LeishMANIAdb
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Putative mitogen-activated protein kinase kinase 5

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative mitogen-activated protein kinase kinase 5
Gene product:
mitogen-activated protein kinase kinase 5
Species:
Leishmania major
UniProt:
Q4Q1Z0_LEIMA
TriTrypDb:
LmjF.36.0860 , LMJLV39_360014300 * , LMJSD75_360014300
Length:
514

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. A subfamily has 2TM regions, but the majority is cytoplasmic.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 13
NetGPI no yes: 0, no: 13
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 3
GO:0110165 cellular anatomical entity 1 3

Expansion

Sequence features

Q4Q1Z0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1Z0

Function

Biological processes
Term Name Level Count
GO:0000165 MAPK cascade 4 2
GO:0001932 regulation of protein phosphorylation 7 2
GO:0001934 positive regulation of protein phosphorylation 8 2
GO:0006468 protein phosphorylation 5 14
GO:0006793 phosphorus metabolic process 3 14
GO:0006796 phosphate-containing compound metabolic process 4 14
GO:0006807 nitrogen compound metabolic process 2 14
GO:0007165 signal transduction 2 2
GO:0008152 metabolic process 1 14
GO:0009893 positive regulation of metabolic process 4 2
GO:0009966 regulation of signal transduction 4 2
GO:0009967 positive regulation of signal transduction 5 2
GO:0009987 cellular process 1 14
GO:0010562 positive regulation of phosphorus metabolic process 6 2
GO:0010604 positive regulation of macromolecule metabolic process 5 2
GO:0010646 regulation of cell communication 4 2
GO:0010647 positive regulation of cell communication 5 2
GO:0016310 phosphorylation 5 14
GO:0019220 regulation of phosphate metabolic process 6 2
GO:0019222 regulation of metabolic process 3 2
GO:0019538 protein metabolic process 3 14
GO:0023051 regulation of signaling 3 2
GO:0023056 positive regulation of signaling 4 2
GO:0031323 regulation of cellular metabolic process 4 2
GO:0031325 positive regulation of cellular metabolic process 5 2
GO:0031399 regulation of protein modification process 6 2
GO:0031401 positive regulation of protein modification process 7 2
GO:0033674 positive regulation of kinase activity 6 2
GO:0035556 intracellular signal transduction 3 2
GO:0036211 protein modification process 4 14
GO:0042325 regulation of phosphorylation 7 2
GO:0042327 positive regulation of phosphorylation 8 2
GO:0043085 positive regulation of catalytic activity 4 2
GO:0043170 macromolecule metabolic process 3 14
GO:0043405 regulation of MAP kinase activity 8 2
GO:0043406 positive regulation of MAP kinase activity 8 2
GO:0043408 regulation of MAPK cascade 6 2
GO:0043410 positive regulation of MAPK cascade 7 2
GO:0043412 macromolecule modification 4 14
GO:0043549 regulation of kinase activity 5 2
