Nfu_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NifU-like domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q1Y8_LEIMA

TriTrypDb:

LmjF.36.0880 , LMJLV39_360014500 , LMJSD75_360014500

Length:

311

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

Q4Q1Y8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1Y8

Function

Biological processes
Term	Name	Level	Count
GO:0006790	sulfur compound metabolic process	3	15
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	15
GO:0009987	cellular process	1	15
GO:0016043	cellular component organization	3	15
GO:0016226	iron-sulfur cluster assembly	4	15
GO:0019538	protein metabolic process	3	3
GO:0022607	cellular component assembly	4	15
GO:0031163	metallo-sulfur cluster assembly	5	15
GO:0043170	macromolecule metabolic process	3	3
GO:0044237	cellular metabolic process	2	15
GO:0044238	primary metabolic process	2	3
GO:0051604	protein maturation	4	3
GO:0071704	organic substance metabolic process	2	3
GO:0071840	cellular component organization or biogenesis	2	15
GO:0097428	protein maturation by iron-sulfur cluster transfer	5	3
GO:1901564	organonitrogen compound metabolic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	15
GO:0005506	iron ion binding	6	15
GO:0043167	ion binding	2	15
GO:0043169	cation binding	3	15
GO:0046872	metal ion binding	4	15
GO:0046914	transition metal ion binding	5	15
GO:0051536	iron-sulfur cluster binding	3	15
GO:0051539	4 iron, 4 sulfur cluster binding	4	3
GO:0051540	metal cluster binding	2	15

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	235	239	PF00656	0.438
CLV_NRD_NRD_1	54	56	PF00675	0.435
CLV_PCSK_KEX2_1	54	56	PF00082	0.475
CLV_PCSK_SKI1_1	188	192	PF00082	0.259
CLV_PCSK_SKI1_1	242	246	PF00082	0.220
CLV_PCSK_SKI1_1	27	31	PF00082	0.433
CLV_PCSK_SKI1_1	274	278	PF00082	0.615
CLV_PCSK_SKI1_1	287	291	PF00082	0.427
CLV_Separin_Metazoa	189	193	PF03568	0.420
DEG_APCC_DBOX_1	291	299	PF00400	0.612
DOC_CKS1_1	67	72	PF01111	0.281
DOC_CYCLIN_RxL_1	185	193	PF00134	0.311
DOC_MAPK_MEF2A_6	214	222	PF00069	0.439
DOC_PP1_RVXF_1	139	145	PF00149	0.316
DOC_PP1_RVXF_1	205	212	PF00149	0.408
DOC_PP1_RVXF_1	97	104	PF00149	0.281
DOC_PP2B_LxvP_1	17	20	PF13499	0.484
DOC_PP4_FxxP_1	123	126	PF00568	0.257
DOC_PP4_FxxP_1	77	80	PF00568	0.260
DOC_USP7_MATH_1	31	35	PF00917	0.687
DOC_USP7_MATH_1	80	84	PF00917	0.328
DOC_USP7_MATH_2	116	122	PF00917	0.278
DOC_USP7_UBL2_3	274	278	PF12436	0.475
DOC_WW_Pin1_4	15	20	PF00397	0.559
DOC_WW_Pin1_4	159	164	PF00397	0.358
DOC_WW_Pin1_4	21	26	PF00397	0.542
DOC_WW_Pin1_4	293	298	PF00397	0.570
DOC_WW_Pin1_4	66	71	PF00397	0.284
LIG_14-3-3_CanoR_1	3	8	PF00244	0.439
LIG_14-3-3_CanoR_1	47	53	PF00244	0.456
LIG_14-3-3_CanoR_1	54	58	PF00244	0.452
LIG_Actin_WH2_2	38	56	PF00022	0.346
LIG_deltaCOP1_diTrp_1	138	144	PF00928	0.258
LIG_eIF4E_1	263	269	PF01652	0.349
LIG_FHA_1	179	185	PF00498	0.418
LIG_FHA_1	213	219	PF00498	0.448
LIG_FHA_1	250	256	PF00498	0.438
LIG_FHA_1	294	300	PF00498	0.475
LIG_FHA_1	4	10	PF00498	0.435
LIG_FHA_1	44	50	PF00498	0.590
LIG_FHA_1	74	80	PF00498	0.203
LIG_FHA_2	133	139	PF00498	0.418
LIG_FHA_2	166	172	PF00498	0.442
LIG_FHA_2	177	183	PF00498	0.443
LIG_FHA_2	233	239	PF00498	0.420
LIG_LIR_Apic_2	121	126	PF02991	0.236
LIG_LIR_Apic_2	76	80	PF02991	0.336
LIG_LIR_Gen_1	132	142	PF02991	0.282
LIG_LIR_Gen_1	166	174	PF02991	0.382
LIG_LIR_Gen_1	301	308	PF02991	0.490
LIG_LIR_Gen_1	82	89	PF02991	0.276
LIG_LIR_Nem_3	132	137	PF02991	0.276
LIG_LIR_Nem_3	138	142	PF02991	0.276
LIG_LIR_Nem_3	264	269	PF02991	0.385
LIG_LIR_Nem_3	301	305	PF02991	0.524
LIG_LIR_Nem_3	82	87	PF02991	0.258
LIG_Pex14_1	44	48	PF04695	0.363
LIG_SH2_CRK	266	270	PF00017	0.418
LIG_SH2_GRB2like	134	137	PF00017	0.262
LIG_SH2_NCK_1	134	138	PF00017	0.262
LIG_SH2_STAT5	134	137	PF00017	0.379
LIG_SH2_STAT5	153	156	PF00017	0.212
LIG_SH2_STAT5	167	170	PF00017	0.331
LIG_SH2_STAT5	7	10	PF00017	0.440
LIG_SH3_2	22	27	PF14604	0.385
LIG_SH3_3	16	22	PF00018	0.561
LIG_TYR_ITIM	300	305	PF00017	0.583
LIG_WRC_WIRS_1	146	151	PF05994	0.239
LIG_WRC_WIRS_1	84	89	PF05994	0.373
MOD_CDC14_SPxK_1	162	165	PF00782	0.366
MOD_CDC14_SPxK_1	24	27	PF00782	0.392
MOD_CDK_SPxK_1	159	165	PF00069	0.367
MOD_CDK_SPxK_1	21	27	PF00069	0.383
MOD_CK1_1	132	138	PF00069	0.328
MOD_CK1_1	145	151	PF00069	0.178
MOD_CK1_1	23	29	PF00069	0.637
MOD_CK1_1	232	238	PF00069	0.446
MOD_CK1_1	33	39	PF00069	0.619
MOD_CK1_1	43	49	PF00069	0.589
MOD_CK1_1	83	89	PF00069	0.290
MOD_CK2_1	137	143	PF00069	0.339
MOD_CK2_1	165	171	PF00069	0.410
MOD_CK2_1	176	182	PF00069	0.378
MOD_GSK3_1	212	219	PF00069	0.408
MOD_GSK3_1	225	232	PF00069	0.434
MOD_GSK3_1	29	36	PF00069	0.647
MOD_GSK3_1	43	50	PF00069	0.646
MOD_N-GLC_1	293	298	PF02516	0.387
MOD_N-GLC_2	158	160	PF02516	0.368
MOD_NEK2_1	154	159	PF00069	0.406
MOD_NEK2_1	30	35	PF00069	0.582
MOD_NEK2_1	48	53	PF00069	0.464
MOD_NEK2_1	73	78	PF00069	0.429
MOD_PIKK_1	105	111	PF00454	0.316
MOD_PIKK_1	229	235	PF00454	0.420
MOD_PK_1	127	133	PF00069	0.260
MOD_PKA_2	53	59	PF00069	0.423
MOD_Plk_1	142	148	PF00069	0.262
MOD_Plk_1	165	171	PF00069	0.450
MOD_Plk_4	118	124	PF00069	0.241
MOD_Plk_4	145	151	PF00069	0.257
MOD_Plk_4	165	171	PF00069	0.284
MOD_Plk_4	3	9	PF00069	0.441
MOD_Plk_4	48	54	PF00069	0.559
MOD_Plk_4	83	89	PF00069	0.354
MOD_ProDKin_1	15	21	PF00069	0.558
MOD_ProDKin_1	159	165	PF00069	0.367
MOD_ProDKin_1	293	299	PF00069	0.570
MOD_ProDKin_1	66	72	PF00069	0.284
MOD_SUMO_rev_2	171	179	PF00179	0.368
MOD_SUMO_rev_2	202	209	PF00179	0.408
TRG_DiLeu_BaEn_1	264	269	PF01217	0.355
TRG_ENDOCYTIC_2	134	137	PF00928	0.309
TRG_ENDOCYTIC_2	153	156	PF00928	0.225
TRG_ENDOCYTIC_2	167	170	PF00928	0.307
TRG_ENDOCYTIC_2	266	269	PF00928	0.343
TRG_ENDOCYTIC_2	302	305	PF00928	0.530
TRG_ER_diArg_1	53	55	PF00400	0.475

