG_LIR_Gen_1	208	215	PF02991	0.720
LIG_LIR_Gen_1	59	67	PF02991	0.659
LIG_LIR_Gen_1	835	846	PF02991	0.533
LIG_LIR_Nem_3	208	213	PF02991	0.724
LIG_LIR_Nem_3	537	542	PF02991	0.618
LIG_LIR_Nem_3	59	64	PF02991	0.657
LIG_LIR_Nem_3	835	841	PF02991	0.509
LIG_MYND_1	585	589	PF01753	0.853
LIG_PCNA_yPIPBox_3	149	162	PF02747	0.402
LIG_SH2_CRK	210	214	PF00017	0.719
LIG_SH2_CRK	26	30	PF00017	0.824
LIG_SH2_NCK_1	26	30	PF00017	0.707
LIG_SH2_STAP1	342	346	PF00017	0.470
LIG_SH3_3	612	618	PF00018	0.706
LIG_SH3_3	734	740	PF00018	0.684
LIG_SH3_3	742	748	PF00018	0.509
LIG_SUMO_SIM_anti_2	865	870	PF11976	0.581
LIG_SUMO_SIM_par_1	459	466	PF11976	0.588
LIG_SUMO_SIM_par_1	647	655	PF11976	0.614
LIG_TRAF2_1	655	658	PF00917	0.586
LIG_TRAF2_1	832	835	PF00917	0.641
LIG_UBA3_1	648	656	PF00899	0.611
LIG_UBA3_1	765	771	PF00899	0.393
MOD_CDC14_SPxK_1	414	417	PF00782	0.737
MOD_CDC14_SPxK_1	588	591	PF00782	0.854
MOD_CDK_SPK_2	411	416	PF00069	0.637
MOD_CDK_SPK_2	744	749	PF00069	0.612
MOD_CDK_SPxK_1	411	417	PF00069	0.749
MOD_CDK_SPxK_1	585	591	PF00069	0.854
MOD_CDK_SPxxK_3	326	333	PF00069	0.656
MOD_CK1_1	117	123	PF00069	0.745
MOD_CK1_1	181	187	PF00069	0.621
MOD_CK1_1	232	238	PF00069	0.801
MOD_CK1_1	240	246	PF00069	0.631
MOD_CK1_1	270	276	PF00069	0.737
MOD_CK1_1	347	353	PF00069	0.683
MOD_CK1_1	354	360	PF00069	0.615
MOD_CK1_1	450	456	PF00069	0.758
MOD_CK1_1	486	492	PF00069	0.559
MOD_CK1_1	541	547	PF00069	0.722
MOD_CK1_1	607	613	PF00069	0.801
MOD_CK1_1	624	630	PF00069	0.599
MOD_CK1_1	652	658	PF00069	0.664
MOD_CK1_1	669	675	PF00069	0.705
MOD_CK1_1	732	738	PF00069	0.688
MOD_CK1_1	752	758	PF00069	0.799
MOD_CK1_1	94	100	PF00069	0.662
MOD_CK2_1	471	477	PF00069	0.679
MOD_CK2_1	647	653	PF00069	0.759
MOD_CK2_1	678	684	PF00069	0.624
MOD_CK2_1	772	778	PF00069	0.420
MOD_Cter_Amidation	531	534	PF01082	0.747
MOD_DYRK1A_RPxSP_1	555	559	PF00069	0.762
MOD_GlcNHglycan	116	119	PF01048	0.780
MOD_GlcNHglycan	128	131	PF01048	0.532
MOD_GlcNHglycan	223	226	PF01048	0.734
MOD_GlcNHglycan	232	235	PF01048	0.665
MOD_GlcNHglycan	26	29	PF01048	0.786
MOD_GlcNHglycan	298	302	PF01048	0.644
MOD_GlcNHglycan	307	310	PF01048	0.578
MOD_GlcNHglycan	353	356	PF01048	0.523
MOD_GlcNHglycan	473	476	PF01048	0.610
MOD_GlcNHglycan	517	520	PF01048	0.594
MOD_GlcNHglycan	554	558	PF01048	0.812
MOD_GlcNHglycan	561	564	PF01048	0.766
MOD_GlcNHglycan	566	569	PF01048	0.660
MOD_GlcNHglycan	668	671	PF01048	0.777
MOD_GlcNHglycan	690	693	PF01048	0.751
MOD_GlcNHglycan	70	74	PF01048	0.645
MOD_GlcNHglycan	82	85	PF01048	0.655
MOD_GlcNHglycan	860	863	PF01048	0.478
MOD_GlcNHglycan	93	96	PF01048	0.639
MOD_GSK3_1	106	113	PF00069	0.600
MOD_GSK3_1	134	141	PF00069	0.686
MOD_GSK3_1	177	184	PF00069	0.668
MOD_GSK3_1	221	228	PF00069	0.720
MOD_GSK3_1	267	274	PF00069	0.672
MOD_GSK3_1	30	37	PF00069	0.665
MOD_GSK3_1	347	354	PF00069	0.469
MOD_GSK3_1	438	445	PF00069	0.726
MOD_GSK3_1	463	470	PF00069	0.590
MOD_GSK3_1	48	55	PF00069	0.605
MOD_GSK3_1	521	528	PF00069	0.708
MOD_GSK3_1	534	541	PF00069	0.626
MOD_GSK3_1	555	562	PF00069	0.762
MOD_GSK3_1	604	611	PF00069	0.766
MOD_GSK3_1	666	673	PF00069	0.755
MOD_GSK3_1	714	721	PF00069	0.831
MOD_GSK3_1	725	732	PF00069	0.645
MOD_GSK3_1	744	751	PF00069	0.821
MOD_GSK3_1	76	83	PF00069	0.832
MOD_GSK3_1	807	814	PF00069	0.586