GO:0044093 positive regulation of molecular function 3 2
GO:0044237 cellular metabolic process 2 14
GO:0044238 primary metabolic process 2 14
GO:0045859 regulation of protein kinase activity 6 2
GO:0045860 positive regulation of protein kinase activity 7 2
GO:0045937 positive regulation of phosphate metabolic process 7 2
GO:0046777 protein autophosphorylation 6 2
GO:0048518 positive regulation of biological process 3 2
GO:0048522 positive regulation of cellular process 4 2
GO:0048583 regulation of response to stimulus 3 2
GO:0048584 positive regulation of response to stimulus 4 2
GO:0050789 regulation of biological process 2 2
GO:0050790 regulation of catalytic activity 3 2
GO:0050794 regulation of cellular process 3 2
GO:0051171 regulation of nitrogen compound metabolic process 4 2
GO:0051173 positive regulation of nitrogen compound metabolic process 5 2
GO:0051174 regulation of phosphorus metabolic process 5 2
GO:0051246 regulation of protein metabolic process 5 2
GO:0051247 positive regulation of protein metabolic process 6 2
GO:0051338 regulation of transferase activity 4 2
GO:0051347 positive regulation of transferase activity 5 2
GO:0060255 regulation of macromolecule metabolic process 4 2
GO:0065007 biological regulation 1 2
GO:0065009 regulation of molecular function 2 2
GO:0071704 organic substance metabolic process 2 14
GO:0071900 regulation of protein serine/threonine kinase activity 7 2
GO:0071902 positive regulation of protein serine/threonine kinase activity 8 2
GO:0080090 regulation of primary metabolic process 4 2
GO:1901564 organonitrogen compound metabolic process 3 14
GO:1902531 regulation of intracellular signal transduction 5 2
GO:1902533 positive regulation of intracellular signal transduction 6 2
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 14
GO:0003824 catalytic activity 1 14
GO:0004672 protein kinase activity 3 14
GO:0004708 MAP kinase kinase activity 5 2
GO:0004712 protein serine/threonine/tyrosine kinase activity 4 2
GO:0005488 binding 1 14
GO:0005515 protein binding 2 2
GO:0005524 ATP binding 5 14
GO:0016301 kinase activity 4 14
GO:0016740 transferase activity 2 14
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 14
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 14
GO:0017076 purine nucleotide binding 4 14
GO:0019899 enzyme binding 3 2
GO:0019900 kinase binding 4 2
GO:0019901 protein kinase binding 5 2
GO:0030554 adenyl nucleotide binding 5 14
GO:0032553 ribonucleotide binding 3 14
GO:0032555 purine ribonucleotide binding 4 14
GO:0032559 adenyl ribonucleotide binding 5 14
GO:0035639 purine ribonucleoside triphosphate binding 4 14
GO:0036094 small molecule binding 2 14
GO:0043167 ion binding 2 14
GO:0043168 anion binding 3 14
GO:0051019 mitogen-activated protein kinase binding 6 2
GO:0097159 organic cyclic compound binding 2 14