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2Q0	Leptomonas seymouri	34%	100%
A0A0N1I735	Leptomonas seymouri	81%	100%
A0A0S4IVB5	Bodo saltans	58%	100%
A0A1X0P8F8	Trypanosomatidae	68%	100%
A0A3S5H7F5	Leishmania donovani	33%	100%
A0A3S7XAI2	Leishmania donovani	95%	100%
A4HEM5	Leishmania braziliensis	34%	100%
A4HNU8	Leishmania braziliensis	89%	100%
A4I1V6	Leishmania infantum	33%	100%
A4ICP6	Leishmania infantum	95%	100%
B3MRT7	Drosophila ananassae	26%	100%
B3NYF7	Drosophila erecta	27%	100%
B4H303	Drosophila persimilis	28%	100%
B4IMF6	Drosophila sechellia	27%	100%
B4JWR9	Drosophila grimshawi	27%	100%
B4M375	Drosophila virilis	28%	100%
B4NE93	Drosophila willistoni	28%	100%
B4PZ52	Drosophila yakuba	29%	100%
B4R3T1	Drosophila simulans	28%	100%
B5DKJ8	Drosophila pseudoobscura pseudoobscura	28%	100%
D0A2R6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	100%
E9ASK8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9AY01	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
P32860	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
Q4Q9H2	Leishmania major	35%	100%
Q8SY96	Drosophila melanogaster	27%	100%
Q9C8J2	Arabidopsis thaliana	31%	100%
Q9QZ23	Mus musculus	33%	100%
V5DRN0	Trypanosoma cruzi	72%	100%