MOD_GSK3_1	822	829	PF00069	0.492
MOD_GSK3_1	90	97	PF00069	0.586
MOD_N-GLC_1	229	234	PF02516	0.780
MOD_N-GLC_1	729	734	PF02516	0.708
MOD_N-GLC_1	812	817	PF02516	0.572
MOD_N-GLC_1	858	863	PF02516	0.625
MOD_N-GLC_2	523	525	PF02516	0.576
MOD_NEK2_1	1	6	PF00069	0.705
MOD_NEK2_1	186	191	PF00069	0.617
MOD_NEK2_1	344	349	PF00069	0.632
MOD_NEK2_1	401	406	PF00069	0.766
MOD_NEK2_1	423	428	PF00069	0.700
MOD_NEK2_1	467	472	PF00069	0.662
MOD_NEK2_1	604	609	PF00069	0.760
MOD_NEK2_1	826	831	PF00069	0.637
MOD_NEK2_1	858	863	PF00069	0.513
MOD_NEK2_1	96	101	PF00069	0.619
MOD_NEK2_2	483	488	PF00069	0.592
MOD_NEK2_2	878	883	PF00069	0.348
MOD_PIKK_1	161	167	PF00454	0.559
MOD_PIKK_1	216	222	PF00454	0.712
MOD_PIKK_1	235	241	PF00454	0.488
MOD_PIKK_1	257	263	PF00454	0.464
MOD_PIKK_1	845	851	PF00454	0.517
MOD_PK_1	370	376	PF00069	0.654
MOD_PKA_1	515	521	PF00069	0.693
MOD_PKA_1	811	817	PF00069	0.569
MOD_PKA_2	126	132	PF00069	0.658
MOD_PKA_2	177	183	PF00069	0.669
MOD_PKA_2	186	192	PF00069	0.537
MOD_PKA_2	401	407	PF00069	0.846
MOD_PKA_2	423	429	PF00069	0.613
MOD_PKA_2	447	453	PF00069	0.569
MOD_PKA_2	499	505	PF00069	0.677
MOD_PKA_2	507	513	PF00069	0.552
MOD_PKA_2	515	521	PF00069	0.506
MOD_PKA_2	624	630	PF00069	0.747
MOD_PKA_2	748	754	PF00069	0.694
MOD_PKA_2	811	817	PF00069	0.569
MOD_Plk_1	344	350	PF00069	0.572
MOD_Plk_1	521	527	PF00069	0.650
MOD_Plk_1	592	598	PF00069	0.600
MOD_Plk_1	732	738	PF00069	0.717
MOD_Plk_1	864	870	PF00069	0.495
MOD_Plk_2-3	678	684	PF00069	0.624
MOD_Plk_2-3	772	778	PF00069	0.457
MOD_Plk_4	370	376	PF00069	0.693
MOD_Plk_4	396	402	PF00069	0.811
MOD_Plk_4	425	431	PF00069	0.545
MOD_Plk_4	463	469	PF00069	0.664
MOD_Plk_4	593	599	PF00069	0.602
MOD_Plk_4	801	807	PF00069	0.424
MOD_Plk_4	864	870	PF00069	0.596
MOD_Plk_4	878	884	PF00069	0.296
MOD_ProDKin_1	15	21	PF00069	0.686
MOD_ProDKin_1	280	286	PF00069	0.773
MOD_ProDKin_1	326	332	PF00069	0.767
MOD_ProDKin_1	411	417	PF00069	0.749
MOD_ProDKin_1	450	456	PF00069	0.762
MOD_ProDKin_1	534	540	PF00069	0.839
MOD_ProDKin_1	555	561	PF00069	0.766
MOD_ProDKin_1	585	591	PF00069	0.821
MOD_ProDKin_1	686	692	PF00069	0.650
MOD_ProDKin_1	725	731	PF00069	0.792
MOD_ProDKin_1	744	750	PF00069	0.810
MOD_ProDKin_1	754	760	PF00069	0.676
MOD_SUMO_rev_2	154	161	PF00179	0.674
MOD_SUMO_rev_2	436	445	PF00179	0.495
MOD_SUMO_rev_2	624	634	PF00179	0.625
MOD_SUMO_rev_2	839	846	PF00179	0.415
TRG_DiLeu_BaEn_1	312	317	PF01217	0.720
TRG_ENDOCYTIC_2	210	213	PF00928	0.723
TRG_ENDOCYTIC_2	435	438	PF00928	0.610
TRG_ER_diArg_1	186	188	PF00400	0.454
TRG_ER_diArg_1	356	359	PF00400	0.577
TRG_ER_diArg_1	401	403	PF00400	0.837
TRG_ER_diArg_1	405	407	PF00400	0.790
TRG_ER_diArg_1	415	417	PF00400	0.619
TRG_ER_diArg_1	505	508	PF00400	0.612
TRG_ER_diArg_1	515	517	PF00400	0.650
TRG_ER_diArg_1	533	535	PF00400	0.543
TRG_ER_diArg_1	542	545	PF00400	0.665
TRG_ER_diArg_1	58	61	PF00400	0.738
TRG_ER_diArg_1	67	69	PF00400	0.615
TRG_Pf-PMV_PEXEL_1	146	151	PF00026	0.679
TRG_Pf-PMV_PEXEL_1	65	70	PF00026	0.757
TRG_Pf-PMV_PEXEL_1	774	778	PF00026	0.556

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IIS1	Leishmania donovani	86%	100%
A4HNU5	Leishmania braziliensis	61%	100%
A4ICP9	Leishmania infantum	86%	100%
E9ASK5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%