GO:0097367 carbohydrate derivative binding 2 14
GO:0140096 catalytic activity, acting on a protein 2 14
GO:1901265 nucleoside phosphate binding 3 14
GO:1901363 heterocyclic compound binding 2 14
GO:0004674 protein serine/threonine kinase activity 4 7
GO:0004707 MAP kinase activity 5 4
GO:0004140 dephospho-CoA kinase activity 5 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 136 140 PF00656 0.288
CLV_C14_Caspase3-7 207 211 PF00656 0.288
CLV_C14_Caspase3-7 430 434 PF00656 0.557
CLV_NRD_NRD_1 102 104 PF00675 0.270
CLV_NRD_NRD_1 304 306 PF00675 0.448
CLV_NRD_NRD_1 414 416 PF00675 0.666
CLV_NRD_NRD_1 74 76 PF00675 0.323
CLV_PCSK_KEX2_1 102 104 PF00082 0.291
CLV_PCSK_KEX2_1 304 306 PF00082 0.382
CLV_PCSK_KEX2_1 74 76 PF00082 0.352
CLV_PCSK_SKI1_1 159 163 PF00082 0.339
CLV_PCSK_SKI1_1 177 181 PF00082 0.448
CLV_PCSK_SKI1_1 404 408 PF00082 0.524
CLV_PCSK_SKI1_1 486 490 PF00082 0.577
CLV_PCSK_SKI1_1 88 92 PF00082 0.343
CLV_Separin_Metazoa 310 314 PF03568 0.382
DEG_APCC_DBOX_1 101 109 PF00400 0.288
DEG_APCC_DBOX_1 158 166 PF00400 0.288
DOC_CKS1_1 113 118 PF01111 0.390
DOC_CKS1_1 334 339 PF01111 0.505
DOC_CYCLIN_yClb1_LxF_4 509 514 PF00134 0.572
DOC_CYCLIN_yCln2_LP_2 145 151 PF00134 0.319
DOC_CYCLIN_yCln2_LP_2 312 318 PF00134 0.280
DOC_MAPK_gen_1 79 87 PF00069 0.342
DOC_PP2B_LxvP_1 280 283 PF13499 0.382
DOC_PP4_FxxP_1 113 116 PF00568 0.442
DOC_USP7_MATH_1 348 352 PF00917 0.632
DOC_USP7_MATH_1 355 359 PF00917 0.585
DOC_USP7_MATH_1 361 365 PF00917 0.640
DOC_USP7_MATH_1 424 428 PF00917 0.644
DOC_USP7_MATH_1 431 435 PF00917 0.563
DOC_USP7_MATH_1 441 445 PF00917 0.559
DOC_USP7_MATH_2 283 289 PF00917 0.280
DOC_WW_Pin1_4 112 117 PF00397 0.323
DOC_WW_Pin1_4 219 224 PF00397 0.288
DOC_WW_Pin1_4 298 303 PF00397 0.319
DOC_WW_Pin1_4 333 338 PF00397 0.603
DOC_WW_Pin1_4 344 349 PF00397 0.590
DOC_WW_Pin1_4 350 355 PF00397 0.528
DOC_WW_Pin1_4 370 375 PF00397 0.661
LIG_14-3-3_CanoR_1 258 267 PF00244 0.328
LIG_14-3-3_CanoR_1 305 315 PF00244 0.278
LIG_14-3-3_CanoR_1 319 325 PF00244 0.422
LIG_14-3-3_CanoR_1 362 369 PF00244 0.671
LIG_14-3-3_CanoR_1 370 374 PF00244 0.748
LIG_14-3-3_CanoR_1 486 495 PF00244 0.736
LIG_Actin_WH2_2 244 260 PF00022 0.319
LIG_Actin_WH2_2 481 496 PF00022 0.558
LIG_APCC_ABBAyCdc20_2 172 178 PF00400 0.348
LIG_APCC_ABBAyCdc20_2 415 421 PF00400 0.536
LIG_BIR_II_1 1 5 PF00653 0.551
LIG_FHA_1 113 119 PF00498 0.382
LIG_FHA_1 169 175 PF00498 0.416
LIG_FHA_1 188 194 PF00498 0.423
LIG_FHA_1 307 313 PF00498 0.319
LIG_FHA_1 319 325 PF00498 0.632
LIG_FHA_1 334 340 PF00498 0.719
LIG_FHA_1 480 486 PF00498 0.523
LIG_FHA_2 205 211 PF00498 0.288
LIG_FHA_2 305 311 PF00498 0.378
LIG_FHA_2 382 388 PF00498 0.474
LIG_FHA_2 428 434 PF00498 0.559
LIG_FHA_2 487 493 PF00498 0.599
LIG_GBD_Chelix_1 394 402 PF00786 0.414
LIG_LIR_Apic_2 112 116 PF02991 0.319
LIG_LIR_Apic_2 217 223 PF02991 0.382
LIG_LIR_Gen_1 130 138 PF02991 0.270
LIG_LIR_LC3C_4 239 244 PF02991 0.323
LIG_LIR_Nem_3 120 125 PF02991 0.272
LIG_LIR_Nem_3 144 149 PF02991 0.492
LIG_LIR_Nem_3 263 269 PF02991 0.288
LIG_LIR_Nem_3 344 349 PF02991 0.603
LIG_NRBOX 508 514 PF00104 0.637
LIG_PDZ_Class_2 509 514 PF00595 0.636
LIG_Pex14_2 121 125 PF04695 0.288
LIG_SH2_CRK 146 150 PF00017 0.319
LIG_SH2_CRK 254 258 PF00017 0.344
LIG_SH2_STAT5 117 120 PF00017 0.382
LIG_SH2_STAT5 167 170 PF00017 0.382
LIG_SH3_3 145 151 PF00018 0.309
LIG_SH3_3 296 302 PF00018 0.382
LIG_SH3_3 328 334 PF00018 0.696
LIG_SH3_3 336 342 PF00018 0.639
LIG_SUMO_SIM_anti_2 52 60 PF11976 0.420
LIG_SUMO_SIM_par_1 46 53 PF11976 0.417
LIG_SUMO_SIM_par_1 83 89 PF11976 0.267
LIG_WRC_WIRS_1 118 123 PF05994 0.260
MOD_CDC14_SPxK_1 222 225 PF00782 0.288
MOD_CDC14_SPxK_1 301 304 PF00782 0.319
MOD_CDK_SPxK_1 219 225 PF00069 0.288
MOD_CDK_SPxK_1 298 304 PF00069 0.319
MOD_CDK_SPxxK_3 298 305 PF00069 0.319
MOD_CDK_SPxxK_3 350 357 PF00069 0.690
MOD_CDK_SPxxK_3 372 379 PF00069 0.681
MOD_CK1_1 364 370 PF00069 0.772
MOD_CK1_1 427 433 PF00069 0.723
MOD_CK1_1 444 450 PF00069 0.446
MOD_CK1_1 69 75 PF00069 0.306
MOD_CK2_1 138 144 PF00069 0.382
MOD_CK2_1 14 20 PF00069 0.582
MOD_CK2_1 199 205 PF00069 0.288
MOD_CK2_1 304 310 PF00069 0.368
MOD_CK2_1 372 378 PF00069 0.690
MOD_CK2_1 49 55 PF00069 0.404
MOD_CK2_1 494 500 PF00069 0.665
MOD_Cter_Amidation 413 416 PF01082 0.505
MOD_DYRK1A_RPxSP_1 370 374 PF00069 0.531
MOD_GlcNHglycan 16 19 PF01048 0.573
MOD_GlcNHglycan 294 297 PF01048 0.377
MOD_GlcNHglycan 350 353 PF01048 0.497
MOD_GlcNHglycan 357 360 PF01048 0.599
MOD_GlcNHglycan 426 429 PF01048 0.746
MOD_GlcNHglycan 433 436 PF01048 0.795
MOD_GlcNHglycan 443 446 PF01048 0.510
MOD_GlcNHglycan 468 471 PF01048 0.706
MOD_GlcNHglycan 473 476 PF01048 0.708
MOD_GlcNHglycan 69 72 PF01048 0.397
MOD_GSK3_1 210 217 PF00069 0.321
MOD_GSK3_1 28 35 PF00069 0.387
MOD_GSK3_1 344 351 PF00069 0.635
MOD_GSK3_1 361 368 PF00069 0.688
MOD_GSK3_1 427 434 PF00069 0.674
MOD_GSK3_1 43 50 PF00069 0.368
MOD_GSK3_1 495 502 PF00069 0.614
MOD_N-GLC_2 45 47 PF02516 0.389
MOD_NEK2_1 138 143 PF00069 0.300
MOD_NEK2_1 168 173 PF00069 0.493
MOD_NEK2_1 185 190 PF00069 0.280
MOD_NEK2_1 198 203 PF00069 0.335
MOD_NEK2_1 204 209 PF00069 0.326
MOD_NEK2_1 214 219 PF00069 0.348
MOD_NEK2_1 369 374 PF00069 0.718
MOD_NEK2_1 493 498 PF00069 0.581
MOD_NEK2_2 117 122 PF00069 0.260
MOD_PKA_1 304 310 PF00069 0.361
MOD_PKA_2 304 310 PF00069 0.348
MOD_PKA_2 318 324 PF00069 0.509
MOD_PKA_2 361 367 PF00069 0.666
MOD_PKA_2 369 375 PF00069 0.743
MOD_PKA_2 493 499 PF00069 0.619
MOD_PKA_2 78 84 PF00069 0.321
MOD_Plk_1 389 395 PF00069 0.408
MOD_Plk_2-3 381 387 PF00069 0.491
MOD_Plk_4 117 123 PF00069 0.331
MOD_Plk_4 127 133 PF00069 0.258
MOD_Plk_4 163 169 PF00069 0.491
MOD_Plk_4 210 216 PF00069 0.351
MOD_Plk_4 28 34 PF00069 0.447
MOD_ProDKin_1 112 118 PF00069 0.323
MOD_ProDKin_1 219 225 PF00069 0.288
MOD_ProDKin_1 298 304 PF00069 0.319
MOD_ProDKin_1 333 339 PF00069 0.603
MOD_ProDKin_1 344 350 PF00069 0.589
MOD_ProDKin_1 370 376 PF00069 0.655
MOD_SUMO_rev_2 188 196 PF00179 0.386
TRG_DiLeu_BaEn_1 508 513 PF01217 0.638
TRG_DiLeu_BaEn_2 127 133 PF01217 0.288
TRG_DiLeu_LyEn_5 508 513 PF01217 0.536
TRG_ENDOCYTIC_2 122 125 PF00928 0.348
TRG_ENDOCYTIC_2 146 149 PF00928 0.319
TRG_ENDOCYTIC_2 254 257 PF00928 0.351
TRG_ER_diArg_1 101 103 PF00400 0.270
TRG_ER_diArg_1 304 306 PF00400 0.319
TRG_ER_diArg_1 73 75 PF00400 0.323
TRG_Pf-PMV_PEXEL_1 463 467 PF00026 0.513
TRG_Pf-PMV_PEXEL_1 486 491 PF00026 0.557

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P8X6 Leptomonas seymouri 33% 100%
A0A0N1I0B6 Leptomonas seymouri 57% 96%
A0A1X0P919 Trypanosomatidae 54% 100%
A0A1X0PAW2 Trypanosomatidae 34% 100%
A0A3Q8IIG1 Leishmania donovani 30% 100%
A0A3Q8IND3 Leishmania donovani 90% 98%
A0A3Q8IPJ5 Leishmania donovani 28% 100%
A0A3Q8IVR8 Leishmania donovani 27% 100%
A0A3S7WYP4 Leishmania donovani 34% 100%
A0A3S7X2W3 Leishmania donovani 37% 100%
A0A3S7X7Y2 Leishmania donovani 35% 100%
A0A422NT49 Trypanosoma rangeli 27% 72%
A4H4S9 Leishmania braziliensis 22% 100%
A4H7V0 Leishmania braziliensis 26% 72%
A4HAS1 Leishmania braziliensis 33% 100%
A4HDU3 Leishmania braziliensis 34% 100%
A4HFA1 Leishmania braziliensis 29% 100%
A4HFC9 Leishmania braziliensis 28% 78%
A4HHN1 Leishmania braziliensis 36% 100%
A4HNT2 Leishmania braziliensis 27% 100%
A4HNU6 Leishmania braziliensis 77% 98%
A4HYH4 Leishmania infantum 28% 100%
A4I140 Leishmania infantum 34% 100%
A4I435 Leishmania infantum 30% 100%
A4I4U6 Leishmania infantum 37% 100%
A4I9Y5 Leishmania infantum 35% 100%
A4ICP8 Leishmania infantum 90% 98%
A4ICR2 Leishmania infantum 27% 100%
A8WUG4 Caenorhabditis briggsae 23% 86%
E9ALJ2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 37% 100%
E9APX7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 72%
E9AS98 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9ASJ2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9ASK6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 98%
E9AX78 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
E9B4Z4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
P51137 Medicago sativa 25% 100%
Q00168 Drosophila melanogaster 24% 97%
Q05116 Xenopus laevis 36% 100%
Q0PKV7 Leishmania mexicana 90% 98%
Q12701 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 28% 87%
Q4Q204 Leishmania major 27% 100%
Q4Q2Z2 Leishmania major 34% 100%
Q4Q7W2 Leishmania major 32% 100%
Q4QA98 Leishmania major 34% 100%
Q4QFK4 Leishmania major 26% 82%
Q9U6V4 Leishmania donovani 28% 100%
Q9Y077 Leishmania major 37% 100%
V5BDF5 Trypanosoma cruzi 27% 78%
V5BQF4 Trypanosoma cruzi 54% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS